近畿大学医学部内科学教室心療内科部門Department of Psychosomatic Medicine, Kindai University, Faculty of Medicine

研究内容

研究内容

心身医学に関する研究

  1. 笑いの有効なタイミングに関する研究
  2. 過敏性腸症候群に対する低FODMAP食の症状改善効果に関する研究
  3. 患者のQOL向上のためのオートノミートレーニングの有効性に関する探索的研究
  4. Coronavirus disease2019流行時における心療内科外来患者の受診および感染症対策を実施した診療に関する意識の調査
  5. 感情表出プロセスにおける心理的介入点を明確にするための解析
  6. 症状が良くなると考える心療内科受診症例に影響を与えている様々な因子の解析
  7. Coronavirus disease2019流行時における心療内科外来患者の受診意識と心理状態の継時的調査
  8. がんサバイバーの健康関連Quolity of life(HRQOL)に対するコメディーの有効性
  9. 表情の動画から抑うつの程度を推定するモデルの開発
    (9.は東京大学ほか国内10施設との共同研究です)

がん緩和医療に関する研究

  1. がん疼痛へのオピオイド治療に対するバイオマーカーを用いたランダム化比較試験(AMED研究)

(①は近畿大学医学部内科学教室腫瘍内科部門との共同研究です)

研究業績(英文論文、筆頭著者、2015年以降のみ)

  • 2022年度
    1. Sakamoto R, Koyama A. Analysis of Various Factors Associated With Opioid Dose Escalation in Patients With Cancer Pain. Cureus. 2022 May; 14(5): e25266. doi: 10.7759/cureus.25266
  • 2021年度
    1. Sakamoto R, Koyama A. Fentanyl Infusion Is Effective in the Treatment of Dyspnea in End-Stage Heart Failure With Renal Failure: A Case Report. Cureus. 2021 Jan; 13(1): e12673. doi: 10.7759/cureus.12673
    2. Sakamoto R, Ohtake Y, Kataoka Y, et al. Efficacy of acceptance and commitment therapy for people with type 2 diabetes: Systematic review and meta-analysis. Journal of Diabetes Investigation. 2021 Sep; 6. doi: 10.1111/jdi.13658
    3. Sakamoto R, Koyama A. Identifying the Needs Based on the Patients’ Performance Status for Palliative Care Team: An Observational Study. Indian Journal of Palliative Care. Jul-Sep 2021;27(3):375-381. doi: 10.25259/IJPC_368_20
  • 2020年度
    1. Matsuoka H, Iwase S, Miyaji T, et al. Predictors of duloxetine response in patients with neuropathic cancer pain: a secondary analysis of a randomized controlled trial-JORTC-PAL08 (DIRECT) study. Support Care Cancer. 2020 Jun;28(6):2931-2939. doi: 10.1007/s00520-019-05138-9.
    2. Sakamoto R, Koyama A. Effective therapy against severe anxiety caused by cancer: A case report and review of the literature. Cureus. 2020 Jun; 12(6): e8414. doi: 10.7759/cureus.8414
  • 2019年度
    1. Sakamoto R, Matsuoka H, Gomi E, et al. Exacerbation of Extrapyramidal Symptoms Associated with Drug-induced Akathisia after Intramuscular Administration of Biperiden in a Patient with End-stage Gastric Cancer: A Case Report. Journal of Palliative Care & Medicine, In press.
    2. Sakamoto R, Matsuoka H, Koyama A. The effect of laughter measured by scoring facial expressions: observation study. Acta Med Kindai Univ. Vol.44, No.1 15-22, 2019.
    3. Matsuoka H, Iwase S, Miyaji T, et al. Predictors of duloxetine response in patients with neuropathic cancer pain: a secondary analysis of a randomized controlled trial—JORTC-PAL08 (DIRECT) study. Supportive Care in Cancer. In press.
    4. Matsuoka H, Iwase S, Miyaji T, et al. Additive Duloxetine for Cancer-Related Neuropathic Pain Nonresponsive or Intolerant to Opioid-Pregabalin Therapy: A Randomized Controlled Trial (JORTC-PAL08). J Pain Symptom Manage. 2019 Jun 26. pii: S0885-3924(19)30364-1. doi: 10.1016/j.jpainsymman.2019.06.020.
    5. Matsuoka H, Tagami K, Ariyoshi K, Oyamada S, Kizawa Y, Inoue A, Koyama A.Attitude of Japanese palliative care specialists towards adjuvant analgesics cancer-related neuropathic pain refractory to opioid therapy: a nationwide cross-sectional survey. Jpn J Clin Oncol. 2019 May 1;49(5):486-490. doi: 10.1093/jjco/hyz002.
  • 2018年度
    1. Matsuoka H, Allingham S, Fazekas B, Brown L, Vandersman Z, Clark K, Agar MR, Currow DC. Comparability of the Australian National Cancer Symptom Trials (CST) Group's Study Populations to National Referrals to Non-CST Specialist Palliative Care Services Participating in the Palliative Care Outcomes Collaboration. J Pain Symptom Manage. 2019 Jan;57(1):e9-e14. doi: 10.1016/j.jpainsymman.2018.09.017. Epub 2018 Sep 29.
    2. Koyama A, Ohtake Y, Yasuda K, Sakai K, Sakamoto R, Matsuoka H, Okumi H, Yasuda T. Avoiding diagnostic errors in psychosomatic medicine: a case series study. Biopsychosoc Med. 2018 Mar 13;12:4. doi: 10.1186/s13030-018-0122-3. eCollection 2018.
    3. Matsuoka H, Ishiki H, Iwase S, Koyama A, Kawaguchi T, Kizawa Y, Morita T, Matsuda Y, Miyaji T, Ariyoshi K, Yamaguchi T. Study protocol for a multi-institutional, randomised, double-blinded, placebo-controlled phase III trial investigating additive efficacy of duloxetine for neuropathic cancer pain refractory to opioids and gabapentinoids: the DIRECT study. BMJ Open. 2017,28;7:e017280. doi: 10.1136/bmjopen-2017-017280.
    4. Hatano Y, Matsuoka H, Lam L, Currow DC. Side effects of corticosteroids in patients with advanced cancer: a systematic review. Support Care Cancer. 2018 Dec;26(12):3979-3983. doi: 10.1007/s00520-018-4339-2.
    5. Hatano Y, Shikata Y, Izumi H, Kawaguchi A. Discrepancies between Reasons of Palliative Care Team Consultation and Palliative Care Team Activities. J Palliat Med. 2018 Sep;21(9):1278-1283. doi: 10.1089/jpm.2018.0086. Epub 2018 Jun 5. Physician Behavior toward Death Pronouncement in Palliative Care Units.
  • 2017年度
    1. Sakai K, Matsuoka H, Ohtake Y, Makimura C, Izumi H, Fujita Y, Otsuka M, Tsurutani J, Nishio K, Nakagawa K, Koyama A. Incidence of carnitine deficiency in patients with cancer pain: A pilot study. Mol Clin Oncol. 2017 Mar;6(3):331-333. doi: 10.3892/mco.2017.1159.
    2. Matsuoka H, Kaneda H, Sakai K, Koyama A, Nishio K, Nakagawa K. Clinical Response to Everolimus of EGFR-Mutation-Positive NSCLC With Primary Resistance to EGFR TKIs. Clin Lung Cancer. 2017 Jan;18(1):e85-e87. doi: 10.1016/j.cllc.2016.08.004.
    3. Matsuoka H, Yoshiuchi K, Koyama A, Makimura C, Fujita Y, Tsurutani J, Sakai K, Sakamoto R, Nishio K, Nakagawa K. Expectation of a Decrease in Pain Affects the Prognosis of Pain in Cancer Patients: a Prospective Cohort Study of Response to Morphine. Int J Behav Med. 2017 Aug;24(4):535-541. doi: 10.1007/s12529-017-9644-5. (日本行動医学会荒記記念賞受賞)
    4. Matsuoka H, Tsurutani J, Chiba Y, Fujita Y, Terashima M, Yoshida T, Sakai K, Otake Y, Koyama A, Nishio K, Nakagawa K. Selection of opioids for cancer-related pain using a biomarker: a randomized, multi-institutional, open-label trial (RELIEF study). BMC Cancer. 2017 Oct 6;17(1):674. doi: 10.1186/s12885-017-3664-z.
    5. Matsuoka H, Makimura C, Koyama A, Fujita Y, Tsurutani J, Sakai K, Sakamoto R, Nishio K, Nakagawa K. Prospective replication study implicates the catechol-O-methyltransferase Val158Met polymorphism as a biomarker for the response to morphine in patients with cancer. Biomed Rep. 2017 Oct;7(4):380-384. doi: 10.3892/br.2017.963.
  • 2016年度
    1. Sakai K, Takeda M, Hayashi H, et al. Clinical outcome of node-negative oligometastatic non-small cell lung cancer. Thorac Cancer. 2016 Nov;7(6):670-675. doi: 10.1111/1759-7714.12386.
    2. Koyama A, Matsuoka H, Ohtake Y, et al. Gender differences in cancer-related distress in Japan: a retrospective observation study. Biopsychosoc Med. 2016 Apr 12;10:10. doi: 10.1186/s13030-016-0062-8. eCollection 2016.
    3. Koyama A, Okumi H, Matsuoka H, et al. The physical and psychological problems of immigrants to Japan who require psychosomatic care: a retrospective observation study. Biopsychosoc Med. 2016 Feb 24;10:7. doi: 10.1186/s13030-016-0052-x. eCollection 2016.
  • 2015年度
    1. Matsuoka H, Yoshiuchi K, Koyama A, et al. Chemotherapeutic drugs that penetrate the blood-brain barrier affect the development of hyperactive delirium in cancer patients. Palliat Support Care. 2015 Aug;13(4):859-64. doi: 10.1017/S1478951514000765. Epub 2014 Jun 26.