研究業績（原著論文のみ）/ Publications(Original Articles only)
2024年度
Detection of Overlooked Rare EGFR Mutations in Non-small Cell Lung Cancer Using Multigene Testing.
Shiraishi N, Takahama T, Sakai K, Tanaka K, Nakagawa Y, Kanemura H, Nakayama T, Kawanaka Y, Kurosaki T, Suzuki S, Iwasa T, Tanizaki J, Inagaki C, Yonesaka K, Fukuoka K, Mitsudomi T, Nishio K, Hayashi H, Nakagawa K.
Thorac Cancer
. 2025 Feb;16(3):e70007. doi: 10.1111/1759-7714.70007.
Efficacy of ramucirumab combined with erlotinib or osimertinib in untreated EGFR-mutated NSCLC patients with asymptomatic brain metastases: insights from molecular biomarkers in the RELAY-brain trial.
Kaneda H, Daga H, Okada A, Nakatani Y, Tani Y, Oka T, Sawa K, Sakai K, Nishio K, Kawaguchi T.
Invest New Drugs
. 2025 Feb;43(1):147-156. doi: 10.1007/s10637-025-01505-y. Epub 2025 Jan 23.
Dual single‑nucleotide polymorphism biomarker combination for opioid selection to treat cancer pain.
Fujita Y, Matsuoka H, Chiba Y, Tsurutani J, Yoshida T, Sakai K, Nakura M, Sakamoto R, Makimura C, Ohtake Y, Tanaka K, Hayashi H, Takahama T, Tanizaki J, Koyama A, Nishio K, Nakagawa K.
Mol Clin Oncol
. 2024 Nov 29;22(2):14. doi: 10.3892/mco.2024.2809. eCollection 2025 Feb.
Final Analysis Data and Exploratory Biomarker Analysis of a Randomized Phase 2 Study of Osimertinib Plus Bevacizumab Versus Osimertinib Monotherapy for Untreated Patients With Nonsquamous NSCLC Harboring EGFR Mutations: The WJOG9717L Study.
Kenmotsu H, Sakai K, Mori K, Kato T, Sugawara S, Kirita K, Yoneshima Y, Azuma K, Nishino K, Teraoka S, Koyama R, Masuda K, Hayashi H, Toyozawa R, Miura S, Sato Y, Nakagawa K, Yamamoto N, Nishio K, Takahashi T.
JTO Clin Res Rep
. 2024 Aug 23;5(11):100716. doi: 10.1016/j.jtocrr.2024.100716. eCollection 2024 Nov.
Afatinib plus bevacizumab combination after osimertinib resistance in advanced EGFR-mutant non-small cell lung cancer: Phase II ABCD-study.
Hata A, Katakami N, Takase N, Kibata K, Yamanaka Y, Tamiya M, Mori M, Kijima T, Morita S, Sakai K, Nishio K.
Lung Cancer
. 2024 Nov:197:107988. doi: 10.1016/j.lungcan.2024.107988. Epub 2024 Oct 5.
A machine learning-based method for feature reduction of methylation data for the classification of cancer tissue origin
De Velasco MA, Sakai K, Mitani S, Kura Y, Minamoto S, Haeno T, Hayashi H, Nishio K.
Int J Clin Oncol
. 2024 Dec;29(12):1795-1810. doi: 10.1007/s10147-024-02617-w. Epub 2024 Sep 18.
Improved platelet separation performance from whole blood using an acoustic fluidics system
Sakai, Kazuko; Ohara, Shuta; Tanaka, Junko; Suda, Kenichi; Muramatsu, Takamichi; Uematsu, Chihiro; Tsutani, Yasuhiro; Mitsudomi, Tetsuya; Nishio, Kazuto.
Cancer Sci
. 2024 Nov;115(11):3795-3803. doi: 10.1111/cas.16337. Epub 2024 Sep 22.
Different characteristics of the tumor immune microenvironment among subtypes of salivary gland cancer
Nagatani Y, Kiyota N, Imamura Y, Koyama T, Funakoshi Y, Komatsu M, Itoh T, Teshima M, Nibu KI, Sakai K, Nishio K, Shimomura M, Nakatsura T, Ikarashi D, Nakayama T, Kitano S, Minami H.
Asia Pac J Clin Oncol
. 2024 Sep 4. doi: 10.1111/ajco.14108. Online ahead of print.
Exploring the relationship between ulcerative colitis, colorectal cancer, and prostate cancer
Kura Y, De Velasco MA, Sakai K, Uemura H, Fujita K, Nishio K.
Hum Cell
. 2024 Aug 20. doi: 10.1007/s13577-024-01118-2. Online ahead of print.
A cross-species analysis of fecal microbiomes in humans and mice reveals similarities and dissimilarities associated with prostate cancer risk
Wakamori C, De Velasco MA, Sakai K, Kura Y, Matsushita M, Fujimoto S, Hatano K, Nonomura N, Fujita K, Nishio K, Uemura H.
Prostate
. 2024 Aug 7. doi: 10.1002/pros.24776. Online ahead of print.
Two Distinct Characteristics of Immune Microenvironment in Human Hepatocellular Carcinoma with Wnt/β-Catenin Mutations
Aoki T, Nishida N, Kurebayashi Y, Sakai K, Morita M, Chishina H, Takita M, Hagiwara S, Ida H, Ueshima K, Minami Y, Tsurusaki M, Nakai T, Sakamoto M, Nishio K, Kudo M.
Liver Cancer
. 2023 Oct 9;13(3):285-305. doi: 10.1159/000533818. eCollection 2024 Jun.
Association of immune-related adverse events with durvalumab efficacy after chemoradiotherapy in patients with unresectable Stage III non-small cell lung cancer
Haratani K, Nakamura A, Mamesaya N, Sawa K, Shiraishi Y, Saito R, Tanizaki J, Tamura Y, Hata A, Tsuruno K, Sakamoto T, Teraoka S, Oki M, Watanabe H, Tokito T, Nagata K, Masuda T, Nakamura Y, Sakai K, Chiba Y, Ito A, Nishio K, Yamamoto N, Nakagawa K, Hayashi H.
Br J Cancer
. 2024 May;130(11):1783-1794. doi: 10.1038/s41416-024-02662-2. Epub 2024 Mar 22.
The Tumor Immune Microenvironment Is Associated With Recurrence in Early-Stage Lung Adenocarcinoma
Kanemura H, Yokoyama T, Nakajima R, Nakamura A, Kuroda H, Kitamura Y, Shoda H, Mamesaya N, Miyata Y, Okamoto T, Okishio K, Oki M, Sakairi Y, Chen-Yoshikawa TF, Aoki T, Ohira T, Matsumoto I, Ueno K, Miyazaki T, Matsuguma H, Yokouchi H, Otani T, Ito A, Sakai K, Chiba Y, Nishio K, Yamamoto N, Okamoto I, Nakagawa K, Takeda M.
JTO Clin Res Rep
. 2024 Mar 8;5(4):100658. doi: 10.1016/j.jtocrr.2024.100658. eCollection 2024 Apr.
Soluble immune checkpoint factors reflect exhaustion of antitumor immunity and response to PD-1 blockade
Hayashi H, Chamoto K, Hatae R, Kurosaki T, Togashi Y, Fukuoka K, Goto M, Chiba Y, Tomida S, Ota T, Haratani K, Takahama T, Tanizaki J, Yoshida T, Iwasa T, Tanaka K, Takeda M, Hirano T, Yoshida H, Ozasa H, Sakamori Y, Sakai K, Higuchi K, Uga H, Suminaka C, Hirai T, Nishio K, Nakagawa K, Honjo T.
J Clin Invest
. 2024 Apr 1;134(7):e168318. doi: 10.1172/JCI168318.
TP53 and/or BRCA1 Mutations Based on CtDNA Analysis as Prognostic Biomarkers for Primary Triple-Negative Breast Cancer
Arimura A, Sakai K, Kaneshiro K, Morisaki T, Hayashi S, Mizoguchi K, Yamada M, Kai M, Ono M, Nishio K, Nakamura M, Kubo M.
Cancers (Basel)
. 2024 Mar 18;16(6):1184. doi: 10.3390/cancers16061184.
ACA-28, an ERK MAPK Signaling Modulator, Exerts Anticancer Activity through ROS Induction in Melanoma and Pancreatic Cancer Cells
Takasaki T, Hamabe Y, Touchi K, Khandakar GI, Ueda T, Okada H, Sakai K, Nishio K, Tanabe G, Sugiura R.
Oxid Med Cell Longev
. 2024 Mar 11:2024:7683793. doi: 10.1155/2024/7683793. eCollection 2024.