研究テーマ

　内分泌・代謝・肝疾患における凝固線溶因子の関与
　骨軟骨修復・再生における凝固線溶因子の関与
　筋・骨の相互作用機構と凝固線溶因子との関連

研究助成金（科研費）

平成30年度

文部科学省　科学研究費基金（基盤研究C）

平成28年度

文部科学省　科学研究費補助金（研究活動スタート支援）

平成30年度

一般社団法人日本血液学会　研究助成 

平成30年度

公益財団法人　成長科学協会　研究助成

平成30年度

公益財団法人　骨粗鬆症財団　財団研究助成

平成29年度

近畿大学 学内研究助成（奨励研究助成）

平成28年度

公益財団法人　三井生命厚生財団　医学研究助成

所属学会・資格

受賞

• Travel Award (2007 Joint Conference of CTS, IPITA, and IXA), 2007.
• 奈良県医師会学術奨励賞, 2008
• Young Investigators Award (XXIII Congress of the International Society on Thrombosis and Haemostasis), 2011
• 日本臓器保存生物医学会 会長賞, 2011.
• Young Investigator Award臨床部門優秀賞 (第12回日本再生医療学会), 2013
• 上原記念生命科学財団　海外留学助成金リサーチフェローシップ, 2013

主要業績（著書・特許・招待講演）

• （著書）辰巳公平.  "肝臓の再生療法　肝臓疾患の組織工学的アプローチ".  「先進医療NAVIGATOR　再生医療・細胞医療の研究と産業化の最前線」（日本医学出版） page 32-34, 2018年（分担執筆） 
• (シンポジウム）Kohei Tatsumi, Silvio Antoniak, Kaji Hiroshi, Nigel Mackman. Role of coagulation factors in a mouse model of influenza virus infection. 第39回日本血栓止血学会 SPCシンポジウム「次世代抗凝固薬の可能性を血液凝固XI、XII因子に求めて―動物モデルからの展望―-Factor XI/XII and animal models for development of next generation anti-coagulant-」, 2017 
• (著書)　辰巳公平、大橋一夫、岡野光夫. “細胞シート工学を用いた再生医療“. 「応用が拡がるDDS ―人体環境から農業・家電まで―」page 265-275、2013年（分担執筆）
• (特許) ADAMTS13による細胞移植増強補助剤、発明者（辰巳公平、杉本充彦、大橋一夫、副島見事）、出願番号：特願2010-280571
• （招待講演) 辰巳公平. Role of the coagulation system, platelets and PARs in influenza infection in mice. 第36回日本血栓止血学会 "海外で活躍する日本人研究者のシンポジウム", 2014.
• (招待講演) 辰巳公平. 遺伝子修飾および細胞表面修飾による細胞シート治療の応用展開、第4回 CSTECシンポジウム、2011.
• (招待講演) Tatsumi K, Tissue Engineering-based Gene and Cell Therapy for Hemophilia B, The 7th ASO International Meeting (AIM): Thrombosis, Hemostasis, and Vascular Science, 2011
• (招待講演) 辰巳公平, 大橋一夫, 嶋　緑倫, 岡野光夫.　凝固第VIII因子動態からみた肝再生過程の新側面、第5回広島肝臓プロジェクト研究センターシンポジウム、2009
• (招待講演) 辰巳公平, 大橋一夫, 立野知世, 吉里勝利, 岡野光夫, 吉岡章, 嶋緑倫.　 血友病に対する肝細胞移植治療の実用化に向けた基盤技術開発、第４回広島肝臓プロジェクト研究センターシンポジウム、2008

主要業績（論文）

• Antoniak S, Tatsumi K, Schmedes CM, Grover SP, Pawlinski R, Mackman N. Protease-activated receptor 1 activation enhances doxorubicin-induced cardiotoxicity. J Mol Cell Cardiol. 2018 in press

• Kasuda S, Sakurai Y, Tatsumi K, Takeda T, Kudo R, Yuui K, Hatake K.　Experimental hypercoagulable state induced by tissue factor expression in monocyte-derived dendritic cells and its modulation by C1 inhibitor.　J Thromb Thrombolysis. 2018 in press
• Utoh R, Komori J, Kuge H, Tatsumi K, Yamada M, Hirohashi S, Tsutsumi M, Amanuma T, Yoshioka A, Nakajima Y, Wake K, Okano T, Lagasse E, Ohashi K.  Adult hepatocytes direct liver organogenesis through non-parenchymal cell recruitment in the kidney. J Hepatol.  2018 in press.
• Tatsumi K, Okano T.  Hepatocyte Transplantation: Cell Sheet Technology for Liver Cell Transplantation.  Curr Transpl Rep. 2017 in press.
• Tatsumi K*, Antoniak S*, Subramaniam S, Gondouin B, Neidich SD, Beck MA, Mickelson J, Monroe DM 3rd, Bastarache JA, Mackman N.  Anticoagulation Increases Alveolar Hemorrhage in Mice Infected with Influenza A.  Physiol Rep. 2016 in press (* contributed equally to this work)
• Antoniak S, Tatsumi K, Bode M, Venja S, Williams JC, Mackman N.　Protease-Activated Receptor 1 Enhances Poly I:C Induction of the Antiviral Response in Macrophages and Mice. J Innate Immu. 2016 in press.
• Rautou PE*, Tatsumi K*, Antoniak S, Owens AP 3rd, Sparkenbaugh E, Holle LA, Wolberg AS, Kopec AK, Pawlinski R, Luyendyk JP, Mackman N. Hepatocyte tissue factor contributes to the hypercoagulable state in a mouse model of chronic liver injury. J Hepatol. 64(1):53-9, 2016. (* contributed equally to this work)
• Antoniak S, Tatsumi K, Hisada Y, Milner JJ, Neidich SD, Shaver CM, Pawlinski R, Beck MA, Bastarache JA, Mackman N. Tissue factor Deficiency Increases Alveolar Hemorrhage and Death in Influenza A Infected Mice. J Thromb Haemost. 2016 in press
• Rondina MT, Tatsumi K, Bastarache JA, Mackman N. Microvesicle Tissue Factor Activity and Interleukin-8 Levels are Associated with Mortality in Patients with Influenza A/H1N1 Infection. Crit Care Med. 2016 in press.
• Arisaka Y, Kobayashi J, Ohashi K, Tatsumi K, Kim KS, Akiyama Y, Yamato M, Okano T. A heparin-modified thermoresponsive surface with heparin-binding epidermal growth factor like growth factor formaintaining hepatic functions in vitro and harvesting hepatocytesheets. Regenerative Therapy. 2016 in press
• Kasuda S, Tatsumi K, Sakurai Y, Shima M, Hatake K. Therapeutic approaches for treating hemophilia A using embryonic stem cells. Hematol Oncol Stem Cell Ther. 2016 in press
• Tatsumi K, Mackman N. Tissue Factor and Atherothrombosis. J Atheroscler Thromb. 22(6):543-9, 2015.
• Tatsumi K, Antoniak S, Monroe DM 3rd, Khorana AA, Mackman N; Subcommittee on Hemostasis and Malignancy of the Scientific and Standardization Committee of the International Society on Thrombosis and Hemostasis. Evaluation of a new commercial assay to measure microparticle tissue factor activity in plasma: communication from the SSC of the ISTH. J Thromb Haemost. 12(11):1932-4, 2014.
• Kasuda S, Sakurai Y, Tatsumi K, Kato J, Takeda T, Shima M, and Hatake K.  Sequential gene expression analysis of coagulation factors and protease activatedreceptors in hematopoietic lineage development. Current Angiogenesis. 3(3): 139-143, 2014.
• Tatsumi K, Sugimoto M, Lillicrap D, Shima M, Ohashi K, Okano T, Matsui H. A novel cell-sheet technology that achieves durable factor VIII delivery in a mouse model of hemophilia A. PLoS One. 8(12), 2013. 12.
• Tatsumi K, Ohashi K, Kanegae K, Shim IK, Okano T. Perioperative haemostatic management of haemophilic mice using normal mouse plasma.Haemophilia. 19(6):e335-43, 2013.
• Tatsumi K, Ohashi K, Matsubara Y, Kohori A, Ohno T, Kakidachi H, Horii A, Kanegae K, Utoh R, Iwata T, Okano T. Tissue factor triggers procoagulation in transplanted mesenchymal stem cells leading to thromboembolism. Biochem Biophys Res Commun.431(2):203-9, 2013.
• Sakurai Y, Kasuda S, Tatsumi K, Takeda T, Kato J, Kubo A, Shima M. Repression of Factor VIII Inhibitor Development with Apoptotic Factor VIII-expressing Embryonic Stem Cells. Hematol Rep. 5(2):30-3, 2013.
• Watanabe N, Ohashi K, Tatsumi K, Utoh R, Shim IK, Kanegae K, Kashiwakura Y,Ohmori T, Sakata Y, Inoue M, Hasegawa M, Okano T. Genetically modified adipose tissue-derived stem/stromal cells, using simian immunodeficiency virus-based lentiviral vectors, in the treatment of hemophilia B.Hum Gene Therr. 24(3):283-94, 2013.
• Tatsumi K, Ohashi K, Teramura Y, Utoh R, Kanegae K, Watanabe N, Mukobata S, Nakayama M, Iwata H, Okano T. The non-invasive cell surface modification of hepatocytes with PEG-lipid derivatives.  Biomaterials. 33(3):821-8, 2012.
• Tatsumi K, Ohashi K, Tateno C, Yoshizato K, Yoshioka A, Shima M, Okano T. Human hepatocyte propagation system in the mouse livers: functional maintenance of the production of coagulation and anticoagulation factors. Cell Transplant.21(2-3):437-45, 2012.
• Tatsumi K, Ohashi K, Mukobata S, Kubo A, Koyama F, Nakajima Y, Shima M, Okano T. Hepatocyte is a sole cell type responsible for the production of coagulation factor IX in vivo. Cell Medicine, 3: 25-31, 2012.
• Ohashi K, Tatsumi K, Tateno C, Kataoka M, Utoh R, Yoshizato K, Okano T. Liver tissue engineering utilizing hepatocytes propagated in mouse livers in vivo. Cell Transplant. 21(2-3):429-36, 2012.
• Yamada M, Utoh R, Ohashi K, Tatsumi K, Yamato M, Okano T, Seki M. Controlled formation of heterotypic hepatic micro-organoids in anisotropic hydrogel microfibers for long-term preservation of liver-specific functions. Biomaterials. 33(33):8304-15, 2012.
• Takagi S, Ohno M, Ohashi K, Utoh R, Tatsumi K, Okano T. Cell shape regulation based on hepatocyte sheet engineering technologies. Cell Transplant. 21(2-3):411-20, 2012.
• Ohashi K, Matsubara Y, Tatsumi K, Kohori A, Utoh R, Kakidachi H, Horii A, Tsutsumi M, Okano T. Cell therapy using adipose-derived stem cells for chronic liver injury in mice. Cell Medicine, 3: 113-119, 2012.
• Tatsumi K, Ohashi K, Taminishi S, Sakurai Y, Ogiwara K, Yoshioka A, Okano T, and Shima M. Regulation of coagulation factors during liver regeneration in mice: mechanism of factor VIII elevation in plasma. Thromb Res, 128(1), 54-61, 2011.
• Kasuda S*, Tatsumi K*, Sakurai Y, Kato J, Taminishi S, Takeda T, Ohashi K, Okano T, Hatake K, and Shima M.  Expression of coagulation factors from murine induced pluripotent stem cell-derived liver cells. Blood Coagul Fibrinolysis, 22(4), 271-9, 2011 (* contributed equally to this work)
• Ohashi K, Tatsumi K, Utoh R, Takagi S, Shima M, Okano T. Engineering liver tissues under the kidney capsule site provides therapeutic effects to hemophilia B mice. Cell Transplant, 19(6), 807-13, 2010.
• Ohashi K, Koyama F, Tatsumi K, Shima M, Park F, Nakajima Y, Okano T. Functional life-long maintenance of engineered liver tissue in mice following transplantation under the kidney capsule. J Tissue Eng Regen Med, 4(2), 141-8, 2010.
• Tatsumi K, Ohashi K, Taminishi S, Takagi S, Utoh R, Yoshioka A, Shima M, Okano T. Effects on coagulation factor production following primary hepatomitogen-induced direct hyperplasia. World J Gastroenterol, 15(42), 5307-15, 2009.
• Kasuda S, Kudo R, Morimura Y, Tatsumi K, Sakurai Y, Shima M, Hatake K. von Willebrand factor in cadaveric urine for forensic investigation. Leg Med (Tokyo), 11(5), 245-7, 2009.
• Takeda T, Sakurai Y, Tatsumi K, Kato J, Kasuda S, Yoshioka A, Shima M. Elevation of B cell-activating factor belonging to the tumour necrosis factor family (BAFF) in haemophilia A patients with inhibitor. Thromb Haemost, 101(2), 408-10, 2009.
• Tatsumi K, Ohashi K, Kataoka M, Tateno C, Shibata M, Naka H, Shima M, Hisanaga M, Kanehiro H, Okano T, Yoshizato K, Nakajima Y, Yoshioka A. Successful in vivo propagation of factor IX-producing hepatocytes in mice: potential for cell-based therapy in haemophilia B. Thromb Haemost, 99(5), 883-91, 2008.
• Tatsumi K, Ohashi K, Shima M, Nakajima Y, Okano T, Yoshioka A. Therapeutic effects of hepatocyte transplantation on hemophilia B. Transplantation, 86(1), 167-70, 2008.
• Tatsumi K, Ohashi K, Taminishi S, Okano T, Yoshioka A, Shima M .Reference gene selection for real-time RT-PCR in regenerating mouse livers. Biochem Biophys Res Commun, 374(1), 106-10, 2008.
• Kasuda S, Kubo A, Sakurai Y, Irion S, Ohashi K, Tatsumi K, Nakajima Y, Saito Y, Hatake K, Pipe SW, Shima M, Yoshioka A. Establishment of embryonic stem cells secreting human factor VIII for cell-based treatment of hemophilia A. J Thromb Haemost, 6(8), 1352-9, 2008.
• Takagi S, Ohashi K, Utoh R, Tatsumi K, Shima M, Okano T. Suitable reference genes for the analysis of direct hyperplasia in mice. Biochem Biophys Res Commun. 26;377(4):1259-64, 2008.

主要業績（日本語論文）

• 辰巳公平、宮田敏行、浅田祐士郎、森下英理子.  Nigel Mackman先生へのインタビュー：Tissue Factor研究の軌跡と研究者としての心得.  日本血栓止血学会誌 28(6): 763-768, 2017

• 辰巳公平、大橋一夫.  肝細胞移植による血友病治療.  Frontiers in Haemophilia. 4(2): 17-22, 2017 (総説）

• 辰巳公平、大橋一夫.  細胞シート工学を用いた血友病新規治療.  Frontiers in Haemophilia. 4(1): 19-24, 2017 (総説）
• 辰巳公平、Nigel Mackman.  血漿中マイクロパーティクルtissue factor活性測定法の比較検討. 日本血栓止血学会誌 26(3): 327-329, 2015 （原著）
• 辰巳公平.  遺伝子改変自己細胞を用いた血友病治療. 最新医学 69: 1570-1580, 2014（総説）
• 辰巳公平.  合成ポリマーを用いた肝細胞表面修飾技術. 日本血栓止血学会誌 23(5): 512-515, 2012（原著）