2021年

• Ehara H, Tatsumi K, Takafuji Y, Kawao N, Ishida M, Okada K, Mackman N, Kaji H. Role of tissue factor in delayed bone repair induced by diabetic state in mice. PLoS One. 16(12):e0260754, 2021.
• Ehara H, Takafuji Y, Tatsumi K, Okada K, Mizukami Y, Kawao N, Matsuo O, Kaji H. Role of plasminogen activator inhibitor-1 in muscle wasting induced by a diabetic state in female mice. Endocrine Journal. 68(12):1421-1428, 2021.
• Ishida M, Kawao N, Mizukami Y, Takafuji Y, Kaji H. Serpinb1a suppresses osteoclast formation. Biochem Biophys Rep. 26;26:101004, 2021.
• Takafuji Y, Tatsumi K, Kawao N, Okada K, Muratani M, Kaji H. Effects of fluid flow shear stress to mouse muscle cells on the bona actions of muscle cell-derived extracellular vesicles. PLoS One. 16(5):e0250741, 2021.
• Ishida M, Kawao N, Mizukami Y, Takafuji Y, Kaji H. Influence of Angptl1 on osteoclast formation and osteoblastic phenotype in mouse cells. BMC Muscloskelt Disord. 22(1):398, 2021.
• Kawao N, Iemura S, Kawaguchi M, Mizukami Y, Takafuji Y, Kaji H. Role of irisin in effects of chronic exercise on muscle and bone in ovariectomized mice. J Bone Miner Metab. 39(4):547-557, 2021.
• Takafuji Y, Tatsumi K, Kawao N, Okada K, Muratani M, Kaji H. Micro RNA 196a-5p in extracellular vesicles secreted from myoblasts suppresses osteoclast-like cell formation in mouse cells. Calcif Tissue Int.108(3):364-376, 2021.
• Iemura S, Kawao N, Akagi M, Kaji H. Role of Dkk2 in the Muscle/bone Interaction of Androgen-Deficient Mice. Exp Clin Endocrinol Diabetes. 129(10):770-775, 2021.
• Zhang S, Ueno D, T Ohira T, Kato H, Izawa T, Yamonouchi S, Yoshida Y, Takahashi A, Ohira Y. Depression of Bone Density at the Weight-Bearing Joints in Wistar Hannover Rats by a Simulated Mechanical Stress Associated With Partial Gravity Environment. Front Cell Dev Biol. 9:707470, 2021.
• Ohira T, Ino Y, Kimura Y, Nakai Y, Kimura A, Kurata Y, Kagawa H, Kimura M, Egashira K, Matsuda C, Ohira Y, Furukawa S, Hirano H. Effects of microgravity exposure and fructo-oligosaccharide ingestion on the proteome of soleus and extensor digitorum longus muscles in developing mice. NPJ Microgravity. 7(1):34, 2021.
  
• Mizukami Y, Takahashi Y, Shimizu K, Konishi S, Takakura Y, Nishikawa M. Calcium Peroxide-Containing Polydimethylsiloxane-Based Microwells for Inhibiting Cell Death in Spheroids through Improved Oxygen Supply. Biol Pharm Bull. 44(10):1458-1464, 2021.

2020年

• Shimoide T, Kawao N, Morita H, Ishida M, Takafuji Y, Kaji H. Roles of olfactomedin 1 in muscle and bone alterations induced by gravity change in mice. Calcif Tissue Int. 107(2):180-190,2020.
• Kawaguchi M, Kawao N, Takafuji Y, Ishida M, Kaji H. Myonectin inhibits the differentiation of osteoblasts and osteoclasts in mouse cells. Heliyon. 6(5):e03967,2020.
• Kawao N, Morita H, Iemura S, Ishida M, Kaji H. Roles of Dkk2 in the linkage from muscle to bone during mechanical unloading in mice. Int J Mol Sci. 21(7):E2547, 2020.
• Okada K, Okamoto T, Okumoto K, Takafuji Y, Ishida M, Kawao N, Matsuo O, Kaji H. PAI-1 is involved in delayed bone repair induced by glucocorticoids in mice. Bone. 134 115310, 2020.
• Takafuji Y, Tatsumi K, Ishida M, Kawao N, Okada K, Kaji H. Extracellular vesicles secreted from mouse muscle cells suppress osteoclast formation: Roles of mitochondrial energy metabolism. Bone. 134:115298, 2020.
• Masayoshi Ishida, Kohei Tatsumi, Katsumi Okumoto, Hiroshi Kaji. Adipose tissue-derived stem cell sheet improves glucose metabolism in obese mice. Stem Cells and Development. 29(8),2020.
• Kawao N, Takafuji Y, Ishida M, Okumoto K, Morita H, Muratani M, Kaji H. Roles of the vestibular system in obesity and impaired glucose metabolism in high-fat diet-fed mice. PLoS One. 15(2):e0228685, 2020.
• Okada K, Nishioka M, Kaji H. Roles of fibrinolytic factors in the alterations in bone marrow hematopoietic stem/progenitor cells during bone repair. Inflamm Regen. 2020 Sep 16;40:22. doi: 10.1186/s41232-020-00128-5.
• Morita H, Kaji H, Ueta Y, Abe C. Understanding vestibular-related physiological functions could provide clues on adapting to a new gravitational environment. J Physiol Sci. 70(1):17, 2020.
• Iemura S, Kawao N, Okumoto K, Akagi M, Kaji H. Role of irisin in androgen-deficient muscle wasting and osteopenia in mice. J Bone Miner Metab. 38(2):161-171,2020
• Mizukami Y, Moriya A, Takahashi Y, Shimizu K, Konishi S, Takakura Y, Nishikawa M. Incorporation of Gelatin Microspheres into HepG2 Human Hepatocyte Spheroids for Functional Improvement through Improved Oxygen Supply to Spheroid Core. Biol Pharm Bull. 43(8):1200-1225, 2020.

2019年

• Kawao N, Ishida M, Kaji H. Roles of leptin in the recovery of muscle and bone by reloading after mechanical unloading in high fat diet-fed obese mice. PLoS One. 14(10):e0224403, 2019.
• Takafuji Y, Tatsumi K, Ishida M, Kawao N, Okada K, Matsuo O, Kaji H. Plasminogen activator inhibitor-1 deficiency suppresses osteoblastic differentiation of mesenchymal stem cells in mice. J Cell Physiol. 234:9687-9697, 2019. 
• Moritake A, Kawao N, Okada K, Ishida M, Tatsumi K, Matsuo O, Akagi M, Kaji H. Plasminogen activator inhibitor-1 is involved in interleukin-1β-induced matrix metalloproteinase expression in murine chondrocytes. Mod Rheumatol. 29(6):959-963, 2019.
  
• Ikeda T, Kaji H, Tamura Y, Akagi M. Once-weekly teriparatide reduces serum sclerostin levels in postmenopausal women with osteoprosis. J Orthop Sci. 24:532-538, 2019. 
• Takafuji Y, Hori M, Mizuno T, Harada-Shiba M.Humoral factors secreted from adipose tissue-derived mesenchymal stem cells ameliorate atherosclerosis in Ldlr-/- mice.Cardiovascular Research. 115:1041-1051, 2019. 

2018年

• Ishida M, Kawao N, Okada K, Tatsumi K, Sakai K, Nishio K, Kaji H. Serpina3n, dominantly expressed in female osteoblasts, suppresses the phenotypes of differentiated osteoblasts in mice. Endocrinology. 159:3775-3790, 2018.
• Shimoide T, Kawao N, Tamura Y, Okada K, Horiuchi Y, Okumoto K, Kurashimo S, Ishida M, Tatsumi K, Matsuo O, Kaji H. Role of macrophages and plasminogen activator inhibitor-1 in delayed bone repair in diabetic female mice. Endocrinology. 159:1875-1885, 2018.
• Kawao N, Morita H, Nishida K, Obata K, Tatsumi K, Kaji H. Effects of hypergravity on the gene levels in anti-gravity muscle and bone through the vestibular system in mice. J Physiol Sci. 68:609-616, 2018.
• Kawao N, Moritake A, Tatsumi K, Kaji H. Roles of irisin in the linkage from muscle to bone during mechanical unloading in mice. Calcif Tissue Int. 103:24-34, 2018.
• Kawao N, Morita H, Obata K, Tatsumi K, Kaji H. Role of follistatin in muscle and bone alterations induced by gravity change in mice. J Cell Physiol. 233:1191-1201, 2018.
• Okada K, Kawao N, Tatsumi K, Ishida M, Takafuji Y, Kurashimo S, Okumoto K, Kojima K, Matsuo O, Kaji H. Roles of plasminogen in the alterations in bone marrow hematopoietic stem cells during bone repair. Bone Rep. 8:195–203, 2018.
• Tamura Y, Kawao N, Shimoide T, Okada K, Matsuo O, Kaji H. Role of plasminogen activator inhibitor-1 in glucocorticoid-induced muscle change in mice. J Bone Miner Metab. 36:148-156, 2018.
  
• Chandy M, Ishida M, Shikatani EA, El-Mounayri O, Park LC, Afroze T, Wang T, Marsden PA, Husain M. c-Myb regulates transcriptional activation of miR-143/145 in vascular smooth muscle cells. PLoS One. 13(8):e0202778, 2018.
  
• Kasuda S, Sakurai Y, Tatsumi K, Takeda T, Kudo R, Yuui K, Hatake K. Experimental hypercoagulable state induced by tissue factor expression in monocyte-derived dendritic cells and its modulation by C1 inhibitor. J Thromb Thrombolysis. 46(2):219-226, 2018.
  
• Utoh R, Komori J, Kuge H, Tatsumi K, Yamada M, Hirohashi S, Tsutsumi M, Amanuma T, Yoshioka A, Nakajima Y, Wake K, Okano T, Lagasse E, Ohashi K. Adult hepatocytes direct liver organogenesis through non-parenchymal cell recruitment in the kidney. J Hepatol. 68(4):744-753, 2018.
  
• Antoniak S, Tatsumi K, Schmedes CM, Grover SP, Pawlinski R, Mackman N. Protease-activated receptor 1 activation enhances doxorubicin-induced cardiotoxicity. J Mol Cell Cardiol. 122:80-87, 2018.
  

2017年

• Moritake A, Kawao N, Okada K, Tatsumi K, Ishida M, Okumoto K, Matsuo O, Akagi M, Kaji H. Plasminogen activator inhibitor-1 deficiency enhances subchondral osteopenia after induction of osteoarthritis in mice. BMC Musculoskelet Disord. 18:392, 2017.
• Okada K, Kojima K, Okumoto K, Kawao N, Matsuo O, Kaji H. A synthetic peptide derived from staphylokinase enhances FGF-2-induced skin wound healing in mice. Thromb Res. 157:7-8, 2017.
  
• Tamura Y, Fujito H, Kawao N, Kaji H. Vitamin D deficiency aggravates diabetes-induced muscle wasting in female mice. Diabetol Int. 8:52-58, 2017.
  
• Ikeda T, Kaji H, Akagi M. Effects of alendronate on trabecular bone score in glucocorticoid-treated patients. Acta Med Kinki Univ. 42:17-23, 2017.
• Tatsumi K, Okano T.  Hepatocyte Transplantation: Cell Sheet Technology for Liver Cell Transplantation.  Curr Transpl Rep. 4:184-192, 2017.
• Antoniak S, Tatsumi K, Bode M, Vanja S, Williams JC, Mackman N. Protease-Activated Receptor 1 Enhances Poly I:C Induction of the Antiviral Response in Macrophages and Mice.  J Innate Immun. 9(2):181-192, 2017.
• Kina-Tanada M, Sakanashi M, Tanimoto A, Kaname T, Matsuzaki T, Noguchi K, Uchida T, Nakasone J, Kozuka C, Ishida M, Kubota H, Taira Y, Totsuka Y, Kina SI, Sunakawa H, Omura J, Satoh K, Shimokawa H, Yanagihara N, Maeda S, Ohya Y, Matsushita M, Masuzaki H, Arasaki A, Tsutsui M. Long-term dietary nitrite and nitrate deficiency causes the metabolic syndrome, endothelial dysfunction and cardiovascular death in mice.  Diabetologia. 60(6):1138-1151, 2017.
• Kanazawa Y, Ikegami K, Sujino M, Koinuma S, Nagano M, Oi Y, Onishi T, Sugiyo S, Takeda I, Kaji H, Shigeyoshi Y. Effects of aging on basement membrane of the soleus muscle during recovery following disuse atrophy in rats. Exp Gerontol. 98:153-161, 2017.

2016年

• Shimoide T, Kawao N, Tamura Y, Morita H, Kaji H. Novel roles of FKBP5 in muscle alteration induced by gravity change in mice. Biochem Biophys Res Commun. 479:602-606, 2016.
  
• Kawao N, Morita H, Obata K, Tamura Y, Kaji H. The vestibular system is critical for the changes in muscle and bone induced by hypergravity in mice. Physiol Rep. 4:e12979, 2016.
• Kaji, H.  Gravity change and muscle/bone relationship.  In:  Adaptation Biology and Medicine:  Current Trends.  Eds. Y. Kawai, A.R. Hargens and P.K. Singal.  Narosa Publishing House, New Delhi, Vol. 8, (In Press), 2016.
• Kaji H. Effects of myokines on bone. Bonekey Rep. 5:826, 2016. doi:10.1038/bonekey.2016.48
• Kaji H. Adipose tissue-derived plasminogen activator inhibitor-1 function and regulation. Compr Physiol. ６:1873-1896, 2016.
• Kawao N, Yano M, Tamura Y, Okumoto K, Okada K, Kaji H. Role of osteoclasts in the heterotopic ossification enhanced by fibrodysplasia ossificans progressiva-related activin-like kinase 2 mutation in mice. J Bone Miner Metab. 34:517-25, 2016.
• Okada K, Kawao N, Yano M, Tamura Y, Kurashimo S, Okumoto K, Kojima K, Kaji H. Stromal cell-derived factor-1 mediates changes of bone marrow stem cells during bone repair process. Am J Physiol Endocrinol Metab. 310:E15-23, 2016.
• Kasuda S, Tatsumi K, Sakurai Y, Shima M, Hatake K. Therapeutic approaches for treating hemophilia A using embryonic stem cells. Hematol Oncol Stem Cell Ther. 9(2):64-70, 2016.
• Rondina MT, Tatsumi K, Bastarache JA, Mackman N. Microvesicle Tissue Factor Activity and Interleukin-8 Levels are Associated with Mortality in Patients with Influenza A/H1N1 Infection. Crit Care Med. 44(7):e574-8, 2016.
• Tatsumi K*, Antoniak S*, Subramaniam S, Gondouin B, Neidich SD, Beck MA, Mickelson J, Monroe DM 3rd, Bastarache JA, Mackman N.  Anticoagulation Increases Alveolar Hemorrhage in Mice Infected with Influenza A.  Physiol Rep. 4:e13071, 2016. (* contributed equally to this work)
• Tanaka K, Kanazawa I, Kaji H, Sugimoto T. Association of osteoglycin and FAM5C with bone turnover markers, bone mineral density, and vertebral fractures in postmenopausal women with type 2 diabetes mellitus. Bone. 95:5-10, 2016.

2015年

• Shiomi A, Kawao N, Yano M, Okada K, Tamura Y, Okumoto K, Matsuo O, Akagi M, Kaji H. α2-Antiplasmin is involved in bone loss induced by ovariectomy in mice. Bone. 79:233-241, 2015.
• Kawao N, Tamura Y, Horiuchi Y, Okumoto K, Yano M, Okada K, Matsuo O, Kaji H. The Tissue Fibrinolytic System Contributes to the Induction of Macrophage Function and CCL3 during Bone Repair in Mice. PLoS One. 10:e0123982, 2015.
• Tamura Y, Kawao N, Yano M, Okada K, Okumoto K, Chiba Y, Matsuo O, Kaji H. Role of plasminogen activator inhibitor-1 in glucocorticoid-induced diabetes and osteopenia in mice. Diabetes. 64:2194-2206, 2015.
• Kawao N, Kaji H. Interactions Between Muscle Tissues and Bone Metabolism. J Cell Biochem. 116：687-695, 2015.
• Yasui M, Tamura Y, Minami M, Higuchi S, Fujikawa R, Ikedo T, Nagata M, Arai H, Murayama T, Yokode M. The Prostaglandin E2 Receptor EP4 Regulates Obesity-Related Inflammation and Insulin Sensitivity. PLoS One. 10:e0136304, 2015.
• Yamamoto J, Tamura Y, Ijiri Y, Iwasaki M, Murakami M, Matsuo O.　Evaluation of antithrombotic effect: Importance of testing components and methodologies. Drug Discov Ther. 9:258-266, 2015.

2014年

• Kawao N, Tamura Y, Okumoto K, Yano M, Okada K, Matsuo O, Kaji H. Tissue-type plasminogen activator deficiency delays bone repair: roles of osteoblastic proliferation and vascular endothelial growth factor.Am J Physiol Endocrinol Metab. 307:E278-288, 2014.
• Yano M, Kawao N, Okumoto K, Tamura Y, Okada K, Kaji H. Fibrodysplasia Ossificans progressiva-related activin-like kinase signaling enhances osteoclast formation during heterotopic ossification in muscle tissues.J Biol Chem. 289:16966-16977, 2014.

• Tamura Y, Kawao N, Yano M, Okada K, Matsuo O, Kaji H. Plasminogen activator inhibitor-1 deficiency ameliorates insulin resistance and hyperlipidemia but not bone loss in obese female mice. Endocrinology. 155:1708-1717, 2014.
• Mao L, Kawao N, Tamura Y, Okumoto K, Okada K, Yano M, Matsuo O, Kaji H. Plasminogen activator inhibitor-1 is involved in impaired bone repair associated with diabetes in female mice. PLOS ONE. 9:e92686, 2014.
• Kaji H. Interaction between muscle and bone. J Bone Metab. 21:29-40, 2014.
• Mao L, Tamura Y, Kawao N, Yano M, Okada K, Okumoto K, Kaji H. Influence of diabetic state and vitamin D deficiency on bone repair in female mice. Bone. 61:102-108, 2014.
• Tanaka K, Kaji H, Yamaguchi T, Kanazawa I, Canaff L, Hendy GN, Sugimoto T. Involvement of the osteoinductive factors, Tmem119 and BMP-2, and the ER stress response PERK-elF2a-ATF4 pathway in the commitment of myoblastic into osteoblastic cells. Calcif Tissue Int. 94:454-464, 2014.
• Yano M, Kawao N, Tamura Y, Okada K, Kaji H. A novel factor, Tmem176b, induced by activin-like kinase 2 signal promotes the differentiation of myoblasts into osteoblasts. Exp Clin Endocrinol Diabet. 122:7-14, 2014.
• Ikeda T, Maruyama K, Kaji H, Akagi M. Effects of alendronate or alfacalcidol on bone metabolic indices and bone mineral density in patients with ophthalmologic disease treated with glucocorticoid. Modern Rheumatol. 24:671-676, 2014.
• Tanaka KI, Kanazawa I, Yamaguchi T, Yano S, Kaji H, Sugimoto T. Active vitamin D possesses beneficial effects on the interaction between muscle and bon. Biochem Biophys Res Commun. 450:482-487, 2014.
• Tamura Y, Mori S, Asada S, Kawao N, Ueshima S, Kaji H, Yamamoto J, Akagi M, Matsuo O. Enhanced pre-operative thrombolytic status is associated with the incidence of deep venous thrombosis in patients undergoing total knee arthroplasty. Thrombosis Journal. 12:11, 2014.
• Tamura Y, Inoue A, Ijiri Y, Naemura A, Yamamoto J. Short- and long-term treatment with folic acid suppresses thrombus formation in atherogenic mice in vivo. Pathophysiology. 21:169-175, 2014.

2013年

• Tamura Y, Kawao N, Oakda K, Yano M, Okumoto K, Matsuo O, Kaji H. Plasminogen activator inhibitor-1 is involved in streptozotocin-induced bone loss in female mice. Diabetes. 62:3170-3179, 2013.
• Kawao N, Tamura Y, Okumoto K, Yano M, Oakda K, Matsuo O, Kaji H. Plasminogen plays a crucial role in bone repair. J Bone Miner Res. 28:1561-1574, 2013.
• Kaji H. Linkage between muscle and bone: Common catabolic signals resulting in osteporosis and sarcopenia. Current Opinion in Clinical Nutrition and Metabolic Care. 16:272-277, 2013.
• Tanaka K, Yamaguchi T, Kaji H, Kanazawa I, Sugimoto T. Advanced glycation end products suppress osteoblastic differentiation of stromal cells by activating endoplasmic reticulum stress. Biochem Biophys Res Commun. 438: 463-467, 2013.
• Mao L, Yano M, Kawao N, Tamura Y, Okada K, Kaji H. Role of matrix metalloproteinase-10 in the BMP-2 inducing osteoblastic differentiation. Endocr J. 60: 1309-1319, 2013.
• Kanno Y, Kawashita E, Kokado A, Okada K, Ueshima S, Matsuo O, Matsuno H. Alpha2-antiplasmin regulates the development of derrnal fibrosis by PGF2a synthesis through ATGL/iPLA2. Arthritis and Rheumatism. 65: 492-502, 2013.
• Sugioka K, Kodama A, Okada K, Iwata M, Yoshida K, Kusaka S, Matsumoto C, Kaji H, Shimomura Y. TGF-β2 promotes RPE cell invasion into a collagen gel by mediating urokinase-type plasminogen activator（uPA）expression. Exp Eye Res. 115C: 13-21, 2013.
• Tamura Y, Yano M, Kawao N, Okumoto K, Ueshima S, Kaji H, Matsuo O. Enzamin ameliorates adipose tissue inflammation with impaired adipocytokine expression and insulin resistance in db/db mice. J Nutr Sci. 2: 1-10, 2013.
• Okada K, Ueshima S, Kawao N, Yano M, Tamura Y, Tanaka M, Sakamoto A, Hatano M, Arima M, Miyata S, Nagai N, Tokuhisa T, Matsuo O. Lack of both α2-antiplasmin and plasminogen activator inhibitor type-1 induces high IgE production. Life Sci. 93: 89-95, 2013.

2012年