Taniguchi, Y., Inoue, N., Morita, S., Nikaido, Y., Nakashima, T., Nagai,
N., Okada, K., Matsuo, O., Miyata, S.: Localization of plasminogen in mouse
hippocampus, cerebral cortex, and hypothalamus. Cell Tissue Res. 343: 303-317, 2011.
Kanno, Y., Ishisaki, A., Kawashita, E., Chosa, N., Nakajima, K., Nishihara, T., Toyoshima, K., Okada, K., Ueshima, S., Matsushita, K., Matsuo, O., Matsuno, H.: Plasminogen/plasmin modulates bone metabolism by regulating the osteoblast and osteoclast function. J Biol Chem. 286 (11): 8952-60, 2011.
2010年
Matsuo, O.: Pathophysiology in Japan. Pathophysiology. 17 (2): 71, 2010.
Nagai, N., Matsuo, O.: Roles of fibrinolytic system components in the nervous
system. Pathophysiology. 17 (2): 141-147, 2010.
Kanno, Y., Kawashita, E., Minamida, M., Kaneiwa, A., Okada, K., Ueshima, S., Matsuo, O., Matsuno, H.: alpha2-antiplasmin is associated with the progression of fibrosis. Am J Pathol. 176 (1): 238-245, 2010.
Nagai, N., Kawao, N., Okada, K., Ishida, C., Okumoto, K., Ueshima, S.,
Suzuki, Y., Umemura, K., Matsuo, O.: Initial brain lesion size affects
the extent of subsequent pathophysiological responses. Brain Res. 1322: 109-117, 2010.
Kawao, N., Nagai, N., Okada, K., Okumoto, K., Ueshima, S., Matsuo, O.:
Role of plasminogen in macrophage accumulation during liver repair. Thromb Res. 125 (5): e214-e221, 2010.
Imamura, Y., Morita, S., Nakatani, Y., Okada, K., Ueshima, S., Matsuo, O., Miyata, S.: Tissue plasminogen activator and plasminogen are critical for osmotic homeostasis by regulating vasopressin secretion. J Neurosci Res. 88 (9): 1995-2006, 2010.
Ishida, C., Ueshima, S., Nagai, N., Kawao, N., Okada, K., Yongzhong, H.,
Shiraishi, K., Matsuo, O.: Enhancement of fibrinolytic activity in vascular
endothelial cells by heterologous expression of adenine nucleotide translocase-1.
Blood Coagul Fibrinolysis. 21 (3): 272-278, 2010.
Kawao, N., Nagai, N., Ishida, C., Okada, K., Okumoto, K., Suzuki, Y., Umemura,
K., Ueshima, S., Matsuo, O.: Plasminogen is essential for granulation tissue
formation during the recovery process after liver injury in mice. J Thromb Haemost. 8 (7): 1555-1566, 2010.
Nishiya, K., Nogami, R., Okada, K., Matsuo, O., Take, M., Ogi, K., Shima, M.: Determination of factor VIII-interactive region within plasmin responsible for plasmin-catalyzed activation and inactivation of factor VIII(a). Thromb Haemost. 104 (1): 105-117, 2010.
Nagai, N., Kawao, N., Okada, K., Okumoto, K., Teramura, T., Ueshima, S.,
Umemura, K., Matsuo, O.: Systemic transplantation of embryonic stem cells
accelerates brain lesion decrease and angiogenesis. Neuroreport. 21 (8): 575-579, 2010.
Kanno, Y., Matsuno, H., Kawashita, E., Okada, K., Suga, H., Ueshima, S.,
Matsuo, O.: Urokinase-type plasminogen activator receptor is associated
with the development of adipose tissue. Thromb Haemost. 104 (6): 1124-1132, 2010.
Tomogane, K., Kanno, Y., Kawashita, E., Okada, K., Takeuchi, K., Ueshima, S., Matsuo, O., Matsuno, H.: The absence of urokinase type plasminogen activator receptor plays a role in the insulin-independent glucose metabolism. J Cardiovasc Pharmacol. 57 (3): 334-9, 2010.
2008年
Kanno, Y., Kuroki, A., Minamida, M., Kaneiwa, A., Okada, K., Tomogane,
K., Takeuchi, K., Ueshima, S., Matsuo, O., Matsuno, H.: The absence of
uPAR attenuates insulin-induced vascular smooth muscle cell migration and
proliferation. Thromb Res. 123 (2): 336-341, 2008.
Mimuro, J., Niimura, M., Kashiwakura, Y., Ishiwata, A., Ono, T., Ohmori,
T., Madoiwa, S., Okada, K., Matsuo, O., Sakata, Y.: Unbalanced expression
of ADAMTS13 and von Willebrand factor in mouse endotoxinemia. Thromb Res. 122 (1): 91-97, 2008.
Okada K, Ueshima S, Kawao N, Okamoto C, Matsuo K, Akao M, Seki T, Ariga T, Tanaka M, Matsuo O. Binding of plasminogen to hepatocytes isolated from injured mice liver and nonparenchymal cell-dependent proliferation of hepatocytes. Blood Coagul Fibrinolysis. 19 (6): 503-511, 2008.
Kanno Y, Kaneiwa A, Minamida M, Kanno M, Tomogane K, Takeuchi K, Okada
K, Ueshima S, Matsuo O, Matsuno H. The absence of uPAR is associated with
the progression of dermal fibrosis. J Invest Dermatol. 128 (12): 2792-2797, 2008.
Hou YZ, Okada K, Okamoto C, Ueshima S, Matsuo O. a2-antiplasmin is a critical
regulator of angiotensin II-mediated vascular remodeling. Arterioscl Thromb Vascul Biol. 28 (7): 1257-1262, 2008.
Li Y, Zhang F, Nagai N, Tang Z, Zhang S, Scotney P, Lennartsson J, Zhu C, Qu Y, Fang C, Hua J, Matsuo O, Fong GH, Ding H, Cao Y, Becker KG, Nash A, Heldin CH, Li X. VEGF-B inhibits apoptosis via VEGFR-1-mediated suppression of the expression of BH3-only protein genes in mice and rats. J Clin Invest. 118(3):913-923, 2008.
Nagai N, Okada K, Kawao N, Ishida C, Ueshima S, Collen D, Matsuo O. Urokinase-type
plasminogen activator receptor (uPAR) augments brain damage in a murine
model of ischemic stroke. Neurosci Lett. 432(1):46-49, 2008.
2007年
Kanno Y, Kuroki A, Okada K, Tomogane K, Ueshima S, Matsuo O, Matsuno H.
a2-antiplasmin is involved in the production of transforming growth factor
beta1 and fibrosis. J Thromb Haemost. 5(11):2266-2273, 2007.
Otaki S, Ueshima S, Shiraishi K, Sugiyama K, Hamada S, Yorimoto M, Matsuo O. Mesenchymal progenitor cells in adult human dental pulp and their ability to form bone when transplanted into immunocompromised mice. Cell Biol Int. 31(10):1191-1197, 2007.
Okada K, Ueshima S, Matsuno H, Kawao N, Okamoto C, Tanaka M, Matsuo O.
Effect of staphylokinase-derived nonadecapeptide on the activation of plasminogen.
Thromb Haemost. 97(5):795-802, 2007.
Matsuo O, Lijnen HR, Ueshima S, Kojima S, Smyth SS. A guide to murine fibrinolytic
factor structure, function, assays, and genetic alterations. J Thromb Haemost. 5(4):680-689, 2007.
Hou Y, Okamoto C, Okada K, Kawao N, Kawata S, Ueshima S, Matsuo O. c-Myc is essential for urokinase plasminogen activator expression on hypoxia-induced vascular smooth muscle cells. Cardiovasc Res. 75:186-194, 2007.
Kawao N, Okada K, Kawata S, Okamoto C, Tsuritani M, Ueshima S, Matsuo O.
Plasmin decreases the BH3-only protein BimEL via the ERK1/2 signaling pathway
in hepatocytes. Biochimica Biophysica Acta. 1773: 718-727, 2007.
2006年
Kanno Y, Hirade K, Ishisaki A, Nakajima K, Suga H, Into T, Matsushita K, Okada K, Matsuo O, Matsuno H. Lack of a2-antiplasmin improves cutaneous wound healing via over-released vascular endothelial growth factor-induced angiogenesis in wound lesions. J Thromb Haemost. 4(7):1602-1610, 2006.
Ueshima S, Matsuo O. Development of new fibrinolytic agents. Curr Pharm Des. 12(7):849-857, 2006.
2005年
Kumada M, Niwa M, Hara A, Matsuno H, Mori H, Ueshima S, Matsuo O, Yamamoto
T, Kozawa O. Tissue type plasminogen activator facilitates NMDA-receptor-mediated
retinal apoptosis through an independent fibrinolytic cascade. Invest Ophthalmol Vis Sci. 46(4):1504-1507, 2005.
Matsuo O. An ideal thrombolytic and antithrombotic agent? J Thromb Haemost.
(10):2154-2155, 2005.
Sejima T, Madoiwa S, Mimuro J, Sugo T, Okada K, Ueshima S, Matsuo O, Ishida T, Ichimura K, Sakata Y. Protection of plasminogen activator inhibitor-1-deficient mice from nasal allergy. J Immunol. 174(12):8135-8143, 2005.
2004年
Okada K, Ueshima S, Imano M, Kataoka K, Matsuo O. The regulation of liver
regeneration by the plasmin/alpha2-antiplasmin system. J Hepatol. 40(1):110-116, 2004.
Ueshima S, Fukao H, Okada K, Matsuo O. Growth inhibition of vascular smooth
muscle cells derived from urokinase receptor (u-PAR)-deficient mice in
the presence of carcinoma cells. Thromb Res. 113:41-49, 2004.
Kumada M, Niwa M, Wang X, Matsuno H, Hara A, Mori H, Matsuo O, Yamamoto T, Kozawa O. Endogenous tissue type plasminogen activator facilitates NMDA-induced retinal damage. Toxicol Appl Pharmacol. 200(1):48-53, 2004.
2003年
Ueshima S, Fukao H, Okada K, Matsuo O. Suppression of the release of type-1
plasminogen activator inhibitor from human vascular endothelial cells by
Hawaii deep sea water. Pathophysiology. 9(2):103-109, 2003.
Akao M, Ueshima S, Okada K, Fukao H, Seki T, Ariga T, Matsuo O. Cellular
density regulation of plasminogen gene expression in mouse hepatocytes. Life Sci. 72(15):1695-1704, 2003.
Hashimoto M, Oiwa K, Matsuo O, Ueshima S, Okada K, Okada Y,
Okamoto S, Gidding JC, Yamamoto J. Suppression of argatroban-induced endogeneous
thrombolytic by a synthetic plasma kallikrein inhibitor, PKSI-527, and
antibody to tPA and uPA, evaluated in a rat arterial thrombolysis model.
Thromb Haemost. 89(2):820-825, 2003.
Matsuno H, Okada K, Ueshima S, Matsuo O, Kozawa O. alpha2-antiplasmin plays a significant role in acute pulmonary emboolism. J Thromb Haemost. 1(3):1734-1739, 2003.
Matsuno H, Ishisaki A, Nakazima S, Okada K, Ueshima S, Matsuo O, Kozawa
O. Lack of alpha2-antiplasmin promotes re-endothelialization via over-release
of VEGF after vascular injury in mice. Blood. 102(10):3621-3628, 2003.
2002年
Matsuno H, Kozawa O, Okada K, Ueshima S, Matsuo O, Uematsu T. Plasmin generation
plays different roles in the formation and removal of arterial and venous
thrombus in mice. Thromb Haemost. 87(1), 98-104, 2002.
Matsuno H, Kozawa O, Okada K, Ueshima S, Matsuo O, Uematsu T. Inhibitors of fibrinolytic components play different roles in the formation and removal of arterial thrombus in mice. J Cardiovasc Pharmacol. 39(2):278-286, 2002.
Ueshima S, Matsuo O. The differences in thrombolytic effects of administrated
recombinant t-PA between Japanese and Caucasians. Thromb Haemost. 87(3), 544-546, 2002.
Ueshima S, Matsuno H, Hayashi M, Horibuchi K, Okada K, Fukao H, Uematsu T, Matsuo O. Function of tissue-type plasminogen activator releaser on vascular endothelial cells and thrombolysis in vivo. Thromb Haemost. 87(6):1069-1074, 2002.
Matsuno H, Kozawa O, Yoshimi N, Akamatsu S, Hara A, Mori H, Okada K, Ueshima
S, Matsuo O, Uematsu T. Lack of alpha2-antiplasmin promotes pulmonary heart
failure via over-release of VEGF after acute myocardial infarction. Blood. 100(7):2487-2493, 2002.
Luttun A, Brusselmans K, Fukao H, Tjwa M, Ueshima S, Herbert JM, Matsuo
O, Collen D, Carmeliet P, and Moons L. Loss of placental growth factor
protects mice against vascular permeability in pathological conditions.
Biochem Biophys Res Commun. 295(2):428-434, 2002.
Moriyama T, Suzuki S, Matsuno K, Okada K, Matsuo O. Influence of low molecular plasminogen activator on onset of labor and hemostatic system. Sem Thromb Heamost. 28(6):529-531,2002.
Takei M, Matsuno H, Okada K, Ueshima S, Matsuo O, Kozawa O. Lack of alpha2-antiplasmin
enhance ADP induced platelet micro-aggregation through the presence of
excess active plasmin in mice. J Thromb Thrombolysis. 14(3):205-211, 2002.
2001年
Shimizu M, Hara A, Okuno M, Matsuno H, Okada K, Ueshima S, Matsuo O, Niwa
M, Akita K, Yamada Y, Yoshimi N, Uematsu T, Kojima S, Friedman S L, Moriwaki
H, Mori H. Mechanism of retarded liver regeneration in plasminogen activator-deficient
mice: Impaored activation of hepatocyte growth factor after Fas-mediated
hepatic apoptosis. Hepatology. 33(3), 569-576, 2001.
Fukao H, Ueshima S, Okada K, Matsuo O. Enhancement of t-PA-mediated plasminogen activation on the surface of endothelial cells by t-PA receptor. Blood Coagul Fibrinolysis. 12(5), 413-414, 2001.
Okada K, Ueshima S, Fukao H, Matsuo O. Analysis of complex formation between
plasmin(ogen) and staphylokinase or streptokinase. Arch Biochem Biophys. 393(2), 339-341, 2001.
Tanaka M, Okada K, Ueshima S, Imano M, Ohyanagi H, Carmeliet P, Matsuo
O. Impaired liver regeneration after partial hepatectomy in plasminogen
deficient mice. Fibrinolysis Proteolysis. 15 (1), 2-8, 2001.
2000年以前
Matsuno H, Kozawa O, Ueshima S, Matsuo O, Collen D, Uematsu T. The interaction between components of the fibrinolytic system and GPIb/V/IX of platelets thrombus formation in mice. Br J Pharmacol. 131(4), 858-864, 2000.
Nishida M, Matsuno H, Kozawa O, Ueshima S, Matsuo O, Collen D, Uenatsu
T. t-PA, butu not uPA, significantly affects antithrombotic therapy by
a glycoprtein IIb/IIa antagonist, but not by a factor Xa inhibitor. J Cadiovasc Pharmacol. 36(6), 770-775, 2000.
Fukao H, Ikeda M, Ichikawa T, Inuhusa H, Okada K, Ueshima S, Matsuo O.
Effect of hyperthemia on the viability and the fibrinolytic potential of
human cancer cell lines. Clin Chim Acta. 296(1-2), 17-33, 2000.
Matsuo O. Introduction of new curriculum in Kinki University School of Medicine. J Med Education. 4(1), 92-96, 2000.
Ueshima S, Fukao H, Okada K, Matsuo O. The effect of argatroban on injured
endothelial cells by thrombin. Blood Coagul Fibrinolysis. 11(7), 631-639, 2000.
Fukao H, Hagiya Y, Ueshima S, Kamiishi H, Okada K, Matsuo O. Fibrinolytic
system in the process of wound healing in rat. Pathophysiol. 6(4), 217-224, 2000.
Matsuno H, Kozawa O, Ueshima S, Matsuo O, Collen D, Uematsu T. Lack of tPA significantly affects antithrombotic therapy by a GPIIb/IIIa antagonist, but not by a thrombin Inhibitor in mice. Thromb Haemost. 83(4), 605-609, 2000.
Fukao H, Matsuo O. Antithrombotic regulation in human endothelial cells
by fibrinolytic factors. Semin Thromb Hemost. 26(1), 33-38, 2000.
Okada K, Ueshima S, Tanaka M, Fukao H, Matsuo O. Analysis of plasminogen
activation by the plasmin-staphylokinase complex in plasma of alpha2-antiplasmin-deficient
mice. Blood Coagul Fibrinolysis. 11(7), 645-655, 2000.
Kataoka K, Asai T, Taneda M, Ueshima S, Matsuo O, Kuroda R, Kawabata A, Carmeliet P. Roles of urokinase type plasminogen activator in a brain stab wound. Brain Res. 887(1), 187-190, 2000.
Ueshima S, Matsumoto H, Izaki S, Mitsui Y, Fukao H, Okada K, Matsuo O.
Co-localization of urokinase and its receptor on established human umbilical
vein endothelial cell. Cell Struct Funct. 24:71-78, 1999.
Kataoka K, Asai T, Taneda M, Ueshima S, Matsuo O, Kuroda R, Carmeliet P,
Collen D. Nigral degeneration following striato-pallidal lesion in tissue
type plasminogen activator deficient mice. Neurosci Lett. 266(3):220-222, 1999.
Matsuno H, Kozawa O, Niwa M, Ueshima S, Matsuo O, Collen D, Uematsu T. Differential role of components of the fibrinolytic system in the formation and removal of thrombus induced by endothelial injury. Thromb Haemost. 81(4):601-604, 1999.
Lijnen HR, Okada K, Matsuo O, Collen D, Dewerchin M. alpha2-antiplasmin
gene deficiency in mice is associated with enhanced fibrinolytic potential
without overt bleeding. Blood. 93(7):2274-2281, 1999.
Fukao H, Matsuo O. Analysis of tissue-type plasminogen activator receptor
(t-PAR) in human endothelial cells. Semin Thromb Haemost. 24 (3): 269-274, 1998.
Mizuno T, Fukao H, Tanaka N, Ueshima S, Okada K, Yasutomi M, Matsuo O. Fibrinolytic factors, matrix metalloprotease-1, and tissue inhibitor of metalloproteinase-1 in gastric carcinoma. Pathophysiology. 5 : 99-104, 1998.
Niiya K, Ozawa T, Tsuzawa T, Ueshima S, Matsuo O, Sakuragawa, N. Transcriptional
regulation of urokinase-type plasminogen activator receptor by cyclic AMP
in PL-21 human myeloid leukemia cells: comparison with the regulation by
phorbol myristate acetate. Thromb Haemost. 79(3):574-578, 1998.
Sugiyama K, Kato K, Kido M, Shiraishi K, Ohga K, Okada K, Matsuo O. Grafting
of vinyl monomers on the surface of a poly(ethylene terephthalate) film
using Ar plasma-post polymerization technique to increase biocompatibility.
Macromol Chem Phys. 199:1201-1208, 1998.
Sugiyama K, Shiraishi K, Okada K, Matsuo O. Biocompatible block copolymers comporsed of polydimethylsiloxane and poly[(2-methacryloyloxy)ethyl phosphorylcholine] segments. Polemer J. 31(10);883-886, 1998.
Ueshima S, Matsuo O. Staphylokinase as a new thrombolytic agent. Curr Topics
Pharmacol. 3(2):77-83, 1997.
Okada K, Lijnen HR, Dewerchin M, Belayew A, Matsuo O, Collen D, Bernaerts
R. Characterization and targeting of the murine alpha2-antiplasmin gene.
Thromb Haemost. 78(3):1104-1011, 1997.
Fukao H, Ueshima S, Takaishi T, Okada K, Matsuo O. Enhancement of tissue-type
plasminogen activator (t-PA) activity by purified t-PA receptor expressed
in human endothelial cells. Biochim Biophys Acta. 1356 (1): 111-120, 1997.
Fukao H, Ueshima S, Okada K, Matsuo O. The role of the pericellular fibrinolytic system in angiogenesis. Jan J Physiol. 47 (2):161-171, 1997.
Takaishi T, Ueshima S, Matsuo O. New aspects of fibrinolytic proteins in
brain development. Cell Struct Funct. 22(2):225-229, 1997.
Siraisi K, Onisi T, Sugiyama K, Okada K, Matsuo O. Surface modified poly(methyl-methacrylate)microspheres
with the O-methacryloyl-L-serine moiety. Chem Lett. 9:863-864, 1997.
Yuasa H, Okada K, Ueshima S, Matsuo O. Effect of sodium ozagrel on platelet rich plasma clot lysis. Pathophysiol. 4:169-174, 1997.
Ueshima S, Okada K, Matsumoto H, Takaishi T, Fukao H, Matsuo O. Effects
of endothelial cells on activity of staphylokinase. Blood Coagul Fibrinolysis. 7: 522-529, 1996.
Ueshima S, Okada K, Matsuo O. Stabilization of plasmin by lysine derivatives.
Clin Chim Acta. 245(1):17-18, 1996.
Okada K, Ueshima S, Takaishi T, Yuasa H, Fukao H, Matsuo O. Effects of
fibrin and alpha2-antiplasmin on plasminogen activation by staphylokinase.
Am J Hematol. 53:151-157, 1996.
Fukao H, Hagiya Y, Okada K, Takaishi T, Ueshima S, Izaki S, Matsuo O. Effect of heat shock on the expression of urokinase-type plasminogen activator receptor in human umbilical vein endothelial cells. Thromb Haemost. 75 (2): 352-358, 1996.
Okada K, Lijnen HR, Moreau H, Vanderschueren S, Collen D. Procoagulant
properties of intravenous staphylokinase versus tissue-type plasminogen
activator. Thromb Haemost. 76(6)857-859, 1996.
Matsumoto H, Ueshima S, Fukao H, Mitsui Y, Matsuo O. Effects of lipopolysaccharide
on the expression of fibrinolytic factors in an established cell line from
human endothelial cells. Life Sci. 59 (2):85-96, 1996.
Hagiya Y, Fukao H, Ueshima S, Okada K, Inufusa H, Kamiishi H, Matsuo O. Enhanced urokinase-type plasminogen activator activity by extracellular matrix protein obtained from highly metastatic human lung adenocarcinoma cell line. Clin Chim Acta. 253(1-2):37-50, 1996.
Yokoyama M, Ichikawa Y, Yatani A, Matsui K, Nakahara H, Kaneko M, Sakurama
T, Ueshima S, Matsuo O. Comparative studies of thrombolysis with single-chain
and two-chain recombinant tissue-type plasminogen activators in canine
coronary thrombosis. J Cardiovasc Pharmacol. 28(4):571-575, 1996.
Kikuchi H, Shimada W, Nonaka T, Ueshima S, Matsuo O, Tanaka S. Significance
of serine proteinase and matrix metalloproteinase systems in the destruction
of human articular cartilage. Clin Exp Pharmacol Physiol. 23:885-889, 1996.
Okada K, Yuasa H, Hagiya Y, Takaishi T, Fukao H, Ueshima S, Matsuo O. Fibrinolytic activity in liver tissues of stroke-prone spontaneously hypertensive rats. Clin Exp Pharmacol Physiol. 5: S275-S276, 1995.
Matsumoto H, Ueshima S, Fukao H, Mitsui Y, Matsuo O. Identification of
urokinase-type plasminogen activator receptor in human endothelial cells
and its modulation by phorbol myristate acetated. Cell Struct Funct. 20, 429-437, 1995.
Nonaka T, Matsumoto H, Shimada W, Miyagi I, Okada K, Fukao H, Ueshima S,
Kikuchi H, Tanaka S, Matsuo O. Effect of cyclic AMP on urokinase-type plasminogen
activator receptor and fibrinolytic factors in a human osteoblast-like
cell line. Biochem Biophys Acta. 1266: 50-56, 1995.
Fukao H, Matsumoto H, Ueshima S, Okada K, Matsuo O. Effects of fibrin on the secretion of plasminogen activator inhibitor-1 from endothelial cells and on protein kinase C. Life Sci. 57 (13): 1267-1276, 1995.
Okada K, Yuasa H, Hagiya Y, Fukao H, Ueshima S, Matsuo O. Kinetic analysis
of plasminogen activation by staphylokinase/plasminogen complex in the
presence of fibrin. Thromb Res. 76:181-191, 1994.
Okada K, Nonaka T, Matsumoto H, Fukao H, Ueshima S, Matsuo O. Effects of
a2-plasmin inhibitor on plasminogen activation by staphylokinase/ plasminogen
complex. Thromb Res. 76:211-220, 1994.
Yahara H, Matsumoto K, Maruyama H, Nagaoka T, Ikenaka Y, Yajima K, Fukao H, Ueshima S, Matsuo O. Recombinant variants of tissue-type plasminogen activator containing amino acid substitutions in the fibronectin finger-like domain and the kringle 1 domain. Thromb Haemost. 72:893-899, 1994.
Okayama T, Nakano M, Odake S, Hagiwara M, Morikawa T, Ueshima S, Okada
K, Fukao H, Matsuo O. Synthetic dipeptide, N-Stearoyl-Ser-L-Pro-OEt, induces
release of tissue-type plasminogen activator in cultured cells and in experimental
animals. Chem Pharm Bull. 42:1854-1858, 1994.
Ueshima S, Holvoet P, Lijnen HR, Nelles L, Seghers V, Collen D. Expression
and characterization of clustered charge-to-alanine mutants of low M(r)
single-chain urokinase-type plasminogen activator. Thromb Haemost. 71(1):134-140, 1994.
Yahara H, Matsumoto K, Maruyama H, Nagaoka T, Okada K, Ueshima S, Matsuo O. Recombinant variants of tissue-type plasminogen activator containing amino acid substitutions between positions 37 and 42. Fibrinolysis. 8:286-293, 1994.
Nonaka T, Okada K, Fukao H, Ueshima S, Kikuchi H, Tanaka S, Matsuo O. Regulation
of scu-PA secretion and u-PA expression in osteoblast-like cells. Cell Struct Funct. 18:355-362, 1993.
Nonaka T, Matsumoto H, Shimada W, Fukao H, Ueshima S, Matsuo O. Effect
of bone resorbing factors on u-PA and its specific receptor in osteosarcoma
cell line. Clinica Chimica Acta. 223:129-142, 1993.
Ueshima S, Silence K, Collen D, Lijnen HR. Molecular conversions of recombinant staphylokinase during plasminogen activation in purified systems and in human plasma. Thromb Haemost. 70(3):495-499, 1993.
Matsuo O, Okada K, Fukao H, Ueshima S, Suzuki A. Cerebral plasminogen activator
activity in spontaneously hypertensive stroke-prone rats. Stroke. 23:995-999, 1992.
Fukao H, Ueshima S, Okada K, Yamamoto K, Matsuo T, Matuso O. Tissue-type
plasminogen activator, type 1 plasminogen activaotr inhibitor and their
complex in plasma with disseminated intravascular coagulation. Thromb Res. 68:57-65, 1992.
Fukao H, Hagiya Y, Nonaka T, Okada K, Matsuo O. Analysis of binding protein for tissue-type plasminogen activator in human endothelial cells. Biochem Biophys Res Commun. 187:956-962, 1992.
Hagiya Y, Fukao H, Ueshima S, Inufusa H, Izaki S, Okada K, Kamiishi H,
Matsuo O. u-PA and its specific receptor in high metastatic and non-metastatic
cell lines derived from human lung adenocarcinoma. Thromb Res. 65:449-456, 1992.
Yahara H, Matsumoto K, Maruyama H, Nagaoka T, Ikenaka S, Yajima K, Fukao
H, Ueshima S, Matsuo O. Recombinant variants of tissue-type plasminogen
activator containing amino acid substitutions in the finger domain. Thromb Haemost. 68:672-677, 1992.
Ikenaka Y, Yajima K, Yahara H, Maruyama H, Matsumoto K, Okada K, Ueshima S, Matsuo O. Characterization of human tissue-type plasminogen activator variants with amino acid mutations in the kringle 1 domain. Blood Coagul Fibrinolysis. 3(4):381-387, 1992.
Aya N, Yoshioka K, Murakami K, Hino S, Okada K, Matsuo O, Maki S. Tissue-type
plasminogen activator and its inhibitor in human glomerulonephritis. J Pathol. 166(3):289-295, 1992.
Lijnen HR, Van Hoef B, Matsuo O, Collen D. On the molecular interactions
between plasminogen-staphylokinase, alpha2-antiplasmin and fibrin. Biochim Biophys Acta. 1118(2):144-148, 1992.
Kikuchi H, Tanaka S, Nakagiri Y, Yamane T, Fujiwara S, Katsuhisa K, Tan A, Matsuo O. Hypofibrinolytic activity after total joint replacement. Vascul Surg. 26:59-64, 1992.
Tanaka N, Fukao H, Ueshima S, Okada K, Yasutomi M, Matsuo O. Plasminogen
activator inhibitor 1 in human carcinoma tissues. Int J Cancer. 48:481-484, 1991.
Lijnen, H.R., Stassen, J.M., Vanlithout, I., Fukao, H., Okada, K., Matsuo,
O. and Collen, D. Comparative fibrinolytic properties of staphylokinase
and streptokinase in animal models of venous thrombosis. Thromb Haemost. 66:468-473, 1991.
Lijnen HR, Van Hoef B, De Cock F, Okada K, Ueshima S, Matsuo O, Collen D. On the mechanism of fibrin-specific plasminogen activation by staphylokinase. J Biol Chem. 266(18):11826-11832, 1991.
Fukao H, Tanaka N, Ueshima S, Okada K, Yasutomi M, Matsuo O. Plasminogen
activator inhibitor in stomach and colorectal carcinomas. Semin Thromb Hemostas. 17:276-279, 1991.
Matsuo O, Okada K, Fukao H, Tomioka Y, Ueshima S, Watanuki M, Sakai M.
Thrombolytic properties of staphylokinase. Blood. 76:925-929, 1990.
Matsuo T, Kadowaki S, Okada K, Matsuo O. Activity of tissue plasminogen activator and plasminogen activator inhibitor in noninsulin-dependent diabetes mellitus. J Diabet Compl. 1990 4(3):119-121, 1990.
Okada K, Fukao H, Tanaka H, Ueshima S, Matsuo O. Purification and characterization
of a plasma factor which cleaves single-chain form of t-PA and u-PA. Thromb Res Supple. 10:27-43, 1990.
Fukao H, Ueshima S,Tanaka S, Okada K, Matsuo O. Suppression of plasminogen
activator inhibitor 1 release by fibrin from human umbilical veinendothelial
cells. Thromb Res Supple. 10:11-20, 1990.