研究業績 学会発表（2006年から）
英語論文
2013年
・Variations in PROKR2, but not PROK2, are associated with hypopituitarism and septo-optic dysplasia.
McCabe MJ, Gaston-Massuet C, Gregory LC, Alatzoglou KS, Tziaferi V, Sbai O, Rondard P, Masumoto KH, Nagano M, Shigeyoshi Y, Pfeifer M, Hulse T, Buchanan CR, Pitteloud N, Martinez-Barbera JP, Dattani MT.
J Clin Endocrinol Metab. 2013 98(3):E547-57・FSH induces the development of circadian clockwork in rat granulosa cells via a gap junction protein Cx43-dependent pathway.
Chen H, Zhao L, Chu G, Kito G, Yamauchi N, Shigeyoshi Y, Hashimoto S, Hattori MA.
Am J Physiol Endocrinol Metab. 2013 304(6):E566-75・Circadian expression and specific localization of a sialyltransferase gene in the suprachiasmatic nucleus.
Hamada Y, Saigoh K, Masumoto KH, Nagano M, Kusunoki S, Shigeyoshi Y.
Neurosci Lett. 2013 535:12-7
2012年
・Transcriptome tomography for brain analysis in the web-accessible anatomical space.
Okamura-Oho Y, Shimokawa K, Takemoto S, Hirakiyama A, Nakamura S, Tsujimura Y, Nishimura M, Kasukawa T, Masumoto KH, Nikaido I, Shigeyoshi Y, Ueda HR, Song G, Gee J, Himeno R, Yokota H.
PLoS One. 2012;7(9):e45373・Profile of tyrosine hydroxylase-expressing neurons in the olfactory bulb of prokineticin type 2 receptor-deficient mice during embryonic development.
Atsuko Kubo, Mamoru Nagano, Mitsugu Sujino, Koh-hei Masumoto, Chihiro Yamazaki, Toshio Terashima and Yasufumi Shigeyoshi Acta Med Kinki Univ Vol.37, No.1 25-33, 2012・Application of layer-specific markers in the evaluation of abnormal cytoarchitecture in the olfactory bulb of prokineticin receptor 2 deficient mice
Chihiro Yamazaki, Mamoru Nagano, Mitsugu Sujino, Atsuko Kubo,Toshio Terashima, Hitoshi Ozawa and Yasufumi Shigeyoshi Acta Med Kinki Univ Vol.37, No.1 35-43, 2012・Rev-erbα regulates circadian rhythms and StAR expression in rat granulosa cells as identified by the agonist GSK4112.
Chen H, Chu G, Shao L, Yamauchi N, Shigeyoshi Y, Hashimoto S, Hattori MA. Biochem Biophys Res Commun.420(2):374-9 2012 Mar 8.・Differential Entrainment of Peripheral Clocks in the Rat by Glucocorticoid and Feeding.
Mitsugu Sujino, Keiichi Furukawa, Satoshi Koinuma, Atsuko Fujioka, Mamoru Nagano,Masayuki Iigo, and Yasufumi Shigeyoshi Endocrinology en.2011-1794・Contribution of FSH and triiodothyronine to the development of circadian clocks during granulosa cell maturation.
Chu G, Misawa I, Chen H, Yamauchi N, Shigeyoshi Y, Hashimoto S, Hattori MA.
Am J Physiol Endocrinol Metab. 2012 Mar 15;302(6):E645-53.2011年
・Prokr2-deficient mice display vascular dysmorphology of the fetal testes: potential implications for Kallmann syndrome aetiology.
Svingen T, McClelland KS, Masumoto K, Sujino M, Nagano M, Shigeyoshi Y, Koopman P.
Sex Dev. 2011;5(6):294-303・Regional variation in mitochondrial DNA copy number in mouse brain.
Fuke S, Kubota-Sakashita M, Kasahara T, Shigeyoshi Y, Kato T. Biochim Biophys Acta.2011 Mar;1807(3):270-4. Epub 2010 Dec 8. PubMed PMID: 21145305.・Quantitative expression profile of distinct functional regions in the adult mouse brain. Kasukawa T, Masumoto KH, Nikaido I, Nagano M, Uno KD, Tsujino K, Hanashima C, Shigeyoshi Y, Ueda HR. PLoS One. 2011;6(8):e23228. Epub 2011 Aug 12.
・Alterations of Circadian Clockworks During Differentiation and Apoptosis of Rat Ovarian Cells.
Chu G, Yoshida K, Narahara S, Uchikawa M, Kawamura M, Yamauchi N, Xi Y, Shigeyoshi Y, Hashimoto S, Hattori MA. Chronobiol Int. 2011 Jul.;28(6):477-487.・Angiopoietin-Like 2, a Circadian Gene, Improves Type 2 Diabetes Through Potentiation of Insulin Sensitivity in Mice Adipocytes. Kitazawa M, Nagano M, Masumoto KH, Shigeyoshi Y, Natsume T, Hashimoto S. Endocrinology 2011 May 17. 152(7):2558-67.
2010年
・「三次元CT画像を用いた冠動脈の起始異常および開口部起始位置の解剖学的調査 」工藤正幸、村上卓道、中内祥文、宮崎俊一、重吉康史 近畿大学医学雑誌 第35巻 3，4号 177p−184p 平成22年12月
・Acute Induction of Eya3 by Late-Night Light Stimulation Triggers TSHβ Expression in Photoperiodism. Masumoto KH, Ukai-Tadenuma M, Kasukawa T, Nagano M, Uno KD, Tsujino K, Horikawa K, Shigeyoshi Y, Ueda HR. Curr Biol. 2010 Dec 1. 20（24）：2199-2206
・Development of the circadian oscillator during differentiation of mouse embryonic stem cells in vitro. Yagita K, Horie K, Koinuma S, Nakamura W, Yamanaka I, Urasaki A, Shigeyoshi Y, Kawakami K, Shimada S, Takeda J, Uchiyama Y. proc Natl .Acad .Sci .U S A 2010 Feb 23 ;107(8):3846-51.
2009年
・Inhibitors Affecting Period-length of Mammalian Cellular Circadian Clock. Yagita K, Yamanaka I, Koinuma S, Shigeyoshi Y, Uchiyama Y. Mini Screening ofKinase Acta Histochem Cytochem. 2009 Jun 27;42(3):89-93.・rPer1 and rPer2 induction during phases of the circadian cycle critical for light resetting of the circadian clock. Mamoru Nagano, Akihito Adachi, Koh-hei Masumoto, Elizabeth Meyer-Bernstein, and Yasufumi Shigeyoshi Brain research 2009 1289:37-48.
・Kinetics of blood glucose in mice carrying hemizygous Pax6. NItta Y, Shigeyoshi Y, Nakagata N, Kaneko T, Nitta K, Harada T, Ishizaki F, and Townsend J. Exp. Anim. 2009 58(2);105-112
・The resetting of the circadian rhythm by Prostaglandin J(2) is distinctly phase-dependent. Koinuma S, Yagita K, Fujioka A, Takashima N, Takumi T, Shigeyoshi Y. FEBS Lett. 2009 583(2):413-8
2008年
・Analysis and synthesis of high-amplitude Cis-elements in the mammalian circadian clock. Kumaki Y, Ukai-Tadenuma M, Uno KD, Nishio J, Masumoto KH, Nagano M, Komori T, Shigeyoshi Y, Hogenesch JB, Ueda HR.
Proc Natl Acad Sci U S A. 2008 105(39) 14946-51.・Leukemia inhibitory factor regulates trophoblast giant cell differentiation via Janus kinase 1-signal transducer and activator of transcription 3-suppressor of cytokine signaling 3 pathway. Takahashi Y, Takahashi M, Carpino N, Jou ST, Chao JR, Tanaka S, Shigeyoshi Y, Parganas E, Ihle JN. Mol Endocrinol. 2008 22(7) 1673-81.
・Modulatory effects of 5-fluorouracil on the rhythmic expression of circadian clock genes: a possible mechanism of chemotherapy-induced circadian rhythm disturbances. Biochem Pharmacol. Terazono H, Hamdan A, Matsunaga N, Hayasaka N, Kaji H, Egawa T, Makino K, Shigeyoshi Y, Koyanagi S, Ohdo S. 2008 75(8) 1616-22
2007年
・Anti-human placental antigen complex X-P2 (hPAX-P2) anti-serum recognizes C-terminus of huntingtin-associated protein 1A common to 1B as a determinant marker for the stigmoid body. Fujinaga R, Yanai A, Nakatsuka H, Yoshida K, Takeshita Y, Uozumi K, Zhao C, Hirata K, Kokubu K, Nagano M, Shinoda K. Histochem Cell Biol. 128(4):335-48,2007 .
・Melanopsin-dependent photo-perturbation reveals desynchronization underlying the singularity of mammalian circadian clocks. Ukai H, Kobayashi1 TJ, Nagano M, Masumoto K, Mitsugu S, Kondo T, Yagita K, Shigeyoshi Y and Ueda H R Nature Cell Biology 9, 1327-1334,2007
・Temporal profile of circadian clock gene expression in a transplanted suprachiasmatic nucleus and peripheral tissues.Sujino M, Nagano M , Fujioka A , Shigeyoshi Y and Inouye ST European Journal of neuroscience 26(10)2731-8, 2007
・Presence of robust circadian clock oscillation under constitutive over-expression of mCry1 in rat-1 fibroblasts. Yamanaka I, Koinuma S, Shigeyoshi Y, Uchiyama Y, Yagita K. FEBS Lett. 581(21):4098-102, 2007
・LA activates posttranscriptional expression of an essential mammalian clock protein, PERIOD1. Kojima S, Matsumoto K, Hirose M, Shimada M, Nagano M, Shigeyoshi Y, Hoshino SI, Ui-Tei K, Saigo K, Green CB, Sakaki Y, Tei H. Proc Natl Acad Sci U S A. 104:1859-1864 , 2007
2006年
・Application of luminescence microscope with novel optical system for detection of gene expression pattern of individual cells. Hatta-Ohashi Y., Hayasaka N., Takahashi T., Shigeyoshi Y., Suzuki H. Bioluminescence and chemiluminescence 45-49,2006
・Gq/11-induced intracellular calcium mobilization mediates Per2 acute inductionin Rat-1 fibroblasts. Takashima N, Fujioka A, Hayasaka N, Matsuo A, Takasaki J & Shigeyoshi Y Genes to Cells 11(9):1039-49 2006
・ Circadian rhythm generation in a glioma cell line. Fujioka A, Takashima N and Shigeyoshi Y. Biochem Biophys Res Commun. 346(1):169-174, 2006
・ Distinct localization of prokineticin 2 and prokineticin receptor 2 mRNAs in the rat suprachiasmatic nucleus. Masumoto KH, Nagano M, Takashima N, Hayasaka N, Hiyama H, Matsumoto S, Inouye ST, and Shigeyoshi Y. Eur J Neurosci. 23(11):2959-2970, 2006
・ Matsushime H, Furuichi K, and Shigeyoshi Y. Abnormal development of the olfactory bulb and reproductive system in mice lacking prokineticin receptor PKR2. Matsumoto S, Yamazaki C, Masumoto KH, Nagano M, Naito M, Soga T, Hiyama H, Matsumoto M, Takasaki J, Kamohara M, Matsuo A, Ishii H, Kobori M, Katoh M, Proc Natl Acad Sci U S A. 103(11), 4140：4145, 2006
2005年
・ System-level identification of transcriptional circuits underlying mammalian circadian clocks. Ueda HR, Hayashi S, Chen W, Sano M, Machida M, Shigeyoshi Y, Iino M, Hashimoto S. Nat Genet. 2005 37(2):187-192. 2005
・Molecular cloning and characterization of a novel Gq-coupled orphan receptor ﾊﾊGPRg1 exclusively expressed in the central nervous system. Matsuo A, Matsumoto SI, Nagano M, Masumoto KH, Takasaki J,ﾊ Matsumoto M, Kobori M, Katoh M, Shigeyoshi Y. Biochem Biophys Res Commun. 27;331(1):363-369. 2005
・In situ Identification of Hepatitis C Virus RNA in muscle. Neurology. Ito H., Ito Hidefumi, Nagano M., Nakano S., Nakano S., Shigeyoshi Y., and Kusaka H. 64(6): 1073-1075. 2005
2004年
・Neuroanatomical distribution of Huntingtin-associated protein 1-mRNA in the male mouse brain. Fujinaga R, Kawano J, Matsuzaki Y, Kamei K, Yanai A, Sheng Z, Tanaka M, Nakahama K, Nagano M, Shinoda K.
J Comp Neurol. 2004 Oct 4;478(1):88-109.・FOS expression in orexin neurons following muscimol perfusion of preoptic area. Satoh, S., Matsumura, H., Fujioka, A., Nakajima, T., Kanbayashi, T., Nishino, S., Shigeyoshi, Y., Yoneda, H. Neuroreport,15, 1127-1131 (2004)
・A partial hepatectomy results in altered expression of clock-related and cyclic glyceraldehyde 3--phosphate dehydrogenase (GAPDH) genes. Iwasaki, T., Ken-ichi Nakahama, K., Mamoru Nagano M., Atsuko Fujioka A., Harumasa Ohyanagi, H., Yasufumi Shigeyoshi, Y. Life Sciences, 74,3093-3102(2004)
2003年
・An abrupt shift in the day:night cycle causes desynchrony in the mammalian circadian center. Nagano, M., Adachi, A., Nakahama, K., Nakamura, T., Tamada, M., Meyer-Bernstein, E., Sehgal, A, and Shigeyoshi, Y. J. Neurosci. 23, 6141-6151 (2003)
・Two types of VIP neuronal components in rat suprachiasmatic nucleus. Kawamoto, K., Nagano, M., Kanda, F., Chihara, K., Shigeyoshi, Y., Okamura, H. J Neurosci. Res. 74, 852-857. (2003)
・ Effect of phosphodiesterase type 4 on circadian clock gene Per1 transcription. Masumoto K.H., Fujioka A., Nakahama K., Inouye S.T., Shigeyoshi Y. Biochem Biophys Res Commun. 306, 781-785 (2003)
・Inhibition of rostral basal forebrain neurons neurons promtes wakefulness and induces FOS in orexin neurons. Satoh S, Nakahama K, Shigeyoshi Y., et al Eur. J. Neurosci. 17(8):1635-45,2003
2002年
・A transcription factor response element for gene expression during circadian night. Ueda HR, Chen W, Adachi A, Wakamatsu H, Hayashi S, Takasugi T, Nagano M, Nakahama K, Suzuki Y, Sugano S, Iino M, Shigeyoshi Y, Hashimoto S. Nature. 418(6897):534-9.20022002年
・A transcription factor response element for gene expression during circadian night. Ueda HR, Chen W, Adachi A, Wakamatsu H, Hayashi S, Takasugi T, Nagano M, Nakahama K, Suzuki Y, Sugano S, Iino M, Shigeyoshi Y, Hashimoto S. Nature. 418(6897):534-9.2002
・A role of the C-terminus of aquaporin 4 in its membrane expression in cultured astrocytes. Nakahama K, Fujioka A, Nagano M, Satoh S, Furukawa K, Sasaki H, Shigeyoshi Y. Genes Cells. 2002 Jul;7(7):731-41.
・ Restoration of circadian behavioural rhythms in a period null Drosophila mutant (per01) by mammalian period homologues mPer1 and mPer2. Shigeyoshi Y, Meyer-Bernstein E, Yagita K, Fu W, Chen Y, Takumi T, Schotland P,Sehgal A, Okamura H. Genes Cells 7(2):163-171,2002
2001年
・Constitutive expression and delayed light response of casein kinase Iepsilon and Idelta mRNAs in the mouse suprachiasmatic nucleus.（Ishida, Y., Yagita, K., Fukuyama, T., Nishimura, M., Nagano, M., Shigeyoshi, Y., Yamaguchi, S., Komori, T., and Okamura, H. J. Neurosci. Res. 64, 612-616 ,2001）
・Expression of the Per1 gene in the Hamster: Brain Atlas and Circadian Characteristics in the Suprachiasmatic Nucleus. Yamamoto, S., (Shigeyoshi, Y., Ishida, Y., Fukuyama, T., Yamaguchi, S., Yagita, K., Moriya, Y., Shibata, S., Yakashima, N., and Okamura, H J. Comp. Neurol. 430, 518-532 ,2001)
・Different developmental profiles of the expression of preprosomatostatin and preprotachykinin-A mRNAs in rat SCN neurons. ( Nakamura, T., Shigeyoshi, Y., Maebayashi, Y., Yamaguchi, S., Yagita, K., and Okamura, Dev. Brain Research, 127, 81-86 ,2001)
・ Different Circadian Expression Profiles of Clock Genes in the Mouse Suprachiasmatic Nucleus（K. Taguchi, R. Okura, K. Yagita, Y. Ishida, H. Onishi, Y. Shigeyoshi, S. Yamaguchi,M. Nishimura, S Masubuchi,and H. Okamura、Biomedical Research 22 (3) 125-131, 2001）
英文著書
・Matsumoto S., Yamazaki, C., Masumoto KH., Nagano M., and Shigeyoshi, Y. (Farley, EP eds), Nova Science Publishers, in press
・Shigeyoshi Y. Synchronin and Desynchrony in the Mammalian Circadian Center In Circadian clock as multi-oscillation system (Ken-ichi Honma eds), Hakkido University Press pp. 141~154, 2003
邦文著書
・「Kallmann症候群の分子機序」重吉康史The Review of Medicine and Pharmacology Pharma Medica 第26巻9号（172頁〜174頁）メデイカルレピュー社 2008・概日リズムと睡眠 重吉康史、筋野 貢、堀川和政 脳と栄養ハンドブック （209頁〜240頁） SCIENCE FORUM 2008
・ウエルネスのススメ：最近睡眠不足で困っているのですが何か対策はありますか？ 重吉 康史 Wellness News 第56巻（14頁） 2008・ 視交叉上核の概日時計 ?形態学的アプローチ 時計遺伝子の分子生物学 長野護 重吉康史（分担）（岡村均、深田吉孝 編）シュプリンガー・フェアラーク東京 pp131-138 2004・ 視交叉上核．細胞構築の組織学的側面、生物時計の分子生物学 重吉康史（分担）海老原史樹文・深田吉孝編 シュプリンガー・フェアラーク東京 pp159-168 1999総説 (和文)・中枢時計として視交叉上核 長野護・重吉康史 Clinical Neuroscience 25(10) 1120-1123・「概日リズムとリズム同調」足立明人 重吉康史 医学のあゆみ 204 (11) 783-787, 2004・生物時計とリミットサイクル 重吉康史（共著） 生体の科学 The biological clock and the limit cycle 50: 162-168，1999翻訳・ショウジョウバエピリオドタンパク（PER）の概日振動モデル 重吉康史（単著） その他 Molecular Medicine A model for circadian oscillations in the Drosophila period protein (Per) 1128-1135 1999