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業績

実験病理

業績　―実験病理―

※下線は当講座メンバー

    ＜in press＞（２０２３.1２現在）

  • Wu X, Azizan EAB, Goodchild E, Garg S, Hagiyama M, Cabrera CP, Fernandes-Rosa FL, Boulkroun S, Kuan JL, Tiang Z, David A, Murakami M, Mein CA, Wozniak E, Zhao W, Marker A, Buss F, Saleeb RS, Salsbury J, Tezuka Y, Satoh F, Oki K, Udager AM, Cohen DL, Wachtel H, King PJ, Drake WM, Gurnell M, Ceral J, Ryska A, Mustangin M, Wong YP, Tan GC, Solar M, Reincke M, Rainey WE, Foo RS, Takaoka Y, Murray SA, Zennaro MC, Beuschlein F, Ito A, Brown MJ: Somatic CADM1 mutations in aldosterone-producing adenomas and gap junction-dependent regulation of aldosterone production. Nat Genet, in press.
  • Haratani K, Nakamura A, Mamesaya N, Mitsuoka S, Yoneshima Y, Saito R, Tanizaki J, Fujisaka Y, Hata A, Tsuruno K, Sakamoto T, Teraoka S, Oki M, Watanabe H, Sato Y, Nakano Y, Otani T, Sakai K, Tomida S, Chiba Y, Ito A, Nishio K, Yamamoto N, Nakagawa K, and Hayashi H: Tumor microenvironment landscape of non?small cell lung cancer reveals resistance mechanisms for PD-L1 blockade following chemoradiotherapy: a multi-center prospective biomarker study (WJOG11518L/SUBMARINE). J Thorac Oncol, in press.
  • Takeuchi F, Sugano A, Yoneshige A, Hagiyama M, Inoue T, Wada A, Takaoka Y, Ito A: Potential contribution of cell adhesion molecule 1 to the binding of SARS-CoV-2 spike protein to mouse nasal mucosa. Cell Tissue Organ, in press.

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    ＜ ２０２３年＞

  • Kuwahara K: DNA Damage, DNA Repair, and Cancer: Second Edition. Int J Mol Sci, doi.org/10.3390/ijms242316835, 2023.

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    ＜ ２０２２年＞

  • Kanemura H, Hayashi H, Tomida S, Tanizaki J, Suzuki S, Kawanaka Y, Tsuya A, Fukuda Y, Kaneda H, Kudo K, Takahama T, Imai R, Haratani K, Chiba Y, Otani T, Ito A, Sakai K, Nishio K, Nakagawa K: The tumor immune microenvironment and frameshift neoantigen load determine response to PD-L1 blockade in extensive-stage small cell lung cancer. JTO Clinical and Research Reports, 3（8）：100373, doi:10.1016/j.jtocrr.2022.100373, 2022.
  • Hagiyama M, Mimae T, Wada A, Takeuchi F, Yoneshige A, Inoue T, Kotoku N, Hamada H, Sekido Y, Okada M, Ito A: Possible therapeutic utility of anti-cell adhesion molecule 1 antibodies for malignant pleural mesothelioma. Front Cell Dev Bio, 10:945007, doi:10.3389/fcell.2022.945007, 2022.
  • Makutani Y, Kawakami H, Tsujikawa T, Yoshimura K, Chiba Y, Ito A, Kawamura J, Haratani K, Nakagawa K: Contribution of MMP14-expressing cancer-associated fibroblasts in the tumor immune microenvironment to progression of colorectal cancer. Front Oncol, 12:956270, doi:10.3389/fonc.2022.956270, 2022.
  • Isomoto K, Haratani K, Tsujikawa T, Makutani Y, Kawakami H, Takeda M, Yonesaka K, Tanaka K, Iwasa T, Hayashi H, Ito A, Nishio K, Nakagawa K: Mechanisms of primary and acquired resistance to immune checkpoint inhibitors in advanced non?small cell lung cancer: a multiplex immunohistochemistry?based single-cell analysis. Lung Cancer, 174:71-82, doi:10.1016/j.lungcan.2022.10.012, 2022.
  • Otani T, Matsumura N, Ito A: HER2-amplified endometrial carcinoma and AFP-producing endometrial carcinoma. Mod Pathol, doi: 10.1038/s41379-022-01156-x, 2022.
  • Sakai Y, Yoshinaga K, Yoshida A, Rezano A, Shiogama K, Kawashima Y, Yoshizawa T, Yoshizawa A, Hatakeyama S, Ohyama C, Ito H, Abe M, Kijima H, Otsuki Y, Ito A, Tsuzuki T, Takeya M, Sakaguchi N, Kuwahara K: Testicular teratomagenesis from primordial germ cells with overexpression of germinal center-associated nuclear protein. Cancer Sci, doi:10.1111/cas.15685, 2022.
  • Yuan J, Kihara T, Kimura N, Yamasaki T, Yoshida M, Isozaki K, Ito A, Hirota S: CADM1 promotes adhesion to vascular endothelial cells and transendothelial migration in cultured GIST cells. Oncol Lett, 23(3):86. doi:10.3892/ol.2022.13206, 2022.
  • Hagiyama M, Takeuchi F, Sugano A, Yoneshige A, Inoue T, Wada A, Kajiyama H, Takaoka Y, Sasaki K, Ito A: Indigo Plant Leaf Extract Inhibits the Binding of SARS-CoV-2 Spike Protein to Angiotensin-Converting Enzyme 2. Exp Ther Med, 23(4):274. doi:10.3892/etm.2022.11200, 2022.

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    ＜２０２１年＞

  • Otani T, Murakami K, Shiraishi N, Hagiyama M, Satou T, Matsuki M, Matsumura N, Ito A: α‐Fetoprotein‐producing endometrial carcinoma is associated with fetal gut-like and/or hepatoid morphology, lymphovascular infiltration, TP53 abnormalities, and poor prognosis: five cases and literature review. Front Med (Lausanne) , 8:799163. doi:10.3389/fmed.2021.799163, 2021.
  • Tanizaki J, Yonemori K, Akiyoshi K, Minami H, Ueda H, Takiguchi Y, Miura Y, Segawa Y, Takahashi S, Iwamoto Y, Kidera Y, Fukuoka K, Ito A, Chiba Y, Sakai K, Nishio K, Nakagawa K, Hayashi H: Open-Label Phase II Study of the Efficacy of Nivolumab for Cancer of Unknown Primary. Ann Oncol, 32(2):216-226. doi:10.1016/j.annonc.2021.11.009, 2021.
  • Suzuki S, Haratani K, Hayashi H, Chiba Y, Tanizaki J, Kato R, Mitani S, Kawanaka Y, Kurosaki T, Hasegawa Y, Okabe T, Tanaka K, Akashi Y, Ozaki T, Nishio K, Ito A, Nakagawa K: Association of Tumor Burden with the Efficacy of PD-1 or PD-L1 Inhibitors for Treatment-Naive Advanced Non?Small Cell Lung Cancer. Eur J Cancer, 161:44-54. doi:10.1016/j.ejca.2021.10.011, 2021.
  • Kimura R, Otani T, Shiraishi N, Hagiyama M, Yoneshige A, Wada A, Kajiyama H, Takeuchi F, Mizuguchi N, Morishita K, Ito A: Expression of cell adhesion molecule 1 in human and murine endometrial glandular cells and its increase during the proliferative phase by estrogen and cell density. Life Sci, 283:119854. doi:10.1016/j.lfs.2021.119854, 2021.
  • Yoneshige A, Hagiyama M, Takashima Y, Ueno S, Inoue T, Kimura R, Koriyama Y, Ito A: Elevated hydrostatic pressure causes retinal degeneration through upregulating lipocalin-2. Front Cell Dev Biol, 9:664327. doi:10.3389/fcell.2021.664327, 2021.
  • Takeda M, Takahama T, Sakai K, Shimizu S, Watanabe S, Kawakami H, Tanaka K, Sato C, Hayashi H, Nonagase Y, Yonesaka K, Takegawa N, Okuno T, Yoshida T, Fumita S, Suzuki S, Haratani K, Saigoh K, Ito A, Mitsudomi T, Handa H, Fukuoka K, Nakagawa K, Nishio K:　Clinical Application of the FoundationOne CDx Assay to Therapeutic Decision-Making for Patients with Advanced Solid Tumors. Oncologist, 26(4):e588-e596. doi:10.1002/onco.13639, 2021.
  • Yuan J, Kihara T, Kimura N, Hashikura Y, Ohkouchi M, Isozaki K, Takahashi T, Nishida T, Ito A, Hirota S: Differential expression of CADM1 in gastrointestinal stromal tumors of different sites and with different gene abnormalities. Pathol Oncol Res, 27:602008.doi:10.3389/pore.2021.602008, 2021.
  • Nakahata S, Syahrul C, Nakatake A, Sakamoto K, Yoshihama M, Nishikata I, Ukai Y, Matsuura T, Kameda T, Shide K, Kubuki Y, Hidaka T, Kitanaka A, Ito A, Takemoto S, Nakano N, Saito M, Iwanaga M, Sagara Y, Mochida K, Amano M, Maeda K, Sueoka E, Okayama A, Utsunomiya A, Shimoda K, Watanabe T, Morishita K: Clinical significance of soluble CADM1 as a novel marker for adult T-cell leukemia/lymphoma. Hematologica, 106(2):532-542. doi:10.3324/haematol.2019.234096. , 2021.
  • Watanabe S, Takeda M, Otani T, Yoshida T, Sakai K, Olek E, Rothenberg SM, Kherani J, French PF, Nishio K, Ito A, Nakagawa K: Complete Response to Selective RET Inhibition with Selpercatinib (LOXO-292) in a Patient with RET Fusion-Positive Breast Cancer. JCO Precision Oncology, 5:103-106, 2021.

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    ＜２０２０年＞

  • Tsuboi Y, Oyama M, Kozuka-Hata H, Ito A, Matsubara D, Murakami Y: CADM1 suppresses c-Src activation by binding with Cbp on membrane lipid rafts and intervenes colon carcinogenesis. Biochem Biophys Res Commun, 529(3):854-860. doi:10.1016/j.bbrc.2020.05.103, 2020.
  • Hagiyama M, Kimura R, Yoneshige A, Inoue T, Otani T, Ito A: Cell adhesion molecule 1 contributes to cell survival in crowded epithelial monolayers. Int J Mol Sci, 21(11):4123. doi:10.3390/ijms21114123, 2020.
  • Takeda M, Takahama T, Sakai K, Shimizu S, Watanabe S, Kawakami H, Tanaka K, Sato C, Hayashi H, Nonagase Y, Yonesaka K, Takegawa N, Okuno T, Yoshida T, Fumita S, Suzuki S, Haratani K, Saigoh K, Ito A, Mitsudomi T, Handa H, Fukuoka K, Nakagawa K, Nishio K: Clinical Application of the FoundationOne CDx Assay to Therapeutic Decision-Making for Patients with Advanced Solid Tumors. Oncologist. doi:10.1002/onco.13639.2020, 2020.
  • Isomoto K, Haratani K, Hayashi H, Shimizu S, Tomida S, Niwa T, Yokoyama T, Fukuda Y, Chiba Y, Kato R, Tanizaki J, Tanaka K, Takeda M, Ogura T, Ishida T, Ito A, Nakagawa K: Impact of EGFR-TKI treatment on the tumor immune microenvironment in EGFR mutation?positive non?small cell lung cancer. Clin Cancer Res, 26(8):2037-2046. doi:10.1158/1078-0432.CCR-19-2027, 2020.
  • Kanemura H, Hayashi H, Hagiwara S, Otani T, Haratani K, Yonesaka K, Ito A, Kudo M, Nakagawa K: Severe immune-related hepatitis treated with plasma exchange. Letter to the Editor, J Thorac Oncol, 15(3):e39-e42. Doi:10.1016/j.jtho.2019.11.014,2020.

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    ＜２０１９年＞

  • Inoue T, Hagiyama M, Maenishi O, Kimura M, Mizuguchi N, Mine Y, Kimura R, Chikugo T, Itoh T, Satou T, Ito A: Ectopic TWEAKR expression in type I fiber of stroke-prone spontaneously hypertensive rats is related to slow muscle-specific hypotrophy. Life Sci, doi:10.1016/j.lfs.2019.116919, 2019.
  • Sakai K, Takeda M, Shimizu S, Takahama T, Yoshida T, Watanabe S, Iwasa T, Yonesaka K, Suzuki S, Hayashi H, Kawakami H, Nonagase Y, Tanaka K, Tsurutani J, Saigoh K, Ito A, Mitsudomi T, Nakagawa K, Nishio K: A comparative study of curated contents by knowledge-based curation system in cancer clinical sequencing. Sci Rep, 9(1):11340. doi: 10.1038/s41598-019-47673-9, 2019.
  • Yamakita I, Mimae T, Tsutani Y, Miyata Y, Ito A, Okada M: Guanylate binding protein 1 (GBP-1) promotes cell motility and invasiveness of lung adenocarcinoma. Biochem Biophys Res Commun, 518(2):266-272. doi: 10.1016/j.bbrc.2019.08.045, 2019.
  • Haratani K, Hayashi H, Takahama T, Nakamura Y, Tomida S, Yoshida T, Chiba Y, Sawada T, Sakai K, Fujita Y, Togashi Y, Tanizaki J, Kawakami H, Ito A, Nishio K, Nakagawa K: Clinical and immune profiling for cancer of unknown primary site. J Immunother Cancer, 7(1):251. doi: 10.1186/s40425-019-0720-z, 2019.
  • Watanabe S, Otani T, Iwasa T, Takahama T, Takeda M, Sakai K, Nishio K, Ito A, Nakagawa K: A case of metastatic malignant breast adenomyoepithelioma with a codon-61 mutation of HRAS. Clin Breast Cancer, doi: 10.1016/j.clbc.2019.05.001, 2019.
  • Hagiyama M, Nakatani Y, Takashima Y, Kato T, Inoue T, Kimura R, Otani T, Sato Y, Mori H, Arima S, Ito A: Urinary cell adhesion molecule 1 is a novel biomarker that links tubulointerstitial damage to glomerular filtration rates in chronic kidney disease. Front Cell Dev Biol, 19(5):e589-e592, 2019.
  • Hiraoka E, Mimae T, Ito M, Kadoya T, Miyata Y, Kondo T, Ito A, Okada M: Breast cancer cell motility is promoted by 14-3-3γ. Breast Cancer, doi:10.1007/s12282-019-00964-5, 2019.
  • Sakai K, Ohira T, Matsubayashi J, Yoneshige A, Ito A, Mitsudomi T, Nagao T, Iwamatsu E, Katayama J, Ikeda N, Nishio K: Performance of Oncomine Fusion Transcript kit for formalin-fixed, paraffin-embedded lung cancer specimens. Cancer Sci, 110(6):2044-2049, 2019.

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    ＜２０１８年＞

  • Kimura R, Yoneshige A, Hagiyama M, Otani T, Inoue T, Shiraishi N, Yanagihara K, Wakayama T, Ito A: Expression of cell adhesion molecule 1 in gastric neck and base glandular cells: possible involvement in peritoneal dissemination of signet ring cells. Life Sci, 15(213):206-213,　2018.
  • Kato T, Hagiyama M, Ito A: Renal ADAM10 and 17: their physiological and medical meanings. Front Cell Dev Biol, 10.3389/fcell.2018.00153,　2018.
  • Watanabe S, Hayashi H, Haratani K, Shimizu S, Tanizaki J, Sakai K, Kawakami H, Yonesaka K, Tsurutani J, Togashi Y, Nishio K, Ito A, Nakagawa K: Mutational activation of the EGFR down-regulates MHC class I expression via the ERK in non?small cell lung cancer. Cancer Sci, 110(1):52-60,　2018.
  • Sakai H, Takeda M, Sakai K, Nakamura Y, Ito A, Hayashi H, Tanaka K, Nishio K, and Nakagawa K: Impact of cytotoxic chemotherapy on PD-L1 expression in patients with non?small cell lung cancer negative for EGFR mutation and ALK fusion. Lung Cancer, 127:59-65,　2018.
  • Ueno S, Yoneshige A, Koriyama Y, Hagiyama M, Shimomura Y, Ito A: Early gene expression profile in retinal ganglion cell layer after optic nerve crush in mice. Invest Ophthalmol Vis Sci, 59(1):370-380, 2018.
  • Nakatani Y, Kawakami H, Ichikawa M, Yamamoto S, Otsuka Y, Mashiko A,　Takashima Y, Ito A, Nakagawa K, Arima S: Nivolumab induced Acute Granulomatous Tubulointestinal Nephritis in Patient with Gastric Cancer. Invest New Drugs, 10.1007/s10637-018-0596-7, 2018.
  • Ri A, Hagiyama M, Inoue T, Takashima Y, Yoneshige A, Kimura R, Murakami Y, Ito A: Progression of pulmonary emphysema and continued increase in ectodomain shedding of cell adhesion molecule 1 after cessation of cigarette smoke exposure in mice. Front Cell Dev Biol, 10.3389/fcell.2018.00052, 2018.
  • MakuuchiY, Hayashi H, Haratani K, Tanizaki J, Tanaka K, Takeda M, Sakai K, Shimizu S, Ito A, Nishio K, Nakagawa K: A case of ALK-rearranged non-small cell lung cancer that responded to ceritinib after development of resistance to alectinib. Oncotarget, 9:23315-23319, 2018.

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    ＜２０１７年＞

  • Inoue T, Takemori K, Mizuguchi N, Kimura M, Chikugo T, Hagiyama M, Yoneshige A, Mori T, Maenishi O, Kometani T, Itoh T, Satou T, Ito A: Heart-bound adiponectin, not serum adiponectin, inversely correlates with cardiac hypertrophy in stroke-prone spontaneously hypertensive rats. Exp Physiol, 102(11):1435-1447, 2017.
  • Kato T, Hagiyama M, Takashima Y, Yoneshige A, Ito A: Cell adhesion molecule-1 (CADM1) shedding induces apoptosis of renal epithelial cells and exacerbates human nephropathies. Am J Physiol-Renal Physiol, 314(3):F388-F398, 2017.
  • Hagiyama M, Yabuta N, Okuzaki D, Inoue T, Takashima Y, Kimura R, Ri A, Ito A: Modest static pressure suppresses columnar epithelial cell growth in association with cell shape and cytoskeletal modifications. Front Physiol, 8:997 doi:10.3389/fphys.2017.00997, 2017.
  • Takashima Y, Murakami T, Inoue T, Hagiyama M, Yoneshige A, Nishimura S, Akagi M, Ito A: Manifestation of osteoblastic phenotypes in the sarcomatous component of epithelial carcinoma and sarcomatoid carcinoma. Tumor Biol, 39:1010428317704365, 2017.
  • Mizukami T, Togashi Y, Naruki S, Banno E, Terashima M, de Velasco MA, Sakai K, Yoneshige A, Hayashi H, Fujita Y, Tomida S, Nakajima TE, Fujino T, Boku N, Ito A, Nakagawa K, Nishio K: Significance of FGF9 gene in resistance to anti-EGFR therapies targeting colorectal cancer: A subset of colorectal cancer patients with FGF9 upregulation may be resistant to anti-EGFR therapies. Mol Carcinog, 56:106-117, 2017.
  • Okada H, Tong K, Ota K, Komuro A, Ueda T, Ito A, Koch CA: Attenuated DNA damage　repair delays therapy-related myeloid neoplasms in a mouse model. Cell Death Dis, 7(10):e2401.10.1038/cddis.2016.298, 2017.
  • Iino T, Hagiyama M, Furuno T, Ito A, Hosokawa Y: Time-course statistical evaluation of intercellular adhesion maturation by femtosecond laser impulse. Biophys J, 111(10):2255-2262, 10.1016/j.bpj.2016.09.044., 2017.
  • Kato T, Mizuguchi N, Ito A: Candesartan suppresses proteinuria and decrease of nephrin expression but hydralazine does not in hypertensive nephropathy. J Biomed, 2:57-63, 2017.

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    ＜２０１６年＞

  • Tanizaki J, Hayashi H, Kimura M, Tanaka K, Takeda M, Shimizu S, Ito A, Nakagawa K: Report of two cases of pseudoprogression in patients with non-small cell lung cancer treated with nivolumab-including histological analysis of one case after tumor regression. Lung Cancer, 102:44-48, 2016.
  • Hibi M, Kaneda H, Tanizaki J, Sakai K, Togashi Y, Terashima M, De Velasco M, Fujita Y, Banno E, Nakamura Y, Takeda M, Ito A, Mitsudomi T, Nakagawa K, Okamoto I, Nishio K: FGFR gene alterations in lung squamous cell carcinoma are potential targets for the multikinase inhibitor nintedanib. Cancer Sci 107(11): 1667-1676, 2016.
  • Yoneshige A, Hagiyama M, Inoue T, Tanaka T, Ri A, Ito A: Modest static pressure can cause enteric nerve degeneration through ectodomain shedding of cell adhesion molecule 1. Mol Neurobiol 54:6378-6390 10.1007/s12035-016-0166-y, 2016.
  • Ohta M, Hosokawa Y, Hatano N, Sugano A, Ito A, Takaoka Y: Efficacy of femtosecond lasers for application of acupuncture therapy. Lasers in Med Sci 10.1007/s10103-016-2124-3, 2016.
  • Nakagawa K, Asamura H, Tsuta K, Nagai K, Yamada E, Ishi G, Mitsudomi T, Ito A, Higashiyama M, Tomita Y, Inoue M, Morii E, Matsuura N, Okumura M: Novel method (OSNA) for the diagnosis of lymph node metastasis in patients with non-small cell lung cancer (NSCLC): Results of a multicenter prospective study. Lung Cancer 97: 1-7, 2016.
  • Kato T, Oka K, Nakamura T, Ito A: Decreased expression of Met during differentiation in rat lung. Eur J Histochem 60(1): 2575, 2016.
  • Yoshioka Y, Togashi Y, Chikugo T, Kogita A, Terashima M, Mizukami T, Hayashi H, Sakai K, de Velasco MA, Tomida S, Fujita Y, Tokoro T, Ito A, Okuno K, and Nishio K: Significance of FGF9 gene in resistance to anti-EGFR therapies targeting colorectal cancer: A subset of colorectal cancer patients with FGF9 upregulation may be resistant to anti-EGFR therapies. Mol Carcinog 10.1002/mc.22476, 2016.

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    ＜２０１５年＞

  • Yoneshige A, Hagiyama M, Inoue T, Mimae T, Kato T, Okada M, Enoki E, Ito A: Increased ectodomain shedding of cell adhesion molecule 1 as a cause of type II alveolar epithelial cell apoptosis in patients with idiopathic interstitial pneumonia. Respiratory Research 16:19, 2015.
  • Hagiyama M, Yoneshige A, Inoue T, Sato Y, Mimae T, Okada M, Ito A: The intracellular domain of cell adhesion molecule 1 is present in emphysematous lungs and induces lung epithelial cell apoptosis. J Biomed Sci 22:67, 2015.
  • Yoneshige A, Hagiyama M, Fujita M, Ito A: Pathogenic actions of cell adhesion molecule 1 in pulmonary emphysema and atopic dermatitis. Front Cell Dev Biol 10.3389/fcell.2015.00075, 2015.
  • Fujita M, Matsui T, Ito A: Biomedical insights into cell adhesion and migration -- from a viewpoint of central nervous system tumor immunology. Front Cell Dev Biol 10.3389/fcell.2015.00055, 2015.
  • Takeda M, Sakai K, Terashima M, Kaneda H, Hayashi H, Tanaka K, Takahama T, Yoshida T, Iwasa T, Shimizu T, Nonagase Y, Kudo K, Tomida S, Mitsudomi T, Saigo K, Ito A, Nakagawa K, Nishio K: Clinical application of amplicon-based next-generation sequencing to therapeutic decision-making in lung cancer. Ann Oncol 26(12): 2477-2482, 2015.
  • Kato T, Mizuguchi N, Ito A: Blood pressure, renal biochemical parameters and histopathology in an original rat model of essential hypertension (SHRSP/Kpo strain). Biomed Res 36:169-177, 2015.
  • Kato T, Mizuguchi N, Ito A: Characteristics of podocyte injury in malignant hypertensive nephropathy of rats (SHRSP/Kpo strain). Biomed Res 36:313-321, 2015.
  • Kato T, Oka K, Nakamura T, Ito A: Bronchioalveolar morphogeneis of human bronchial epithelial cells depending upon hepatocyte growth factor. J Cell Mol Med 19(12): 2818-2826, 2015.
  • Yoshioka Y, Togashi Y, Chikugo T, Kogita A, Terashima M, Mizukami T, Hayashi H, Sakai K, de Velasco MA, Tomida S, Fujita Y, Tokoro T, Ito A, Okuno K, Nishio K: Clinicopathological and genetic differences between low-grade and high-grade colorectal mucinous adenocarcinoma. Cancer 121(24): 4359-4368, 2015.
  • Kano H, Okada K, Morimoto K, Bao W, Fukase K, Ito A, Okita Y: Prediction of reversibility of intestinal mucosal damage after ischemia-reperfusion injury by plasma intestinal fatty acid-binding protein levels in pigs. Perfusion 30(8):617-625, 2015.
  • Mimae T, Ito A: New challenges in pseudopodial proteomics by a laser-assisted cell etching technique. BBA-Proteins Proteomics 1854(6):538-546, 2015.
  • Hayashi H, Arao T, Togashi Y, Kato H, Fujita Y, De Velasco MA, Kimura H, Matsumoto K, Tanaka K, Okamoto I, Ito A, Yamada Y, Nakagawa K, Nishio K: The OCT4 pseudogene POU5F1B is amplified and promotes an aggressive phenotype in gastric cancer. Oncogene 34(2):199-208, 2015.
  • Kato T, Sakiyama R, Oka K, Nakamura T: Identification of core active disaccharides in heparin for HGF-inducing activity. J Pharmacol Pharmacother 6(2):77-82, 2015.
  • Ohnishi H, Mizuno S, Mizuno Y, Kato T: Stromal cell-derived factor-1 (SDF1)-dependent recruitment of bone marrow-derived renal endothelium-like cells in a mouse model of acute kidney injury. J Vet Med Sci 77(3):313-319, 2015.
  • Sakai K, Yoneshige A, Ito A, Ueda Y, Kondo S, Nobumasa H, Fujita Y, Togashi Y, Terashima M, de Velasco MA, Tomida S, Nishio K: Performance of a novel KRAS mutation assay for formalin-fixed paraffin embedded tissues of colorectal cancer. SpringerPlus 4:7, 2015.
  • Sakai K, Tsurutani J, Yamanaka T, Yoneshige A, Ito A, Togashi Y, de Velasco MA, Terashima M, Fujita Y, Tomida S, Tamura T, Nakagawa K, Nishio K: Extended RAS and BRAF mutation analysis using next-generation sequencing. Plos One 10:e0121891, 2015.
  • 村上哲平、井上敬夫、西村俊司、伊藤彰彦、赤木将男：上皮悪性腫瘍の肉腫様変化は骨芽細胞分化の側面を有する：骨分化マーカーを用いた検討と解析. 近畿大学医学雑誌 40(1-2):39-46, 2015.

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    ＜２０１４年＞

  • Mimae T, Hagiyama M, Inoue T, Yoneshige A, Kato T, Okada M, Murakami Y, Ito A: Increased ectodomain shedding of lung-epithelial cell adhesion molecule 1 as a cause of increased alveolar cell apoptosis in emphysema. Thorax 69:223-231, 2014.
  • Inoue T, Hagiyama M, Yoneshige A, Kato T, Enoki E, Maenishi O, Chikugo T, Kimura M, Satou T, Ito A: Increased ectodomain shedding of cell adhesion molecule 1 from pancreatic islets in type 2 diabetic pancreata: correlation with hemoglobin A1c levels. Plos One 9:e100988, 2014.
  • Sakurai MA, Ozaki Y, Okuzaki D, Naito Y, Sasakura T, Okamoto A, Tabara H, Inoue T, Hagiyama M, Ito A, Yabuta N, Nojima H: Gefitinib and luteolin cause growth arrest of human prostate cancer PC-3 cells via inhibition of cyclin G-associated kinase and induction of miR-630. Plos One 9:e100124, 2014.
  • Ito M, Hagiyama M, Mimae T, Inoue T, Kato T, Yoneshige A, Nakanishi J, Kondo T, Okada M Ito A: α-Parvin, a pseudopodial constituent, promotes cell motility and is associated with lymph node metastasis of lobular breast carcinoma. Breast Cancer Res Treat 144:59-69, 2014.
  • Mimae T, Ito A, Hagiyama M, Nakanishi J, Ito M, Hosokawa Y, Okada M, Murakami Y, Kondo T: A novel approach to pseudopodia proteomics: excimer laser etching, two-dimensional difference gel electrophoresis, and confocal imaging. Protocol Exchange 2014. doi:10.1038/protex.2014.007
  • Kato T, Mizuno S, Ito A: A decrease in glomerular endothelial cells and endothelial-mesenchymal transition during glomerulosclerosis in the Tensin2-deficient mice (ICGN strain). Acta Histochem Cytochem 47:265-271, 2014.
  • Togashi Y, Sakamoto H, Hayashi H, Terashima M, de Velasco MA, Fujita Y, Kodera Y, Sakai K, Tomida S, Kitano M, Ito A, Kudo M, Nishio K: Homozygous deletion of the activin A receptor, type IB gene is associated with an aggressive cancer phenotype in pancreatic cancer. Mol Cancer 13:126, 2014.
  • 伊藤彰彦：　ヒトに由来する研究試料の取り扱い 〜病理学の立場から〜. 近畿大学医学雑誌 39(3-4):155-161, 2014.

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    ＜２０１３年＞

  • Muso E, Okuzaki D, Kobayashi S, Iwasaki Y, Sakurai MA, Ito A, Nojima H: Ficolin-1 is upregulated in leukocytes and glomeruli from microscopic polyangiitis patients. Autoimmunity 46:513-524, 2013.
  • Nagi-Miura N, Okuzaki D, Torigata K, Sakurai MA, Ito A, Ohno N, Nojima H: Expression of complement factors is induced in DBA/2 mice following administration of CAWS. BMC Immunol 14:44, 2013.
  • de Haan JJ, Hadfoune M, Lubbers T, Hodin C, Lenaerts K, Ito A, Verbaeys I, Skynner MJ, Cailotto C, van der Vliet J, de Jonge WJ, Greve JMM, Buurman WA: Lipid-rich enteral nutrition regulates mucosal mast cell activation via the vagal anti-inflammatory reflex. Am J Physiol -Gastr L 305:G383-391, 2013.
  • Hosokawa Y, Iino T, Hagiyama M, Ito A: Estimating cell adhesion strength. SPIE Newsroom doi: 10.1117/2.1201302.004619, 2013.
  • Hosokawa Y, Ohta M, Ito A, Takaoka Y: Photomechanical ablation of biological tissue induced by focused femtosecond laser and its application for acupuncture. Appl Phys A-Mater 110:613-616, 2013.
  • Kondo S, Yagi H, Kamiya Y, Ito A, Kuhara M, Kudoh A, Takahashi N, Kato K: N-glycosylation profiles of chicken immunoglobulin Y glycoproteins expressed by different production vehicles. J Glycomics Lipidomics S5:002. doi:10.4172/2153-0637.S5-002, 2012.
  • Hagiyama M, Inoue T, Furuno T, Iino T, Itami S, Nakanishi M, Asada H, Hosokawa Y, Ito A: Increased expression of cell adhesion molecule 1 by mast cells as a cause of enhanced nerve-mast cell interaction in a hapten-induced mouse model of atopic dermatitis. Brit J Dermatol 168:771-778, 2013.
  • Inoue T, Hagiyama M, Enoki E, Sakurai MA, Tan A, Wakayama T, Iseki S, Murakami Y, Fukuda K, Hamanishi C, Ito A: Cell adhesion molecule 1 is a new osteoblastic cell adhesion molecule and a diagnostic marker for osteosarcoma. Life Sci 92:91-99, 2013.
  • Yabuta N, Mukai S, Okamoto A, Okuzaki D, Suzuki H, Torigata K, Okada N, Miura D, Ito A, Ikawa M, Okabe M, Nojima H: N-terminal truncation of Lats1 causes abnormal cell growth control and chromosomal instability. J Cell Sci 126:508-520, 2013.
  • Nishikawa Y, Sone M, Nagahama Y, Kumagai E, Doi Y, Omori Y, Yoshioka T, Tokairin T, Yoshida M, Yamamoto Y, Ito A, Sugiyama T, Enomoto K: Tumor necrosis factor-α promotes bile ductular transdifferentiation of mature rat hepatocytes in vitro. J Cell Biochem 114:831-843, 2013.
  • Oboki K, Hagiyama M, Inoue T, Ito A: Mast cells (version 3.0). Encyclopedia of Life Sciences doi: 10.1002/9780470015902.a0001203.pub3, 2013
  • Takaoka Y, Ohta M, Sugano A, Ito A, Hosokawa Y: New Technology:Femtosecond laser may be used for future acupuncture therapy. In Acupuncture in Modern Medicine (eds, Lucy L. Chen and Tsung O. Cheng), InTech-OpenAccess Publishers, pp.221-231, 2013.
  • Hatabe S, Kimura H, Arao T, Kato H, Hayashi H, Nagai T, Matsumoto K, DE Velasco M, Fujita Y, Yamanouchi G, Fukushima M, Yamada Y, Ito A, Okuno K, Nishio K: Overexpression of heparan sulfate 6-O-sulfotransferase-2 in colorectal cancer. Mol Clin Oncol 1:845-850, 2013.
  • Imano M, Itoh T, Satou T, Yasuda A, Nishiki K, Kato H, Shiraishi O, Peng YF, Shinkai M, Tsubaki M, Yasuda T, Imamoto H, Nishida S, Takeyama Y, Furkawa H, Okuno K, Shiozaki H: High expression of epithelial cellular adhesion molecule in peritoneal metastasis of gastric cancer. Target Oncol 231-235, 2013.
  • Itoh T, Imano M, Nishida S, Tsubaki M, Mizuguchi N, Hashimoto S, Ito A, Satou T: Increased apoptotic neuronal cell death and cerebral dysfunction after traumatic brain injury in aged rats. Brain Struct Funct 218:209-220, 2013.
  • Itoh T, Tabuchi M, Mizuguchi N, Imano M, Tsubaki M, Nishida S, Hashimoto S, Matsuo K, Nakayama T, Ito A, Munakata H, Satou T: Neuroprotective effect of (-)-epigallocatechin-3-gallate in rats when administered pre- or post-traumatic brain injury. J Neural Transm 120:767-783, 2013.
  • Itoh T, Imano M, Nishida S, Tsubaki M, Mizuguchi N, Yamanaka S, Tabuchi M, Munakata H, Hashimoto S, Ito A, Satou T: Appearance of neural stem cells around the damaged area following traumatic brain injury in aged rats. J Neural Transm 120:361-374, 2013.
  • Imano M, Itoh T, Satou T, Kido A, Tsubaki M, Yasuda A, Kato H, Imamoto H, Nishida S, Furukawa H, Takeyama Y, Okuno K, Shiozaki H: Establishment of a novel peritoneal model of carcinomatosis of peritoneal extension type. Anticancer Res 33:1439-1446, 2013.
  • Imano M, Itoh T, Satou T, Yasuda A, Nishiki K, Kato H, Shiraishi O, Peng YF, Shinkai M, Tsubaki M, Yasuda T, Imamoto H, Nishida S, Takeyama Y, Furukawa H, Okuno K, Shiozaki H: Phase II Study of Single Intraperitoneal Chemotherapy Followed by Systemic Chemotherapy for Gastric Cancer with Peritoneal Metastasis. J Gastrointest Surg 16:2190-2196, 2013.
  • Chiba T, Itoh T, Tabuchi M, Nakazawa T, Satou T: Interleukin-1beta accelerates the onset of stroke in stroke-prone spontaneously hypertensive rats. Mediat Inflamm 2012:ID;701976 1-11, 2013.
  • Tsubaki M, Itoh T, Satou T, Imano M, Komai M, Ogawa N, Mukai J, Nishida S: Nitrogen-containing bisphosphonates induce apoptosis of hematopoietic tumor cells via inhibition of Ras signaling pathways and Bim-mediated activation of the intrinsic apoptotic pathway. Biochem Pharmacol 85:163-172, 2013.
  • 伊藤彰彦、萩山満、細川陽一郎：細胞の接着・遊走を司る偽足突起の単離とプロテオミクス―先端レーザー微細加工技術の応用．生体の科学．医学書院．Vol. 46, No.3, pp.244-248, 2013.
  • 見前隆洋、伊藤彰彦、宮田義浩、岡田守人：微小浸潤肺腺癌の悪性化進展に相関する転写因子の単離．日本臨床 Vol. 71, Suppl. 6, pp.114-117, 2013.

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    ＜２０１２年＞

  • Mimae T, Okada M, Hagiyama M, Miyata Y, Tsutani Y, Inoue T, Murakami Y, Ito A: Upregulation of Notch2 and Six1 is associated with progression of early-stage lung adenocarcinoma and a more aggressive phenotype at advanced stages. Clin Cancer Res 18:945-955, 2012.
  • Ito A, Mimae T, Yamamoto YSZ, Hagiyama M, Nakanishi J, Ito M, Hosokawa Y, Okada M, Murakami Y, Kondo T: Novel application for pseudopodia proteomics using excimer laser ablation and two-dimensional difference gel electrophoresis. Lab Invest 92:1374-1385, 2012.
  • Nagara Y, Hagiyama M, Hatano N, Futai E, Suo S, Takaoka Y, Murakami Y, Ito A, Ishiura S: Tumor suppressor cell adhesion molecule 1 (CADM1) is cleaved by a disintegrin and metalloprotease 10 (ADAM10) and subsequently cleaved by c-secretase complex. Biochem Biophys Res Commun 417:462-467, 2012.
  • Ito A, Ichiyanagi N, Ikeda Y, Hagiyama M, Inoue T, Kimura KB, Sakurai MA, Hamaguchi K, Murakami Y: Adhesion molecule CADM1 contributes to gap junctional communication among pancreatic islet α cells and prevents their excessive secretion of glucagon. Islets 4:49-55, 2012.
  • Furuno T, Hagiyama M, Sekimura M, Okamoto K, Suzuki R, Ito A, Hirashima N, Nakanishi M: Cell adhesion molecule 1 (CADM1) on mast cells promotes interaction with dorsal root ganglion neurites by heterophilic binding to nectin-3. J Neuroimmunol 250:50-58, 2012.
  • Takahashi Y, Iwai M, Kawai T, Arakawa A, Ito T, Sakurai-Yageta M, Ito A, Goto A, Saito M, Kasumi F, and Murakami Y: Aberrant expression of tumor suppressors, CADM1 and 4.1B, in invasive lesions of primary breast cancer. Breast Cancer 19:242-252, 2012.
  • Okuzaki D, Kobayashi S, Sakurai MA, Torigata K, Okamoto A, Matsumoto T, Daida H, Ito A, Nojima H: Ficolin 1 expression is elevated in the peripheral blood mononuclear cells of Takayasu’s vasculitis patients. J Mol Biomark Diagn 2:125. doi:10.4172/2155-9929.1000125, 2012.
  • Imamoto H, Imano M, Satou T, Itoh T, Okuno K, Shiozaki H: The expression of human epidermal growth factor receptor2 in peritoneal metastasis of gastric cancer. Acta Med Kinki Univ 37:19-23, 2012.
  • Imano M, Yasuda A, Itoh T, Satou T, Peng YF, Kato H, Shinkai M, Tsubaki M, Yasuda T, Imamoto H, Nishida S, Takeyama Y, Okuno K, Furukawa H, Shiozaki H: Safety of intraperitoneal administration of paclitaxel after gastrectomy with en-bloc D2 lymph node dissection. J Surg Oncol 16:2190-2196, 2012.
  • Imano M, Imamoto H, Itoh T, Satou T, Peng YF, Yasuda A, Kato H, Shiraishi O, Shinkai M, Yasuda T, Takeyama Y, Okuno K, Furukawa H, Shiozaki H: Phase II Study of Single Intraperitoneal Chemotherapy Followed by Systemic Chemotherapy for Gastric Cancer with Peritoneal Metastasis. J Gastrointest Surg 16:2190-2196, 2012.
  • Imano M, Satou T, Itoh T, Yasuda A, Kato H, Shinkai M, Peng Y, Tsubaki M, Yasuda T, Imamoto H, Nishida S, Takeyama Y, Okuno K, Shiozaki H: Peritoneal metastatic lesions of gastric cancer exhibit low expression of human epidermal growth factor receptor 2. Target Oncol 7:213-216, 2012.
  • Imano M, Peng YF, Itoh T, Nishikawa M, Satou T, Yasuda A, Inoue K, Kato H, Shinkai M, Tsubaki M, Yasuda T, Imamoto H, Nishida S, Takeyama Y, Furukawa H, Okuno K, Shiozaki H: A preliminary study of single intraperitoneal administration of paclitaxel follwoed by sequential systemic chemotherapy with S-1 plis paclitaxel for advanced gastric cancer with peritoneal metastasis. Anticancer Res 32:4071-4075, 2012.
  • Tsubaki M, Satou T, Itoh T, Imano M, Komai M, Nishinobo M, Yamashita M, Yanae M, Yamazoe Y, Nishida S: Overexpression of MDR1 and survivin, and decreased Bim expression mediate multidrug-resistance in multiple myeloma cells. Leuk Res 36:1315-1322, 2012.
  • Tsubaki M, Satou T, Itoh T, Imano M, Yanae M, Kato C, Takagoshi R, Komai M, Nishida S: Bisphosphonate- and statin-induced enhancement of OPG expression and inhibition of CD9, M-CSF, and RANKL expressions via inhibition of the Ras/MEK/ERK pathway and activation of p38MAPK in mouse bone marrow stromal cell line ST2. Mol Cell Endocrinol 361:219-231, 2012.
  • Itoh T, Imano M, Nishida S, Tsubaki M, Mizuguchi N, Hashimoto S, Ito A, Satou T: (-)-Epigallocatechin-3-gallate increases the number of neural stem cells around the damaged area after rat traumatic brain injury. J Neural Transm 119:877-890, 2012.
  • Sakamoto H, Kimura H, Sekijima M, Matsumoto K, Arao T, Chikugo T, Yamada Y, Kitano M, Ito A, Takeyama Y, Kudo M, Nishio K: Plasma Concentrations of Angiogenesis-related Molecules in Patients with Pancreatic Cancer. Jpn J Clin Oncol 42:105-112, 2012.
  • Chiba T, Itoh T, Tabuchi M, Oshima K, Satou T, Ezaki O: Delay of stroke onset by milk proteins in stroke-prone spontaneously hypertensive rats. Stroke 43:470-477, 2012.
  • Tsubaki M, Satou T, Itoh T, Imano M, Ogaki M, Yanae M, Nishida S: Reduction of metastasis, cell invasion, and adhesion in mouse osteosarcoma by YM529/ONO-5920-induced blockade of the Ras/MEK/ERK and Ras/PI3K/Akt pathway. Toxicol Appl Pharm 259:402-410, 2012.
  • Itoh T, Imano M, Nishida S, Tsubaki M, Hashimoto S, Ito A, Satou T: Expression and cerebral function of amyloid precursor protein after rat traumatic brain injury. Alzheimer Book, InTech Publisher（著書), in press.
  • Itoh T, Imano M, Nishida S, Tsubaki M, Hashimoto S, Ito A, Satou T: Stem Cells and Cancer Stem Cells. Therapeutic Applications in Disease and Injury 59-72, Springer Publisher, 2012（著書).
  • Itoh T, Takemori K, Imano M, Nishida S, Tsubaki M, Hashimoto S, Ito H, Ito A, Satou T: Stem Cells and Cancer Stem Cells 2:199-209, Springer Publisher（著書), 2012.
  • Itoh T, Imano M, Nishida S, Tsubaki M, Hashimoto S, Ito A, Satou T: Forced running exercise inhibits neuronal degeneration and improves cerebral function following rat traumatic brain injury. Brain injury, Nova Science Publishers（著書), in press.
  • Itoh T, Imano M, Nishida S, Tsubaki M, Hashimoto S, Ito A, Satou T: Study of amyloid precursor protein expression after traumatic brain injury in the rat. Amyloids: Composition, Functions and Pathology 61-82, Nova Science Publishers（著書), 2012.

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    ＜２０１１年＞

  • Hosokawa Y, Hagiyama M, Iino T, Murakami Y, and Ito A: Noncontact estimation of intercellular breaking force using a femtosecond laser impulse quantified by atomic force microscopy. Proc Natl Acad Sci U S A, 108:1777-1782, 2011.
  • Fukui R, Saitoh S, Kanno A, Onji M, Shibata T, Ito A, Onji M, Matsumoto M, Akira S, Yoshida N, Miyake K: Unc93B1 Restricts Systemic Lethal Inflammation by Orchestrating Toll-like Receptor 7 and 9 Trafficking. Immunity 35:69-81, 2011.
  • Tsubaki M, Yamazoe Y, Yanae M, Satou T, Itoh T, Kaneko J, Kidera Y, Moriyama K, Nishida S: Blockade of the Ras/MEK/ERK and Ras/PI3K/Akt pathways by statins reduces the expression of bFGF, HGF, and TGF-β as angiogenic factors in mouse osteosarcoma. Cytokine 54:100-107, 2011.
  • Yanae M, Tsubaki M, Satou T, Itoh T, Imano M, Yamazoe Y, Nishida S: Statin-induced apoptosis via the suppression of ERK1/2 and Akt activation by inhibition of the geranylgeranyl-pyrophosphate biosynthesis in glioblastoma. J Exp Clin Canc Res 30:74, 2011.
  • Imano M, Okuno K, Itoh T, Satou T, Ishimaru E, Yasuda T, Hida J, Imamoto H, Takeyama Y, Shiozaki H: Osteopontin induced by macrophages contribute to metachronous liver metastases in colorectal cancer. AM Surgeon 77:1515-1520, 2011.
  • Tabara H, Naito Y, Ito A, Katsuma A, Sakurai MA, Ohno S, Shimizu H, Yabuta N, Nojima H: Neonatal Lethality in Knockout Mice Expressing the Kinase-Dead Form of the Gefitinib Target GAK Is Caused by Pulmonary Dysfunction. Plos One 6:e26034, 2011.
  • Itoh T, Imano M, Nishida S, Tsubaki M, Hashimoto S, Ito A, Satou T: (-)-Epigallocatechin-3-gallate protects against neuronal cell eath and improves cerebral function after traumatic brain injury in rats. Neuromol Med 13:300-309, 2011.
  • Takemori K, Kimura T, Shirasaka N, Inoue T, Masuno K, Ito H: Food restriction improves glucose and lipid metabolism through Sirt1 expression: A study using a new rat model with obesity and severe hypertension. Life Sci 88:1088-1094, 2011.
  • Shoji K, Tsubaki M, Yamazoe Y, Satou T, Itoh T, Kidera Y, Tanimori Y, Yanae M, Matsuda H, Taga A, Nakamura H, Nishida S: Mangiferin induces apoptosis by suppressing Bcl-xL and XIAP expressions and muclear entry of NF-κB in HL-60 cells. Arch Pharm Res 34:469-475, 2011.
  • Hagiwara S, Kudo M, Ueshima K, Chung H, Yamaguchi M, Takita M, Haji S, Kimura M, Arao T, Nishio K, Park A-M, Munakata H: The cancer stem cell marker CD133 is a predictor of the effectiveness of S1+ pegylated interferon α-2b therapy against advanced hepatocellular carcinoma. J Gastroenterol 46:212-221, 2011.
  • Itoh T, Imano M, Nishida S, Tsubaki M, Hashimoto S, Ito A, Satou T: Exercise increases neural stem cell proliferation surrounding the area of damage following rat traumatic brain injury. J Neural Transm 118:193-202, 2011.
  • Hagiyama M, Furuno T, Hosokawa Y, Iino T, Ito T, Inoue T, Nakanishi M, Murakami Y, and Ito A: Enhanced nerve−mast cell interaction by a neuronal short isoform of cell adhesion molecule-1, CADM1. J Immunol 186:5983-5992, 2011.
  • Itoh T, Imano M, Nishida S, Tsubaki M, Hashimoto S, Ito A, Satou T: Exercise inhibits neuronal apoptosis and improves cerebral function following rat traumatic brain injury. J Neural Transm 118:1263?1272, 2011.
  • Nagata M, Sakurai-Yageta M, Yamada D, Ito A, Fukuhara H, Kume H, Morikawa T, Fukayama M, Homma Y, and Murakami Y: Aberrations of a cell adhesion molecule CADM4 in renal clear cell carcinoma. Int J Cancer 130:1329-1337, 2011.
  • Ito T, Williams-Nate Y, Iwai M, Tsuboi Y, Hagiyama M, Ito A, Sakurai-Yageta M, and Murakami Y: Transcriptional regulation of the CADM1 gene by retinoic acid during the neural differentiation of murine embryonal carcinoma P19 cells. Genes Cells 16:791-802, 2011.
  • Shoji K, Tsubaki M, Yamazoe Y, Satou T, Itoh T, Kidera Y, Tanimori Y, Yanae M, Matsuda H, Taga A, Nakamura H, and Nishida S: Mangiferin Induces Apoptosis by Suppressing Bcl-xL and XIAP Expressions and Nuclear Entry of NF-κB in HL-60 Cells. Arch Pharm Res 34, 469-475, 2011.
  • Itoh T, Imano M, Nishida S, Tsubaki M, Hashimoto S, Ito A, Satou T: Expression and Cerebral function of amyloid precursor protein after rat traumatic brain injury. Alzheimer's disease pathogenesis-core concepts, shifting paradigmas and therapeutic targets. InTech-Open Access Publisher 31-52, 2011.
  • Sakurai S, Kudo M, Fukuda N, Nakatani T, Kimura M, Park AM, Munakata H: Involvement of angiotensin II and reactive oxygen species in pancreatic fibrosis. Pancreatology 11：7-13，2011.
  • 伊藤龍生：脳の病態病理．若さの栄養学　147:2-9, 2011.

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    ＜２０１０年＞

  • Masuda M, Maruyama T, Ohta T, Ito A, Hayashi T, Tsukasaki K, Kamihira S, Yamaoka S, Hoshino H, Yoshida T, Watanabe T, Stanbridge EJ, Murakami Y: CADM1 interacts with Tiam1 and promotes invasive phenotype of human T-cell leukemia virus type I-transformed cells and adult T-cell leukemia cells. J Biol Chem 285:15511-15522, 2010.
  • Tsubaki M, Kato C, Isono A, Kaneko J, Isozaki M, Satou T, Itoh T, Kidera Y, Tanimori Y, Yanae M, Nishida S: Macrophage inflammatory protein-1α induces osteoclast formation by activation of the MEK/ERK/c-Fos pathway and inhibition of the p38MAPK/IRF-3/IFN-β pathway. J Cell Biochem 111:1661-1672, 2010.
  • Kidera Y, Tsubaki M, Yamazoe Y, Shoji K, Nakamura H, Ogaki M, Satou T, Itoh T, Isozaki M, Kaneko J, Tanimori Y, Yanae M, Nishida S: Reduction of lung metastasis, cell invasion, and adhesion in mouse melanoma by statin-induced blockade of the Rho/Rho-associated coiled-coilcontaining protein kinase pathway. J Exp Clin Cancer Res 29:127-137, 2010.
  • Itoh T, Satou T, Nishida S, Tsubaki M, Imano M, Hashimoto S, Ito H: Edaravone protects against apoptotic neuronal cell death and improves cerebral function after traumatic brain injury in rats. Neurochem Res 35:348-355, 2010.
  • Itoh T, Satou T, Takemori K, Hashimoto S, Ito H: Neural stem cells and new neurons in the cerebral cortex of stroke-prone spontaneously hypertensive rats after stroke. J Mol Neurosci 41:55-65, 2010.
  • Inoue T, Takemori K, Yamamoto K, Ito H: Characterization of Wistar-Kyoto rats showing hyperadiponectinemia. Life Sci 86:344-350, 2010.
  • Tanimori Y, Tsubaki M, Yamazoe Y, Satou T, Itoh T, Kidera Y, Yanae M, Yamamoto C, Kaneko J, Nishida S: Nitrogen-containing bisphosphonate, YM529/ONO-5920, inhibits tumor metastasis in mouse melanoma through suppression of the Rho/ROCK pathway. Clin Exp Metastasis 27:529-538, 2010.
  • Murray PG, Fan Y, Davies G, Ying J, Geng H, Ng KM, Li H, Gao Z, Wei W, Bose S, Anderton J, Kapatai G, Reynolds G, Ito A, Marafioti T, Woodman CB, Ambinder R, Tao Q: Epigenetic silencing of a proapoptotic cell adhesion molecule, the immunoglobulin superfamily member IGSF4, by promoter CpG methylation protects Hodgkin lymphoma cells from apoptosis. Am J Pathol, 177:1480-1490, 2010.
  • Mimae T, Hirayasu T, Kimura KB, Ito A, Miyata Y, and Okada M: Advantage of absorbable suture material for pulmonary artery ligation. Gen Thorac Cardiovasc Surg, 58:511-515, 2010.
  • Chung SH, Seki K, Choi BI, Kimura KB, Ito A, Fujikado N, Saijo S, and Iwakura Y: CXC chemokine receptor 4 expressed in T cells plays an important role in the development of collagen-induced arthritis. Arthritis Res Ther, 12:R188, 2010.
  • Imano M, Okuno K, Itoh T, Ishimaru E, Satou T, Shiozaki H: Increased osteopontin-positive macrophage expression in colorectal cancer stroma with synchronous liver metastasis. World J Surg 34:1930-6, 2010.
  • Imano M, Itoh T, Satou T, Sogo Y, Hirai H, Kato H, Yasuda A, Peng YF, Shinkai M, Yasuda T, Imamoto H, Okuno K, Shiozaki H, Ohyanagi H: Prospective randomized trial of short-term neoadjuvant chemotherapy for advanced gastric cancer. Eur J Surg Oncol 36:963-968, 2010.
  • Ito A, Hagiyama M, Inoue T: Heterotypic cell-cell interaction mediated by Cell Adhesion Molecule-1, CADM1: Physiological, pathological and physical aspects. Acta Med Kinki Univ 35:77-85, 2010.