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Kindai University Hospital   Department of Clinical Laboratory Medicine





















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教授 上硲 俊法

2006年以前の研究業績

Toshinori Kamisako, Yukihiko Adachi, Toshio Yamamoto. Effect of UDP-glucuronic acid depletion by salicylamide on biliary bilirubin excretion in the rat. J Pharmacol Exp Ther 254, 380-382, 1990. 

 Yukihiko Adachi, Toshinori Kamisako, Toshio Yamamoto. The effects of temporary occlusion of the superior mesenteric vein or splenic vein on bilirubin and bile acid excretion in rats. 
J Lab Clin Med, 118, 261-268, 1991.           

Toshinori Kamisako, Yukihiko Adachi, Jun-ichi Chihara, Toshio Yamamoto.Interstitial pneumonitis and interferon alfa. Br Med J 306, 896, 1993. 

Toshinori Kamisako, Yasushi Saika, Yukihiko Adachi, Tadashi Itoh, Ryouichi Fujii, Toshio Yamamoto. Thrombocytepenia associated with platelet-associated immunoglobulin G in alcoholic hepatitis.  J Gastroenterol Hepatol 9, 527-529, 1994.        

Toshinori Kamisako, Yukihiko Adachi, Hirotaka Nakagawa, Toshio Yamamoto.Torsades de Pointes associated with terfenadine in a case of liver cirrhosis and hepatocellular carcinoma.  Internal Medicine 34, 92-95, 1995.               

Toshinori Kamisako, Yukihiko Adachi. Marked improvement of cholestasis and hypercholesterolemia with simvastatin in a patient with primary biliary cirrhosis.Am J Gastroenterol 90, 1187-1188, 1995.      

Osamu Koiwai, Sachiko Aono, Yukihiko Adachi, Toshinori Kamisako, Yoshihiro Yasui, Miyako Nishizawa, Hiroshi Sato. Crigler-Najjar syndrome II is inherited as a dominant and as a recessive trait. Hum Mol Genet 5, 645-647, 1996.             

Yukihiko Adachi, Toshinori Kamisako, Osamu Koiwai, Kazuo Yamamoto, Toshio Yamamoto. Genetic background of constitutional unconjugated hyperbilirubinemia.Int Hepatol Communs 5, 297-307, 1996.                                                    

Yukihiko Adachi, Yoshifumi Okuyama, Hirohisa Miya, Toshinori Kamisako.Presence of ATP-dependent copper transport in the hepatocytes canalicular membrane of Long-Evans Cinnamon Rat, an animal model of Wilson disease. J Hepatol 26, 216-217, 1997.         

Toshinori Kamisako, Yoko Soeda, Kazuo Yamamoto, Hiroshi Sato, Yukihiko Adachi. Multiplicity of mutation in UDP-glucuronosyltransferase 1*1 gene in Gilbert's syndrome.  Int Hepatol Communs 6, 249-252, 1997.  

Toshinori Kamisako, Kazuo Tsubaki, Yukihiko Adachi. Autoimmune hepatitis after cytomegalovirus infection in a bone marrow transplanted patient. Am J Gastroenterol 92, 1238-1239, 1997.      

Toshinori Kamisako, Akira Kamei, Noriko Kawamura, Tomoaki Ishihara, Esteban C Gabazza, Yukihiko Adachi. Efflux of bilirubin glucuronides from liver to blood in bilirubin-loaded bile duct-ligated rats.  Med Sci Res 25, 739-740, 1997.         

Kazuo Yamamoto,  Yoko Soeda, Toshinori Kamisako, H Hosaka, Fukano M, Hiroshi Sato, Y Fujiyama, Yukihiko Adachi, Y Satoh,  T Bamba. Analysis of bilirubin uridine 5'-diphosphate (UDP) -glucuronosyltransferase gene mutations in seven patients with Crigler-Najjar syndrome type II.  J Hum Genet 43, 111-114, 1998.     

Toshinori Kamisako, Shozo Miyawaki, Estaban Gabazza, Tomoaki Ishihara, Akira Kamei, Noriko Kawamura, Yukihiko Adachi. Polyethylene Glycol-modified bilirubin oxidase improves hepatic energy charge and urinary prostaglandin levels in rats with obstructive jaundice.  
J Hepatol 29, 424-429, 1998        

Toshinori Kamisako, Esteban C Gabazza, Toshiaki Ishihara, Yukihiko Adachi.  Molecular aspects of organic compound transport across the plasma membrane of hepatocyte. 
J Gastroenterol Hepatol 14, 405-412, 1999.

Toshinori Kamisako, Inka Leier, Yunhai Cui, Jorg Konig, Ulrike Buchholz, Johanna Hummel-Eisenweis, Dietrich Keppler. Transport of monoglucuronosyl and bisglucuronosyl bilirubin by recombinant human and rat multidrug resisstance protein2.  Hepatology 30, 485-490, 1999.             

Christoph Reichel, Bo Gao, Jessica von Montfoort, Valentino Cattori, Christian Rahner, Bruno Hagenbuch, Bruno Stieger, Toshinori Kamisako, Peter J Meier. Localization and function of the organic anion transporting polypeptide Oatp2 in rat liver.  Gastroenterology 117, 688-695, 1999.                      

Dietrich Keppler, Toshinori Kamisako, Inka Leier, Yunhai Cui, Anne T Nies, Hiroyuki Tsujii, Jorg Konig. Localization, substrate specificity, and drug resistance conferred by conjugate export pumps of the MRP family. Adv. Enzyme Regul 40, 339-349, 2000.

Ryousuke Nakaoka, Toshinori Kamisako, Mikio Shiomi, Masatoshi Kudo. Repeated hepatic arterial chemoembolization therapy for management of a patient with metastatic carcinoid tumors of the liver. Am J Gastroenterol 95,1842-1843, 2000

Toshinori Kamisako, Yoshinao Kobayashi, Keisuke Takeuchi, Tomoaki Ishihara, Kunihiro Higuchi, Yuji Tanaka, Esteban C Gabazza, Yukihiko Adachi.  Recent advances in bilirubin metabolism research : Molecular mechanism of hepatocyte transport and its clinical relevance. J. Gastroenterol. 35, 659-664, 2000           

Toshinori Kamisako, Inka Leier. Characterization of ATP dependent monoglucuronosyl bilirubin transport across rat canalicular membrane vesicles. Hepatology Research 19, 103-107, 2001.

Mikio Shiomi, Toshinori Kamisako, Ituro Yutani, Masatoshi Kudo, Hironori Shigeoka, Akira Tanaka, Kiyotaka Okuno, Masayuki Yasutomi. Two cases of histopathologically advanced (stage IV) early gastric cancers. Tumori. 2001;87(3):191-5.

Qiu-Ling Pei, Yoshinao Kobayashi, Yuji Tanaka, Yukari Taguchi, Kunihiro Higuchi, Masahiko Kaito, Ning Ma, Reiji Semba, Toshinori Kamisako, Yukihiko Adachi. Increased expression of multidrug resistance-associated protein 1 (mrp1) in hepatocyte basolateral membrane and renal tubular epithelia after bile duct ligation in rats. Hepatol Res. 2002;22(1):58-64.

Shigenaga Matsui, Toshinori Kamisako, Masatoshi Kudo, Ryoichi Inoue. Endoscopic band ligation for control of nonvariceal upper GI hemorrhage: Comparison with bipolar electrocoagulation. Gastrointest Endosc. 2002; 55(2): 214-8.

Yuji Tanaka, Yoshinao Kobayashi , Esteban C. Gabazza, Kunihiro Higuchi, Toshinori Kamisako, Makoto Kuroda, Keisuke Takeuchi, Motoh Iwasa, Masahiko Kaito, Yukihiko Adachi. Increased renal expression of of bilirubin glucuronide transporters in a rat model of obstructive jaundice. Am J Physiol GastrointestiLiver Physiology. 2002; 282:G656-662.

Toshinori Kamisako, Hiroshi Ogawa Effect of obstructive Jaundice on the regulation of hepatic cholesterol metabolism in the rat. Hepatology Research, 2003;25: 99-104.

Mikihisa Kihara, Osamu Matsuo, Toshinori Kamisako, Kanji Fukuda, Taskashi Ashida, Tsukasa Takemura, Ichiro Iwamoto, Toshio Miyazaki, Naoki Hashimoto. Effect of clinical clerkship on students' attitudes toward medical learning in Japan: a case study at Kinki University School of Medicine. Pathophysiology, 2003: 9:111-113.

Toshinori Kamisako, Keisuke Takeuchi, Tadashi Ito, Shigenori Tamaki, Tetsuya Kosakad and Yukihiko Adachi. Serum platelet-activating factor acetylhydrolase (PAF-AH) activity in patients with hyperbilirubinemic hepatobiliary disease. Hepatology Research, 2003: 26; 23-27.

Toshinori Kamisako, and Hiroshi Ogawa. Regulation of biliary cholesterol secretion is associated with abcg5 and abcg8 expressions in the rats: Effects of diosgenin and ethinyl estradiol. Hepatology Research, 2003: 26; 348-352.

Hiroshi Ogawa, Kazuo Yamamoto, Toshinori Kamisako, Tadamichi Meguro. Phytosterol additives increase blood pressure and promote stroke onset in salt-loaded stroke-prone spontaneously hypertensive rats. Clin Exp Pharmacol Physiol. 2003; 30: 919-24.

Toshinori Kamisako, and Hiroshi Ogawa. Effects of pravastatin and bezafibrate on biliary lipid excretion and hepatic expressions of Abcg5 and Abcg8 in the rats. J Gastroenterol Hepatol, 2004; 19; 879-883.

Toshinori Kamisako. What is Gilbert's syndrome? Lesson from Genetic polymorphisms of UGT1A1 in Gilbert's syndrome from Asia. J Gastroenterol Hepatol, 2004; 19; 995-997.

Mikio Shiomi, Toshinori Kamisako, Itsuro Yutani, Rie Yoshimoto, Masatoshi Kudo, Ryouichi Fujii. Anisakiasis in the biopsy specimen from the edge of gastric ulcer. Report of a case. Gastrointestinal Endoscopy; 2004. 60: 854-6.

Toshinori Kamisako, and Hiroshi Ogawa. Alteration of the expression of adenosine triphosphate-binding cassette transporters associated with bile acid and cholesterol transport in the rat liver and intestine during cholestasis. J Gastroenterol Hepatol, 2005; 20; 1429-1434.

2007年以降の研究業績

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