研究
2019 研究業績・論文発表
論文
Oka N, Nishimura S, Tanaka H, Hashimoto K, Kakinoki R, Akagi M.
Angiolymphoid hyperplasia with eosinophilia in a hand treated with a reverse digital island flap and artificial skin: a case report
Journal of Medical Case Reports 13(1) 2019年12月
Moritake A, Kawao N, Okada K, Ishida M, Tatsumi K, Matsuo O, Akagi M, Kaji H.
Plasminogen activator inhibitor-1 is involved in interleukin-1β-induced matrix metalloproteinase expression in murine chondrocytes
Mod Rheumatol. 29(6) 959 - 963 2019年11月
Iemura S, Kakinoki R, Otani K, Hashimoto K, Nakamura F, Tanaka H, Akagi M.
Treatment of a patient suffering from posttraumatic painful neuromas formed at the bilateral digital nerves of the left middle finger using two neurovascular island flaps
JPRAS Open 19 1 - 5 2019年3月
宮本 裕史, Ikeda T, Akagi M
Usefulness of dynamic contrast-enhanced magnetic resonance images for distinguishing between pyogenic spondylitis and tuberculous spondylitis
Eur Spine J 2019年6月 IF2.634
Methods
Forty-five consecutive patients diagnosed with PS (68.6 ± 11.1 years old, males 30 and females 15) and 14 with TB (73.9 ± 9.1 years old, males 6 and females 8) were involved. DCE-MRI consisted of serial six sagittal images which were taken every 20 s after intravenous gadolinium administration. Degree of enhancement, presence of epidural abscess, presence of necrosis in vertebra, presence of enhancement in disc lesion, pattern of diffusion, and maximum contrast index were examined and compared between PS and TB.
Results
Degree of enhancement, percentage of epidural abscess, and percentage of necrosis in vertebra were 2.1 ± 0.5 and 1.8 ± 0.8, 60.7% and 100%, 50.0% and 66.7% for PS and TB, respectively, without statistical difference. Maximum contrast index, percentage of the diffusion pattern from the disc, and percentage of enhanced disc were 108.1 ± 22.3 and 78.2 ± 35.6 s, 89.3% and 0%, and 53.6% and 0% for PS and TB, respectively, with statistical significance.
Conclusions
This study indicated that longer maximum contrast index, higher likelihood of diffusion pattern from the disc, and higher likelihood of enhanced disc are more specific to PS than TB. This less invasive imaging technique is useful for more accurate diagnosis of PS and TB
家村 駿輝, Kawao N, Okumoto K, Akagi M, Kaji H
Role of irisin in androgen-deficient muscle wasting and asteopenia in mice
2019年9月 J Bone Miner Metab IF 2.31
アンドロゲン欠乏症は、男性の骨粗しょう症とサルコペニアの病因に重要な役割を果たしています。アンドロゲン欠乏症がマウスの骨格筋におけるアイリシンの発現を減少させ、筋骨格系に悪影響を与えることが明らかとなりました。
橋本 和彦, Nishimura S, Hara Y, Oka N, Tanaka H, Iemura S, Akagi M.
Clinical outcomes of patients with primary malignant bone and soft tissue tumor aged 65 years or older
Exp Ther Med. 2019年 1月 IF 1.448
65歳以上の高齢者の骨軟部肉腫の症例をまとめたものです。外科的手術により適切なマージンを確保することで良好な予後が得られることがわかりました。
宮本 裕史, Ikeda T, Akagi M
Radiologic Analysis of Pedicle Marker for the Cervical Spine
J Orthop Sci. 2019年1月 IF 1.257
Purpose
To elucidate the usefulness of the pedicle marker (PM) for more accurate insertion of cervical pedicle screws (CPSs).
Methods
Artificial bone study. Fifty pedicles of five artificial bone specimens were examined. PMs were inserted in five different positions (confirmed by computed tomography (CT)); (1) insertion angle correct, insertion point too medial, (2) both insertion angle and insertion point correct, (3) insertion angle correct, insertion point too lateral, (4) insertion point correct, insertion angle too big, and (5) insertion point correct, insertion angle too small. Oblique radiographs were taken to assess the relationships between the pedicle and the PM as IN and OUT. Clinical series. A total of 228 CPSs were inserted in 59 consecutive patients using either CT cutout technique or navigation. During surgery, PMs were inserted, and the locations were confirmed on oblique fluoroscopic views in CT cutout technique and intraoperative CT in navigation. Intraoperative misplaced PM and postoperative misplaced CPS were assessed.
Results
Artificial bone study. Evaluation found 67% of Types 1 and 100% of Type 5 seemed to be IN on the oblique views at 10, 20, and 30° because the pedicle and PM overlapped. All cases of Type 2 were IN at any angles. Almost all Types 3 and 4 were OUT at any angle. Clinical series. The route was modified under the recognition of misplaced PM during surgery in 3.7% (all Type 4) of CT cutout and 4.2% (four Type 4 and one Type 5) of navigation. One CPS was malpositioned (0.9%, Type 1) in CT cutout and none in navigation by postoperative CT.
Conclusions
By applying PM, lateral displacement is easier to recognize in fluoroscopy. Medial misplacement should be aware because the PM and the rim of the pedicle overlap. Even after launching navigation, PM helped to indicate the wrong route before inserting the CPS during surgery.