英文原著

1. Noso S, Ikegami H, Fujisawa T, Kawabata Y, Asano K, Hiromine Y, Tsurumaru M, Sugihara S, Lee I, Kawasaki E, Awata T, Ogihara T: Genetic heterogeneity in association of SUMO4 M55V variant with susceptibility to type 1 diabetes.
   Diabetes 54: 3582-3586, 2005
2. Babaya N, Ikegami H, Fujisawa T, Nojima K, Itoi-Babaya M, Inoue K, Ohno T, Shibata M, Ogihara T: Susceptibility to streptozotocin-induced diabetes is mapped to mouse chromosome 11.
   Biochem Biophys Res Commun 328:158-164, 2005
3. Yamaji K, Ikegami H, Fujisawa T, Noso S, Nojima K, Babaya N, Itoi-Babaya M, Makino S, Sakamoto T, Ogihara T: Evidence for Cd101 but not Fcgr1 as candidate for type 1 diabetes locus, Idd10.
   Biochem Biophys Res Commun 331:536-542, 2005
4. Inoue K, Ikegami H, Fujisawa T, Noso S, Nojima K, Babaya N, Itoi-Babaya M, Makino S, Ogihara T: Allelic variation in class I K gene as candidate for second component of MHC-linked susceptibility to type 1 diabetes in NOD mouse.
   Diabetologia, 47:739-747, 2004
5. Babaya N, Ikegami H, Fujisawa T, Nojima K, Itoi-Babaya M, Inoue K, Nakura J, Abe M, Yamamoto M, Jin J, Wu Z, Miki T, Fukuda M, Ogihara T: Association of I27L polymorphism of hepatocyte nuclear factor 1 gene with high density lipoprotein cholesterol level.
   J Clin Endocrinol Metab 88:2548-2551, 2003
6. Inoue K, Ikegami H, Fujisawa T, Shintani M, Kawabata Y, Nojima K, Ono M, Nisino M, Babaya M, Babaya N, Ogihara T: High degree of mitochondrial 3243 mutation in gastric biopsy specimen in a patient with MELAS and diabetes complicated by marked gastrointestinal abnormalities.
   Diabetes Care 26:2219, 2003
7. Kawabata Y, Ikegami H, Kawaguchi Y, Fujisawa T, Shintani M, Ono M, Nishino M, Uchigata Y, Lee I, Ogihara T: Asian-specific HLA haplotypes reveal heterogeneity of the contribution of HLA-DR and -DQ haplotypes to susceptibility to type 1 diabetes.
   Diabetes 51:545-551, 2002
8. Shintani M, Ikegami H, Kawaguchi Y, Fujisawa T, Ohishi M, Katsuya T, Jitsuo H, Shimamoto K, Ogihara T: Leptin gene polymorphism is associated with hypertension independent of obesity.
   J Clin Endocrinol Metab 87:2909-2912, 2002
9. Mori H, Ikegami H, Kawaguchi Y, Seino S, Yokoi N, Takeda J, Inoue I, Seino Y, Yasuda K, Hanafusa T, Yamagata K, Awata T, Kadowaki T, Hara K, Yamada N, Gotoda T, Iwasaki N, Iwamoto Y, Sanke T, Nanjo K, Oka Y, Matsutani A, Maeda E, Kasuga M: The Pro12Ala substitution in PPARg is associated with resistance to development of diabetes in the general population. Possible involvement in impairment of insulin secretion in individuals with type 2 diabetes.
   Diabetes 50:891-894, 2001
10. Ueda H, Ikegami H, Kawaguchi Y, Fujisawa T, Nojima K, Babaya N, Yamada K, Shibata M, Yamato E, Ogihara T: Age-dependent changese in phenotypes and candidate gene analysis in a polygenic animal model of type II diabetes; NSY mouse.
    Diabetologia 43:932-938, 2000
11. Ueda H, Ikegami H, Kawaguchi Y, Fujisawa T, Yamato E, Shibata M, Ogihara T: Genetic analysis of late-onset type 2 diabetes in a mouse model of human complex trait.
    Diabetes 48:1168-1174, 1999
12. Fujisawa T, Ikegami H, Kawaguchi Y, Hamada Y, Ueda H, Shintani M, Fukuda M, Ogihara T: Meta-analysis of the association of Insertion/deletion polymorphism of angiotensin I-converting enzyme gene with diabetic nephropathy and retinopathy.
    Diabetologia 41:47-53, 1998
13. Fu J, Ikegami H, Kawaguchi Y, Fujisawa T, Kawabata Y, Hamada Y, Ueda H, Shintani M, Nojima K, Babaya N, Shen Q-J, Uchigata Y, Urakami T, Omori Y, Shima K, Ogihara T: Association of distal chromosome 2q with IDDM in Japanese subjects.
    Diabetologia 41:228-232, 1998
14. Fujisawa T, Ikegami H, Kawaguchi Y, Ogihara T: Meta-analysis of the association of Trp64Arg polymorphism of beta3-adrenergic receptor gene with body mass index.
    J Clin Endocrinol Metab 83:2441-2444, 1998
15. Hotta M, Tashiro F, Ikegami H, Niwa H, Ogihara T, Yodoi J, Miyazaki J-I: Pancreatic beta-cell-specific expression of thioredoxin, an antioxidative and anti-apoptotic protein, prevents autoimmune and streptozotocin-induced diabetes.
    J Exp Med 188:1445-1451, 1998
16. Shen G-Q, Ikegami H, Kawaguchi Y, Fujisawa T, Hamada Y, Ueda H, Shintani M, Nojima K, Kawabata Y, Yamada K, Babaya N, Ogihara T: Asp905Tyr polymorphism of skeletal muscle-specific glycogen-targeting subunit of protein phosphatase 1 gene in non-insulin-dependent diabetes mellitus.
    Diabetes Care 21:1086-1089, 1998
17. Kawaguchi Y, Ikegami H, Shen G-Q, Nakagawa Y, Fujisawa T, Hamada Y, Ueda H, Fu J, Uchigata Y, Kaitagawa Y, Omori Y, Shima K, Ogihara T: Insulin gene region contributes to genetic susceptibility to, but may not to low incidence of, insulin-dependent diabetes mellitus in Japanese.
    Biochem Biophys Res Commun 233:283-287, 1997
18. Shen GQ, Ikegami H, Fujisawa T, Hamada Y, Kamide K, Rakugi H, Higaki J, Murakami H, Shimamoto K, Ogihara T: Asp905Tyr polymorphism of protein phosphatase 1 G-subunit gene in hypertension.
    Hypertension 30:236-239, 1997
19. Fujisawa T, Ikegami H, Yamato E, Takekawa K, Nakagawa Y, Hamada Y, Oga T, Ueda H, Shintani M, Fukuda M, Ogihara T: Association of Trp64Arg mutation of beta3-adrenergic receptor with NIDDM and body weight gain.
    Diabetologia 39:349-352, 1996
20. Yamato E, Ikegami H, Miyazaki J-I, Ogihara T: Identification of genes regulated by glucose in a pancreatic beta cell line by means of a new method for subtraction of mRNA.
    Diabetologia 39:1269-1275, 1996
21. Shintani M, Ikegami H, Yamato E, Kawaguchi Y, Fujisawa T, Nakagawa Y, Hamada Y, Ueda H, Miki T, and Ogihara T: A novel microsatellite polymorphism in the human OB gene: a highly polymorphic marker for linkage analysis.
    Diabetologia 39:1398-1401, 1996
22. Ikegami H, Makino S, Yamato E, Kawaguchi Y, Ueda H, Sakamoto T, Takekawa K, Ogihara T: Identification of a new susceptibility locus for insulin-dependent diabetes mellitus by ancestral haplotype congenic mapping.
    J Clin Invest 96:1936-1942, 1995
23. Ueda H, Ikegami H, Yamato E, Fu J, Fukuda M, Shen G-Q, Kawaguchi Y, Takekawa K, Fujioka Y, Fujisawa T, Nakagawa Y, Hamada Y, Shibata M, Ogihara T: The NSY mouse: a new animal model of spontaneous NIDDM with moderate obesity.
    Diabetologia 38:503-508, 1995
24. Nakagawa Y, Ikegami H, Yamato E, Takekawa K, Fujisawa T, Hamada Y, Ueda H, Uchigata Y, Miki T, Kumahara Y, Ogihara T: A new mitochondrial DNA mutation associated with non-insulin-dependent diabetes mellitus.
    Biochem Biophys Res Comm 209:664-668, 1995
25. Fukuda M, Ikegami H, Kawaguchi Y, Sano T, Ogihara T: Antioxidant, probucol, can inhibit the generation of hydrogen peroxide in islet cells induced by macrophages and prevent islet cell destruction in NOD mice.
    Biochem Biophys Res Comm 209:953-958, 1995
26. Fujisawa T, Ikegami H, Yamato E, Takekawa K, Nakagawa Y, Hamada Y, Ueda H, Ogihara T: A mutation in the glucagon receptor gene (Gly40Ser): heterogeneity in the association with diabetes mellitus.
    Diabetologia 38:983-985, 1995
27. Fujisawa T, Ikegami H, Shen G-Q, Yamato E, Takekawa K, Nakagawa Y, Hamada Y, Ueda H, Rakugi H, Higaki J, Ohishi M, Fujii K, Fukuda M, Ogihara T: Angiotensin I-converting enzyme gene polymorphism is associated with myocardial infarction, but not with retinopathy or nephropathy, in non-insulin-dependent diabetes mellitus.
    Diabetes Care 18:983-985, 1995
28. Fujisawa T, Ikegami H, Yamato E, Takekawa K, Nakagawa Y, Hamada Y, Ueda H, Ogihara T: Class I HLA is associated with age-at-onset of IDDM, while class II HLA confers susceptibility to IDDM.
    Diabetologia 38:1494-1496, 1995
29. Ikegami H, Kawaguchi Y, Ueda H, Fukuda M, Takekawa K, Fujioka Y, Fujisawa T, Uchida K, Ogihara T: MHC-linked diabtogenic gene of the NOD mouse: Molecular mapping of the 3' boundary of the diabtogenic region.
    Biochem Biophys Res Comm 192:677-682, 1993
30. Ikegami H, Kawaguchi Y, Yamato E, Kuwata S, Tokunaga K, Noma Y, Shima K, Ogihara T: Analysis by the polymerase chain reaction of histocompatibility leucocyte antigen-DR9-linked susceptibility to insulin-dependent diabetes mellitus.
    J Clin Endocrinol Metab 75:1381-1385, 1992
31. Yoneda H, Ikegami H, Yamamoto Y, Yamato E, Cha T, Kawaguchi Y, Tahara Y, Ogihara T: Analysis of early phase insulin responses in non-obese subjects with mild glucose intolerance. Diabetes Care 15:1517-1521, 1992
32. Ikegami H, Eisenbarth GS, Hattori M: Major histocompatibility complex-linked diabetogenic gene of the nonobese diabetic mouse: analysis of genomic DNA amplified by the polymerase chain reaction.
    J Clin Invest 85:18-24, 1990
33. Ikegami H, Tahara Y, Cha T, Yamato E, Ogihara T, Noma Y, Shima K: Aspartic acid at position 57 of the HLA-DQ beta chain is not protective against insulin-dependent diabetes mellitus in Japanese people.
    J Autoimmunity 3:167-174, 1990
34. Ikegami H, Makino S, Harada M, Eisenbarth GS, Hattori M: The cataract Shionogi mouse, a sister strain of the non-obese diabetic mouse: similar class II but different class I gene products.
    Diabetologia 31:254-258, 1988

英文総説・著書

1. Ikegami H, Fujisawa T, Ogihara T: Mouse models of type 1 and type 2 diabetes derived from the same closed colony: genetic susceptibility shared between two types of diabetes? ILAR Journal 45:267-276, 2004
2. Ikegami H: Animal models of autoimmune polyglandular syndrome. Endocrinol Metab Clin N Am 31, 431-439, 2002
3. Ueda H, Ikegami H, Shibata M, Ogihara T: The NSY mouse: an animal model of human type 2 diabetes mellitus with polygenic inheritance. In: Animal Models of Diabetes A Primer, Sima AAF and Shafrir E (eds.), Harwood Academic Publishers, Amsterdam, 2000, pp43-61
4. Ikegami H, Makino S: The NOD mouse and its related strains. In: Animal Models of Diabetes A Primer, Sima AAF and Shafrir E (eds.), Harwood Academic Publishers, Amsterdam, 2000, pp43-61
5. Ikegami H, Ogihara T: Genetics of insulin-dependent diabetes mellitus. Endocrine J 43:605-613, 1996
6. Ikegami H, Makino S, Ogihara T: Molecular genetics of insulin-dependent diabetes mellitus: analysis of congenic strains. In: Frontiers in Diabetes Research: Lessons from Animal Diabetes VI, Shafrir E (ed.), Birkhauser, Boston, 1996, pp33-46
7. Ikegami H, Makino S: Genetic susceptibility to insulin-dependent diabetes mellitus: from the NOD mouse to man. In: Frontiers in Diabetes Research: Lessons from Animal Diabetes IV, Shafrir E (ed.), Smith-Gordon, London, 1993, pp39-50
8. Ikegami H, Yano N, Sato T, Hattori M: Immunogenetics and immunopathogenesis of the NOD mouse. In: Immunotherapy of diabetes and selected autoimmune diseases. Eisenbarth GS (ed.), CRC press, Boca Raton, 1989, pp22-33

 英文

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