研究テーマ

　骨組織修復・再生過程における幹細胞分化誘導機構の解明

所属学会・資格

受賞

• 日本血液学会奨励賞（平成4年3月）
• 北里大学若手研究者奨励賞（平成4年5月）
• 関西血栓フォーラム学術奨励賞（平成16年1月）
• 日本炎症・再生医学会優秀演題賞（令和元年7月）

研究助成金（代表者）

平成30～令和2年度

文部科学省　科学研究費補助金（基盤研究C）

平成27～29年度

文部科学省　科学研究費補助金（基盤研究C）

平成23～25年度

文部科学省　科学研究費補助金（基盤研究C）

平成20～22年度

文部科学省　科学研究費補助金（基盤研究C）

平成15～16年度

文部科学省　科学研究費補助金（基盤研究C）

平成 9～10年度

文部科学省　科学研究費補助金（基盤研究C）

平成 4年度

横山応用薬理財団

主要業績（著書）

• Okada K, Ueshima S, Matsuo O. Role of fibrinolysis in hepatic regeneration. In: Recent Advances in Thrombosis and Hemostasis 2008 (Tanaka K, Davie EW eds), Tokyo, Springer Japan, pp336-347, 2008.
• Okada K, Bando H, Kakidani H, Numao N, Matsuo O. Characterization of finger-domain lacking tissue-type plasminogen activator. In: Fibrinolysis: current prospects (Castellino PJ, Plow EF, Takada A eds), London, John Libbey, pp19-26, 1988.

主要業績（論文）

• Okada K, Kawao N, Nakai D, Wakabayashi R, Horiuchi Y, Okumoto K, Kurashimo S, Takafuji Y, Matsuo O, Kaji H. Role of macrophages and plasminogen activator inhibitor-1 in delayed bone repair induced by glucocorticoids in mice. Int J Mol Sci. 23(1), 478, 2022.
• Okada K, Nishioka M, Kaji H. Roles of fibrinolytic factors in the alterations in bone marrow hematopoietic stem/progenitor cells during bone repair. Inflammation and Regeneration. 40, 22, 2020.
• Okada K, Okamoto T, Okumoto K, Takafuji Y, Ishida M, Kawao N, Matsuo O, Kaji H. PAI-1 is involved in delayed bone repair induced by glucocorticoids in mice. Bone. 134:115310–115310, 2020.
• Okada K, Kawao N, Tatsumi K, Ishida M, Takafuji Y, Kurashimo S, Okumoto K, Kojima K, Matsuo O, Kaji H. Roles of plasminogen in the alterations in bone marrow hematopoietic stem cells during bone repair. Bone Rep. 8:195–203, 2018.
• Okada K, Kojima K, Okumoto K, Kawao N, Matsuo O, Kaji H. A synthetic peptide derived from staphylokinase enhances FGF-2-induced skin wound healing in mice. Thromb Res. 157:7-8, 2017.
• Okada K, Kawao N, Yano M, Tamura Y, Kurashimo S, Okumoto K, Kojima K, Kaji H. Stromal cell-derived factor-1 mediates changes of bone marrow stem cells during bone repair process. Am J Physiol Endocrinol Metab. 310: E15-23, 2016.
• Okada K, Ueshima S, Kawao N, Yano M, Tamura Y, Tanaka M, Sakamoto A, Hatano M, Arima M, Miyata S, Nagai N, Tokuhisa T, Matsuo O. Lack of both α2-antiplasmin and plasminogen activator inhibitor type-1 induces high IgE production. Life Sci. 93: 89-95, 2013.
• Okada K, Ueshima S, Matsuno H, Nagai N, Kawao N, Tanaka M, Matsuo O. A synthetic peptide derived from staphylokinase enhances plasminogen activation by tissue-type plasminogen activator. J Thromb Haemost. 9: 997-1006, 2011.
• Okada K, Ueshima S, Kawao N, Okamoto C, Matsuo K, Akao M, Seki T, Ariga T, Tanaka　M, Matsuo O. Binding of plasminogen to hepatocytes isolated from injured mice liver and nonparenchymal cell-dependent proliferation of hepatocytes. Blood Coagul Fibrin. 19: 503-511, 2008.
• Okada K, Ueshima S, Matsuno H, Kawao N, Okamoto C, Tanaka M, Matsuo O. Effect of staphylokinase-derived nonadecapeptide on the activation of plasminogen. Thromb Haemost. 97: 795-802, 2007.
• Okada K, Ueshima S, Imano M, Kataoka K, Matsuo O. The regulation of liver regeneration by the plasmin/α2-antiplasmin system. J Hepatology. 40: 110-116, 2004.
• Okada K, Ueshima S, Matsuo O. Relationship between the variations in blood coagulation/fibrinolytic factors and inflammatory reactions induced by LPS. Sysmex J Int. 12: 80-84, 2002.
• Okada K, Ueshima S, Fukao H, Matsuo O. Analysis of complex formation between plasmin(ogen) and staphylokinase or streptokinase. Arch Biochem Biophys. 393: 339-341, 2001.
• Tanaka M, Okada K, Ueshima S, Imano M, Ohyanagi H, Carmeliet P, Matsuo O. Impaired liver regeneration after partial hepatectomy in plasminogen deficient mice. Fibrinolysis Proteolysis. 15: 2-8, 2001.
• Okada K, Ueshima S, Tanaka M, Fukao H, Matsuo O. Analysis of plasminogen activation by the plasmin-staphylokinase complex in plasma of α2-antiplasmin-deficient mice. Blood Coagul Fibrin. 11: 645-655, 2000.
• Lijnen HR, Okada K, Matsuo O, Collen D, Dewerchin M. α2-antiplasmin gene deficiency in mice is associated with enhanced fibrinolytic potential without overt bleeding. Blood. 93: 2274-2281, 1999.
• Okada K, Lijnen HR, Dewerchin M, Belayew A, Matsuo O, Collen D, Bernaerts R. Characterization and targeting of the murine α2-antiplasmin gene. Thromb Haemost. 78: 1104-1011, 1997.
• Okada K, Ueshima S, Takaishi T, Yuasa H, Fukao H, Matsuo O. Effects of fibrin and α2-antiplasmin on plasminogen activation by staphylokinase. Am J Hematol. 53: 151-157, 1996.
• Okada K, Lijnen HR, Moreau H, Vanderschueren S, Collen D. Procoagulant properties of intravenous staphylokinase versus tissue-type plasminogen activator. Thromb Haemost. 76: 857-859, 1996.
• Okada K, Yuasa H, Hagiya Y, Takaishi T, Fukao H, Ueshima S, Matsuo O. Fibrinolytic activity in liver tissues of stroke-prone spontaneously hypertensive rats. Clin Exp Pharmacol Physiol. 5: 275-276, 1995.
• Okada K, Yuasa H, Hagiya Y, Fukao H, Ueshima S, Matsuo O. Kinetic analysis of plasminogen activation by staphylokinase/plasminogen complex in the presence of fibrin. Thromb Res. 76: 181-191, 1994.
• Okada K, Nonaka T, Matsumoto H, Fukao H, Ueshima S, Matsuo O. Effects of α2-plasmin inhibitor on plasminogen activation by staphylokinase/ plasminogen complex. Thromb Res. 76: 211-220, 1994.
• Matsuo O, Okada K, Fukao H, Ueshima S, Suzuki A. Cerebral plasminogen activator activity in spontaneously hypertensive stroke-prone rats. Stroke. 23: 995-999, 1992.
• Matsuo O, Okada K, Fukao H, Tomioka Y, Ueshima S, Watanuki M, Sakai M. Thrombolytic properties of staphylokinase. Blood. 76: 925-929, 1990.
• Okada K, Fukao H, Tanaka H, Ueshima S, Matsuo O. Purification and characterization of a plasma factor which cleaves single-chain form of t-PA and u-PA. Thromb Res. 57: 27-43, 1990.