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Kindai University Hospital 　 Department of Clinical Laboratory Medicine























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サイトマップ 		講師　田中　裕滋

主な研究業績

　論文

  1. Toda H, Tanaka Y,Yamade K, Yoshitomi K, Yoshida K, Kamisako T. Strategic retesting to reduce false positive SARS-CoV-2 PCR test results. Clin Lab 2024;70:993-9.
  2. Toda H, Tanaka Y,Yamade K ,Tsujimoto M, Takada H, Ueno M, Tsuda Y, Kishino Y, Kubo S, Kamisako T, Yoshida K. Evaluation of the analytical performance of the fully automated gene analyzer μTASWako g1 for the detection of SARS-CoV-2. Clin Lab 2023;69:425-9.
  3. Kamisako T, Tanaka Y. Oltipraz ameliorates the progression of steatohepatitis in Nrf2-null mice fed a high-fat diet. J Clin Biochem Nutr 2022;70:147-53.
  4. Tanaka Y, Kamisako T. Regulation of the expression of cholesterol transporters by lipid-lowering drugs ezetimibe and pemafibrate in rat liver and intestine. Biochim Biophys Acta Mol Basis Dis 2021;1867:166215.
  5. Tanaka Y, Ikeda T, Ogawa H, Kamisako T. Ezetimibe markedly reduces hepatic triglycerides and cholesterol in rats fed on fish oil by increasing the expression of cholesterol efflux transporters. J Pharmacol Exp Ther 2020;374:175-83.
  6. Toda H, Tanaka Y, Satoh K, Wada Y, Tobe T, Kamisako T. Epidemiological and molecular characterization of invasive Streptococcus pneumoniae isolated following introduction of 7-valent conjugate vaccine in Kinki region, Japan, 2008-2013. J Infect Chemother 2020;26:451-8.
  7. Tanaka Y, Ikeda T, Yamamoto K, Masuda S, Ogawa H, Kamisako T. Gender-divergent expression of lipid and bile acid metabolism related genes in adult mice offspring of dams fed a high-fat diet. J Biosci 2018;43:329-37.
  8. Toda H, Satoh K, Komatsu M, Fukuda S, Nakamura T, Jikimoto T, Nishio H, Yamasaki K, Maede T, Orita T, Sueyoshi N, Kita M, Toyokawa M, Nishi I, Akagi M, Higuchi T, Kofuku T, Nakai I, Ono T, Shimakawa K, Hikita Y, Moro K, Kida K, Oohama M, Wada Y, Tobe T, Kamisako T, Tanaka Y. Laboratory surveillance of antimicrobial resistance and multidrug resistance among Streptococcus pneumoniae isolated in the Kinki region of Japan, 2001-2015. J Infect Chemother 2018;24:171-6.
  9. Tanaka Y, Ikeda T, Yamamoto K, Masuda S, Ogawa H, Kamisako T. 6-Methylsulfinyl- hexyl isothiocyanate prevents high-fat diet-induced fatty liver but fails to attenuate hepatic iron accumulation in mice. Clin Exp Pharmacol Physiol 2016;43:1153-6.
  10. Masuda S, Ichihara K, Yamanishi H, Hirano Y, Tanaka Y, Kamisako T. Evalution of menstrual cycle-related changes in 85 clinical laboratory analytes. Ann Clin Biochem 2016;53:365-76.
  11. Ikeda T, Tanaka Y, Yamamoto K, Morii H, Kamisako T, Ogawa H. Geranium dielsianum extract powder(MISKAMISKATM) improves the intestinal environment through alteration of microbiota and microbial metabolites in rats. J Funct Foods 2014;11:12-9.
  12. Kamisako T, Tanaka Y, Kishino Y, Ikeda T, Yamamoto K, Masuda S, Ogawa H. Role of Nrf2 in the alteration of cholesterol and bile acid metabolism-related gene expression by dietary cholesterol in high fat-fed mice. J Clin Biochem Nutr 2014;54:90-4.
  13. Kamisako T, Masuda S, Tanaka Y. Relationship between serum bilirubin and remnant lipoprotein cholesterol level. Clin Lab 2013;59:435-8.
  14. Kishino Y, Tanaka Y, Ikeda T, Yamamoto K, Ogawa H, Iwatani Y, Kamisako T. Ezetimibe increases hepatic iron levels in mice fed a high-fat diet. J Pharmacol Exp Ther 2013;345:483-91.
  15. Tanaka Y, Ikeda T, Yamamoto K, Ogawa H, Kamisako T. Dysregulated expression of fatty acid oxidation enzymes and iron-regulatory genes in livers of Nrf2-null mice. J Gastroenterol Hepatol 2012;27:1711-7.
  16. Cui JY, Aleksunes LM, Tanaka Y, Fu ZD, Guo Y, Guo GL, Lu H, Zhong XB, Klaassen CD. Bile acids via FXR initiate the expression of major transporters involved in the enterohepatic circulation of bile acids in newborn mice. Am J Physiol Gastrointest Liver Physiol 2012;302:G979-96.
  17. Kamisako T, Tanaka Y, Ikeda T, Yamamoto K, Ogawa H. Dietary fish oil regulates gene expression of cholesterol and bile acid transporters in mice. Hepatol Res 2012;42:321-6.
  18. Kishino Y, Tanaka Y, Naitoh S, Kamisako T. Danazol falsely increased values in estradiol immunoassays. Clin Chim Acta 2010;411:1380-1.
  19. Zhang YK, Yeager RL, Tanaka Y, Klaassen CD. Enhanced expression of Nrf2 in mice attenuates the fatty liver produced by a methionine- and choline-deficient diet. Toxicol Appl Pharmacol 2010;245:326-34.
  20. Csanaky IL, Aleksunes LM, Tanaka Y, Klaassen CD. Role of hepatic transporters in prevention of bile acid toxicity after partial hepatectomy in mice. Am J Physiol Gastrointest Liver Physiol 2009;297:G419-33.
  21. Cui YJ, Aleksunes LM, Tanaka Y, Goedken MJ, Klaassen CD. Compensatory induction of liver efflux transporters in response to ANIT-induced liver injury is impaired in FXR-null mice. Toxicol Sci 2009;110:47-60.
  22. Reisman SA, Buckley DB, Tanaka Y, Klaassen CD. CDDO-Im protects from acetaminophen hepatotoxicity through induction of Nrf2-dependent genes. Toxicol Appl Pharmacol 2009;236:109-14.
  23. Tanaka Y, Aleksunes LM, Cui YJ, Klaassen CD. ANIT-induced intrahepatic cholestasis alters hepatobiliary transporter expression via Nrf2-dependent and independent signaling. Toxicol Sci 2009;108:247-57.
  24. Gyamfi MA, Tanaka Y, He L, Klaassen CD, Wan YJ. Hepatic effects of a methionine-choline-deficient diet in hepatocyte RXRalpha-null mice. Toxicol Appl Pharmacol 2009;234:166-78.
  25. Maher JM, Aleksunes LM, Dieter MZ, Tanaka Y, Peters JM, Manautou JE, Klaassen CD. Nrf2- and PPAR alpha-mediated regulation of hepatic Mrp transporters after exposure to perfluorooctanoic acid and perfluorodecanoic acid. Toxicol Sci 2008;106:319-28.
  26. Tanaka Y, Aleksunes LM, Goedken MJ, Chen C, Reisman SA, Manautou JE, Klaassen CD. Coordinated induction of Nrf2 target genes protects against iron nitrilotriacetate (FeNTA)-induced nephrotoxicity. Toxicol Appl Pharmacol 2008;231:364-73.
  27. Tanaka Y, Aleksunes LM, Yeager RL, Gyamfi MA, Esterly N, Guo GL, Klaassen CD. NF-E2-related factor 2 inhibits lipid accumulation and oxidative stress in mice fed a high-fat diet. J Pharmacol Exp Ther 2008;325:655-64.
  28. Tanaka Y, Chen C, Maher JM, Klaassen CD. Ischemia-reperfusion of rat livers decreases liver and increases kidney multidrug resistance associated protein 2 (Mrp2). Toxicol Sci 2008;101:171-8.
  29. Maher JM, Dieter MZ, Aleksunes LM, Slitt AL, Guo G, Tanaka Y, Scheffer GL, Chan JY, Manautou JE, Chen Y, Dalton TP, Yamamoto M, Klaassen CD. Oxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathway. Hepatology 2007;46:1597-610.
  30. Chen C, Cheng X, Dieter MZ, Tanaka Y, Klaassen CD. Activation of cAMP-dependent signaling pathway induces mouse organic anion transporting polypeptide 2 expression. Mol Pharmacol 2007;71:1159-64.
  31. Tanaka Y, Maher JM, Chen C, Klaassen CD. Hepatic ischemia-reperfusion induces renal heme oxygenase-1 via NF-E2-related factor 2 in rats and mice. Mol Pharmacol 2007;71:817-25.
  32. Tanaka Y, Chen C, Maher JM, Klaassen CD. Kupffer cell-mediated downregulation of hepatic transporter expression in rat hepatic ischemia-reperfusion. Transplantation 2006;82:258-66.
  33. Maher JM, Cheng X, Tanaka Y, Scheffer GL, Klaassen CD. Hormonal regulation of renal multidrug resistance-associated proteins 3 and 4 (Mrp3 and Mrp4) in mice. Biochem Pharmacol 2006;71:1470-8.
  34. Chen C, Slitt AL, Dieter MZ, Tanaka Y, Scheffer GL, Klaassen CD. Up-regulation of Mrp4 expression in kidney of Mrp2-deficient TR- rats. Biochem Pharmacol 2005;70:1088-95.
  35. Tanaka Y, Slitt AL, Leazer TM, Maher JM, Klaassen CD. Tissue distribution and hormonal regulation of the breast cancer resistance protein (Bcrp/Abcg2) in rats and mice. Biochem Biophys Res Commun 2005;326:181-7.
  36. Itani T, Kobayashi Y, Kuroda M, Ma N, Mifuji R, Urawa N, Tanaka Y, Kaito M, Adachi Y. Transfecting the multidrug resistance protein 2 gene improves transcellular organic anion transport. Int J Mol Med 2005;16:821-5.
  37. Higuchi K, Kobayashi Y, Kuroda M, Tanaka Y, Itani T, Araki J, Mifuji R, Kaito M, Adachi Y. Modulation of organic anion transporting polypeptide 1 and multidrug resistance protein 3 expression in the liver and kidney of Gunn rats. Hepatol Res 2004;29:60-6.
  38. Kuroda M, Kobayashi Y, Tanaka Y, Itani T, Mifuji R, Araki J, Kaito M, Adachi Y. Increased hepatic and renal expressions of multidrug resistance-associated protein 3 in Eisai hyperbilirubinuria rats. J Gastroenterol Hepatol 2004;19:146-53.
  39. Mifuji R, Iwasa M, Tanaka Y, Hori Y, Araki J, Kaito M, Adachi Y. "Green juice"-associated granulomatous hepatitis. Am J Gastroenterol 2003;98:2334-5.
  40. Tanaka Y, Yoshikawa M, Kobayashi Y, Kuroda M, Kaito M, Shiroi A, Yamao J, Fukui H, Ishizaka S, Adachi Y. Expression of hepatobiliary organic anion transporters and bilirubin-conjugating enzyme in differentiating embryonic stem cells. Biochem Biophys Res Commun 2003;309:324-30.
  41. Iwasa M, Yamamoto M, Tanaka Y, Kaito M, Adachi Y. Spirulina-associated hepatotoxicity. Am J Gastroenterol. 2002;97:3212-3.
  42. Iwasa M, Kaito M, Ikoma J, Kobayashi Y, Tanaka Y, Higuchi K, Takeuchi K, Iwata K, Watanabe S, Adachi Y. Dietary iron restriction improves aminotransferase levels in chronic hepatitis C patients. Hepatogastroenterology 2002;49:529-31.
  43. Tanaka Y, Kobayashi Y, Gabazza EC, Higuchi K, Kamisako T, Kuroda M, Takeuchi K, Iwasa M, Kaito M, Adachi Y. Increased renal expression of bilirubin glucuronide transporters in a rat model of obstructive jaundice. Am J Physiol Gastrointest Liver Physiol 2002;282:G656-62.
  44. Pei QL, Kobayashi Y, Tanaka Y, Taguchi Y, Higuchi K, Kaito M, Ma N, Semba R, Kamisako T, Adachi Y. Increased expression of multidrug resistance-associated protein 1 (mrp1) in hepatocyte basolateral membrane and renal tubular epithelia after bile duct ligation in rats. Hepatol Res 2002;22:58-64.
  45. Tanaka Y, Koshiyama H, Nakao K, Makita Y, Kobayashi Y, Yoshida Y, Kimura M, Adachi Y. Rapid progress of acute suppurative cholangitis to secondary sclerosing cholangitis sequentially followed-up by endoscopic retrograde cholangiography. Endoscopy 2001;33:633-5.
  46. Ishihara T, Kaito M, Takeuchi K, Gabazza EC, Tanaka Y, Higuchi K, Ikoma J, Watanabe S, Sato H, Adachi Y. Role of UGT1A1 mutation in fasting hyperbilirubinemia. J Gastroenterol Hepatol 2001;16:678-82.
  47. Kamisako T, Kobayashi Y, Takeuchi K, Ishihara T, Higuchi K, Tanaka Y, Gabazza EC, Adachi Y. Recent advances in bilirubin metabolism research: the molecular mechanism of hepatocyte bilirubin transport and its clinical relevance. J Gastroenterol 2000;35:659-64.

　学会発表

  1. Tanaka Y, Kamisako T. Differential regulation of intestinal sterol efflux transporters and non-biliary cholesterol excretion by dietary oil in bile duct-ligated rats. The 63rd Annual Meeting of the Society of toxicology (SOT) (Salt Lake City) 2024
  2. 田中 裕滋、上硲俊法　油脂成分の体内蓄積が小腸コレステロール排泄機構に及ぼす影響-大豆油と魚油の比較　第62回日本栄養・食糧学会近畿支部大会 (奈良) 2023
  3. 田中 裕滋、上硲俊法　魚油を摂取したラットにおけるエゼチミブのコレステロール排泄トランスポーターの誘導と著明な肝脂質低下作用　第75回日本栄養・食糧学会大会 2021
  4. 田中 裕滋、池田 高紀、小川 博、上硲 俊法　母マウスの高脂肪食摂取による出生仔の胆汁酸代謝関連遺伝子発現の性差 第74回日本栄養・食糧学会大会 2020
  5. Tanaka Y, Ikeda T, Ogawa H, Kamisako T. Adaptive regulation of bile acid and cholesterol transporters in mouse kidney and intestine during alpha-naphthylisothiocyanate (ANIT)-induced cholestasis. The59th Annual Meeting of the Society of toxicology (SOT) 2020
  6. Tanaka Y, Ikeda T, Ogawa H, Kamisako T. Ezetimibe markedly reduces hepatic triglycerides and cholesterol in fish oil-fed rats. The 70th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD) (Boston) 2019
  7. 田中 裕滋、上硲 俊法　高脂肪食を摂取した母親から生まれた仔マウスの成長後の胆汁酸関連遺伝子発現の性差　第55回日本肝臓学会総会 (東京) 2019
  8. 田中 裕滋、池田 高紀、小川 博、上硲 俊法　高脂肪食摂取マウスにおけるワサビ由来6-メチルスルフィニルヘキシルイソチオシアネートのNrf2を介した脂肪肝改善作用 第73回日本栄養・食糧学会大会 (静岡) 2019
  9. Tanaka Y, Ikeda T, Ogawa H, Kamisako T. Increased non-biliary cholesterol excretion during alpha-naphthylisothiocyanate (ANIT)-induced cholestasis in mice. The58th Annual Meeting of the Society of toxicology (SOT) (Baltimore) 2019
  10. 田中 裕滋、池田高紀、山本和夫、小川博、上硲俊法　魚油含有食摂取がマウスの脂質・胆汁酸代謝に及ぼす影響　第72回日本栄養・食糧学会大会（岡山）2018
  11. Tanaka Y, Ikeda T, Yamamoto K, Ogawa H, Kamisako T. Gender-divergent expression of lipid and bile acid metabolism related genes in adult mice offspring of dams fed a long-term high-fat diet before and during pregnancy and lactation. The 67th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD) (Boston) 2016
  12. 田中 裕滋、池田高紀、山本和夫、小川博、上硲俊法　酸化ストレス応答制御因子Nrf2は鉄と脂質の代謝を制御する　第55回日本栄養・食糧学会近畿支部大会 (堺) 2016
  13. 田中 裕滋、上硲俊法　コレステロールとジオスゲニンの同時摂取がコレステロールおよび胆汁酸代謝に及ぼす影響　第51回日本肝臓学会総会（熊本）2015
  14. Tanaka Y, Kamisako T. Ezetimibe prevents diosgenin-induced cholestatic liver injury in mice. The 65th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD) (Boston) 2014
  15. 田中 裕滋、池田高紀、山本和夫、小川博、上硲俊法　ワサビ由来6-メチルスルフィニルへキシルイソチオシアネートはマウスの高脂肪食誘発性脂肪肝をNrf2依存性に改善する 　第50回日本肝臓学会総会（東京）2014
  16. 田中 裕滋、池田高紀、山本和夫、小川博、上硲俊法　エゼチミブ投薬によるジオスゲニン誘発胆汁鬱滞性肝障害の抑制効果　第50回日本肝臓学会総会（東京）2014
  17. Tanaka Y, Kamisako T. Wasabi derivative 6-methylsulfinyl-hexyl, a potent Nrf2 activator, prevents the fatty liver produced by a high-fat diet but does not attenuate hepatic iron overload in mice. The 64th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD) (Washington,DC) 2013
  18. 田中裕滋、岸野好純、池田高紀、山本和夫、小川博、上硲俊法　高脂肪食摂取マウスにおけるエゼチミブ投薬による肝内鉄値増加 第49回日本肝臓学会総会（東京）2013
  19. 田中裕滋、池田高紀、山本和夫、小川博、上硲俊法　高脂肪食摂取Nrf2欠損マウスにおけるオルチプラズによる肝障害の改善効果 第49回日本肝臓学会総会（東京）2013
  20. Tanaka Y, Kamisako T. The Nrf2 activator oltipraz alters cholesterol and bile acid metabolism　related genes expression via Nrf2- dependent and independent signalingin mice fed a high-fat diet. The 63rd Annual Meeting of the American Association for the Study of Liver Diseases (AASLD) (Boston) 2012
  21. 田中裕滋、池田高紀、山本和夫、小川博、上硲俊法 Nrf2 activatorであるoltiprazはNrf2非依存性に脂質・胆汁酸代謝に影響を及ぼす 第48回日本肝臓学会総会（金沢）2012
  22. Tanaka Y, Kamisako T. Dysregulation of hepcidin and lipid metabolism-related gene expression in livers of Nrf2-null mice. The 62nd Annual Meeting of the American Association for the Study of Liver Diseases (AASLD) (San Francisco) 2011
  23. 田中裕滋、池田高紀、山本和夫、小川博、上硲俊法　Nrf2欠損マウスにおける鉄代謝および脂質代謝の調節不全 第47回日本肝臓学会総会（東京）2011
  24. Tanaka Y, Kamisako T. Dietary fish oil up-regulates gene expression of cholesterol and bile acidmetabolism in mouse liver and intestine.　The 61st Annual Meeting of the American Association for the Study of Liver Diseases (AASLD) (Boston) 2010
  25. 田中裕滋、岸野好純、池田高紀、山本和夫、小川博、上硲俊法　脂肪酸組成の異なる食餌の肝臓及び小腸の脂質・胆汁酸代謝関連遺伝子への影響 第46回日本肝臓学会総会（山形）2010
  26. 田中裕滋、池田高紀、山本和夫、小川博、上硲俊法　脂肪酸組成の異なる高脂肪食負荷マウスにおける腸肝循環関連遺伝子発現の変動 第45回日本肝臓学会総会（神戸）2009
  27. 田中裕滋、池田高紀、山本和夫、小川博、上硲俊法　高脂肪食摂取がマウスの脂質および胆汁酸代謝に及ぼす影響-大豆油とラードの比較 第63回日本栄養・食糧学会大会（長崎）2009
  28. 田中裕滋、上硲俊法、Klaassen CD　高脂肪食負荷マウスにおける抗酸化酵素制御転写因子NF-E2-related factor 2 (Nrf2)の肝内遊離脂肪酸と酸化ストレスの阻害 第44回日本肝臓学会総会（松山）2008
  29. Tanaka Y, Slitt AL, Klaassen CD, Copple BL. Nuclear factor E2 p45-related factor(Nrf2) promotes liver injury in mice after bile-duct ligation. The57th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD) (Boston) 2006
  30. Tanaka Y, Maher JM, Chen C, Klaassen CD. Hepatic ischemia-reperfusion induces renal heme oxygenase-1 via nf-e2-related factor 2 in rats and mice. The45th Annual Meeting of the Society of toxicology (SOT) (San Diego) 2005
  31. Tanaka Y, Chen C, Maher JM, Klaassen CD. Kupffer cell-mediated downregulationof heaptic transporter expression in rat hepatic ischemia-reperfusion. The 13th North American International Society for the Study of Xenobiotics (ISSX) (Maui) 2005
  32. Tanaka Y, Slitt AL, Leazer T, Maher JM, Klaassen CD. Tissue distribution and hormonal regulation of the breast cancer resistance protein (BCRP/ABCG2) in rats and mice.The 43rd Annual Meeting of the Society of toxicology (SOT) (Baltimore) 2004

    　　著書
    （分担執筆）

    田中裕滋　薬剤師のための検査値判読ドリル 2021 p64-68,p88-92,p188- 192,p224-234.
    田中裕滋　薬剤師のための基礎からの検査値の読み方 2018 p12-15,p20-22,p26-29.
    田中裕滋　別冊 新領域別症候群 20 先天性代謝異常症候群 下 2012 p348-352.
    田中裕滋    　Annual Review 消化器 2003　代謝性肝疾患 p323-28.
    田中裕滋　消化器疾患のとらえかた 2002 p151-160.

    　受賞

    2006年　米国毒性学会　最優秀演題賞

    2012年　米国肝臓学会　優秀演題賞

    2019年　日本栄養・食糧学会　トピックス演題

    2020年　2018年度Best Teacher賞

    　

    　科学研究費

    科学研究費（基盤研究C）課題番号23580188「酸化ストレス制御転写因子を標的とした脂肪肝炎の発症機構の解明と食品成分による予防」 平成23年～25年 研究代表 田中裕滋

    科学研究費（基盤研究C）課題番号18K11006「胆汁鬱滞による脂質代謝異常に対する小腸の役割の解明」 平成30年～令和2年 研究代表 田中裕滋

    科学研究費（基盤研究C）課題番号21K11740「植物ステロールの効能と毒性における小腸コレステロール排泄機構の役割」 令和3年～5年 研究代表 田中裕滋
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