研究テーマ

　骨軟骨の修復・再生に適した組織環境の解明
　筋と骨の相互作用機構の解明

研究助成金（科研費）

平成３１〜令和3年度

文部科学省　科学研究費補助金（基盤研究C）

平成28〜30年度〜

文部科学省　科学研究費補助金（基盤研究C）

平成25〜27年度

文部科学省　科学研究費補助金（基盤研究C）

平成23〜24年度

文部科学省　科学研究費補助金（若手研究B）

平成20〜21年度

文部科学省　科学研究費補助金（若手研究B）

平成18〜19年度

文部科学省　科学研究費補助金（若手研究B）

研究助成金（科研費以外）

平成29年度

公益財団法人　三井生命厚生財団　医学研究助成

平成27年度

公益財団法人　武田科学振興財団　医学研究奨励（基礎）

平成27年度

公益財団法人　骨粗鬆症財団　研究助成金

平成26年度

公益財団法人　中冨健康科学振興財団　研究助成金

平成26年度

公益財団法人　神澤医学研究振興財団　研究助成金

平成25年度

公益財団法人　大阪難病研究財団　医学助成

平成24年度

財団法人　大阪難病研究財団　医学助成

平成23年度

財団法人　大阪難病研究財団　医学助成

受賞

• Young Investigators Awards. 22nd International Congress on Fibrinolysis & Proteolysis, 2014.
• Young Investigators Award. XXIII Congress of the International Society on Thrombosis and Haemostasis, 2011.
• 優秀ポスター賞．第32回日本血栓止血学会学術集会．2009.

シンポジウム・招待講演

• Naoyuki Kawao. Roles of Plasminogen Activator Inhibitor-1 in Bone Metabolism. Plasminogen Activation and Extracellular Proteolysis, Gordon Research Conference. 2020.
• Naoyuki Kawao. Hironobu Morita, Hiroshi Kaji. Roles of Dkk2 in the effects of gravity change on the interactions between muscle and bone in mice. The 97th Annual Meeting of the Physiological Society of Japan. 2020.
• 河尾直之. 組織修復・再生と線溶. 第38回日本血栓止血学会学術集会. 2016.
• 河尾直之. 骨修復・再生機構における組織線溶系因子の役割. 第17回骨代謝研究会. 2014.
• 河尾直之. 骨修復機構における組織線溶系. 生体機能と創薬シンポジウム2014. 2014.
• Naoyuki Kawao, Hiroshi Kaji. Plasminogen plays a primary role in bone repair. Anti-Aging International Mini-Symposium 2014: Cell Signaling and Therapeutic Targets for Geriatric and Inflammatory Diseases. 2014.
• Naoyuki Kawao, Nobuo Nagai, Yukinori Tamura, Masato Yano, Kiyotaka Okada, Yasuhiro Suzuki, Kazuo Umemura, Hiroshi Kaji, Osamu Matsuo. Role of the fibrinolytic system in recovery responses after liver injury. 第35回日本血栓止血学会学術集会. 2013.
• Osamu Matsuo, Naoyuki Kawao. Role of plasminogen in liver repair. 6th Japanese-German Conference on Thrombosis and Hemostasis. 2011.

主要業績

• Kawao N, Iemura S, Kawaguchi M, Mizukami Y, Takafuji Y, Kaji H. Role of irisin in effects of chronic exercise on muscle and bone in ovariectomized mice. J Bone Miner Metab. 39:547-557, 2021.
• Kawao N, Morita H, Iemura S, Ishida M, Kaji H. Roles of Dkk2 in the linkage from muscle to bone during mechanical unloading in mice. Int J Mol Sci. 21(7):E2547, 2020.
• Kawao N, Takafuji Y, Ishida M, Okumoto K, Morita H, Muratani M, Kaji H. Roles of the vestibular system in obesity and impaired glucose metabolism in high-fat diet-fed mice. PLoS One. 15(2):e0228685, 2020.
• Kawao N, Ishida M, Kaji H. Roles of leptin in the recovery of muscle and bone by reloading after mechanical unloading in high fat diet-fed obese mice. PLoS One. 14(10):e0224403, 2019.
• Kawao N, Morita H, Nishida K, Obata K, Tatsumi K, Kaji H. Effects of hypergravity on the gene levels in anti-gravity muscle and bone through the vestibular system in mice. J Physiol Sci. 68:609-616, 2018.
• Kawao N, Moritake A, Tatsumi K, Kaji H. Roles of irisin in the linkage from muscle to bone during mechanical unloading in mice. Calcif Tissue Int. 103:24-34, 2018.
• Kawao N, Morita H, Obata K, Tatsumi K, Kaji H. Role of follistatin in muscle and bone alterations induced by gravity change in mice. J Cell Physiol. 233:1191-1201, 2018.
• Kawao N, Morita H, Obata K, Tamura Y, Kaji H. The vestibular system is critical for the changes in muscle and bone induced by hypergravity in mice. Physiol Rep. 4:e12979, 2016.
• Kawao N, Yano M, Tamura Y, Okumoto K, Okada K, Kaji H. Role of osteoclasts in the heterotopic ossification enhanced by fibrodysplasia ossificans progressiva-related activin-like kinase 2 mutation in mice. J Bone Miner Metab. 34:517-25, 2016.
• Kawao N, Kaji H. Interactions Between Muscle Tissues and Bone Metabolism. J Cell Biochem. 116：687-695, 2015.Review.
• Kawao N, Tamura Y, Horiuchi Y, Okumoto K, Yano M, Okada K, Matsuo O, Kaji H. The Tissue Fibrinolytic System Contributes to the Induction of Macrophage Function and CCL3 during Bone Repair in Mice. PLoS One. 10:e0123982, 2015.
• Kawao N, Tamura Y, Okumoto K, Yano M, Okada K, Matsuo O, Kaji H. Tissue-type plasminogen activator deficiency delays bone repair: roles of osteoblastic proliferation and vascular endothelial growth factor. Am J Physiol Endocrinol Metab. 2014;307:E278-88.
• Kawao N, Tamura Y, Okumoto K, Yano M, Okada K, Matsuo O, Kaji H. Plasminogen plays a crucial role in bone repair. J Bone Miner Res. 2013;28:1561-74.
• Kawao N, Nagai N, Tamura Y, Horiuchi Y, Okumoto K, Okada K, Suzuki Y, Umemura K, Yano M, Ueshima S, Kaji H, Matsuo O. Urokinase-type plasminogen activator and plasminogen mediate activation of macrophage phagocytosis during liver repair in vivo. Thromb Haemost. 2012;107:749-59.
• Kawao N, Nagai N, Tamura Y, Okada K, Yano M, Suzuki Y, Umemura K, Ueshima S, Matsuo O. Urokinase-type plasminogen activator contributes to heterogeneity of macrophages at the border of damaged site during liver repair in mice. Thromb Haemost. 2011;105:892-900.
• Kawao N, Nagai N, Ishida C, Okada K, Okumoto K, Suzuki Y, Umemura K, Ueshima S, Matsuo O. Plasminogen is essential for granulation tissue formation during the recovery process after liver injury in mice. J Thromb Haemost. 2010;8:1555-66.
• Kawao N, Nagai N, Okada K, Okumoto K, Ueshima S, Matsuo O. Role of plasminogen in macrophage accumulation during liver repair. Thromb Res. 2010;125:e214-21.
• Kawao N, Okada K, Kawata S, Okamoto C, Tsuritani M, Ueshima S, Matsuo O. Plasmin decreases the BH3-only protein BimEL via the ERK1/2 signaling pathway in hepatocytes. Biochim Biophys Acta. 2007;1773:718-27.
• Kawao N, Nagataki M, Nagasawa K, Kubo S, Cushing K, Wada T, Sekiguchi F, Ichida S, Hollenberg MD, MacNaughton WK, Nishikawa H, Kawabata A. Signal transduction for proteinase-activated receptor-2-triggered prostaglandin E2 formation in human lung epithelial cells. J Pharmacol Exp Ther. 2005;315:576-89.
• Kawabata A, Kawao N. Physiology and pathophysiology of proteinase-activated receptors (PARs): PARs in the respiratory system: cellular signaling and physiological/pathological roles. J Pharmacol Sci. 2005;97:20-4. Review.
• Kawao N, Ikeda H, Kitano T, Kuroda R, Sekiguchi F, Kataoka K, Kamanaka Y, Kawabata A. Modulation of capsaicin-evoked visceral pain and referred hyperalgesia by protease-activated receptors 1 and 2. J Pharmacol Sci. 2004;94(3):277-85.
• Kawao N, Hiramatsu K, Inoi N, Kuroda R, Nishikawa H, Sekiguchi F, Kawabata A. The PAR-1-activating peptide facilitates pepsinogen secretion in rats. Peptides. 2003;24(9):1449-51.
• Kawao N, Shimada C, Itoh H, Kuroda R, Kawabata A. Capsazepine inhibits thermal hyperalgesia but not nociception triggered by protease-activated receptor-2 in rats. Jpn J Pharmacol. 2002;89(2):184-7.
• Kawao N, Sakaguchi Y, Tagome A, Kuroda R, Nishida S, Irimajiri K, Nishikawa H, Kawai K, Hollenberg MD, Kawabata A. Protease-activated receptor-2 (PAR-2) in the rat gastric mucosa: immunolocalization and facilitation of pepsin/pepsinogen secretion. Br J Pharmacol. 2002;135:1292-6.
• Kawabata A, Kawao N, Kuroda R, Tanaka A, Itoh H, Nishikawa H. Peripheral PAR-2 triggers thermal hyperalgesia and nociceptive responses in rats. Neuroreport. 2001;12:715-9.

所属学会、資格