研究

Ambreen Muhammed, Claudia Angela Maria Fulgenzi, Sirish Dharmapuri, Matthias Pinter, Lorenz Balcar, Bernhard Scheiner, Thomas U Marron, Tomi Jun, Anwaar Saeed, Hannah Hildebrand, Mahvish Muzaffar, Musharraf Navaid, Abdul Rafeh Naqash, Anuhya Gampa, Umut Ozbek, Junk-Yi Lin, Ylenia Perone, Bruno Vincenzi, Marianna Silletta, Anjana Pillai, Yinghong Wang, Uqba Khan, Yi-Hsiang Huang, Dominik Bettinger, Yehia I Abugabal, Ahmed Kaseb, Tiziana Pressiani, Nicola Personeni, Lorenza Rimassa, Naoshi Nishida, Luca Di Tommaso, Masatoshi Kudo, Arndt Vogel, Francesco A Mauri, Alessio Cortellini, Rohini Sharma, Antonio D'Alessio, Celina Ang, David J Pinato

The Systemic Inflammatory Response Identifies Patients with Adverse Clinical Outcome from Immunotherapy in Hepatocellular Carcinoma.

Fumitaka Suzuki, Yoshiyuki Suzuki, Yoshiyasu Karino, Yasuhito Tanaka, Masayuki Kurosaki, Hiroshi Yatsuhashi, Tomofumi Atarashi, Masanori Atsukawa, Tsunamasa Watanabe, Masaru Enomoto, Masatoshi Kudo, Naoto Maeda, Hiroshi Kohno, Kouji Joko, Kojiro Michitaka, Koichiro Miki, Kazuhiro Takahashi, Tatsuya Ide, Shigetoshi Fujiyama, Tomoko Kohno, Hiroshi Itoh, Sakiyo Tsukamoto, Yuko Suzuki, Yoshiaki Kawano, Wataru Sugiura, Hiromitsu Kumada

Switching from entecavir to tenofovir disoproxil fumarate for HBeAg-positive chronic hepatitis B patients: a phase 4, prospective study.

Tomoko Aoki, Naoshi Nishida, Masatoshi Kudo

Current Perspectives on the Immunosuppressive Niche and Role of Fibrosis in Hepatocellular Carcinoma and the Development of Antitumor Immunity.

Masatoshi Kudo

A Novel Treatment Strategy for Patients with Intermediate-Stage HCC Who Are Not Suitable for TACE: Upfront Systemic Therapy Followed by Curative Conversion.

Petros Fessas, Muntaha Naeem, Matthias Pinter, Thomas U Marron, David Szafron, Lorenz Balcar, Anwaar Saeed, Tomi Jun, Sirish Dharmapuri, Anuhya Gampa, Yinghong Wang, Uqba Khan, Mahvish Muzaffar, Musharraf Navaid, Pei-Chang Lee, Anushi Bulumulle, Bo Yu, Sonal Paul, Neil Nimkar, Dominik Bettinger, Hannah Hildebrand, Yehia I Abugabal, Tiziana Pressiani, Nicola Personeni, Naoshi Nishida, Masatoshi Kudo, Ahmed Kaseb, Yi-Hsiang Huang, Celina Ang, Anjana Pillai, Lorenza Rimassa, Abdul Rafeh Naqash, Elad Sharon, Alessio Cortellini, David J Pinato

Early Antibiotic Exposure Is Not Detrimental to Therapeutic Effect from Immunotherapy in Hepatocellular Carcinoma.

Tomoko Aoki, Naoshi Nishida, Kazuomi Ueshima, Masahiro Morita, Hirokazu Chishina, Masahiro Takita, Satoru Hagiwara, Hiroshi Ida, Yasunori Minami, Akira Yamada, Keitaro Sofue, Masakatsu Tsurusaki, Masatoshi Kudo

Higher Enhancement Intrahepatic Nodules on the Hepatobiliary Phase of Gd-EOB-DTPA-Enhanced MRI as a Poor Responsive Marker of Anti-PD-1/PD-L1 Monotherapy for Unresectable Hepatocellular Carcinoma.

Masatoshi Kudo

Changing the Treatment Paradigm for Hepatocellular Carcinoma Using Atezolizumab plus Bevacizumab Combination Therapy.

Kosuke Minaga, Mamoru Takenaka, Masatoshi Kudo

Endoscopic ultrasound-guided biliary drainage with a 22-gauge needle and a 0.018-inch guidewire: Can it be the new standard?

Kentaro Yamao, Masakatsu Tsurusaki, Kota Takashima, Hidekazu Tanaka, Akihiro Yoshida, Ayana Okamoto, Tomohiro Yamazaki, Shunsuke Omoto, Ken Kamata, Kosuke Minaga, Mamoru Takenaka, Takaaki Chikugo, Yasutaka Chiba, Tomohiro Watanabe, Masatoshi Kudo

Analysis of Progression Time in Pancreatic Cancer including Carcinoma In Situ Based on Magnetic Resonance Cholangiopancreatography Findings.

Masatoshi Kudo

Adjuvant Immunotherapy after Curative Treatment for Hepatocellular Carcinoma.

Masatoshi Kudo, Richard S Finn, Manabu Morimoto, Kun-Ming Rau, Masafumi Ikeda, Chia-Jui Yen, Peter R Galle, Josep M Llovet, Bruno Daniele, Ho Yeong Lim, David W McIlwain, Reigetsu Yoshikawa, Kenichi Nakamura, Kun Liang, Chunxiao Wang, Paolo Abada, Ryan C Widau, Andrew X Zhu

Ramucirumab for Patients with Intermediate-Stage Hepatocellular Carcinoma and Elevated Alpha-Fetoprotein: Pooled Results from Two Phase 3 Studies (REACH and REACH-2).

Arndt Vogel, Catherine Frenette, Max Sung, Bruno Daniele, Ari Baron, Stephen L Chan, Jean Frédéric Blanc, Toshiyuki Tamai, Min Ren, Howard J Lim, Daniel H Palmer, Yuko Takami, Masatoshi Kudo

Baseline Liver Function and Subsequent Outcomes in the Phase 3 REFLECT Study of Patients with Unresectable Hepatocellular Carcinoma.

Satoru Hagiwara, Naoshi Nishida, Masatoshi Kudo

Improved Tumor Response to Lenvatinib Re-Treatment after Failure of Immune Checkpoint Inhibitors in a Patient with Advanced Hepatocellular Carcinoma.

Yasuo Otsuka, Ken Kamata, Tomoko Hyodo, Takaaki Chikugo, Akane Hara, Hidekazu Tanaka, Tomoe Yoshikawa, Rei Ishikawa, Ayana Okamoto, Tomohiro Yamazaki, Atsushi Nakai, Shunsuke Omoto, Kosuke Minaga, Kentaro Yamao, Mamoru Takenaka, Yasutaka Chiba, Tomohiro Watanabe, Takuya Nakai, Ippei Matsumoto, Yoshifumi Takeyama, Masatoshi Kudo

Utility of contrast-enhanced harmonic endoscopic ultrasonography for T-staging of patients with extrahepatic bile duct cancer

Yasunobu Yamashita, Toshio Shimokawa, Reiko Ashida, Christoph F Dietrich, Mirko D'Onofrio, Yoshiki Hirooka, Masatoshi Kudo, Hideaki Mori, Atsushi Sofuni, Masayuki Kitano

Value of Low-Mechanical-Index Contrast-Enhanced Transabdominal Ultrasound for Diagnosis of Pancreatic Cancer: A Meta-analysis.

Ryutaro Takada, Kosuke Minaga, Akane Hara, Yasuo Otsuka, Shunsuke Omoto, Ken Kamata, Kentaro Yamao, Mamoru Takenaka, Satoru Hagiwara, Hajime Honjo, Shigenaga Matsui, Takaaki Chikugo, Tomohiro Watanabe, Masatoshi Kudo

Diagnostic Value of EUS-Guided Fine-Needle Aspiration Biopsy for Gastric Linitis Plastica with Negative Endoscopic Biopsy

Robin Kate Kelley, Bruno Sangro, William Harris, Masafumi Ikeda, Takuji Okusaka, Yoon-Koo Kang, Shukui Qin, David W-M Tai, Ho Yeong Lim, Thomas Yau, Wei-Peng Yong, Ann-Lii Cheng, Antonio Gasbarrini, Silvia Damian, Jordi Bruix, Mitesh Borad, Johanna Bendell, Tae-You Kim, Nathan Standifer, Philip He, Mallory Makowsky, Alejandra Negro, Masatoshi Kudo, Ghassan K Abou-Alfa

Safety, Efficacy, and Pharmacodynamics of Tremelimumab Plus Durvalumab for Patients With Unresectable Hepatocellular Carcinoma: Randomized Expansion of a Phase I/II Study.

Toshiharu Sakurai, Marco A De Velasco, Kazuko Sakai, Tomoyuki Nagai, Hiroki Nishiyama, Kentaro Hashimoto, Hirotsugu Uemura, Hisato Kawakami, Kazuhiko Nakagawa, Hiroyuki Ogata, Kazuto Nishio, Masatoshi Kudo

Integrative analysis of gut microbiome and host transcriptomes reveals associations between treatment outcomes and immunotherapy-induced colitis.

Yasunori Minami, Masahiro Morita, Hirokazu Chishina, Tomoko Aoki, Masahiro Takita, Satoru Hagiwara, Hiroshi Ida, Kazuomi Ueshima, Naoshi Nishida, Masatoshi Kudo

Can the Entire Ablative Hyperechoic Zone be Regarded as a Necrotic Lesion After Radiofrequency Ablation of the Liver?

Yasuhiro Masuta, Yoriaki Komeda, Ikue Sekai, Akane Hara, Masayuki Kurimoto, Keisuke Yoshikawa, Yasuo Otsuka, Ryutaro Takada, Tomoe Yoshikawa, Ken Kamata, Kosuke Minaga, Osamu Maenishi, Tomohiro Watanabe, Masatoshi Kudo

Immunohistochemical characterization of granulomatosis with polyangiitis exhibiting spontaneous regression.

Kota Takashima, Yoriaki Komeda, Toshiharu Sakurai, Sho Masaki, Tomoyuki Nagai, Shigenaga Matsui, Satoru Hagiwara, Mamoru Takenaka, Naoshi Nishida, Hiroshi Kashida, Konosuke Nakaji, Tomohiro Watanabe, Masatoshi Kudo

Castor oil as booster for colon capsule endoscopy preparation reduction: A prospective pilot study and patient questionnaire.

Koichiro Kawano, Mamoru Takenaka, Reiko Kawano, Daisuke Kagoshige, Yuta Kawase, Tomonori Moriguchi, Hiroshi Tanabe, Takao Katoh, Katsuhisa Nishi, Masatoshi Kudo

Efficacy of Over-The-Scope Clip Method as a Novel Hemostatic Therapy for Colonic Diverticular Bleeding.

Akihiro Yoshida, Mamoru Takenaka, Kota Takashima, Hidekazu Tanaka, Ayana Okamoto, Tomohiro Yamazaki, Atsushi Nakai, Shunsuke Omoto, Kosuke Minaga, Ken Kamata, Kentaro Yamao, Yoriaki Komeda, Naoshi Nishida, Masatoshi Kudo

Usefulness of the Novel Snare-over-the-Guidewire Method for Transpapillary Plastic Stent Replacement (with Video).

Peter R Galle, Masatoshi Kudo, Josep M Llovet, Richard S Finn, Mark Karwal, Denis Pezet, Tae-You Kim, Tsai-Sheng Yang, Sara Lonardi, Jiri Tomasek, Jean-Marc Phelip, Yann Touchefeu, Su-Jin Koh, Guido Stirnimann, Kun Liang, Kenyon D Ogburn, Chunxiao Wang, Paolo Abada, Ryan C Widau, Andrew X Zhu

Ramucirumab in patients with previously treated advanced hepatocellular carcinoma: Impact of liver disease etiology.

Ryutaro Takada, Tomohiro Watanabe, Akane Hara, Ikue Sekai, Masayuki Kurimoto, Yasuo Otsuka, Yasuhiro Masuta, Tomoe Yoshikawa, Ken Kamata, Kosuke Minaga, Masatoshi Kudo

NOD2 deficiency protects mice from the development of adoptive transfer colitis through the induction of regulatory T cells expressing forkhead box P3.

Mamoru Takenaka, Atsushi Nakai, Masatoshi Kudo

Novel troubleshooting technique for the migration of a biliary plastic stent using a thin balloon catheter (with video).

Makoto Hosono, Mamoru Takenaka, Hajime Monzen, Mikoto Tamura, Masatoshi Kudo, Yasumasa Nishimura

Cumulative radiation doses from recurrent PET/CT examinations.

Atsushi Hiraoka, Takashi Kumada, Toshifumi Tada, Masashi Hirooka, Kazuya Kariyama, Joji Tani, Masanori Atsukawa, Koichi Takaguchi, Ei Itobayashi, Shinya Fukunishi, Kunihiko Tsuji, Toru Ishikawa, Kazuto Tajiri, Hironori Ochi, Satoshi Yasuda, Hidenori Toyoda, Chikara Ogawa, Takashi Nishimura, Takeshi Hatanaka, Hideko Ohama, Kazuhiro Nouso, Asahiro Morishita, Akemi Tsutsui, Takuya Nagano, Norio Itokawa, Tomomi Okubo, Taeang Arai, Michitaka Imai, Yohei Koizumi, Shinichiro Nakamura, Kouji Joko, Hiroko Iijima, Yoichi Hiasa, Masatoshi Kudo

Atezolizumab plus bevacizumab treatment for unresectable hepatocellular carcinoma: Early clinical experience.

Mamoru Takenaka, Makoto Hosono, Madan M Rehani, Yasutaka Chiba, Rei Ishikawa, Ayana Okamoto, Tomohiro Yamazaki, Atsushi Nakai, Shunsuke Omoto, Kosuke Minaga, Ken Kamata, Kentaro Yamao, Shiro Hayashi, Tsutomu Nishida, Masatoshi Kudo

Comparison of radiation exposure between endoscopic ultrasound-guided drainage and transpapillary drainage by endoscopic retrograde cholangiopancreatography for pancreatobiliary diseases.

Richard S Finn, Masatoshi Kudo, Ann-Lii Cheng, Lucjan Wyrwicz, Roger Kai-Cheong Ngan, Jean-Frederic Blanc, Ari D Baron, Arndt Vogel, Masafumi Ikeda, Fabio Piscaglia, Kwang-Hyub Han, Shu-Kui Qin, Yukinori Minoshima, Michio Kanekiyo, Min Ren, Ryo Dairiki, Toshiyuki Tamai, Corina E Dutcus, Hiroki Ikezawa, Yasuhiro Funahashi, Thomas R Jeffry Evans

Pharmacodynamic Biomarkers Predictive of Survival Benefit with Lenvatinib in Unresectable Hepatocellular Carcinoma: From the Phase 3 REFLECT Study.

Koichiro Kawano, Mamoru Takenaka, Reiko Kawano, Daisuke Kagoshige, Takao Kato, Katsuhisa Nishi, Masatoshi Kudo

Nontraumatic tube method for detecting a vessel responsible for colonic diverticular hemorrhage.

Masatoshi Kudo

Surveillance, Diagnosis, and Treatment Outcomes of Hepatocellular Carcinoma in Japan: 2021 Update.

Masatoshi Kudo, Yusuke Kawamura, Kiyoshi Hasegawa, Ryosuke Tateishi, Kazuya Kariyama, Shuichiro Shiina, Hidenori Toyoda, Yasuharu Imai, Atsushi Hiraoka, Masafumi Ikeda, Namiki Izumi, Michihisa Moriguchi, Sadahisa Ogasawara, Yasunori Minami, Kazuomi Ueshima, Takamichi Murakami, Shiro Miyayama, Osamu Nakashima, Hirohisa Yano, Michiie Sakamoto, Etsuro Hatano, Mitsuo Shimada, Norihiro Kokudo, Satoshi Mochida, Tetsuo Takehara

Management of Hepatocellular Carcinoma in Japan: JSH Consensus Statements and Recommendations 2021 Update.

Masatoshi Kudo; Kenta Motomura; Yoshiyuki Wada; Yoshitaka Inaba; Yasunari Sakamoto; Masayuki Kurosaki; Yoshiko Umeyama; Yoichi Kamei; Junichiro Yoshimitsu; Yosuke Fujii; Mana Aizawa; Paul B Robbins; Junji Furuse

Avelumab in Combination with Axitinib as First-Line Treatment in Patients with Advanced Hepatocellular Carcinoma: Results from the Phase 1b VEGF Liver 100 Trial.

Masatoshi Kudo, Ho Yeong Lim, Ann-Lii Cheng, Yee Chao, Thomas Yau, Sadahisa Ogasawara, Masayuki Kurosaki, Naoki Morimoto, Kazuyoshi Ohkawa, Tatsuya Yamashita, Kyung-Hun Lee, Erluo Chen, Abby B Siegel, Baek-Yeol Ryoo

Pembrolizumab as Second-Line Therapy for Advanced Hepatocellular Carcinoma: A Subgroup Analysis of Asian Patients in the Phase 3 KEYNOTE-240 Trial.

Arndt Vogel, Shukui Qin, Masatoshi Kudo, Yun Su, Stacie Hudgens, Tatsuya Yamashita, Jung-Hwan Yoon, Laetitia Fartoux, Krzysztof Simon, Carlos López, Max Sung, Kalgi Mody, Tatsuroh Ohtsuka, Toshiyuki Tamai, Lee Bennett, Genevieve Meier, Valery Breder

Lenvatinib versus sorafenib for first-line treatment of unresectable hepatocellular carcinoma: patient-reported outcomes from a randomised, open-label, non-inferiority, phase 3 trial.

Takuji Okusaka, Kenji Ikeda, Masatoshi Kudo, Richard Finn, Shukui Qin, Kwang-Hyub Han, Ann-Lii Cheng, Fabio Piscaglia, Masahiro Kobayashi, Max Sung, Minshan Chen, Lucjan Wyrwicz, Jung-Hwan Yoon, Zhenggang Ren, Kalgi Mody, Corina Dutcus, Toshiyuki Tamai, Min Ren, Seiichi Hayato, Hiromitsu Kumada

Safety and efficacy of lenvatinib by starting dose based on body weight in patients with unresectable hepatocellular carcinoma in REFLECT.

Masatoshi Kudo, Namiki Izumi, Norihiro Kokudo, Michiie Sakamoto, Shuichiro Shiina, Tadatoshi Takayama, Ryosuke Tateishi, Osamu Nakashima, Takamichi Murakami, Yutaka Matsuyama, Arata Takahashi, Hiroaki Miyata, Shoji Kubo

Report of the 22nd Nationwide Follow-Up Survey of Primary Liver Cancer in Japan (2012-2013).

Peter R Galle, Richard S Finn, Shukui Qin, Masafumi Ikeda, Andrew X Zhu, Tae-You Kim, Masatoshi Kudo, Valeriy Breder, Philippe Merle, Ahmed Kaseb, Daneng Li, Sohail Mulla, Wendy Verret, Derek-Zhen Xu, Sairy Hernandez, Beiying Ding, Juan Liu, Chen Huang, Ho Yeong Lim, Ann-Lii Cheng, Michel Ducreux

Patient-reported outcomes with atezolizumab plus bevacizumab versus sorafenib in patients with unresectable hepatocellular carcinoma (IMbrave150): an open-label, randomised, phase 3 trial.

Masaki Kaibori, Kengo Yoshii, Kosuke Kashiwabara, Takashi Kokudo, Kiyoshi Hasegawa, Namiki Izumi, Takamichi Murakami, Masatoshi Kudo, Shuichiro Shiina, Michiie Sakamoto, Osamu Nakashima, Yutaka Matsuyama, Susumu Eguchi, Md, Tatsuya Yamashita, Md, Tadatoshi Takayama, Norihiro Kokudo, Shoji Kubo

Impact of hepatitis C virus on survival in patients undergoing resection of intrahepatic cholangiocarcinoma: report of a Japanese nationwide survey.

Akane Hara, Tomohiro Watanabe, Kosuke Minaga, Tomoe Yoshikawa, Ken Kamata, Masatoshi Kudo

Biomarkers in autoimmune pancreatitis and immunoglobulin G4-related disease.

Masatoshi Kudo, Ana Matilla, Armando Santoro, Ignacio Melero, Antonio Cubillo Gracián, Mirelis Acosta-Rivera, Su-Pin Choo, Anthony B El-Khoueiry, Ryoko Kuromatsu, Bassel El-Rayes, Kazushi Numata, Yoshito Itoh, Francesco Di Costanzo, Oxana Crysler, Maria Reig, Yun Shen, Jaclyn Neely, Marina Tschaika, Tami Wisniewski, Bruno Sangro

CheckMate 040 Cohort 5: A phase I/II study of nivolumab in patients with advanced hepatocellular carcinoma and Child-Pugh B cirrhosis.

Mamoru Takenaka, Tomohiro Yamazaki, Yasuo Otsuka, Rei Ishikawa, Masatoshi Kudo

Successful use of two guidewires with different properties using a double-lumen catheter for postoperative biliary stricture.

Satoru Hagiwara, Tomohiro Watanabe, Masatoshi Kudo, Kosuke Minaga, Yoriaki Komeda, Ken Kamata, Masatomo Kimura, Hidetoshi Hayashi, Kazuhiko Nakagawa, Kazuomi Ueshima, Yasunori Minami, Tomoko Aoki, Masahiro Takita, Masahiro Morita, Hirokazu Cishina, Hiroshi Ida, Ah-Mee Park, Naoshi Nishida

Clinicopathological analysis of hepatic immune-related adverse events in comparison with autoimmune hepatitis and graft-versus host disease.

Satoru Hagiwara, Naoshi Nishida, Kazuomi Ueshima, Akihiro Yoshida, Yasunori Minami, Masatoshi Kudo

Comparison of efficacy and safety of entecavir and switching from entecavir to tenofovir alafenamide fumarate in chronic hepatitis B: Long-term effects from a prospective study.

Tomohiro Yamazaki, Mamoru Takenaka, Shunsuke Omoto, Tomoe Yoshikawa, Rei Ishikawa, Ayana Okamoto, Atsushi Nakai, Kosuke Minaga, Ken Kamata, Kentaro Yamao, Yoriaki Komeda, Tomohiro Watanabe, Naoshi Nishida, Keiko Kamei, Ippei Matsumoto, Yoshifumi Takeyama, Takaaki Chikugo, Yasutaka Chiba, Masatoshi Kudo

Should Contrast-Enhanced Harmonic Endoscopic Ultrasound Be Incorporated into the International Consensus Guidelines to Determine the Appropriate Treatment of Intraductal Papillary Mucinous Neoplasm?

Yoshikuni Kawaguchi, Kiyoshi Hasegawa, Yasuhiro Hagiwara, Mario De Bellis, Simone Famularo, Elena Panettieri, Yutaka Matsuyama, Ryosuke Tateishi, Tomoaki Ichikawa, Takashi Kokudo, Namiki Izumi, Shoji Kubo, Michiie Sakamoto, Shuichiro Shiina, Tadatoshi Takayama, Osamu Nakashima, Takamichi Murakami, Jean-Nicolas Vauthey, Felice Giuliante, Luciano De Carlis, Fabrizio Romano, Andrea Ruzzenente, Alfredo Guglielmi, Masatoshi Kudo, Norihiro Kokudo

Effect of Diameter and Number of Hepatocellular Carcinomas on Survival After Resection, Transarterial Chemoembolization, and Ablation.

Hajime Honjo, Tomohiro Watanabe, Natsuki Okai, Masashi Kono, Ken Kamata, Kosuke Minaga, Yoriaki Komeda, Shigeyoshi Tsuji, Masatoshi Kudo

A case with Crohn's disease-associated spondyloarthritis exhibiting enhanced pro-inflammatory cytokine responses to Toll-like receptor ligands.

Atsushi Hiraoka; Takashi Kumada; Takeshi Hatanaka; Toshifumi Tada; Kazuya Kariyama; Joji Tani; Shinya Fukunishi; Masanori Atsukawa; Masashi Hirooka; Kunihiko Tsuji; Toru Ishikawa; Koichi Takaguchi; Ei Itobayashi; Kazuto Tajiri; Noritomo Shimada; Hiroshi Shibata; Hironori Ochi; Kazuhito Kawata; Satoshi Yasuda; Hidenori Toyoda; Ogawa Chikara; Tsutomu Tamai; Satoru Kakizaki; Hiroki Tojima; Tamon Nagashima; Takashi Ueno; Daichi Takizawa; Atsushi Naganuma; Hideko Ohama; Kazuhiro Nouso; Akemi Tsutsui; Takuya Nagano; Norio Itokawa; Tomomi Okubo; Taeang Arai; Michitaka Imai; Yohei Koizumi; Shinichiro Nakamura; Kouji Joko; Kojiro Michitaka; Yoichi Hiasa; Masatoshi Kudo

Therapeutic efficacy of lenvatinib as third-line treatment after regorafenib for unresectable hepatocellular carcinoma progression.

Masatoshi Kudo

Sequential Therapy for Hepatocellular Carcinoma after Failure of Atezolizumab plus Bevacizumab Combination Therapy.

Atsushi Hiraoka, Takashi Kumada, Toshifumi Tada, Kazuya Kariyama, Joji Tani, Shinya Fukunishi, Masanori Atsukawa, Masashi Hirooka, Kunihiko Tsuji, Toru Ishikawa, Koichi Takaguchi, Ei Itobayashi, Kazuto Tajiri, Noritomo Shimada, Hiroshi Shibata, Hironori Ochi, Kazuhito Kawata, Satoshi Yasuda, Hidenori Toyoda, Hideko Ohama, Kazuhiro Nouso, Akemi Tsutsui, Takuya Nagano, Norio Itokawa, Korenobu Hayama, Taeang Arai, Michitaka Imai, Yohei Koizumi, Shinichiro Nakamura, Kouji Joko, Kojiro Michitaka, Yoichi Hiasa, Masatoshi Kudo

What Can Be Done to Solve the Unmet Clinical Need of Hepatocellular Carcinoma Patients following Lenvatinib Failure?

Atsushi Hiraoka, Takashi Kumada, Toshifumi Tada, Chikara Ogawa, Joji Tani, Shinya Fukunishi, Masanori Atsukawa, Masashi Hirooka, Kunihiko Tsuji, Toru Ishikawa, Koichi Takaguchi, Kazuya Kariyama, Ei Itobayashi, Kazuto Tajiri, Noritomo Shimada, Hiroshi Shibata, Hironori Ochi, Kazuhito Kawata, Hidenori Toyoda, Hideko Ohama, Kazuhiro Nouso, Akemi Tsutsui, Takuya Nagano, Norio Itokawa, Korenobu Hayama, Taeang Arai, Michitaka Imai, Yohei Koizumi, Shinichiro Nakamura, Kojiro Michitaka, Yoichi Hiasa, Masatoshi Kudo

Therapeutic efficacy of ramucirumab after lenvatinib for post-progression treatment of unresectable hepatocellular carcinoma.

Masatoshi Kudo

Combination immunotherapy with anti-VEGF/TKI for hepatocellular carcinoma: present and future perspective.

Ti Zhang, Philippe Merle, Huaqi Wang, Haitao Zhao, Masatoshi Kudo

Combination therapy for advanced hepatocellular carcinoma: do we see the light at the end of the tunnel?

Masatoshi Kudo; Namiki Izumi; Norihiro Kokudo; Michiie Sakamoto; Shuichiro Shiina; Tadatoshi Takayama; Ryosuke Tateishi; Osamu Nakashima; Takamichi Murakami; Yutaka Matsuyama; Arata Takahashi; Hiroaki Miyata; Shoji Kubo

Report of the 21st Nationwide Follow-up Survey of Primary Liver Cancer in Japan (2010-2011).

Dominik Pfister, Nicolás Gonzalo Núñez, Roser Pinyol, Olivier Govaere, Matthias Pinter, Marta Szydlowska, Revant Gupta, Mengjie Qiu, Aleksandra Deczkowska, Assaf Weiner, Florian Müller, Ankit Sinha, Ekaterina Friebel, Thomas Engleitner, Daniela Lenggenhager, Anja Moncsek, Danijela Heide, Kristin Stirm, Jan Kosla, Eleni Kotsiliti, Valentina Leone, Michael Dudek, Suhail Yousuf, Donato Inverso, Indrabahadur Singh, Ana Teijeiro, Florian Castet, Carla Montironi, Philipp K Haber, Dina Tiniakos, Pierre Bedossa, Simon Cockell, Ramy Younes, Michele Vacca, Fabio Marra, Jörn M Schattenberg, Michael Allison, Elisabetta Bugianesi, Vlad Ratziu, Tiziana Pressiani, Antonio D'Alessio, Nicola Personeni, Lorenza Rimassa, Ann K Daly, Bernhard Scheiner, Katharina Pomej, Martha M Kirstein, Arndt Vogel, Markus Peck-Radosavljevic, Florian Hucke, Fabian Finkelmeier, Oliver Waidmann, Jörg Trojan, Kornelius Schulze, Henning Wege, Sandra Koch, Arndt Weinmann, Marco Bueter, Fabian Rössler, Alexander Siebenhüner, Sara De Dosso, Jan-Philipp Mallm, Viktor Umansky, Manfred Jugold, Tom Luedde, Andrea Schietinger, Peter Schirmacher, Brinda Emu, Hellmut G Augustin, Adrian Billeter, Beat Müller-Stich, Hiroto Kikuchi, Dan G Duda, Fabian Kütting, Dirk-Thomas Waldschmidt, Matthias Philip Ebert, Nuh Rahbari, Henrik E Mei, Axel Ronald Schulz, Marc Ringelhan, Nisar Malek, Stephan Spahn, Michael Bitzer, Marina Ruiz de Galarreta, Amaia Lujambio, Jean-Francois Dufour, Thomas U Marron, Ahmed Kaseb, Masatoshi Kudo, Yi-Hsiang Huang, Nabil Djouder, Katharina Wolter, Lars Zender, Parice N Marche, Thomas Decaens, David J Pinato, Roland Rad, Joachim C Mertens, Achim Weber, Kristian Unger, Felix Meissner, Susanne Roth, Zuzana Macek Jilkova, Manfred Claassen, Quentin M Anstee, Ido Amit, Percy Knolle, Burkhard Becher, Josep M Llovet, Mathias Heikenwalder

NASH limits anti-tumour surveillance in immunotherapy-treated HCC.

Andrew X Zhu, Richard S Finn, Yoon-Koo Kang, Chia-Jui Yen, Peter R Galle, Josep M Llovet, Eric Assenat, Giovanni Brandi, Kenta Motomura, Izumi Ohno, Bruno Daniele, Arndt Vogel, Tatsuya Yamashita, Chih-Hung Hsu, Guido Gerken, John Bilbruck, Yanzhi Hsu, Kun Liang, Ryan C Widau, Chunxiao Wang, Paolo Abada, Masatoshi Kudo

Serum alpha-fetoprotein and clinical outcomes in patients with advanced hepatocellular carcinoma treated with ramucirumab.

Masatoshi Kudo, Peter R Galle, Giovanni Brandi, Yoon-Koo Kang, Chia-Jui Yen, Richard S Finn, Josep M Llovet, Eric Assenat, Philippe Merle, Stephen L Chan, Daniel H Palmer, Masafumi Ikeda, Tatsuya Yamashita, Arndt Vogel, Yi-Hsiang Huang, Paolo B Abada, Reigetsu Yoshikawa, Kenta Shinozaki, Chunxiao Wang, Ryan C Widau, Andrew X Zhu

Effect of ramucirumab on ALBI grade in patients with advanced HCC: Results from REACH and REACH-2.

Mamoru Takenaka, Tomohiro Yamazaki, Yasuo Otsuka, Kota Takashima, Rei Ishikawa, Masatoshi Kudo

Across-the-papilla side-by-side placement of 6-mm fully covered metallic stents for malignant hilar biliary obstruction: a novel concept that may facilitate reintervention.

Yasunori Minami; Tomohiro Minami; Kazuomi Ueshima; Yukinobu Yagyu; Masakatsu Tsurusaki; Takuya Okada; Masatoshi Hori; Masatoshi Kudo; Takamichi Murakami

Three-Dimensional Radiological Assessment of Ablative Margins in Hepatocellular Carcinoma: Pilot Study of Overlay Fused CT/MRI Imaging with Automatic Registration.

Masatoshi Kudo; Masafumi Ikeda; Peter R Galle; Tatsuya Yamashita; Richard S Finn; Kun Liang; Chunxiao Wang; Sachi Sakaguchi; Paolo Abada; Ryan C Widau; Andrew X Zhu

Ramucirumab in patients with advanced hepatocellular carcinoma and elevated α-fetoprotein: Outcomes by treatment-emergent ascites.

Ikue Sekai, Satoru Hagiwara, Tomohiro Watanabe, Masatoshi Kudo

A case with hepatic immune-related adverse events caused by nivolumab exhibiting impaired accumulation of regulatory T cells.

Mamoru Takenaka, Koichiro Kawano, Reiko Kawano, Takao Katoh, Katsuhisa Nishi, Masatoshi Kudo

A novel method of papilla fixation for difficult biliary cannulation without using a pancreatic duct guidewire: non-guidewire fixation method.

Masayuki Kitano, Yasunobu Yamashita, Ken Kamata, Tiing Leong Ang, Hiroo Imazu, Eizaburo Ohno, Yoshiki Hirooka, Pietro Fusaroli, Dong-Wan Seo, Bertrand Napoléon, Anthony Yuen Bun Teoh, Tae Hyeon Kim, Christoph F Dietrich, Hsiu-Po Wang, Masatoshi Kudo

The Asian Federation of Societies for Ultrasound in Medicine and Biology (AFSUMB) Guidelines for Contrast-Enhanced Endoscopic Ultrasound.

Tomoe Yoshikawa, Kosuke Minaga, Akane Hara, Ikue Sekai, Yasuo Otsuka, Ryutaro Takada, Ken Kamata, Tomohiro Watanabe, Masatoshi Kudo

A unique profile of serum cytokines in type 1 autoimmune pancreatitis and chronic rhinosinusitis.

Mamoru Takenaka, Masatoshi Kudo

Endoscopic papillotomy and papilloplasty: Effects on sphincter of Oddi functionality and outcomes.

Ken Kamata, Akira Kurita, Satoru Yasukawa, Yasutaka Chiba, Hiroko Nebiki, Masanori Asada, Hiroaki Yasuda, Hideyuki Shiomi, Takeshi Ogura, Makoto Takaoka, Noriyuki Hoki, Reiko Ashida, Minoru Shigekawa, Akio Yanagisawa, Masatoshi Kudo, Masayuki Kitano

Utility of a 20G needle with a core trap in EUS-guided fine-needle biopsy for gastric submucosal tumors: A multicentric prospective trial.

Shunsuke Omoto, Masayuki Kitano, Mitsuharu Fukasawa, Reiko Ashida, Hironari Kato, Hideyuki Shiomi, Kazuya Sugimori, Atsushi Kanno, Yasutaka Chiba, Shinichi Takano, Naoki Yamamoto, Takeshi Ezaki, Haruo Miwa, Akitaka Yokomura, Masato Hoshikawa, Takamitsu Tanaka, Masatoshi Kudo

Tissue Harmonic versus Contrast-Enhanced Harmonic Endoscopic Ultrasonography for the Diagnosis of Pancreatic Tumors: A Prospective Multicenter Study.

Saur Hajiev, Elias Allara, Leila Motedayеn Aval, Tadaaki Arizumi, Dominik Bettinger, Mario Pirisi, Lorenza Rimassa, Tiziana Pressiani, Nicola Personeni, Laura Giordano, Masatoshi Kudo, Robert Thimme, Joong-Won Park, Tamar H Taddei, David E Kaplan, Ramya Ramaswami, David J Pinato, Rohini Sharma

Correction: Impact of age on sorafenib outcomes in hepatocellular carcinoma: an international cohort study.

Masatoshi Kudo

Impact of Multi-Drug Sequential Therapy on Survival in Patients with Unresectable Hepatocellular Carcinoma.

Mingyu Chen, Jiasheng Cao, Jiahao Hu, Win Topatana, Shijie Li, Sarun Juengpanich, Jian Lin, Chenhao Tong, Jiliang Shen, Bin Zhang, Jennifer Wu, Christine Pocha, Masatoshi Kudo, Amedeo Amedei, Franco Trevisani, Pil Soo Sung, Victor M Zaydfudim, Tatsuo Kanda, Xiujun Cai

Clinical-Radiomic Analysis for Pretreatment Prediction of Objective Response to First Transarterial Chemoembolization in Hepatocellular Carcinoma.

Dow-Mu Koh, Ahmed Ba-Ssalamah, Giuseppe Brancatelli, Ghaneh Fananapazir, M Isabel Fiel, Satoshi Goshima, Sheng-Hong Ju, Nikolaos Kartalis, Masatoshi Kudo, Jeong Min Lee, Takamichi Murakami, Max Seidensticker, Claude B Sirlin, Cher Heng Tan, Jin Wang, Jeong Hee Yoon, Mengsu Zeng, Jian Zhou, Bachir Taouli

Consensus report from the 9th International Forum for Liver Magnetic Resonance Imaging: applications of gadoxetic acid-enhanced imaging.

Mamoru Takenaka, Masatoshi Kudo

Current status of endoscopic re-intervention for hilar malignant biliary obstruction.

Shunya Ikeda; Masatoshi Kudo; Namiki Izumi; Masahiro Kobayashi; Mie Azuma; Genevieve Meier; Janice Pan; Mika Ishii; Shuichi Kaneko

Cost-Effectiveness of Lenvatinib in the Treatment of Patients With Unresectable Hepatocellular Carcinomas in Japan: An Analysis Using Data From Japanese Patients in the REFLECT Trial.

Kosuke Minaga, Tomohiro Watanabe, Masatoshi Kudo

Probiotic-Derived Polyphosphate Prevents Pancreatitis.

Masakatsu Tsurusaki, Keitaro Sofue, Masatoshi Hori, Kosuke Sasaki, Kazunari Ishii, Takamichi Murakami, Masatoshi Kudo

Dual-Energy Computed Tomography of the Liver: Uses in Clinical Practices and Applications.

Akihiro Yoshida, Yasutake Uchima, Naoki Hosaka, Kosuke Minaga, Masatoshi Kudo

Transverse colonic volvulus due to mesenteric fibromatosis: a case report.

Ikue Sekai, Tomohiro Watanabe, Keisuke Yoshikawa, Ryutaro Takada, Akane Hara, Tomoe Yoshikawa, Ken Kamata, Kosuke Minaga, Masatoshi Kudo

A case with eosinophilic gastroenteritis exhibiting enhanced TNF-α and IL-6 responses.

Masatoshi Kudo, Kaoru Tsuchiya, Naoya Kato, Atsushi Hagihara, Kazushi Numata, Hiroshi Aikata, Yoshitaka Inaba, Shunsuke Kondo, Kenta Motomura, Junji Furuse, Masafumi Ikeda, Manabu Morimoto, Meguru Achira, Shingo Kuroda, Akiko Kimura

Cabozantinib in Japanese patients with advanced hepatocellular carcinoma: a phase 2 multicenter study.

Mihir Gandhi, Wen-Huan Ling, Chien-Hung Chen, Joon Hyeok Lee, Masatoshi Kudo, Rawisak Chanwat, Simone I Strasser, Zhu Xu, Soh-Han Lai, Pierce Kah-oe Chow

Impact of COVID-19 on Hepatocellular Carcinoma Management: A Multicountry and Region Study.

Arndt Vogel, Philippe Merle, Chris Verslype, Richard S Finn, Andrew X Zhu, Ann-Lii Cheng, Stephen Lam Chan, Thomas Yau, Baek-Yeol Ryoo, Jennifer Knox, Bruno Daniele, Shukui Qin, Ziwen Wei, Yanna Miteva, Usha Malhotra, Abby B Siegel, Masatoshi Kudo

ALBI score and outcomes in patients with hepatocellular carcinoma: post hoc analysis of the randomized controlled trial KEYNOTE-240.

Masayuki Kurimoto, Tomohiro Watanabe, Ken Kamata, Kosuke Minaga, Masatoshi Kudo

IL-33 as a Critical Cytokine for Inflammation and Fibrosis in Inflammatory Bowel Diseases and Pancreatitis.

Kazuko Sakai, Toshiharu Sakurai, Marco A De Velasco, Tomoyuki Nagai, Takaaki Chikugo, Kazuomi Ueshima, Yurie Kura, Takayuki Takahama, Hidetoshi Hayashi, Kazuhiko Nakagawa, Masatoshi Kudo, Kazuto Nishio

Intestinal Microbiota and Gene Expression Reveal Similarity and Dissimilarity Between Immune-Mediated Colitis and Ulcerative Colitis.

松井繁長, 樫田博史, 工藤正俊

異所性静脈瘤の診断と治療

松井繁長, 工藤正俊

食道・胃静脈瘤

Masatoshi Kudo

Lack of response to immunotherapy in non-alcoholic steatohepatitis related hepatocellular carcinoma

Ryutaro Takada, Tomohiro Watanabe, Ikue Sekai, Keisuke Yoshikawa, Akane Hara, Yasuo Otsuka, Tomoe Yoshikawa, Ken Kamata, Kosuke Minaga, Yoriaki Komeda, Takaaki Chikugo, Yasuyuki Arai, Kohei Yamashita, Masatoshi Kudo

Case Report: Concurrent Occurrence of Abdominal Double Expressor Lymphoma and Jejunum Follicular Lymphoma.

Yoriaki Komeda, Hisashi Handa, Ryoma Matsui, Shohei Hatori, Riku Yamamoto, Toshiharu Sakurai, Mamoru Takenaka, Satoru Hagiwara, Naoshi Nishida, Hiroshi Kashida, Tomohiro Watanabe, Masatoshi Kudo

Artificial intelligence-based endoscopic diagnosis of colorectal polyps using residual networks.

Keisuke Yoshikawa, Tomohiro Watanabe, Ikue Sekai, Ryutaro Takada, Akane Hara, Masayuki Kurimoto, Yasuhiro Masuta, Yasuo Otsuka, Tomoe Yoshikawa, Sho Masaki, Ken Kamata, Kosuke Minaga, Yoriaki Komeda, Takaaki Chikugo, Masatoshi Kudo

Case Report: A Case of Intestinal Behçet's Disease Exhibiting Enhanced Expression of IL-6 and Forkhead Box P3 mRNA After Treatment With Infliximab.

Tomi Jun, Umut Ozbek, Sirish Dharmapuri, Camille Hardy-Abeloos, Huili Zhu, Jung-Yi Lin, Nicola Personeni, Tiziana Pressiani, Naoshi Nishida, Pei-Chang Lee, Chieh-Ju Lee, Hannah Hildebrand, Neil Nimkar, Sonal Paul, Petros Fessas, Muntaha Naeem, Dominik Bettinger, Uqba Khan, Anwaar Saeed, Yi-Hsiang Huang, Masatoshi Kudo, Lorenza Rimassa, Thomas U Marron, David J Pinato, Celina Ang

Antacid exposure and immunotherapy outcomes among patients with advanced hepatocellular carcinoma.

Hajime Honjo, Tomohiro Watanabe, Ken Kamata, Kosuke Minaga, Masatoshi Kudo

RIPK2 as a New Therapeutic Target in Inflammatory Bowel Diseases.

Tomoe Yoshikawa, Tomohiro Watanabe, Ken Kamata, Akane Hara, Kosuke Minaga, Masatoshi Kudo

Intestinal Dysbiosis and Autoimmune Pancreatitis.

Yasunori Minami, Masatoshi Kudo

Image Guidance in Ablation for Hepatocellular Carcinoma: Contrast-Enhanced Ultrasound and Fusion Imaging.