研究テーマ

　脂肪由来幹細胞を用いた新たな治療方法の探索


　骨芽細胞・破骨細胞分化誘導機構の解明と骨粗鬆症病態解明

所属学会・資格

研究助成金

平成29～30年度

文部科学省　科学研究費補助金（若手研究B）
骨芽細胞における骨粗鬆症発症を規定する斬新的な性差因子探索と発症メカニズムの解明

平成27～28年度

文部科学省　科学研究費補助金（若手研究B）
脂肪組織中の慢性炎症制圧を目指した新たな脂肪幹細胞治療戦略の開発

平成27～28年度

沖縄県医科学研究財団　研究助成

主要業績（論文）

• Mika Kina-Tanada, Mayuko Sakanashi, Akihide Tanimoto, Tadashi Kaname, Toshihiro Matsuzaki, Katsuhiko Noguchi, Taro Uchida, Junko Nakasone, Chisayo Kozuka, Masayoshi Ishida, Haruaki Kubota, Yuji Taira, Yuichi Totsuka, Shin-Ichiro Kina, Hajime Sunakawa, Junichi Omura, Kimio Satoh, Hiroaki Shimokawa, Nobuyuki Yanagihara, Shiro Maeda, Yusuke Ohya, Masayuki Matsushita, Hiroaki Masuzaki, Akira Arasaki, Masato Tsutsui: Long-term dietary nitrite and nitrate deficiency causes the metabolic syndrome, endothelial dysfunction and cardiovascular death in mice. Diabetologia 03/2017
• Shusuke Yagi, Ken-Ichi Aihara, Masashi Akaike, Daiju Fukuda, Hotimah Masdan Salim, Masayoshi Ishida, Tomomi Matsuura, Takayuki Ise, Koji Yamaguchi, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro, Toshio Matsumoto, Masataka Sata: Predictive Factors for Efficacy of Dipeptidyl Peptidase-4 Inhibitors in Patients with Type 2 Diabetes Mellitus. Diabetes & metabolism journal 08/2015; 39(4):342-7.
• Shusuke Yagi, Akira Takashima, Minoru Mitsugi, Toshihiro Wada, Junko Hotchi, Ken-Ichi Aihara, Tomoya Hara, Masayoshi Ishida, Daiju Fukuda, Takayuki Ise, Koji Yamaguchi, Takeshi Tobiume, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro, Masashi Akaike, Masataka Sata: Effect of combination tablets containing amlodipine 10 mg and irbesartan 100 mg on blood pressure and cardiovascular risk factors in patients with hypertension. Therapeutics and Clinical Risk Management 01/2015; 11(default):83-8.
• Masayoshi Ishida, Michio Shimabukuro, Shusuke Yagi, Sachiko Nishimoto, Chisayo Kozuka, Daiju Fukuda, Takeshi Soeki, Hiroaki Masuzaki, Masato Tsutsui, Masataka Sata: MicroRNA-378 Regulates Adiponectin Expression in Adipose Tissue: A New Plausible Mechanism. PLoS ONE 11/2014; 9(11):e111537.
• Shusuke Yagi, Masashi Akaike, K.-I. Aihara, Daiju Fukuda, Masayoshi Ishida, Takayuki Ise, Toshiyuki Niki, Yuka Sumitomo-Ueda, Koji Yamaguchi, Takashi Iwase, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro, Masataka Sata: Pharmacology of Aldosterone and the Effects of Mineralocorticoid Receptor Blockade on Cardiovascular Systems. Acta Cardiologica Sinica 05/2013; 29(3):201-207.
• Michio Shimabukuro, Chisayo Kozuka, Shin-Ichiro Taira, Koichi Yabiku, Munkhbaatar Dagvasumberel, Masayoshi Ishida, Sachiko Matsumoto, Shusuke Yagi, Daiju Fukuda, Ken Yamakawa, Moritake Higa, Takeshi Soeki, Hisashi Yoshida, Hiroaki Masuzaki, Masataka Sata: Ectopic fat deposition and global cardiometabolic risk: New paradigm in cardiovascular medicine. The Journal of Medical Investigation 04/2013; 60(1-2):1-14.
• Masayoshi Ishida, Omar El-Mounayri, Steven Kattman, Peter Zandstra, Hiroshi Sakamoto, Minetaro Ogawa, Gordon Keller, Mansoor Husain: Regulated Expression and Role of c-Myb in the Cardiovascular-Directed Differentiation of Mouse Embryonic Stem Cells. Circulation Research 11/2011; 110(2):253-64.
• Taku Okazaki, Yoshimasa Tanaka, Ryosuke Nishio, Tamotsu Mitsuiye, Akira Mizoguchi, Jian Wang, Masayoshi Ishida, Hiroshi Hiai, Akira Matsumori, Nagahiro Minato, Tasuku Honjo: Autoantibodies against troponin-I are responsible for dilated cardiomyopathy in PD-1 deficient mice. Nature Medicine 01/2004; 9(12):1477-83.
• Masayoshi Ishida, Yoshiko Iwai, Yoshimasa Tanaka, Taku Okazaki, Gordon J Freeman, Nagahiro Minato, Tasuku Honjo: Differential expression of PD-L1 and PD-L2, ligands for an inhibitory receptor PD-1, in the cells of lymphohematopoietic tissues. Immunology Letters 11/2002; 84(1):57-62.
• Yoshiko Iwai*, Masayoshi Ishida*, Yoshimasa Tanaka, Taku Okazaki, Tasuku Honjo, Nagahiro Minato: Iwai Y, Ishida M, Tanaka Y, Okazaki T, Honjo T, Minato N.. Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade. Proc Natl Acad Sci USA 99: 12293-12297. Proceedings of the National Academy of Sciences 10/2002; 99(19):12293-7. (*equal contribution)