研究

Uzawa A, Suzuki S, Kuwabara S, Akamine H, Onishi Y, Yasuda M, Ozawa Y, Kawaguchi N, Kubota T, Takahashi M P. Suzuki Y, Watanabe G, Kimura T, Sugimoto T, Samukawa M, Minami N, Masauda M.

Impact of Early Treatment with Intravenous High-Dose Methylprednisolone for Ocular Myasthenia Gravis.

Uzawa A, Suzuki S, Kuwabara S, Akamine H, Onishi Y, Yasuda M, Ozawa Y, Kawaguchi N, Kubota T, Takahashi M P, Suzuki Y, Watanabe G, Kimura T, Sugimoto T, Samukawa M, Minami N, Masuda M.

Effectiveness of early cycles of fast-acting treatment in generalized myasthenia gravis.

Minamino M, Miyamoto K, Kuwahara M, Yoshikawa K, Koh J, Kusunoki S, Nagai Y, Ito H.

Characteristics of Guillain-Barré syndrome in super-elderly individuals.

Sato R, Shimizu F, Kuwahara M, Mizukami Y, Watanabe K, Maeda T, Sano Y, Takeshita Y, Koga M, Kusunoki S, Kanda T.

Autocrine TNF-α Increases Penetration of Myelin-Associated Glycoprotein Antibodies Across the Blood-Nerve Barrier in Anti-MAG Neuropathy.

Taminato T, Takeuchi T, Ueyama M, Mori K, Ikeda M, Mochizuki H, Nagai Y.

Therapeutic reduction of GGGGCC repeat RNA levels by hnRNPA3 suppresses neurodegeneration in Drosophila models of C9orf72-linked ALS/FTD.

Nitta Y, Kawai H, Maki R, Osaka J, Hakeda-Suzuki S, Nagai Y, Doubková K, Uehara T, Watanabe K., Kosaki K., Suzuki T, Tavosanis G., Sugie A.

Direct evaluation of neuroaxonal degeneration with the causative genes of neurodegenerative diseases in Drosophila using the automated axon quantification system, MeDUsA.

Takeuchi T, Maeta K, Xin D, Oe Y, Takeda A, Inoue M, Nagano S, Fujihara T, Matsuda S, Ishigaki S, Sahashi K, Minakawa E.N, Mochizuki H, Neya M, Sobue G, Nagai Y.

Sustained therapeutic benefits by transient reduction of TDP-43 using ENA-modified antisense oligonucleotides in ALS/FTD mice.

Choong C.J, Aguirre C, Kakuda K., Kimura Y, Beck G, Nabekura K, Hideshima M, Doi J., Yamaguchi K., Nakajima K., Wadayama T., Hayakawa H., Baba K., Ogawa K, Takeuchi T, Murayama S, Nagano S, Goto Y, Miyanoiri Y, Nakanishi H, Nagai Y, Mochizuki H, Ikenaka K.

Phosphatidylinositol-3,4,5-trisphosphate interacts with alpha-synuclein and initiates its aggregation and formation of Parkinson’s disease-related fibril polymorphism.

Miyamoto K, Minamino M, Kuwahara M, Tsujimoto H, Ohtani K, Wakamiya N, Katayama K, Norimitsu I, Ito H.

Complement biomarkers reflect the pathological status of neuromyelitis optica spectrum disorders.

Wang E.T, Freudenreich C.H, Gromak ., Jain A, Todd P.K., Nagai Y.

What repeat expansion disorders can teach us about the Central Dogma.

Fujino Y, Mori K., Nagai Y.

Repeat-associated non-AUG translation in neuromuscular diseases: Mechanisms and therapeutic insights.

Minamino M, Miyamoto K, Kuwahara M, Yoshikawa K, Koh J, Kusunoki S, Nagai Y, Ito H.

Characteristics of Guillain-Barré syndrome in super-elderly individuals.

Taminato T, Takeuchi T, Ueyama M, Mori K, Ikeda M, Mochizuki H, Nagai Y.

Therapeutic reduction of GGGGCC repeat RNA levels by hnRNPA3 suppresses neurodegeneration in Drosophila models of C9orf72-linked ALS/FTD.

1. Nitta Y, Kawai H, Maki R, Osaka J, Hakeda-Suzuki S, Nagai Y, Doubková K, Uehara T, Watanabe K, Kosaki K, Suzuki T, Tavosanis G, Sugie A.

Direct evaluation of neuroaxonal degeneration with the causative genes of neurodegenerative diseases in Drosophila using the automated axon quantification system, MeDUsA.

Choong C.J, Aguirre C, Kakuda K., Kimura Y, Beck G, Nabekura K, Hideshima M, Doi J., Yamaguchi K., Nakajima K., Wadayama T., Hayakawa H., Baba K., Ogawa K, Takeuchi T, Murayama S, Nagano S, Goto Y, Miyanoiri Y, Nakanishi H, Nagai Y, Mochizuki H, Ikenaka K.

Phosphatidylinositol-3,4,5-trisphosphate interacts with alpha-synuclein and initiates its aggregation and formation of Parkinson’s disease-related fibril polymorphism.

1. Al-Hakem H, Doets AY, Stino AM, Zivkovic SA, Andersen H, Willison HJ, Cornblath DR, Gorson KC, Islam Z, Mohammad QD, Sindrup SH, Kusunoki S, Davidson A, Casasnovas C, Bateman K, Miller JAL, van den Berg B, Verboon C, Roodbol J, Leonhard SE, Arends S, Luijten LWG, Benedetti L, Kuwabara S, Van den Bergh P, Monges S, Marfia GA, Shahrizaila N, Galassi G, Pereon Y, Bürmann J, Kuitwaard K, Kleyweg RP, Marchesoni C, Sedano Tous MJ, Querol L, Martín-Aguilar L, Wang Y, Nobile-Orazio E, Rinaldi S, Schenone A, Pardo J, Vermeij FH, Waheed W, Lehmann HC, Granit V, Stein B, Cavaletti G, Gutiérrez-Gutiérrez G, Barroso FA, Visser LH, Katzberg HD, Dardiotis E, Attarian S, van der Kooi AJ, Eftimov F, Wirtz PW, Samijn JPA, Gilhuis HJ, Hadden RDM, Holt JKL, Sheikh KA, Kolb N, Karafiath S, Vytopil M, Antonini G, Feasby TE, Faber C, Kramers H, Busby M, Roberts RC, Silvestri NJ, Fazio R, van Dijk GW, Garssen MPJ, Verschuuren J, Harbo T, Jacobs BC; IGOS Consortium.

CSF Findings in Relation to Clinical Characteristics, Subtype, and Disease Course in Patients With Guillain-Barré Syndrome.

Moriguchi K, Nakamura Y, Park AM, Sato F, Kuwahara M, Khadka S, Omura S, Ahmad I, Kusunoki S, Tsunoda I.

Anti-Glycolipid Antibody Examination in Five EAE Models and Theiler's Virus Model of Multiple Sclerosis: Detection of Anti-GM1, GM3, GM4, and Sulfatide Antibodies in Relapsing-Remitting EAE.

Terayama A, Yoshikawa K, Michiura T, Fujii K, Inada R, Mitsui Y, Nishino I, Nagai Y.

A case of thymoma-associated myasthenia gravis accompanied with myositis showing the clusters of histiocyte along the fascicles in perimysium.

Hirano M, Samukawa M, Isono C, Nagai Y.

The effects of safinamide on dysphagia in Parkinson's disease.

Fujino Y, Ueyama M, Ishiguro T, Ozawa D, Sugiki T, Ito H, Murata A, Ishiguro A, Gendron T.F, Mori K, Tokuda E, Taminato T, Konno T, Koyama A, Kawabe Y, Takeuchi T, Furukawa Y, Fujiwara T, Ikeda M, Mizuno T, Mochizuki H, Mizusawa H, Wada K, Ishikawa K, Onodera O, Nakatani K, Taguchi H, Petrucelli L, Nagai Y.

FUS regulates RAN translation through modulating the G-quadruplex structure of GGGGCC repeat RNA in C9orf72-linked ALS/FTD.

武内敏秀、永井義隆

脊髄小脳失調症のバイオマーカー開発をめざして

藤井佳奈子、永井義隆

Huntington病

Fujino Y, Mori K, Nagai Y.

Repeat-associated non-AUG translation in neuromuscular diseases: Mechanisms and therapeutic insights.

小澤大作, 永井義隆.

ポリグルタミン蛋白質の構造転移・凝集機序と毒性

永井義隆.

脊髄小脳変性症の治療の現状と新規治療法開発の進捗

永井義隆, 藤野雄三

ポリグルタミン病とリピート関連脊髄小脳失調症

永井義隆.

脊髄小脳変性症の治療の現状と新規治療法開発の進捗

藤井佳奈子, 永井義隆.

Huntington病

山岸裕子, 三井良之.

Guillain-Barré症候群の予後と予後予測因子