研究

Yoriaki Komeda, Toshiharu Sakurai, Kazuko Sakai, Yasuyoshi Morita, Arito Hashimoto, Tomoyuki Nagai, Satoru Hagiwara, Itaru Matsumura, Kazuto Nishio, Masatoshi Kudo

Refractory case of ulcerative colitis with idiopathic thrombocytopenic purpura successfully treated by Janus kinase inhibitor tofacitinib: A case report.

Masatoshi Kudo

Limited Impact of Anti-PD-1/PD-L1 Monotherapy for Hepatocellular Carcinoma.

Masatoshi Kudo

Recent Advances in Systemic Therapy for Hepatocellular Carcinoma in an Aging Society: 2020 Update.

Kazuya Kariyama, Kazuhiro Nouso, Atsushi Hiraoka, Akiko Wakuta, Ayano Oonishi, Teiji Kuzuya, Hidenori Toyoda, Toshifumi Tada, Kunihiko Tsuji, Ei Itobayashi, Toru Ishikawa, Koichi Takaguchi, Akemi Tsutsui, Noritomo Shimada, Masatoshi Kudo, Takashi Kumada

EZ-ALBI Score for Predicting Hepatocellular Carcinoma Prognosis.

Toshiharu Sakurai, Naoshi Nishida, Masatoshi Kudo

Promising anticancer therapy: combination of immune checkpoint inhibitors and molecular-targeted agents.

Baek-Yeol Ryoo, Philippe Merle, Amit S Kulkarni, Ann-Lii Cheng, Mohamed Bouattour, Ho Yeong Lim, Valeriy Breder, Julien Edeline, Yee Chao, Sadahisa Ogasawara, Thomas Yau, Marcelo Garrido, Stephen L Chan, Bruno Daniele, Josephine M Norquist, Erluo Chen, Abby B Siegel, Andrew X Zhu, Richard S Finn, Masatoshi Kudo

Health-related quality-of-life impact of pembrolizumab versus best supportive care in previously systemically treated patients with advanced hepatocellular carcinoma: KEYNOTE-240.

Maria Reig, Peter R Galle, Masatoshi Kudo, Richard Finn, Josep M Llovet, Andrea L Metti, William R Schelman, Kun Liang, Chunxiao Wang, Ryan C Widau, Paolo Abada, Andrew X Zhu

Pattern of progression in advanced hepatocellular carcinoma treated with ramucirumab.

Atsushi Hiraoka, Takashi Kumada, Kazuya Kariyama, Toshifumi Tada, Joji Tani, Shinya Fukunishi, Masanori Atsukawa, Masashi Hirooka, Kunihiko Tsuji, Toru Ishikawa, Koichi Takaguchi, Ei Itobayashi, Kazuto Tajiri, Noritomo Shimada, Hiroshi Shibata, Hironori Ochi, Kazuhito Kawata, Satoshi Yasuda, Hidenori Toyoda, Hideko Ohama, Kazuhiro Nouso, Akemi Tsutsui, Takuya Nagano, Norio Itokawa, Korenobu Hayama, Taeang Arai, Michitaka Imai, Yohei Koizumi, Shinichiro Nakamura, Kouji Joko, Kojiro Michitaka, Yoichi Hiasa, Masatoshi Kudo

Clinical importance of muscle volume in lenvatinib treatment for hepatocellular carcinoma: Analysis adjusted with inverse probability weighting.

Toshiharu Sakurai, Hiroki Nishiyama, Kazuko Sakai, Marco A De Velasco, Tomoyuki Nagai, Yoriaki Komeda, Hiroshi Kashida, Akiyoshi Okada, Isao Kawai, Kazuto Nishio, Hiroyuki Ogata, Masatoshi Kudo

Mucosal microbiota and gene expression are associated with long-term remission after discontinuation of adalimumab in ulcerative colitis.

Taku Aoki, Keiichi Kubota, Shoji Kubo, Susumu Eguchi, Namiki Izumi, Norihiro Kokudo, Michiie Sakamoto, Shuichiro Shiina, Tadatoshi Takayama, Osamu Nakashima, Yutaka Matsuyama, Takamichi Murakami, Masatoshi Kudo

Analysis of Patient Outcome after Non-curative Resection for Hepatocellular Carcinoma Using Nationwide Survey Data in Japan.

Tomoko Aoki, Masatoshi Kudo, Kazuomi Ueshima, Masahiro Morita, Hirokazu Chishina, Masahiro Takita, Satoru Hagiwara, Hiroshi Ida, Yasunori Minami, Masakatsu Tsurusaki, Naoshi Nishida

Exploratory Analysis of Lenvatinib Therapy in Patients with Unresectable Hepatocellular Carcinoma Who Have Failed Prior PD-1/PD-L1 Checkpoint Blockade.

Saur Hajiev, Elias Allara, Leila Motedayеn-Aval, Tadaaki Arizumi, Dominik Bettinger, Mario Pirisi, Lorenza Rimassa, Tiziana Pressiani, Nicola Personeni, Laura Giordano, Masatoshi Kudo, Robert Thimme, Joong-Won Park, Tamar H Taddei, David E Kaplan, Ramya Ramaswami, David J Pinato, Rohini Sharma

Impact of age on sorafenib outcomes in hepatocellular carcinoma: an international cohort study.

Rei Ishikawa, Ken Kamata, Akane Hara, Hidekazu Tanaka, Ayana Okamoto, Tomohiro Yamazaki, Atsushi Nakai, Shunsuke Omoto, Kosuke Minaga, Kentaro Yamao, Mamoru Takenaka, Yasunori Minami, Tomohiro Watanabe, Yasutaka Chiba, Takaaki Chikugo, Ippei Matsumoto, Yoshifumi Takeyama, Yuko Matsukubo, Tomoko Hyodo, Masatoshi Kudo

Utility of contrast-enhanced harmonic endoscopic ultrasonography for predicting the prognosis of pancreatic neuroendocrine neoplasms.

Thomas Yau, Yoon-Koo Kang, Tae-You Kim, Anthony B El-Khoueiry, Armando Santoro, Bruno Sangro, Ignacio Melero, Masatoshi Kudo, Ming-Mo Hou, Ana Matilla, Francesco Tovoli, Jennifer J Knox, Aiwu Ruth He, Bassel F El-Rayes, Mirelis Acosta-Rivera, Ho-Yeong Lim, Jaclyn Neely, Yun Shen, Tami Wisniewski, Jeffrey Anderson, Chiun Hsu

Efficacy and Safety of Nivolumab Plus Ipilimumab in Patients With Advanced Hepatocellular Carcinoma Previously Treated With Sorafenib: The CheckMate 040 Randomized Clinical Trial.

Ken Kamata, Reiko Ashida, Satoru Yasukawa, Yasutaka Chiba, Nobuyasu Fukutake, Hiroko Nebiki, Akira Kurita, Makoto Takaoka, Takeshi Ogura, Hideyuki Shiomi, Masanori Asada, Hiroaki Yasuda, Minoru Shigekawa, Akio Yanagisawa, Masatoshi Kudo, Masayuki Kitano

Histological diagnosis and grading of pancreatic neuroendocrine tumor by endoscopic ultrasound-guided fine needle biopsy using a 25-gauge needle with a core trap: A multicenter prospective trial.

Christoph F Dietrich, Christian Pállson Nolsøe, Richard G Barr, Annalisa Berzigotti, Peter N Burns, Vito Cantisani, Maria Cristina Chammas, Nitin Chaubal, Byung Ihn Choi, Dirk-André Clevert, Xinwu Cui, Yi Dong, Mirko D'Onofrio, J Brian Fowlkes, Odd Helge Gilja, Pintong Huang, Andre Ignee, Christian Jenssen, Yuko Kono, Masatoshi Kudo, Nathalie Lassau, Won Jae Lee, Jae Young Lee, Ping Liang, Adrian Lim, Andrej Lyshchik, Maria Franca Meloni, Jean Michel Correas, Yasunori Minami, Fuminori Moriyasu, Carlos Nicolau, Fabio Piscaglia, Adrian Saftoiu, Paul S Sidhu, Ioan Sporea, Guido Torzilli, Xiaoyan Xie, Rongqin Zheng

Guidelines and Good Clinical Practice Recommendations for Contrast-Enhanced Ultrasound (CEUS) in the Liver-Update 2020 WFUMB in Cooperation with EFSUMB, AFSUMB, AIUM, and FLAUS.

Daisuke Morimoto, Tomoko Hyodo, Ken Kamata, Tomoya Kadoba, Makoto Itoh, Hiroyuki Fukushima, Yasutaka Chiba, Mamoru Takenaka, Tomohiro Mochizuki, Yu Ueda, Keizou Miyagoshi, Masatoshi Kudo, Kazunari Ishii

Navigator-triggered and breath-hold 3D MRCP using compressed sensing: image quality and method selection factor assessment.

Kosuke Minaga, Tomohiro Watanabe, Akane Hara, Ken Kamata, Shunsuke Omoto, Atsushi Nakai, Yasuo Otsuka, Ikue Sekai, Tomoe Yoshikawa, Kentaro Yamao, Mamoru Takenaka, Yasutaka Chiba, Masatoshi Kudo

Identification of serum IFN-α and IL-33 as novel biomarkers for type 1 autoimmune pancreatitis and IgG4-related disease.

Hajime Honjo, Tomohiro Watanabe, Yasuyuki Arai, Ken Kamata, Kosuke Minaga, Yoriaki Komeda, Kouhei Yamashita, Masatoshi Kudo

ATG16L1 negatively regulates RICK/RIP2-mediated innate immune responses.

Richard S Finn, Masafumi Ikeda, Andrew X Zhu, Max W Sung, Ari D Baron, Masatoshi Kudo, Takuji Okusaka, Masahiro Kobayashi, Hiromitsu Kumada, Shuichi Kaneko, Marc Pracht, Konstantin Mamontov, Tim Meyer, Tomoki Kubota, Corina E Dutcus, Kenichi Saito, Abby B Siegel, Leonid Dubrovsky, Kalgi Mody, Josep M Llovet

Phase Ib Study of Lenvatinib Plus Pembrolizumab in Patients With Unresectable Hepatocellular Carcinoma.

Stephen Lam Chan, Masatoshi Kudo

Impacts of COVID-19 on Liver Cancers: During and after the Pandemic.

Masatoshi Kudo

Gd-EOB-DTPA-MRI Could Predict WNT/β-Catenin Mutation and Resistance to Immune Checkpoint Inhibitor Therapy in Hepatocellular Carcinoma.

Mamoru Takenaka, Shunsuke Omoto, Masatoshi Kudo

Endoscopic Ultrasound Fine-Needle Biopsy May Contribute to the Diagnosis of Malignant Lymph Nodes.

Mamoru Takenaka, Tomoe Yoshikawa, Kosuke Minaga, Kentaro Yamao, Masatoshi Kudo

A novel teaching tool for visualizing the invisible bile duct axis in 3 dimensions during biliary cannulation (Compact Disc method).

Kazuomi Ueshima, Sadahisa Ogasawara, Masafumi Ikeda, Yutaka Yasui, Takeshi Terashima, Tatsuya Yamashita, Shuntaro Obi, Shinpei Sato, Hiroshi Aikata, Takumi Ohmura, Hidekatsu Kuroda, Takamasa Ohki, Kengo Nagashima, Yoshihiko Ooka, Masahiro Takita, Masayuki Kurosaki, Kazuaki Chayama, Shuichi Kaneko, Namiki Izumi, Naoya Kato, Masatoshi Kudo, Masao Omata

Hepatic Arterial Infusion Chemotherapy versus Sorafenib in Patients with Advanced Hepatocellular Carcinoma.

Akihiro Yoshida, Kosuke Minaga, Osami Takeda, Hajime Hanno, Shigenori Takayanagi, Toshio Dozaiku, Masatoshi Kudo

Successful biliary cannulation using a novel rotatable sphincterotome in a patient with situs inversus totalis.

Laura L de Guevara, Lucy Dagher, Vanessa Mv Arruda, Keiko Nakajima, Masatoshi Kudo

Sorafenib treatment by Child-Pugh score in Latin American patients with hepatocellular carcinoma.

Masatoshi Kudo

A Paradigm Change in the Treatment Strategy for Hepatocellular Carcinoma.

Chia-Jui Yen, Masatoshi Kudo, Ho-Yeong Lim, Chih-Hung Hsu, Arndt Vogel, Giovanni Brandi, Rebecca Cheng, Ioana Simona Nitu, Paolo Abada, Yanzhi Hsu, Andrew X Zhu, Yoon-Koo Kang

Efficacy and Safety of Ramucirumab in Asian and Non-Asian Patients with Advanced Hepatocellular Carcinoma and Elevated Alpha-Fetoprotein: Pooled Individual Data Analysis of Two Randomized Studies.

Andrew X Zhu, Ryan D Nipp, Richard S Finn, Peter R Galle, Josep M Llovet, Jean-Frederic Blanc, Takuji Okusaka, Ian Chau, David Cella, Allicia Girvan, Jonathon Gable, Lee Bowman, Chunxiao Wang, Yanzhi Hsu, Paolo B Abada, Masatoshi Kudo

Ramucirumab in the second-line for patients with hepatocellular carcinoma and elevated alpha-fetoprotein: patient-reported outcomes across two randomised clinical trials.

Masatoshi Kudo

A new era of systemic therapy for intermediate and advanced stage hepatocellular carcinoma.

Naoshi Nishida, Kazuko Sakai, Masahiro Morita, Tomoko Aoki, Masahiro Takita, Satoru Hagiwara, Yoriaki Komeda, Mamoru Takenaka, Yasunori Minami, Hiroshi Ida, Kazuomi Ueshima, Kazuto Nishio, Masatoshi Kudo

Association between Genetic and Immunological Background of Hepatocellular Carcinoma and Expression of Programmed Cell Death-1.

Naoko Tsuji, Yasuko Umehara, Mamoru Takenaka, Yasunori Minami, Tomohiro Watanabe, Naoshi Nishida, Masatoshi Kudo

Verrucous antral gastritis in relation to Helicobacter pylori infection, nutrition, and gastric atrophy.

Saki Yoshida, Mariko Matsumura, Kiyoshi Maekawa, Kosuke Minaga, Ken Kamata, Masahiro Nozawa, Tomohiro Watanabe, Masatoshi Kudo

Recurrent abdominal pain caused by nephroptosis.

Masatoshi Kudo, Kazuomi Ueshima, Masafumi Ikeda, Takuji Torimura, Nobukazu Tanabe, Hiroshi Aikata, Namiki Izumi, Takahiro Yamasaki, Shunsuke Nojiri, Keisuke Hino, Hidetaka Tsumura, Teiji Kuzuya, Norio Isoda, Kohichiroh Yasui, Hajime Aino, Akio Ido, Naoto Kawabe, Kazuhiko Nakao, Yoshiyuki Wada, Osamu Yokosuka, Kenichi Yoshimura, Takuji Okusaka, Junji Furuse, Norihiro Kokudo, Kiwamu Okita, Philip James Johnson, Yasuaki Arai

Randomised, multicentre prospective trial of transarterial chemoembolisation (TACE) plus sorafenib as compared with TACE alone in patients with hepatocellular carcinoma: TACTICS trial.

Sho Masaki, Tomohiro Watanabe, Kosuke Minaga, Ken Kamata, Yoriaki Komeda, Masatomo Kimura, Masatoshi Kudo

Possible involvement of autophagy in esophageal ulcers in anorexia nervosa.

Masatoshi Kudo, Manabu Morimoto, Michihisa Moriguchi, Namiki Izumi, Tetsuji Takayama, Hitoshi Yoshiji, Keisuke Hino, Takayoshi Oikawa, Tetsuhiro Chiba, Kenta Motomura, Junko Kato, Kentaro Yasuchika, Akio Ido, Takashi Sato, Daisuke Nakashima, Kazuomi Ueshima, Masafumi Ikeda, Takuji Okusaka, Kazuo Tamura, Junji Furuse

A randomized, double-blind, placebo-controlled, phase 3 study of tivantinib in Japanese patients with MET-high hepatocellular carcinoma.

Christoph F Dietrich, Christian Pállson Nolsøe, Richard G Barr, Annalisa Berzigotti, Peter N Burns, Vito Cantisani, Maria Cristina Chammas, Nitin Chaubal, Byung Ihn Choi, Dirk-André Clevert, Xinwu Cui, Yi Dong, Mirko D'Onofrio, J Brian Fowlkes, Odd Helge Gilja, Pintong Huang, Andre Ignee, Christian Jenssen, Yuko Kono, Masatoshi Kudo, Nathalie Lassau, Won Jae Lee, Jae Young Lee, Ping Liang, Adrian Lim, Andrej Lyshchik, Maria Franca Meloni, Jean Michel Correas, Yasunori Minami, Fuminori Moriyasu, Carlos Nicolau, Fabio Piscaglia, Adrian Saftoiu, Paul S Sidhu, Ioan Sporea, Guido Torzilli, Xiaoyan Xie, Rongqin Zheng

Guidelines and Good Clinical Practice Recommendations for Contrast Enhanced Ultrasound (CEUS) in the Liver - Update 2020 - WFUMB in Cooperation with EFSUMB, AFSUMB, AIUM, and FLAUS.

Mariko Matsumura, Yoriaki Komeda, Tomohiro Watanabe, Masatoshi Kudo

Purpura-free small intestinal IgA vasculitis complicated by cytomegalovirus reactivation.

Guohong Han, Sarah Berhane, Hidenori Toyoda, Dominik Bettinger, Omar Elshaarawy, Anthony W H Chan, Martha Kirstein, Cristina Mosconi, Florian Hucke, Daniel Palmer, David J Pinato, Rohini Sharma, Diego Ottaviani, Jeong W Jang, Tim A Labeur, Otto M van Delden, Mario Pirisi, Nick Stern, Bruno Sangro, Tim Meyer, Waleed Fateen, Marta García-Fiñana, Asmaa Gomaa, Imam Waked, Eman Rewisha, Guru P Aithal, Simon Travis, Masatoshi Kudo, Alessandro Cucchetti, Markus Peck-Radosavljevic, R B Takkenberg, Stephen L Chan, Arndt Vogel, Philip J Johnson

Prediction of Survival Among Patients Receiving Transarterial Chemoembolization for Hepatocellular Carcinoma: A Response-Based Approach.

Kentaro Yamao, Mamoru Takenaka, Rei Ishikawa, Ayana Okamoto, Tomohiro Yamazaki, Atsushi Nakai, Shunsuke Omoto, Ken Kamata, Kosuke Minaga, Ippei Matsumoto, Yoshifumi Takeyama, Isao Numoto, Masakatsu Tsurusaki, Takaaki Chikugo, Yasutaka Chiba, Tomohiro Watanabe, Masatoshi Kudo

Partial Pancreatic Parenchymal Atrophy Is a New Specific Finding to Diagnose Small Pancreatic Cancer (≤10 mm) Including Carcinoma in Situ: Comparison with Localized Benign Main Pancreatic Duct Stenosis Patients.

Jae Young Lee, Yasunori Minami, Byung Ihn Choi, Won Jae Lee, Yi-Hong Chou, Woo Kyoung Jeong, Mi-Suk Park, Nobuki Kudo, Min Woo Lee, Ken Kamata, Hiroko Iijima, So Yeon Kim, Kazushi Numata, Katsutoshi Sugimoto, Hitoshi Maruyama, Yasukiyo Sumino, Chikara Ogawa, Masayuki Kitano, Ijin Joo, Junichi Arita, Ja-Der Liang, Hsi-Ming Lin, Christian Nolsoe, Odd Helge Gilja, Masatoshi Kudo

The AFSUMB Consensus Statements and Recommendations for the Clinical Practice of Contrast-Enhanced Ultrasound using Sonazoid.

Shuya Maeshima, Yoshiyuki Ida, Ryo Shimizu, Yuki Kawaji, Takashi Tamura, Junya Nuta, Keiichi Hatamaru, Masahiro Itonaga, Masatoshi Kudo, Masayuki Kitano

Endoscopic ultrasound-guided radiofrequency ablation of porcine liver.

Yasuyuki Fukami, Yuji Kaneoka, Atsuyuki Maeda, Takashi Kumada, Junko Tanaka, Tomoyuki Akita, Shoji Kubo, Namiki Izumi, Masumi Kadoya, Michiie Sakamoto, Osamu Nakashima, Yutaka Matsuyama, Takashi Kokudo, Kiyoshi Hasegawa, Tatsuya Yamashita, Kosuke Kashiwabara, Tadatoshi Takayama, Norihiro Kokudo, Masatoshi Kudo

Liver Resection for Multiple Hepatocellular Carcinomas: A Japanese Nationwide Survey.

Masatoshi Kudo, Masayuki Kurosaki, Masafumi Ikeda, Hiroshi Aikata, Atsushi Hiraoka, Takuji Torimura, Naoya Sakamoto

Treatment of Hepatocellular Carcinoma (HCC) during the COVID-19 Outbreak: The Working Group Report of JAMTT-HCC.

Kosuke Minaga, Masayuki Kitano, Atsushi Nakai, Shunsuke Omoto, Ken Kamata, Kentaro Yamao, Mamoru Takenaka, Masakatsu Tsurusaki, Takaaki Chikugo, Ippei Matsumoto, Yasutaka Chiba, Tomohiro Watanabe, Masatoshi Kudo

Improved liver metastasis detection using Kupffer-phase imaging in contrast-enhanced harmonic EUS in patients with pancreatic cancer (with video).

Masatoshi Kudo

Better Efficacy of Ramucirumab in Japanese Patients than in the Global Population with Unresectable Hepatocellular Carcinoma.

Masatoshi Kudo, Kwang-Hyub Han, Sheng-Long Ye, Jian Zhou, Yi-Hsiang Huang, Shi-Ming Lin, Chung-Kwe Wang, Masafumi Ikeda, Stephen Lam Chan, Su Pin Choo, Shiro Miyayama, Ann Lii Cheng

A Changing Paradigm for the Treatment of Intermediate-Stage Hepatocellular Carcinoma: Asia-Pacific Primary Liver Cancer Expert Consensus Statements.

Fabio Piscaglia, Federico Stefanini, Vito Cantisani, Paul S Sidhu, Richard Barr, Annalisa Berzigotti, Maria Cristina Chammas, Jean-Michel Correas, Christoph Frank Dietrich, Steven Feinstein, Pintong Huang, Christian Jenssen, Yuko Kono, Masatoshi Kudo, Ping Liang, Andrej Lyshchik, Christian Nolsøe, Xyaoyan Xie, Francesco Tovoli

Benefits, Open questions and Challenges of the use of Ultrasound in the COVID-19 pandemic era. The views of a panel of worldwide international experts.

Masatoshi Kudo, Takuji Okusaka, Kenta Motomura, Izumi Ohno, Manabu Morimoto, Satoru Seo, Yoshiyuki Wada, Shinpei Sato, Tatsuya Yamashita, Masayuki Furukawa, Takeshi Aramaki, Seijin Nadano, Kazuyoshi Ohkawa, Hirofumi Fujii, Toshihiro Kudo, Junji Furuse, Hiroki Takai, Gosuke Homma, Reigetsu Yoshikawa, Andrew X Zhu

Ramucirumab after prior sorafenib in patients with advanced hepatocellular carcinoma and elevated alpha-fetoprotein: Japanese subgroup analysis of the REACH-2 trial.

Josep M Llovet, Augusto Villanueva, Jorge A Marrero, Myron Schwartz, Tim Meyer, Peter R Galle, Riccardo Lencioni, Tim F Greten, Masatoshi Kudo, Sumithra J Mandrekar, Andrew X Zhu, Richard S Finn, Lewis R Roberts

Trial Design and Endpoints in hepatocellular carcinoma: AASLD Consensus Conference.

Naoshi Nishida, Masatoshi Kudo

Immune Phenotype and Immune Checkpoint Inhibitors for the Treatment of Human Hepatocellular Carcinoma.

Richard S Finn, Shukui Qin, Masafumi Ikeda, Peter R Galle, Michel Ducreux, Tae-You Kim, Masatoshi Kudo, Valeriy Breder, Philippe Merle, Ahmed O Kaseb, Daneng Li, Wendy Verret, Derek-Zhen Xu, Sairy Hernandez, Juan Liu, Chen Huang, Sohail Mulla, Yulei Wang, Ho Yeong Lim, Andrew X Zhu, Ann-Lii Cheng

Atezolizumab plus Bevacizumab in Unresectable Hepatocellular Carcinoma.

David M Hughes, Sarah Berhane, C A Emily de Groot, Hidenori Toyoda, Toshifumi Tada, Takashi Kumada, Shinji Satomura, Naoshi Nishida, Masatoshi Kudo, Toru Kimura, Yukio Osaki, Ruwanthi Kolamunage-Dona, Ruben Amoros Salvador, Tom Bird, Marta García-Fiñana, Philip Johnson

Serum Levels of α-Fetoprotein Increased More Than 10 Years Before Detection of Hepatocellular Carcinoma.

Mamoru Takenaka, Atsushi Nakai, Masatoshi Kudo

Novel concept of bared type metallic stent for endoscopic bilateral stent-in-stent placement in patients with hilar malignant biliary obstruction (with video).

Kosuke Minaga, Mamoru Takenaka, Ayana Okamoto, Shunsuke Omoto, Ken Kamata, Kentaro Yamao, Masatoshi Kudo

Revisionary antireflux metal stent placement for stent occlusion after endoscopic ultrasound-guided hepaticojejunostomy.

Changhoon Yoo, Do-Youn Oh, Hye Jin Choi, Masatoshi Kudo, Makoto Ueno, Shunsuke Kondo, Li-Tzong Chen, Motonobu Osada, Christoph Helwig, Isabelle Dussault, Masafumi Ikeda

Phase I study of bintrafusp alfa, a bifunctional fusion protein targeting TGF-β and PD-L1, in patients with pretreated biliary tract cancer.

椎名 毅, 山川 誠, 西田 直生志, 工藤 正俊, 津川 浩一郎, 中島 康雄

【US Today 2020 超音波検査・診断最前線-表在(乳腺・甲状腺)領域の最新動向を中心に】表在(乳腺・甲状腺)領域の技術と臨床の最新動向 AI超音波診断の最新動向と今後の展望

Stephen P Hack, Jessica Spahn, Minshan Chen, Ann-Lii Cheng, Ahmed Kaseb, Masatoshi Kudo, Han Chu Lee, Adam Yopp, Pierce Chow, Shukui Qin

IMbrave 050: a Phase III trial of atezolizumab plus bevacizumab in high-risk hepatocellular carcinoma after curative resection or ablation.

Kosuke Minaga, Tomohiro Watanabe, Yasuyuki Arai, Masahiro Shiokawa, Akane Hara, Tomoe Yoshikawa, Ken Kamata, Kouhei Yamashita, Masatoshi Kudo

Activation of interferon regulatory factor 7 in plasmacytoid dendritic cells promotes experimental autoimmune pancreatitis.

Yukihiro Watanabe, Yutaka Matsuyama, Namiki Izumi, Shoji Kubo, Norihiro Kokudo, Michiie Sakamoto, Shuichiro Shiina, Tadatoshi Takayama, Osamu Nakashima, Masatoshi Kud

Effect of surgical margin width after R0 resection for intrahepatic cholangiocarcinoma: A nationwide survey of the Liver Cancer Study Group of Japan.

Masatoshi Kudo

Scientific Rationale for Combined Immunotherapy with PD-1/PD-L1 Antibodies and VEGF Inhibitors in Advanced Hepatocellular Carcinoma.

Toshihiko Doi, Yutaka Fujiwara, Takafumi Koyama, Masafumi Ikeda, Christoph Helwig, Morihiro Watanabe, Yulia Vugmeyster, Masatoshi Kudo

Phase I Study of the Bifunctional Fusion Protein Bintrafusp Alfa in Asian Patients with Advanced Solid Tumors, Including a Hepatocellular Carcinoma Safety-Assessment Cohort.

Masatoshi Kudo, Peter R Galle, Josep M Llovet, Richard S Finn, Arndt Vogel, Kenta Motomura, Eric Assenat, Philippe Merle, Giovanni Brandi, Bruno Daniele, Takuji Okusaka, Jiří Tomášek, Christophe Borg, Vincenzo Dadduzio, Manabu Morimoto, Marc Pracht, Min-Hua Jen, Nora Drove Ubreva, Ryan C Widau, Kenta Shinozaki, Reigetsu Yoshikawa, Andrew X Zhu

Ramucirumab in elderly patients with hepatocellular carcinoma and elevated alpha-fetoprotein after sorafenib in REACH and REACH-2.

Keitaro Sofue, Minori Onoda, Masakatsu Tsurusaki, Daisuke Morimoto, Norihisa Yada, Masatoshi Kudo, Takamichi Murakami

Dual-frequency MR elastography to differentiate between inflammation and fibrosis of the liver: Comparison with histopathology.

Noboru Yamamoto, Baek-Yeol Ryoo, Bhumsuk Keam, Masatoshi Kudo, Chia-Chi Lin, Futoshi Kunieda, Howard A Ball, Diarmuid Moran, Kanji Komatsu, Kentaro Takeda, Musashi Fukuda, Junji Furuse, Satoshi Morita, Toshihiko Doi

A phase 1 study of oral ASP5878, a selective small-molecule inhibitor of fibroblast growth factor receptors 1-4, as a single dose and multiple doses in patients with solid malignancies.

西田 直生志, 工藤 正俊

画像診断の新展開 人工知能を用いた腹部超音波からのリアルタイム肝腫瘤検出支援

萩原 智, 盛田 真弘, 青木 智子, 田北 雅弘, 南 康範, 依田 広, 上嶋 一臣, 西田 直生志, 工藤 正俊

B型慢性肝炎患者(CH-B)に対する,ETVとTAFの前向き比較観察研究

Masatoshi Kudo

A New Era in Systemic Therapy for Hepatocellular Carcinoma: Atezolizumab plus Bevacizumab Combination Therapy.

Yasunori Minami, Masatoshi Kudo

Ultrasound fusion imaging technologies for guidance in ablation therapy for liver cancer.

Alessandro Cucchetti, Jianhong Zhong, Sarah Berhane, Hidenori Toyoda, KeQing Shi, Toshifumi Tada, Charing C N Chong, Bang-De Xiang, Le-Qun Li, Paul B S Lai, Giorgio Ercolani, Vincenzo Mazzaferro, Masatoshi Kudo, Matteo Cescon, Antonio Daniele Pinna, Takashi Kumada, Philip J Johnson

The chances of hepatic resection curing hepatocellular carcinoma.

Kentaro Yamao, Tomohiro Watanabe, Masatoshi Kudo

Response to the Letter to the Editor 'Reply to "Clinical Safety and Efficacy of Secondary Prophylactic Pegylated G-CSF in Advanced Pancreatic Cancer Patients Treated with mFOLFIRINOX: A Single-center Retrospective Study" by Dr. Peng Chen'.

Kosuke Minaga, Mamoru Takenaka, Kentaro Yamao, Ken Kamata, Shunsuke Omoto, Atsushi Nakai, Tomohiro Yamazaki, Ayana Okamoto, Rei Ishikawa, Tomoe Yoshikawa, Yasutaka Chiba, Tomohiro Watanabe, Masatoshi Kudo

Clinical utility of treatment method conversion during single-session endoscopic ultrasound-guided biliary drainage.

Mamoru Takenaka, Kosuke Minaga, Ken Kamata, Kentaro Yamao, Tomoe Yoshikawa, Rei Ishikawa, Ayana Okamoto, Tomohiro Yamazaki, Atsushi Nakai, Shunsuke Omoto, Yoriaki Komeda, Toshiharu Sakurai, Tomohiro Watanabe, Naoshi Nishida, Yasutaka Chiba, Chang-Il Kwon, Seok Jeong, Tae Hoon Lee, Masatoshi Kudo

Efficacy of a modified double-guidewire technique using an uneven double lumen cannula (uneven method) in patients with surgically altered gastrointestinal anatomy (with video).

竹中 完, 中井 敦史, 大本 俊輔, 三長 孝輔, 鎌田 研, 山雄 健太郎, 工藤 正俊

【肝膵内視鏡治療におけるトラブルシューティング】ERCP関連治療における偶発症予防とトラブルシューティング 失敗しない内視鏡的胆管結石除去術

鎌田 研, 原 茜, 岡本 彩那, 山崎 友裕, 中井 敦史, 大本 俊介, 三長 孝輔, 山雄 健太郎, 竹中 完, 工藤 正俊

【EUSの現状と将来】診断 造影ハーモニック超音波内視鏡の実際と将来展望

Hiroaki Kanemura, Hidetoshi Hayashi, Satoru Hagiwara, Tomoyuki Otani, Koji Haratani, Kimio Yonesaka, Akihiko Ito, Masatoshi Kudo, Kazuhiko Nakagawa

Severe Immune-Related Hepatitis Treated With Plasma Exchange.

Kentaro Yamao, Mamoru Takenaka, Takeshi Ogura, Hiroaki Hashimoto, Hisakazu Matsumoto, Masashi Yamamoto, Tsukasa Ikeura, Akira Kurita, Zhao Liang Li, Hideyuki Shiomi, Yasutaka Chiba, Masatoshi Kudo, Tsuyoshi Sanuki

Utility and Safety of a Novel Fully Covered Metal Stent in Unresectable Distal Malignant Biliary Obstruction.

渡邉 智裕, 三長 孝輔, 原 茜, 鎌田 研, 工藤 正俊

【慢性膵炎診療2020】基礎研究・病態 腸内細菌は慢性膵炎発症に関連するのか

竹中 完, 中井 敦史, 大本 俊介, 三長 孝輔, 鎌田 研, 山雄 健太郎, 渡邉 智裕, 松本 逸平, 竹山 宜典, 工藤 正俊

【慢性膵炎診療2020】診断 早期慢性膵炎のEUS所見は特異的か 加齢や他疾患の影響は

Kota Takashima, Shigenaga Matsui, Yoriaki Komeda, Tomoyuki Nagai, Sakurai Toshiharu, Hiroshi Kashida, Masatoshi Kudo

Endoscopic sclerotherapy under balloon-assisted enteroscopy for hemorrhagic jejunal varices after choledocho-jejunostomy.

Ann-Lii Cheng, Chiun Hsu, Stephen L Chan, Su-Pin Choo, Masatoshi Kudo

Challenges of combination therapy with immune checkpoint inhibitors for hepatocellular carcinoma.

Yoriaki Komeda, Tomohiro Watanabe, Masatoshi Kudo

Requirement of Additional Surgery after Non-Curative Endoscopic Submucosal Dissection for Early Colorectal Cancer.

Richard S Finn, Baek-Yeol Ryoo, Philippe Merle, Masatoshi Kudo, Mohamed Bouattour, Ho Yeong Lim, Valeriy Breder, Julien Edeline, Yee Chao, Sadahisa Ogasawara, Thomas Yau, Marcelo Garrido, Stephen L Chan, Jennifer Knox, Bruno Daniele, Scot W Ebbinghaus, Erluo Chen, Abby B Siegel, Andrew X Zhu, Ann-Lii Cheng

Pembrolizumab As Second-Line Therapy in Patients With Advanced Hepatocellular Carcinoma in KEYNOTE-240: A Randomized, Double-Blind, Phase III Trial.

Toshiharu Sakurai, Hiroki Nishiyama, Tomoyuki Nagai, Susumu Goto, Hiroyuki Ogata, Masatoshi Kudo

Deficiency of Gankyrin in the small intestine is associated with augmented colitis accompanied by altered bacterial composition of intestinal microbiota.

Daisuke Morimoto, Tomoko Hyodo, Ken Kamata, Tomoya Kadoba, Makoto Itoh, Hiroyuki Fukushima, Yasutaka Chiba, Mamoru Takenaka, Tomohiro Mochizuki, Yu Ueda, Keizou Miyagoshi, Masatoshi Kudo, Kazunari Ishii

Navigator-triggered and breath-hold 3D MRCP using compressed sensing: image quality and method selection factor assessment.

Masatoshi Kudo, Namiki Izumi, Shoji Kubo, Norihiro Kokudo, Michiie Sakamoto, Shuichiro Shiina, Ryosuke Tateishi, Osamu Nakashima, Takamichi Murakami, Yutaka Matsuyama, Arata Takahashi, Hiroaki Miyata, Tadatoshi Takayama

Report of the 20th Nationwide follow-up survey of primary liver cancer in Japan.

Tatsuya Yamashita, Masatoshi Kudo, Kenji Ikeda, Namiki Izumi, Ryosuke Tateishi, Masafumi Ikeda, Hiroshi Aikata, Yasunori Kawaguchi, Yoshiyuki Wada, Kazushi Numata, Yoshitaka Inaba, Ryoko Kuromatsu, Masahiro Kobayashi, Takuji Okusaka, Toshiyuki Tamai, Chifumi Kitamura, Kenichi Saito, Katsuya Haruna, Kiwamu Okita, Hiromitsu Kumada

REFLECT-a phase 3 trial comparing efficacy and safety of lenvatinib to sorafenib for the treatment of unresectable hepatocellular carcinoma: an analysis of Japanese subset.

Naoshi Nishida, Masatoshi Kudo

Artificial Intelligence in Medical Imaging and Its Application in Sonography for the Management of Liver Tumor.

工藤 正俊, 黒崎 雅之, 小笠原 定久, 森口 理久, 寺島 健志

座談会; 予後延長を目指した肝細胞癌全身薬物治療の展望

南 康範, 工藤 正俊

抗PD-1/PD-L1抗体や抗CTLA-4抗体併用のRationale. 特集“肝細胞癌治療のパラダイムチェンジ—進化する薬物療法2020 Update Part I—（免疫療法）”

盛田 真弘, 工藤 正俊

ICI-Anti-VEGF/TKI併用療法のrationale. 特集“肝細胞癌治療のパラダイムチェンジ—進化する薬物療法2020 Update Part I—（免疫療法）”

西田 直生志, 工藤 正俊

肝細胞癌における微小免疫環境と免疫チェックポイント阻害剤. 特集“肝細胞癌治療のパラダイムチェンジ—進化する薬物療法2020 Update Part I—（免疫療法）”

工藤 正俊

アテゾリズマブ+ベバシズマブ併用療法登場後の進行肝細胞癌に対するシークエンシャル治療の今後. 特集“肝細胞癌治療のパラダイムチェンジ—進化する薬物療法2020 Update Part I—（免疫療法）”

工藤 正俊

WNT/β-catenin変異と免疫チェックポイント阻害剤の治療抵抗性—EOB-MRIのbiomarkerとしての可能性—. 特集“肝細胞癌治療のパラダイムチェンジ—進化する薬物療法2020 Update Part I—（免疫療法）

工藤 正俊

免疫チェックポイント阻害剤の単剤治療はなぜ限界があるのか. 特集“肝細胞癌治療のパラダイムチェンジ—進化する薬物療法2020 Update Part I—（免疫療法）”

工藤 正俊, 池田 公史, 小笠原 定久, 坂元 亨宇

特別座談会「免疫療法の登場により肝細胞癌の治療は新たなステージに」, 特集“肝細胞癌治療のパラダイムチェンジ—進化する薬物療法2020 Update Part I—（免疫療法）”

西田 直生志, 工藤 正俊

超音波デジタル画像とAI診断

Minami Y, Kudo M

Contrast-enhanced ultrasonography with sonazoid in hepatocellular carcinoma diagnosis

Lee JY, Minami Y, Choi BI, Lee WJ, Chou YH, Jeong WK, Park MS, Kudo N, Lee MW, Kamata K, Iijima H, Kim SY, Numata K, Sugimoto K, Maruyama H, Sumino Y, Ogawa C, Kitano M, Joo I, Arita J, Liang JD, Lin HM, Nolsoe C, Gilja OH, Kudo M

The AFSUMB consensus statements and recommendations for the clinical practice of contrast-enhanced ultrasound using sonazoid

Yamakawa M, Shiina T, Nishida N, Kudo M

Optimal cropping for input images used in a convolutional neural network for ultrasonic diagnosis of liver tumors

Aoki T, Kubota K, Kubo S, Kudo M

Author response to: Comment on: Significance of the surgical hepatic resection margin in patients with a single hepatocellular carcinoma

Masatoshi Kudo

Management of Hepatocellular Carcinoma in Japan: Current Trends.

Kosuke Minaga, Mamoru Takenaka, Takeshi Ogura, Takashi Tamura, Taira Kuroda, Toyoma Kaku, Yoshito Uenoyama, Chishio Noguchi, Hidefumi Nishikiori, Hajime Imai, Ryota Sagami, Nao Fujimori, Kazuhide Higuchi, Masatoshi Kudo, Yasutaka Chiba, Masayuki Kitano

Endoscopic ultrasound-guided biliary drainage for malignant biliary obstruction with surgically altered anatomy: a multicenter prospective registration study.

三長 孝輔, 加藤 博也, 鎌田 英紀, 奥田 篤, 佐上 亮太, 橋本 宏明, 樋口 和秀, 千葉 康敬, 工藤 正俊, 北野 雅之, 小倉 健, 塩見 英之, 今井 元, 伯耆 徳之, 竹中 完, 錦織 英史, 山下 幸孝, 比佐 岳史

切除不能遠位悪性胆道閉塞に対する超音波内視鏡下胆道ドレナージにおけるcholedochoduodenostomyおよびhepaticogastrostomyのアプローチルートの有効性と安全性を比較検討する多施設共同前向き無作為化試験

Angel Alsina, Masatoshi Kudo, Arndt Vogel, Ann-Lii Cheng, Won Young Tak, Baek-Yeol Ryoo, Thomas R Jeffry Evans, Carlos López López, Bruno Daniele, Soamnauth Misir, Min Ren, Namiki Izumi, Shukui Qin, Richard S Finn

Effects of Subsequent Systemic Anticancer Medication Following First-Line Lenvatinib: A Post Hoc Responder Analysis from the Phase 3 REFLECT Study in Unresectable Hepatocellular Carcinoma.

Atsushi Hiraoka, Takashi Kumada, Shinya Fukunishi, Masanori Atsukawa, Masashi Hirooka, Kunihiko Tsuji, Toru Ishikawa, Koichi Takaguchi, Kazuya Kariyama, Ei Itobayashi, Kazuto Tajiri, Noritomo Shimada, Hiroshi Shibata, Hironori Ochi, Toshifumi Tada, Hidenori Toyoda, Keisuke Yokohama, Kazuhiro Nouso, Akemi Tsutsui, Takuya Nagano, Norio Itokawa, Korenobu Hayama, Taeang Arai, Michitaka Imai, Kouji Joko, Yohei Koizumi, Yoichi Hiasa, Kojiro Michitaka, Masatoshi Kudo

Post-Progression Treatment Eligibility of Unresectable Hepatocellular Carcinoma Patients Treated with Lenvatinib.

Shigenaga Matsui, Hiroshi Kashida, Kenji Nomura, Yoriaki Komeda, Masatoshi Kudo

Multiple Gastrointestinal Stromal Tumors of the Duodenum Associated with Neurofibromatosis Type

Aoki T, Kubota K, Hasegawa K, Kubo S, Izumi N, Kokudo N, Sakamoto M, Shiina S, Takayama T, Nakashima O, Matsuyama Y, Murakami T, Kudo M

Significance of the surgical hepatic resection margin in patients with a single hepatocellular carcinoma [Epub ahead of print]

Atsushi Hiraoka, Takashi Kumada, Toshifumi Tada, Shinya Fukunishi, Masanori Atsukawa, Masashi Hirooka, Kunihiko Tsuji, Toru Ishikawa, Koichi Takaguchi, Kazuya Kariyama, Ei Itobayashi, Kazuto Tajiri, Noritomo Shimada, Hiroshi Shibata, Hironori Ochi, Kazuhito Kawata, Hidenori Toyoda, Hideko Ohama, Akemi Tsutsui, Norio Itokawa, Korenobu Hayama, Taeang Arai, Michitaka Imai, Shinichiro Nakamura, Kojiro Michitaka, Yoichi Hiasa, Masatoshi Kudo

Nutritional Index as Prognostic Indicator in Patients Receiving Lenvatinib Treatment for Unresectable Hepatocellular Carcinoma.

Masahiro Morita, Chikara Ogawa, Akina Omura, Teruyo Noda, Atsushi Kubo, Toshihiro Matsunaka, Hiroyuki Tamaki, Mitsushige Shibatoge, Hiroshi Seno, Yasunori Minami, Kazuomi Ueshima, Toshiharu Sakurai, Naoshi Nishida, Masatoshi Kudo

The Efficacy of Sonazoid-enhanced Ultrasonography in Decision-making for Liver Abscess Treatment.

Yasunori Minami, Tomohiro Minami, Masahiro Takita, Satoru Hagiwara, Hiroshi Ida, Kazuomi Ueshima, Naoshi Nishida, Masatoshi Kudo

Radiofrequency ablation for hepatocellular carcinoma: Clinical value of ultrasound-ultrasound overlay fusion for optimal ablation and local controllability.