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English 日本語





2017
2016

1993年ー2015年 (角田郁生業績: 東北大学、ユタ大学、ルイジアナ州立大学)
I. 原著
II. 著書
III. PROCEEDINGS
IV. 和文 エッセー
V. 抄録
VI. 招待講演

2017

英文原著・総説

1. Kanai K, Park A-M, Yoshida H, Tsunoda I, and Yoshie O. IL-35 suppresses lipopolysaccharide-induced airway eosinophilia in EBI3-defieicent mice. J Immunol 198:116-127.
PDF

2. Sato F, Omura S, Martinez NE and Tsunoda I. Animal models for multiple sclerosis. In: Neuroinflammation (2nd edition). Minagar A (Ed), Elsevier, Burlington, MA. in press.

3. Tsunoda I. Lymphatic system and gut microbiota affect immunopathology of neuroinflammatory diseases, including multiple sclerosis, neuromyelitis optica, and Alzheimer’s disease. Clin Exp Neuroimmunol, 8(3): 177-179. PDF.

4. Park A-M, Omura S, Fujita M, Sato F, and Tsunoda I. Helicobacter pylori and gut microbiota in multiple sclerosis versus Alzheimer’s disease: 10 pitfalls of microbiome studies. Clin Exp Neuroimmunol, 8(3): 215-232. PDF

5. Tanaka T, Fujita M* (corresponding author), Hasegawa H, Arimoto A, Nishi M, Fukuoka E, Sugita Y, Matsuda T, Sumi Y, Suzuki S, Kakeji Y, Yamashita K. Frequency of Myeloid-derived Suppressor Cells in the Peripheral Blood Reflects the Status of Tumor Recurrence. Anticancer Res. 37(7):3863-3869. PDF

6. Okuda T, Tasaki T, Nakata S, Yamashita K, Yoshioka H, Izumoto S, Kato A, Fujita M* (corresponding author). Efficacy of Combination Therapy with MET and VEGF Inhibitors for MET-overexpressing Glioblastoma. Anticancer Res. 37(7):3871-3876. PDF

7. Tsukagawa T, Katsumata R, Fujita M* (corresponding author), Yasui K, Akhoon C, Ono K, Dohi K, Aruga T. Elevated Serum High-Mobility Group Box-1 Protein Level Is Associated with Poor Functional Outcome in Ischemic Stroke. J Stroke Cerebrovasc Dis. in press

8. Kubota H, Sanada Y, Murakami S, Miyauchi M, Iwakura M, Nagatsuka K, Furukawa K, Kato A and Fujita M* (corresponding author). Long-term follow-up for ossfication of autologous bone plug and skin sinking after periosteum-preserved burr hole surgery. Surg Neurol Int. in press

9. Yasuda Y and Fujita M* (corresponding author). Significance of erythropoietin receptor antagnist EMP9 in cancers. In: Vitamines and Hormones, Volume 105. pp297-310.

10. Fujita M* (corresponding author), Omura S, Sato F, Park AM, and Tsunoda I. Influx and efflux of immune cells in the central nervous system. Anat Physiol 7 (4): 274. PDF

11. Sato F, Kawai E, Martinez NE, Omura S, Park A-M, Takahashi S, Yoh K, and Tsunoda I. T-bet, but not Gata3, overexpression is detrimental in a neurotropic viral infection. Sci. Rep. PDF.

12. Hagiwara S, Nishida N, Park AM, Komeda Y, Sakurai T, Watanabe T, and Kudo M. Contribution of C1485T mutation in the HBx gene to human and murine hepatocarcinogenesis. Sci. Rep. 7(1):10440. PDF.

13. Okuda T, Kato A, Fujita M* (corresponding author). Successful treatment of large intracranial granulocytic sarcomas. J Clin Neurol Neurosurg Spine. in press.

14. Fujita M* (corresponding author), Nakata S. Significance of immune cell migration/adhesion in central nervous system tumors. J Adv Oncol. in press.

15. Nishiwaki H, Fujita M, Yamauchi M, Isogai N, Tabata Y, Kusuhara H. Novel method to induce cartilage regeneration with cubic micro-cartilage. Cells Tissues Organs. in press.



英文抄録

1. (招待講演) Omura S, Sato F, Martinez NE, Park A-M, Fujita M, Kilgore PCSR, Cvek, U, Trutschl M, Minagar A, Alexander JS, and, Tsunoda I. Computational analysis determined the homogeneities and heterogeneieties between two distinct EAE models for progressive multiple sclerosis. 7th Sendai Conference 2017. July 8, 2017. Sendai, Japan. Abstract book p20, OS2-3. PDF

2. (招待講演) Sato F, Legaux KN, Creason TG, Omura S, Park A-M, Fujita M, Stokes KY and Tsunoda I. An RNA virus triggers inflammatory demyelination in the central nervous system by activating anti-myelin autoimmune T cells. 7th Sendai Conference 2017. July 8, 2017. Sendai, Japan. Abstract book p21, OS2-4. PDF

3. Omura S, Shimizu K, Morikawa M, Kuwahara M, Kawamura T, Mori T, Kusunoki S, and Tsunoda I. Factor Analysis Associated Anti-Glycolipid Antibodies with Clinical Data in Guillain-Barré Syndrome. Informatics in Biology, Medicine and Pharmacology (IIBMP2017). September 27-29, 2017. Sapporo, Japan. 第6回生命医薬情報学連合大会。北海道大学。PDF

4. Sato F, Omura S, Park A-M, Fujita M, Stokes KY, and Tsunoda I. Viral infection activates myelin-specific T cells, triggering MS-like CNS inflammatory demyelination. XXIII World Congress of Neurology, September 16-21, 2017. Kyoto, Japan. PDF

5. Omura S, Sato F, Martinez NE, Park A-M, Cvek U, Minagar A, Alexander JS, and Tsunoda I. Bioinformatics analysis determined the CNS and peripheral lymphoid surrogate biomarker candidates between two distinct EAE models for progressive multiple sclerosis. XXIII World Congress of Neurology, September 16-21, 2017. Kyoto, Japan. PDF

6. Omura S, Sato F, Park A-M, Fujita M, Alexander JS, Kilgore CSR, Cvek U, and Tsunoda I. Bioinformatics analyses identified phase-specific heart biomarkers and blood surrogate markers for a mouse model of viral myocarditis. The 65th Annual Meeting of the Japanese Society for Virology. October 24-26, 2017. Osaka, Japan. PDF


和文原著・総説

1.  角田郁生, 尾村誠一, 佐藤文孝, 崎山奈美江, 朴雅美, 藤田貢. ウイルス感染によって誘発される"軸索型”多発性硬化症動物モデル:インサイド-アウト・モデル. Neuroinfection 神経感染症 22(1):28-35 PDF

2. 角田郁生.  MSの動物モデルについて教えてください 吉良潤一編集 <シリーズ>神経内科 Clinical Questions & Pearls「中枢性脱髄疾患」中外医学社 東京 日本 in press.

3. 藤田貢. 第 14 回日本免疫治療学研究会総会に参加して、日本免疫治療学研究会 年報 Vol 5 (2017)

4.  角田郁生.  中枢神経系の免疫疾患 宮澤正顕編集 カラーイラストで学ぶ 集中講義 免疫学 メジカルビュー社 東京 日本  in press.

5.  角田郁生.  末梢神経系の免疫疾患 宮澤正顕編集 カラーイラストで学ぶ 集中講義 免疫学 メジカルビュー社 東京 日本  in press.

和文抄録

1. (招待講演) 角田郁生、尾村誠一、佐藤文孝、朴雅美、藤田貢. 多発性硬化症の遺伝子プロファイル主成分分析PCAによるリンパ管バイオマーカーの同定. 第90回日本産業衛生学会 アレルギー・免疫毒性研究会 2017年5月21-22日 東京ビッグサイトTFTビル

2. 佐藤文孝、Nicolas Martinez, Fridrik Karlsson, 尾村誠一、朴雅美、藤田貢, Matthew Grishma, 角田郁生. タイラーウイルス誘導性脳脊髄炎モデルにおける制御性T細胞の役割. 第27回日本サイトメトリー学会学術集会 2017年6月10-11日 神戸国際会議場. サイトメトリーリサーチ 2017, 27:Suppl, p54

3. 藤田貢, 田崎貴之、奥田武司、米重あずさ、中田晋。グリオーマ幹細胞における薬剤排出分子ABCG2の役割. 第27回日本サイトメトリー学会学術集会 2017年6月10-11日 神戸国際会議場. サイトメトリーリサーチ 2017, 27:Suppl, p66

4. 金井亨輔, 朴雅美, 渡部明子, 有川智博, 安居輝人, 吉田裕樹, 角田郁生, 義江修. マウスγヘルペスウイルスを用いた Epstein-Barr virus 肝炎の発症機序の研究. 第32回中国四国ウイルス研究会  2017年6月10-11日 川崎医科大学 倉敷市 岡山県

5. 朴雅美、義江修、角田郁生. 肺線維化における細胞周期制御因子の役割. 第38回日本炎症・再生医学会 2017年7月18-19日 大阪国際会議場. プログラム予稿集 p146
優秀演題賞

6. 尾村誠一、佐藤文孝、Nicholas E. Martinez、朴雅美、藤田貢、Phillip C.S.R. Kilgore、Urška Cvek、Marjan Trutschl、Alireza Minagar、J. Steven Alexander、角田郁生. Rを用いた主成分分析による多発性硬化症マウスモデル病態・病理像関連バイオマーカーの同定. 第76回近畿大学医学会学術講演会 2017年7月19日 近畿大学医学部、大阪狭山市、大阪.

7. 佐藤文孝、尾村誠一、朴雅美、藤田貢、角田郁生. ウイルスによる自然発症自己免疫モデルの増悪. 第76回近畿大学医学会学術講演会 2017年7月19日 近畿大学医学部、大阪狭山市、大阪.  近畿大学医学会一般演題優秀賞

8. 藤田貢、田崎貴之、奥田武司、米重あずさ、中田晋、山下公大: 膠芽腫幹細胞における HGFR/VEGFR 発現の意義、第 14 回日本免疫治療学研究会総会 2017年2月11日 東京

9. 茂山千愛美、藤田貢、飯居宏美、谷口恵香、吉貫達寛、中田晋: Stat5b は発がんマウスモデル由来膠芽腫幹細胞様細胞の増殖促進に寄与する、第 76 回日本癌学会学術集会 2017年9月30日 横浜

10. 佐藤文孝、川合英一郎、ニコラス・マルチネス、尾村誠一、藤田貢、朴雅美、崎山奈美江、高橋智、楊景堯、角田郁生. 転写因子T-bet過剰発現は神経向性ウイルス感染を増悪させる. 第29回日本神経免疫学会 2017年10月6-7日 札幌

11. 藤田貢、吉岡宏真、田崎貴之、奥田武司、加藤 天美: グリオーマ幹細胞における薬剤排出分子 ABCG2 の役割. 第 76 回日本脳神経外科学会学術集会 2017年10月12日 名古屋

12. 尾村誠一、佐藤文孝、藤田貢、朴雅美、J. Steven Alexander、Phillip C.S.R. Kilgore、Urška Cvek、角田郁生.  次世代シークエンシングを用いたウイルス性脳脊髄炎モデルの解析; リンパ管分子発現低下が免疫細胞の中枢神経内停滞に関連する. 第22回日本神経感染症学会総会・学術大会 2017年10月13-14日 北九州市小倉

13. (招待講演)角田郁生. 多発性硬化症ウイルスモデルリンパ管分子マーカーの主成分分析(PCA)による解析. 多発性硬化症セミナー. 2017年10月31日. 宮崎大学医学部 宮崎市 宮崎県

14. (招待講演)角田郁生. 免疫病理学、バイオインフォマティクスによる多発性硬化症動物モデルの研究. 第47回神戸ラボ全体研究会議. 2017年11月24日 神戸大学大学院医学研究科神戸BTセンター 神戸市 兵庫県

テレビ出演

1. 角田郁生 毎日放送「ちちんぷいぷい」刻み海苔によるノロウイルス集団食中毒 第4149回 2017年3月1日 ちちんぷいぷい

2016

英文原著・総説

1. Sato F, Omura S, Jaffe SL and Tsunoda I. Role of CD4+ T lymphocytes in pathophysiology of multiple sclerosis. In: Multiple Sclerosis: A Mechanistic View. Minagar A (Ed), Elsevier, London, UK. pp. 41-69.
PDF

2. Tsunoda I, Sato F, Omura S, Fujita M, Sakiyama N, and Park AM. Three immune-mediated disease models induced by Theiler’s virus: multiple sclerosis, seizures, and myocarditis. Clin Exp Neuroimmunol, 7 (4):330-345.PDF

3. Becker F, Kurmaeva, E, Gavins FNE, Stevenson EV, Navratil AR, Jin L, Tsunoda I, Orr AW, Alexander JS, and Ostanin DV. (2016). A critical role for monocytes/macrophages during intestinal inflammation-associated lymphangiogenesis. Inflamm. Bowel Dis.  22:1326-1345. PMID: 26950310PDF

4. Park AM, Kanai K, Itoh T, Sato T, Tsukui T, Inagaki Y, Selman M, Matsushima K, and Yoshie O. Heat Shock Protein 27 Plays a Pivotal Role in Myofibroblast Differentiation and in the Development of Bleomycin-Induced Pulmonary Fibrosis. PLoS One. 2016 Feb 9;11(2):e0148998.PDF

5. Park AM, Hagiwara S, Hsu DK, Liu FT, and Yoshie O. Galectin-3 Plays an Important Role in Innate Immunity to Gastric Infection by Helicobacter pylori. Infect Immun. 84(4):1184-93.PDF

6. Tsunoda I, Omura S, Kusunoki S, Sato F, Fujita M, Park A-M, Hasaonvic F, Yanagihara R, Nagata S. (2016). Neuropathogenesis of Zika virus infection: Potential roles of antibody-mediated pathogy. Acta Medica Kindai Univ. 41 (2): 37-52. PDF

7. Yun J.W. Xiao A, Tsunoda I, Minagar A, Alexander JS. (2016). From trash to treasure: The untapped potential of endothelial microparticles in neurovascular diseases. Pathophysiology 23 (4): 265-274. PMID: 27531185.PDF

8. Matsuo K, Koizumi K, Fujita M, Morikawa T, Jo M, Shibahara N, Saiki I, Yoshie O, Nakayama T. Efficient use of a crude drug/herb library reveals Ephedra Herb as a specific antagonist for TH2-specific chemokine receptors CCR3, CCR4, and CCR8. Front Cell Dev Biol. 4:54. PDF

9. Tasaki T, Fujita M* (corresponding author), Okuda T, Yoneshige A, Nakata S, Yamashita K, Yoshioka H, Kato A. MET expressed in glioma stem cells is a potent therapeutic target for glioblastoma multiforme. Anticancer Res. 36(7):3571-3577. PDF

10. Yamashita K, Hasegawa H, Fujita M, Nishi M, Tanaka T, Arimoto A, Suzuki S, Kamigaki T, Kakeji Y. Host CD40 is essential for DCG treatment against metastatic lung cancer. Anticancer Res. 36 (7):3659-3665. PDF


和文原著・総説

1. 藤田貢.  医学論文の書き方.  近畿大医誌 (Med J. Kindai Univ) 41(1-2):47-54 PDF

2. 角田郁生. 多発性硬化症と心筋炎のウイルスモデル. 近畿大医誌 (Med J. Kindai Univ) 41(3-4):7A-9A  PDF

英文抄録

1. Becker F, Gavins FN, Vowinkel T, Tsunoda I, Rijcken E, Ostanin DV, and Alexander JS. (2016). Contributions of monocytes to gut inflammation in acute and chronic colitis models. 11th Congress of European Crohn’s and Colitis Organization (ECCO). March 16-19, 2016. Amsterdam, Netherlands.

2. Yun JW, Minagar A, Tsunoda I, and Alexander JS. (2016). Brain endothelial lymphatic-venous biomarkers into microparticles following inflammatory cytokine stimulation. Experimental Biology 2016, April 2-6, 2016, San Diego, California.

3. Becker F, Vowinkel T, Rijcken E, Tsunoda I, Ostanin DV and Alexander JS. (2016). Monocytes/macrophages play a contributing role in lymphangiogenesis independent of their role in intestinal inflammation. 133. Kongress Deutsche Gesellschaft für Chirurgie. April 26-29, 2016. Berlin, Germany.

4. Omura S, Sato F, Alexander JS, Kilgore PCSR, Cvek U, Trutschl M, and Tsunoda I. (2016). Upregulation of lymphatic markers and vascular adhesion molecules in CNS RNAseq transcriptome of a viral model for multiple sclerosis. The 6th Annual International Society for Neurovascular Disease (ISNVD) Scientific Meeting, April 29-30, 2016. New York, New York. Best Poster Award

5. Minagar A, Tsunoda I, and Alexander JS. (2016). Multiple sclerosis as a vascular disease. The 6th Annual International Society for Neurovascular Disease (ISNVD) Scientific Meeting, April 29-30, 2016. New York, New York.


和文抄録

1. 朴 雅美、義江 修. ヘリコバクター・ピロリ菌感染おけるガレクチン-3の生体防御的役割. 第81回日本インターフェロン・サイトカイン学会 2016年 5月13日ー14日.長崎大学 坂本キャンパス

2. 金井 亨輔、朴 雅美、角田 郁生、吉田 裕樹、義江 修.  L-35は気道における好酸球浸潤を抑制する.第81回日本インターフェロン・サイトカイン学会 2016年 5月13日ー14日.長崎大学 坂本キャンパス

3. (招待講演) 角田郁生. 多発性硬化症と心筋炎のウイルスモデル. 近畿大学医学会総会 特別講演. 近畿大学. 大阪狭山市. 大阪府. 2016年6月15日.

4. 尾村誠一、佐藤文孝、J. Steven Alexander, Phillip C.S.R. Kilgore, Urska Cvek, Marjan Trutschl, 角田郁生. 進行型多発性硬化症モデルでは血管接着分子の発現増加、BBB/リンパ管分子の発現減少が病因に相関する。 第28回日本神経免役学会学術集会 長崎市. 長崎県. 2016年9月29-30日 Neuroimmunology 神経免疫学 21(1):120PDF

5. (招待講演) 角田郁生、佐藤文孝、尾村誠一、崎山奈美江、朴雅美、藤田貢. ウイルス感染によって誘発される炎症性脱髄と軸索変性のメカニズム。 第21回日本神経感染症学会総会・学術大会 金沢市. 石川県. 2016年10月21-22日 Neuroinfection 21(2):174PDF

6. 朴 雅美、角田郁生. HSP27ノックダウンによる線維芽細胞の細胞周期停止におけるE2F-4の役割. 第39回日本分子生物学会 2016年 11月30日ー12月2日.パシフィコ横浜

テレビ出演

1. 藤田貢 毎日放送「医のココロ」「頭部打撲」について 2016年8月20日

2. 藤田貢 毎日放送「ちちんぷいぷい」O-157による食中毒について 2016年11月2日 ちちんぷいぷい

1993年ー2015年 (角田郁生業績: 東北大学、ユタ大学、ルイジアナ州立大学)

I. 原著

1. Iwasaki Y, Sako K, Tsunoda I and Ohara Y. (1993). Phenotypes of mononuclear cell infiltrates in human CNS. Acta Neuropathol. (Berl) 85 (6): 653-657.
PDF

2. Tsunoda I, Awano H, Kayama H, Tsukamoto T, Ueno S, Fujiwara T, Watanabe M and Yamamoto T. (1994). Idiopathic AA amyloidosis manifested by autonomic neuropathy, vestibulocochleopathy, and lattice corneal dystrophy. J. Neurol. Neurosurg. Psychiatry 57 (5): 635-637. PDF

3. Saito T, Hida C, Tsunoda I, Tsukamoto T and Yamamoto T. (1994). Melkerson-Rosenthal syndrome: distal facial nerve branch palsies, masseter myopathy and corticosteroid treatment. Fukushima J. Med. Sci. 40 (1): 39-44. PDF

4. Tsunoda I, Kanno H, Watanabe M, Shimoji S, Hirayama K, Sumita H and Yamamoto T. (1994). Acute simultaneous bilateral vestibulocochlear impairment in neuro-Behcet's disease: A case report. Auris Nasus Larynx 21 (4): 243-247.PDF

5. Tsunoda I, Endo K, Hirayama K, Saito N, Hida C, Tsukamoto T and Yamamoto T. (1995). The POEMS syndrome with intracranial hypertension. Fukushima J. Med. Sci. 41 (1): 61-69. PDF

6. Tsunoda I, Iwasaki Y, Sako K, Terunuma H and Ohara Y. (1996). A comparative study on acute and chronic diseases induced by two subgroups of Theiler's murine encephalomyelitis viruses (TMEV). Acta Neuropathol. (Berl) 91 (6): 595-602.PDF

7. Tsunoda I and Fujinami RS. (1996). Two models for multiple sclerosis: Experimental allergic encephalomyelitis and Theiler’s murine encephalomyelitis virus. J. Neuropathol. Exp. Neurol. 55 (6): 673-686.PDF

8. Tsunoda I, Kurtz CIB and Fujinami RS. (1997). Apoptosis in acute and chronic central nervous system disease induced by Theiler’s murine encephalomyelitis virus. Virology 228 (2): 388-393.PDF

9. Tsunoda I, McCright IJ, Kuang L-Q, Zurbriggen A and Fujinami RS. (1997). Hydrocephalus in mice infected with Theiler’s murine encephalomyelitis virus variant. J. Neuropathol. Exp. Neurol. 56 (12): 1302-1313. PDF

10. Rose J, Hill K, Wada Y, Kurtz C, Tsunoda I, Fujinami RS and Cross A. (1998). Nitric oxide synthase inhibitor, aminoguanidine, alters inflammation and demyelination produced by Theiler’s virus infection. J. Neuroimmunol. 81 (1-2): 82-89.PDF

11. Tsunoda I, Kuang L-Q, Tolley ND, Whitton JL and Fujinami RS. (1998). Enhancement of experimental allergic encephalomyelitis (EAE) by DNA immunization with myelin proteolipid protein (PLP) plasmid DNA. J. Neuropathol. Exp. Neurol. 57 (8): 758-767. PDF

12. Wada Y, McCright IJ, Whitby FG, Tsunoda I and Fujinami RS. (1998). Replacement of loop II of VP1 of the DA strain with loop II of the GDVII strain of Theiler’s murine encephalomyelitis virus alters neurovirulence, viral persistence and demyelination. J. Virol. 72 (9): 7557-7562. PDF

13. Tolley ND, Tsunoda I and Fujinami RS. (1999). DNA vaccination of SJL/J mice against Theiler’s murine encephalomyelitis virus leads to alternations in CNS disease. J. Virol. 73 (2): 993-1000.PDF

14. Tsunoda I, Sette A, Fujinami RS, Oseroff C, Ruppert J, Dahlberg C, Southwood, S, Arrhenius T, Kuang L-Q, Kubo RT, Chesnut RW and Ishioka G. (1999). Lipopeptide particles as the immunologically active component of CTL inducing vaccines. Vaccine 17 (7-8): 675-685.PDF

15. McCright IJ, Tsunoda I, Whitby FG and Fujinami RS. (1999). Theiler’s viruses with mutations in loop I of VP1 lead to altered tropism and pathogenesis. J. Virol. 73 (4): 2814-2824. PDF

16. Tsunoda I, Tolley ND, Theil DJ, Whitton JL, Kobayashi H and Fujinami RS. (1999). Exacerbation of viral and autoimmune animal models for multiple sclerosis by bacterial DNA. Brain Pathol. 9 (3): 481-493.PDF

17. Theil DJ, Tsunoda I, Libbey JE, Derfuss TJ and Fujinami RS. (2000). Alterations in cytokine but not chemokine mRNA expression during three distinct Theiler’s virus infections. J. Neuroimmunol. 104 (1): 22-30.PDF

18. Tsunoda I, Kuang, L-Q, Theil DJ and Fujinami RS. (2000). Antibody association with a novel model for primary progressive multiple sclerosis: Induction of relapsing-remitting and progressive forms of EAE in H2S mouse strains. Brain Pathol. 10 (3): 402-418.PDF

19. Libbey JE, McCright IJ, Tsunoda I, Wada Y and Fujinami RS. (2001). Peripheral nerve protein, P0, as a potential receptor for Theiler’s murine encephalomyelitis virus. J. NeuroVirol. 7 (2): 97-104.PDF

20. Tsunoda I, Wada Y, Libbey JE, Cannon TS, Whitby FG and Fujinami RS. (2001). Prolonged gray matter disease without demyelination caused by Theiler’s murine encephalomyelitis virus with a mutation in VP2 puff B. J. Virol. 75 (16): 7494-7505. PDF

21. Theil DJ, Tsunoda I, Rodriguez F, Whitton JL and Fujinami RS. (2001). Viruses can silently prime for and trigger central nervous system autoimmune disease. J. NeuroVirol. 7 (3): 220-227.PDF

22. Libbey JE, Tsunoda I and Fujinami RS. (2002). Altered cell growth and morphology in a BHK-21 cell mutant that lacks a receptor for Theiler’s murine encephalomyelitis virus (TMEV). Virology 294 (1): 85-93.PDF

23. McCright IJ, Tsunoda I and Fujinami RS. (2002). Mutation in loop I of VP1 of Theiler’s virus delays viral RNA release into cells and enhances antibody-mediated neutralization: A mechanism for the failure of persistence by the mutant virus. J. NeuroVirol. 8 (2): 100-110.PDF

24. Tsunoda I and Fujinami RS. (2002). Inside-Out versus Outside-In models for virus induced demyelination: Axonal damage triggering demyelination. Springer Semin. Immunopathol. 24 (2): 105-125. PDF

25. Tsunoda I, Kuang L-Q and Fujinami RS. (2002). Induction of autoreactive CD8+ cytotoxic T cells during Theiler’s murine encephalomyelitis virus infection: Implications for autoimmunity. J. Virol. 76 (24): 12834-12844.PDF

26. Wang M, Libbey JE, Tsunoda I and Fujinami RS. (2003). Modulation of immune system function by measles virus infection. II. Infection of B cells leads to the production of a soluble factor that arrests uninfected B cells in G0/G1. Viral. Immunol. 16 (1): 45-56.PDF

27. Tsunoda I, Kuang L-Q, Libbey JE and Fujinami RS. (2003). Axonal injury heralds virus-induced demyelination. Am. J. Pathol. 162 (4): 1259-1269.PDF

28. Tsunoda I, Lane TE, Blackett J and Fujinami RS. (2004). Distinct roles for IP-10/CXCL10 in three animal models, Theiler's virus infection, EAE, and MHV infection, for multiple sclerosis: implication of differing roles for IP-10. Mult. Scler. 10 (1): 26-34.PDF

29. Tsunoda I, Kuang L-Q, Igenge IZM and Fujinami RS. (2005). Converting relapsing remitting to secondary progressive experimental allergic encephalomyelitis (EAE) by ultraviolet B irradiation. J. Neuroimmunol. 160 (1-2): 122-134.PDF

30. Tsunoda I, Kuang L-Q, Kobayashi-Warren M and Fujinami RS. (2005). Central nervous system pathology caused by autoreactive CD8+ T cell clones following virus infection. J. Virol. 79 (23): 14640-14646.PDF

31. Tsunoda I, Libbey JE, Kuang L-Q, Terry EJ and Fujinami RS. (2005). Massive apoptosis in lymphoid organs in animal models for primary and secondary progressive multiple sclerosis. Am. J. Pathol. 167 (6): 1631-1646.PDF

32. Tsunoda I, Libbey JE, Kobayashi-Warren M and Fujinami RS. (2006). IFN-γ production and astrocyte recognition by autoreactive T cells induced by Theiler’s virus infection: role of viral strains and capsid proteins. J. Neuroimmunol. 172 (1-2): 85-93.PDF

33. McCoy L, Tsunoda I and Fujinami RS. (2006). Multiple sclerosis and virus induced immune responses: Autoimmunity can be primed by molecular mimicry and augmented by bystander activation. Autoimmunity 39 (1): 9-19.

34. Libbey JE, Peterson LK, Tsunoda I and Fujinami RS. (2006). Monoclonal MOG-reactive autoantibody from progressive EAE has the characteristics of a natural antibody. J. Neuroimmunol. 173 (1-2): 135-145.

35. Carlson NG, Hill KE, Tsunoda I, Fujinami RS and Rose JW. (2006). The pathologic role for COX-2 in apoptotic oligodendrocytes in virus induced demyelinating disease: Implications for multiple sclerosis. J. Neuroimmunol. 174 (1-2): 21-31.

36. Libbey JE, Tsunoda I and Fujinami RS. (2006). Autologous hematopoietic stem cell transplantation: A cure for multiple sclerosis? Future Neurol. 1 (4): 403-408.

37. Tsunoda I, Tanaka T, Terry EJ and Fujinami RS. (2007). Contrasting roles for axonal degeneration in an autoimmune versus viral model of multiple sclerosis: When can axonal injury be beneficial? Am. J. Pathol. 170 (1): 214-226. PDF

38. Libbey JE, Tsunoda I, Whitton JL and Fujinami RS. (2007). Infectious RNA isolated from the spinal cords of mice chronically infected with Theiler’s murine encephalomyelitis virus. J. Virol. 81 (6): 3009-3011. PDF

39. Tsunoda I, Terry EJ, Marble BJ, Lazarides E, Woods C and Fujinami RS. (2007). Modulation of experimental autoimmune encephalomyelitis by VLA-2 blockade. Brain Pathol. 17 (1): 45-55.PDF

40. Peterson LK, Tsunoda I, Masaki T and Fujinami RS. (2007). Polyreactive myelin oligodendrocyte glycoprotein antibodies: Implications for systemic autoimmunity in progressive experimental autoimmune encephalomyelitis. J. Neuroimmunol. 183 (1-2): 69-80. PDF

41. Tsunoda I, Libbey JE and Fujinami RS. (2007). Sequential polymicrobial infections lead to CNS inflammatory disease: Possible involvement of bystander activation in heterologous immunity. J. Neuroimmunol. 188: 22-33.PDF

42. Tsunoda I, Tanaka T, Saijoh Y and Fujinami RS. (2007). Targeting inflammatory demyelinating lesions to sites of Wallerian degeneration. Am. J. Pathol. 171 (5): 1563-1575.PDF

43. Tsunoda I, Libbey JE and Fujinami RS. (2007). TGF-β suppresses T cell infiltration and VP2 puff B mutation enhances apoptosis in acute polioencephalitis induced by Theiler’s virus. J. Neuroimmunol. 190 (1-2): 80-89.PDF

44. Peterson LK, Tsunoda I and Fujinami RS. (2008). Role of CD5+ B-1 cells in EAE pathogenesis. Autoimmunity 41 (5): 353-362.

45. Peterson LK, Tsunoda I, Libbey JE, and Fujinami RS. (2008). Role of B:T cell ratio in suppression of clinical signs: a model for silent MS. Exp. Mol. Pathol. 85 (1): 28-39.PDF

46. Tsunoda I. (2008). Axonal degeneration as a self-destructive defense mechanism against neurotropic virus infection. Future Virol. 3 (6): 579-593. PDF

47. Peterson LK, Masaki T, Wheelwright SR, Tsunoda I and Fujinami RS. (2008). Cross-reactive myelin antibody induces renal pathology. Autoimmunity 41 (7): 526-36.PDF

48. Theil DJ, Libbey LE, Rodriguez F, Whitton JL, Tsunoda I, Derfuss TJ and Fujinami RS. (2008). Targeting myelin proteolipid protein to the MHC class I pathway by ubiqitination modulates the course of experimental autoimmune encephalomyelitis. J. Neuroimmunol. 204 (1-2): 92-100.PDF

49. Tsunoda I, Tanaka T and Fujinami RS. (2008). Regulatory role of CD1d in neurotropic virus infection. J. Virol. 82 (20): 10279-10289.PDF

50. Tsunoda I, Libbey JE and Fujinami RS. (2009). Theiler's murine encephalomyelitis virus attachment to the gastrointestinal tract is associated with sialic acid binding. J. NeuroVirol. 15 (1): 81-89.PDF

51. Penberthy WT and Tsunoda I. (2009). The importance of NAD in multiple sclerosis. Curr. Pharm. Des. 15 (1): 64-99.PDF

52. Tsunoda I, Tanaka T, Taniguchi M and Fujinami RS. (2009). Contrasting roles for V14+ NKT cells in a viral model for multiple sclerosis. J NeuroVirol, 15 (1): 90-98.PDF

53. Tsunoda I and Fujinami RS. (2010). Neuropathogenesis of Theiler’s murine encephalomyelitis virus infection, a viral model for multiple sclerosis. J. Neuroimmune Pharmacol. 5 (3): 355-369. PDF

54. Libbey JE, Tsunoda I and Fujinami RS. (2010). Studies in the modulation of experimental autoimmune encephalomyelitis. J. Neuroimmune Pharmacol. 5 (2): 168-175.PDF

55. Greenlee JE, Clawson SA, Hill KE, Wood BL, Tsunoda I and Carlson NG. (2010). Purkinje cell death after uptake of anti-Yo antibodies in cerebellar slice cultures. J Neuropathol Exp Neurol., 69 (10): 997-1007.PDF

56. Sato F, Tanaka H, Hasanovic F and Tsunoda I. (2011). Theiler’s virus infection: Pathophysiology of demyelination and neurodegeneration. Pathophysiology 18 (1): 31-41. PDF

57. Sato F, Martinez NE, Omura S and Tsunoda I. (2011). Heterogeneity versus homogeneity of multiple sclerosis. Expert Rev Clin Immunol, 7 (2): 165-167. PDF

58. Libbey JE, Cusick MF, Tsunoda I and Fujinami RS. (2012). Antiviral CD8+ T cells cause an experimental autoimmune encephalomyelitis-like disease in naive mice. J. NeuroVirol. 18 (1): 45-54. PMCID: PMC3327473 PDF

59. Tsunoda I, Libbey JE and Fujinami RS. (2012). Immunization with structural and non-structural proteins of Theiler's murine encephalomyelitis virus alters demyelinating Disease. J. NeuroVirol. 18 (2): 127-137. PMCID: PMC3335973 PDF

60. Martinez NE, Sato F, Kawai E, Omura S, Chervenak RP and Tsunoda I. (2012). Regulatory T cells and Th17 cells in viral infections: implications for multiple sclerosis and myocarditis. Future Virol. 7 (6): 593-608. PDF

61. Libbey JE, Tsunoda I and Fujinami RS. (2012). Possible role of interleukin-17 in a prime/challenge model of multiple sclerosis. J. NeuroVirol. 18 (6): 471-478. PDF

62. Karlsson F, Martinez NE, Gray L, Zhang S, Tsunoda I and Grisham MB. (2013). Therapeutic evaluation of ex vivo-generated vs. natural regulatory T-cells in a mouse model of chronic gut inflammation. Inflamm Bowel Dis. 19 (11): 2282-2294. PDF

63. Martinez NE, Sato F, Omura S, Minagar A, Alexander JS and Tsunoda I. (2013). Immunopathological patterns from EAE and Theiler’s virus infection: Is multiple sclerosis a homogenous 1-stage or heterogeneous 2-stage disease? Pathophysiology 20 (1): 71-84. PMCID: PMC3430756 PDF

64. Sato F, Martinez NE, Shahid M, Rose JW, Carlson NG and Tsunoda I. (2013). Resveratrol exacerbates both autoimmune and viral models for multiple sclerosis. Am. J. Pathol. 275(5): 1390-1396. PDF

65. Chaitanya GV, Omura S, Sato S, Martinez NE, Minagar A, Ramanadhan M, Guttman BW, Zivadinov R, Tsunoda I and Alexander JS. (2013). Inflammation induces neuro-lymphatic protein expression in multiple sclerosis brain neurovasculature. J. Neuroinflammation 10 (1): 125. PDF

66. Alexander JS, Prouty L, Tsunoda I, Ganta CV and Minagar A. (2013). Venous endothelial injury in central nervous system diseases. BMC Medicine 11: 219. PDF

67. Fernando V, Omura S, Martinez NE, Sato F, Kawai E, Elliott SF, Takahashi S, Yoh K, and Tsunoda I. (2014). Regulation of an autoimmune model for multiple sclerosis in Th2-biased GATA3 transgenic mice. Int J Mol Sci, 15: 1700-1718. PDF

68. Martinez NE, Karlsson F, Sato F, Kawai E, Omura S, Grisham MB, Minagar A and Tsunoda I. (2014). Protective and detrimental roles for regulatory T cells in a viral model for multiple sclerosis.  Brain Pathol. 24 (5): 436-51. PMID: 24417588 PDF

69. Omura S, Kawai E, Sato F, Martinez NE, Chaitanya GV, Rollyson P, Cvek U, Trutschl M, Alexander JS, and Tsunoda I. (2014). Bioinformatics multivariate analysis determined a set of phase-specific biomarker candidates in a novel mouse model for viral myocarditis. Cir Cardiovasc Genet, 7: 444-454. PMID: 25031303 PDF

70. Greenlee JE, Clawson SA, Hill KE, Wood B, Clardy SL, Tsunoda I, Jaskowski TD, and Carlson NG. (2014). Neuronal uptake of anti-Hu antibody but not anti-Ri antibody leads to cell death in brain slice cultures. J Neuroinflammation, 11(1): 160. PMID: 25228406 PDF

71. Martinez NE, Sato F, Kawai E, Omura S, Takahashi S, Yoh K and Tsunoda I. (2014). RORγt, but not T-bet, overexpression exacerbates an autoimmune model for multiple sclerosis in novel Th17-biased transgenic mice. J Neuroimmunol, 276: 142-149. PMID: 25288300 PDF

72. Sato F, Omura S, Kawai E, Martinez NE, Acharya MM, Reddy PC, Chaitanya GV, Alexander JS and Tsunoda I. (2014). Distinct kinetics of viral replication, T cell infilatration, and fibrosis in three phases of myocarditis following Theiler’s virus infection. Cell Immunol, 292 (1-2): 85-93. PDF

73. Kawai E, Sato F, Omura S, Martinez NE, Reddy PC, Taniguchi M., and Tsunoda I. (2015). Organ-specific protective role of NKT Cells in virus-induced inflammatory demyelination and myocarditis depends on mouse strain. J. Neuroimmunol., 278 (1-2):174-784. PMID: 25434008 PDF

74. Martinez NE, Sato F, Kawai E, Omura S, Takahashi S, Yoh K and Tsunoda I. (2015). Th17-biased RORγt transgenic mice become susceptible to a viral model for multiple sclerosis. Brain Behav. Immun., 43: 86-97. PMID:25046854 PDF

75. Becker F, Potepalov S, Shehzahdi R, Bernas M, Witte M, Abreo F, Traylor J, Orr WA, Tsunoda I, Alexander JS. (2015). Downregulation of FoxC2 increased susceptibility to experimental colitis: Influence of lymphatic drainage function? Inflamm. Bowel Dis., 21 (6): 1282-96. PMID:25822012 PDF

76. Greenlee JE, Clawson SA, Hill KE, Wood B, Clardy SL, Tsunoda I, and Carlson NG. (2015). Anti-Yo antibody uptake and interaction with its intracellular target antigen causes Purkinje cell death in rat cerebellar slice cultures: a possible mechanism for paraneoplastic cerebellar degeneration in humans with gynecological or breast cancers. PLoS One, 10 (4):e0123446. PMID: 25885452 PDF

77. Al-Kofahi M, Becker F, Gavins FNE, Woolard M, Tsunoda I, Wang Y, Ostanin D, Zawieja DC, Muthuchamy M, von der Weid PY, and Alexander JS. (2015). IL-1β reduces tonic contraction of mesenteric lymphatic muscle cells, with involvement of cyclooxygenase-2 and prostaglandin E2. Br. J. Pharmacol. 172 (16): 4038-51. PMID: 25989136 PDF

78. Alexander JS, Chervenak R, Weinstock-Guttman B, Tsunoda I, Ramanthan M, Martinez N, Sato F, Chaitanya GV, Minagar A, Monceaux C, McGee J, Jennings MH, Becker F, Cvek U, Trutschl M, and Zivadinov R. Blood circulating microparticle species in relapsing-remitting and secondary progressive multiple sclerosis. A case-control, cross sectional study with conventional MRI and advanced iron content imaging outcomes. J Neurol. Sci. 355 (1-2): 84-9. PMID: 26073484 PDF

79. Sato F, Martinez NE, Stewart EC, Omura S, Alexander JS, and Tsunoda I. (2015). “Microglial nodule” and “newly forming lesion” may be a Janus face of early MS lesions; Implications from virus-induced demyelination, the Inside-Out model. BMC Neurol., 15:219 PDF





II. 著書

1. Tsunoda I and Fujinami RS. (1999). Theiler’s murine encephalomyelitis virus (TMEV). In: Persistent Viral Infections. Ahmed R and Chen ISY (Eds.), John Wiley & Sons, Ltd., Chichester, West Sussex, England, pp. 517-536.
PDF

2. Tsunoda I and Fujinami RS. (2005). TMEV and neuroantigens: Myelin genes and proteins, molecular mimicry, epitope spreading and autoantibody-mediated remyelination. In: Experimental Models of Multiple Sclerosis. Lavi E and Constantinescu CS (Eds.), Springer, New York NY. pp. 593-616.PDF

3. Tsunoda I, Kobayashi-Warren, M, Libbey JE and Fujinami RS. (2009). Central nervous system degeneration caused by autoimmune cytotoxic CD8+ T cell clones and hybridomas. In: Encyclopedia of Neuroscience. Binder MD, Hirokawa N, Windhorst U (Eds), Springer-Verlag GmbH Berlin Heidelberg. pp. 619-625.PDF

4. Sato F, Omura S Martinez NE and Tsunoda I. (2011). Animal models for multiple sclerosis. In: Neuroinflammation. Minagar A (Ed), Elsevier, Burlington, MA. pp. 55-79. ISBN-10: 0123849136 PDF

III. PROCEEDINGS

1. Terry EJ, Tsunoda I and Fujinami RS. (2004). Ultraviolet irradiation alters autoimmune responses, leading to disease progression in an animal model for multiple sclerosis. Proceedings of the NCUR 2004, pp. 1-8.
PDF

2. Tsunoda I, Tanaka T, Saijoh Y, Doyle SE, Terry EJ and Fujinami RS. (2007). Axonal damage targets inflammatory demyelinating lesions to sites of Wallerian degeneration: Inside-Out model for multiple sclerosis. In: Tabira T, Yamamura T, and Kira J (eds), 8th International Congress of Neuroimmunology. MEDIMOND S.r.l., Bolonga, Italy, 2007, pp. 37-40. PDF

IV. 和文 エッセー

1. 角田郁生、粟野裕行、斉藤佐、塚本哲朗、山本悌司. (1991). 胃切除後亜急性連合性脊髄変性症の1例. 消化器科15 (5): 490-494.
PDF

2. 角田郁生. (2011). 望小達大 ルイジアナ州シュリーブポートより-Louisiana State University Health Sciences Center. 実験医学 29 (9): 1460-1462. PDF

V. 抄録

1. Sako K, Iwasaki Y, Ohara Y, Tsunoda I and Okumura K. (1993). Anti-very late antigen-4 antibody suppresses acute active experimental allergic encephalomyelitis in Lewis rats. 69th Annual Meeting American Association of Neuropathologists, Salt Lake City, Utah, June 10-13, 1993. J. Neuropathol. Exp. Neurol. 52 (3): 310.

2. Ohara Y, Iwasaki Y, Terunuma H, Tsunoda I and Mizobuchi M. (1994). Latent infection of human T-cell Leukemia type I (HTLV-I) in human monocytic cell (THP-1). Tenth International Conference on AIDS, Yokohama, Japan, August 7-12, Abstract Book, Vol. 1, p. 136.

3. Terunuma H, Ohara Y, Mizobuchi M, Tsunoda I and Iwasaki Y. (1994). Transcriptional alteration of TNF- and IL-6 in an HIV-infected monocyte/macrophage lineage cell lines. Tenth International Conference on AIDS, Yokohama, Japan, August 7-12, Abstract Book, Vol. 2, p. 97.

4. Ohara Y, Iwasaki Y, Tsunoda I, Terunuma H and Mizobuchi M. (1994). Establishment of human monocytic cells (THP-1) infected with human T-cell leukemia virus type I (HTLV-I). XIIth International Congress of Neuropathology, Toronto, Canada, September 18-23. Brain Pathol 4 (4): 474.

5. Mizobuchi M, Sako K, Iwasaki Y, Ohara Y, Terunuma H and Tsunoda I. (1994). Suppression of acute active experimental allergic selective reduction of CD4+CD45RC- cells in the peripheral blood in Lewis rats. XIIth International Congress of Neuropathology, Toronto, Canada, September 18-23. Brain Pathol. 4 (4): 497.

6. Terunuma H, Ohara Y, Mizobuchi M, Tsunoda I and Iwasaki Y. (1994). Transcriptional activation of TNF- in HIV infected monocyte/macrophage lineage cell lines. XIIth International Congress of Neuropathology, Toronto, Canada, September 18-23. Brain Pathol. 4 (4): 486.

7. Tsunoda I, Ohara Y, Sako K, Terunuma H, Mizobuchi M and Iwasaki Y. (1994). A comparative study on acute and chronic diseases induced by two subgroups of Theiler's murine encephalomyelitis viruses (TMEV). XIIth International Congress of Neuropathology, Toronto, Canada, September 18-23. Brain Pathol. 4 (4): 497.

8. Mizobuchi M, Iwasaki Y, Ohara Y, Terunuma H, Sako K, Tsunoda I, Kaneko Y, Mimura T and Okumura K. (1994). Suppression of acute active EAE with a derivative of mycophenolic acid. IVth International Congress of Neuroimmunology, Amsterdam, Netherland, October 23-27. J. Neuroimmunol. 54 (1-2): 183.

9. Tsunoda I, Kurtz CIB and Fujinami RS. (1996). Apoptosis as a possible mechanism for the central nervous system leading to demyelinating disease. Cell Biology of Virus Entry, Replication and Pathogenesis, Keystone Symposia on Molecular and Cellular Biology, Santa Fe, New Mexico, February 10-16, p. 45.

10. Tsunoda I, Kurtz CIB and Fujinami RS. (1996). Apoptosis in Theiler’s murine encephalomyelitis virus (TMEV) infection and experimental allergic encephalomyelitis (EAE). Society for Experimental Neuropathology, Miami, Florida, October 12-13. Brain Pathol. 6 (3): 257.

11. Tsunoda I, Tolley, ND, Whitten JL, Kuang L-Q and Fujinami RS. (1998). Enhancement of Theiler’s murine encephalomyelitis virus (TMEV) infection by immunization with plasmid DNA. The Fifth International Symposium on Positive Strand RNA Viruses, St. Petersburg, Florida, May 23-28.

12. Wada Y, McCright IJ, Whitby FG, Tsunoda I and Fujinami RS. (1998). Substitution of loop II of VP-1 of DA strain with loop II of the GDVII strain of Theiler’s murine encephalomyelitis virus alters neurovirulence, viral persistence and demyelination. EUROPIC ’98, Xth Meeting of the European Study Group on the Molecular Biology of Picornaviruses, Jena, Germany, September 5-11, Vol. 22.

13. Theil DJ, Tsunoda I, Libbey JE and Fujinami RS. (1999). Chemokine and cytokine mRNA expression in GDVII, DA and H101 strains of TMEV infection. Keystone Symposia on Molecular and Cellular Biology, Infections of the Nervous System: Host-Pathogen Interactions, Taos, New Mexico, March 9-14, p. 26.

14. Tsunoda I, Kuang L-Q, Theil DJ and Fujinami RS. (1999). Chronic progressive EAE induced with MOG peptide, possible role of NK1.1+ T cell and Th2-type immune response. Keystone Symposia on Molecular and Cellular Biology, Effects of Inflammation in the CNS, Taos, New Mexico, March 9-14, p. 58.

15. Tsunoda I, Cannon TS and Fujinami RS. (1999). Splenic autoreactive cytotoxic response in Theiler’s murine encephalomyelitis virus (TMEV) infection. American Society for Virology, 18th Annual Meeting, University of Massachusetts, Amherst, Massachusetts, July 10-14, pp. 79.

16. Theil DJ, Tsunoda I, Rodriguez F, Whitton JL and Fujinami RS. (2000). Viruses can silently prime and trigger autoimmune disease. 2000 FASEB Summer Research Conferences, Neural Immune Interactions in Injury and Disease: Pathways to Therapy. Copper Mountain, Colorado, June 18-23.

17. Theil DJ, Tsunoda I, Rodriguez F, Whitton JL and Fujinami RS. (2000). Viruses can silently prime for autoimmune CNS disease. Third International Symposium on NeuroVirology 2000, San Francisco, California, September 14-16, 2000. J NeuroVirol. 6 (5): 436.

18. Theil DJ, Tsunoda I, Rodriguez F, Whitton JL and Fujinami RS. (2001). Virus infections that protect against or silently prime and trigger autoimmune disease. Keystone Symposium on Molecular and Cellular Biology: Molecular Aspects of Viral Immunity, Keystone, Colorado April 17-22.

19. Tsunoda I, Kuang L-Q, Libbey JE and Fujinami RS. (2002). Axonal injury heralds demyelination in Theiler’s murine encephalomyelitis virus infection, animal model for multiple sclerosis. American Society for Microbiology, 102nd General Meeting, Salt Lake City, Utah, May 19-23.

20. Libbey JE, Tsunoda I and Fujinami RS. (2002). Use of a BHK-21 cell mutant resistant to infection with Theiler’s murine encephalomyelitis virus to search for the receptor. American Society for Microbiology, 102nd General Meeting, Salt Lake City, Utah, May 19-23.

21. Tsunoda I and Fujinami RS. (2002) Induction of autoreactive CD8+ cytotoxic T cells during Theiler’s murine encephalomyelitis virus infection: Implications for Autoimmunity. Fourth International Symposium on Neurovirology/Tenth Conference on Neuroscience of HIV Infection (Conjoint Meeting), Düsseldorf, Germany, June 19-22.

22. Tsunoda I, Libbey JE, Igenge IZM and Fujinami RS. (2003). Lesion development from the axon (inside) to the myelin (outside) in Theiler’s virus infection, Inside-Out model: Retrograde axonal transport of toxic lectin targets inflammatory demyelinating lesions to the site of Wallerian degeneration. Fifth International Symposium of NeuroVirology--HIV Molecular and Clinical Neuroscience Workshop, Baltimore, Maryland, September 2-6. J. NeuroVirol. 9 (Suppl 3): 34.

23. Terry EJ, Tsunoda I and Fujinami RS. (2004). Ultraviolet irradiation alters autoimmune responses leading to disease progression in an animal model for multiple sclerosis. 18th National Conference on Undergraduate Research (NCUR), Indianapolis, Indiana, April 15-27, p. 40-41.

24. Fujinami RS and Tsunoda I. (2004). VP1 of TMEV is required for the generation of autoreactive T cells. American Society for Microbiology, 104th General Meeting, New Orleans, Louisiana, May 23-27.

25. Fujinami RS, Theil DJ, Tsunoda I, Jones MV and Whitton JL. (2004). Viruses Can Silently Prime or Protect and/or Trigger CNS Autoimmune Disease. 12th International Congress of Immunology and 4th Annual Conference of FOCIS, Montreal, Canada, July 18-23.

26. Fujinami RS. Theil DJ, Tsunoda I, Jones MV and Whitton JL. Viruses can silently prime and trigger CNS autoimmune disease. 6th International Symposium on NeuroVirology. Sardina, Italy, September 10-14, 2004. J. NeuroVirol. 10 (Suppl 3): 47-48, 2004

27. Peterson LK, Tsunoda I, Masaki T and Fujinami RS. (2004). Generation and characterization of natural autoantibodies in an animal model for multiple sclerosis. FASEB Summer Research Conferences. Neuro-Immune Interactions: Physiological and Pathological Relevance. Tucson, Arizona, August 7-12.

28. Tsunoda I, Tanaka T, Terry EJ and Fujinami RS. (2005). Is the lack of axonal injury in C57BL/Wlds mice beneficial or detrimental in animal models for multiple sclerosis? Central Nervous System Inflammation: Mechanisms, Consequences and Therapeutic Strategies. Keystone Symposium, Snowbird, Utah, January 11-15.

29. Kobayashi-Warren M, Tsunoda I, Kuang L-Q, Libbey JE and Fujinami RS. (2005). Interferon-γ ELISPOT assay for delineation of epitope specificity of autoreactive cytotoxic T cell clones and hybridomas established from Theiler’s virus infection. Central Nervous System Inflammation: Mechanisms, Consequences and Therapeutic Strategies. Keystone Symposium, Snowbird, Utah, January 11-15.

30. Peterson LK, Tsunoda I, Tanaka T, Masaki T and Fujinami RS. (2005). Polyreactivity, lymphocytotoxicity and CNS disease modulation by two MOG92-106 monoclonal antibodies. Central Nervous System Inflammation: Mechanisms, Consequences and Therapeutic Strategies. Keystone Symposium, Snowbird, Utah, January 11-15.

31. Carlson NG, Hill KE, Tsunoda I, Fujinami RS and Rose JW. (2005). Dying oligodendrocytes express COX-2 in Theiler’s virus infection, an animal model for MS. American Academy of Neurology, Miami Beach, Florida, April 9-16, 2005. Neurology 64 (6) Suppl 1: A84.

32. Tsunoda I, Libbey JE, Kobayashi-Warren M and Fujinami RS. (2005). TMEV infection leading to demyelination: Role for CD8+ autoreactive T cells. Third International Conference on Polyomaviruses and Human Diseases: Basic and Clinical Perspectives. Providence, Rhode Island, September 11-14, J. NeuroVirol. 11 (Suppl 2): 17

33. Smith MCP, Tanaka T, Kirkman NJ, McCoy LL, Tsunoda I and Fujinami RS. (2005). A novel infections animal model for seizure disorders. American Neurological Association 130th Annual Meeting. September 25-28, San Diego, California, Ann. Neurol. 58 (6).

34. Tsunoda I. Contrasting roles of axonal degeneration in autoimmune versus viral models for MS. (2006). The 2006 Consortium of Multiple Sclerosis Centers Annual Meeting. Scottsdale, Arizona, May 31-June 3.

35. Tsunoda I, Tanaka T, Saijoh Y, Doyle SE, Terry EJ and Fujinami RS. (2006). Axonal transport of toxic lectin from the PNS targets inflammatory demyelinating lesions to sites of Wallerian degeneration in the CNS in Theiler’s virus infection: Lesion development from the axon (inside) to the myelin (outside). The 8th International Congress of Neuroimmunology, October 16-19, Nagoya, Japan. J. Neuroimmunol. 178 (Suppl 1): 73.

36. Fujinami RS, McCoy LL, Tsunoda I and Whitton JL. (2006). Viral infection and neurological diseases. The 8th International Congress of Neuroimmunology, October 16-19, Nagoya, Japan. J. Neuroimmunol. 178 (Suppl 1): 11.

37. Hasanovic F, Tsunoda I, Morrey JD, Siddharthan V and Fujinami RS. (2007). Detection of West Nile virus antigen in the brain using immunohistochemistry. UCUR 2007, February 2, Salt Lake City, Utah. UCUR 2007, abstract book, p. 96.

38. Tsunoda I, Tanaka T, Taniguchi M, Hasanovic F and Fujinami RS. (2008). Roles of CD1d-restricted V14+ NKT cells in Theiler’s virus infection, a viral model for multiple sclerosis. The 95th American Association of Immunologist (AAI) Annual Meeting at Experimental Biology 2008, San Diego, California, April 5-9, 2008. FASEB J. 22: 856.6.

39. Tsunoda I, Tanaka T, Hasanovic F and Fujinami RS. (2008). Axonal degeneration as a self-destructive defense mechanism against neurotropic virus infection. American Society for Investigative Pathology (ASIP) Annual Meeting at Experimental Biology 2008, San Diego, California, April 5-9. FASEB J. 22: 59.9.

40. Tsunoda I, Carlson NG, Rojas M, Hasanovic F and Rose JW. (2008). Treatment with a red wine component, resveratrol, in a virus-induced murine model for multiple sclerosis. World Congress on Treatment and Research in Multiple Sclerosis (WCTRIMS), ACTRIMS + ECTRIMS + LACTRIMS. Montreal, Canada, September 17-20. Mult. Scler. 14 (Suppl 1): S91.
Modern Medicine article.

41. Tsunoda I, Rose JW, Rojas M, Hasanovic F and Carlson NG. (2008). Treatment of an animal model for multiple sclerosis with resveratrol, a natural compound in red wine. 9th International Congress of NeuroImmunology. Forth Worth, Texas, October 26-30. J. Neuroimmunol. 203 (2): 247.
雑誌"M.S. Circle of Friends Journal" Nov – Dec 2008 p13.に記事が掲載されました。

42. Tsunoda I, Carlson NG, Wood BL, Hasanovic F and Rose JW. (2009). Possible neural protection by a red wine component, resveratrol, in a viral model for multiple sclerosis. Keystone Symposium Multiple Sclerosis. Santa Fe, New Mexico, January 21-26, p78.

43. Fujinami RS and Tsunoda I. (2009). Viral infection of the CNS leads to CD8+ T cells with dual specificities to virus and self. Keystone Symposium Multiple Sclerosis. Santa Fe, New Mexico, January 21-26, p59.

44. Fujinami RS and Tsunoda I. (2009). Viral infection leads to CD8+ T cells with dual specificities to virus and self. The 9th International Symposium on NeuroVirology. Miami Beach, Florida, June 2-6, J. NeuroVirol. 15 (Suppl 1): p29-30.

45. Tsunoda I, Carlson NG, Wood BL, Hasanovic F and Rose JW. (2009). Possible neuroprotection by a red wine component, resveratrol, in CNS neurotropic virus infection. The 9th International Symposium on NeuroVirology. Miami Beach, Florida, June 2-6, J. NeuroVirol. 15 (Suppl 1): p100.

46. Tsunoda I, Carlson NG, Kirkman NJ, Doty DJ Saijoh Y and Rose JW. (2009). Inflammation, demyelination, neurodegeneration, and neuroprotection in the pathogenesis of a viral model for multiple sclerosis. A joint symposium supported by High-Tech Research Center Grant and Japan Health Sciences Foundation International Research Grant on Animal Models for Human Diseases. Izumisano, Osaka, Japan, June 13.

47. Sato F, Carlson NG, Rose JW, Wood BL and Tsunoda I. (2009). Possible neuroprotection by a red wine component, resveratrol, in an animal model for multiple sclerosis. Neuroscience Research Day. The Shreveport Chapter of the Society for Neuroscience and the Department of Pharmacology, Toxicology, and Neuroscience. Louisiana State University Health Sciences Center, September 23, Shreveport, Louisiana.

48. Sato F, Carlson NG, Rose JW, Wood BL, Martinez NE and Tsunoda I. (2010). Neuroprotection and suppression of IL-17A and IFN-gamma production by resveratrol, a red wine component, in neurotropic CNS Theiler's virus Infection. 2010 Louisiana NCRR/IDeA Biomedical Research Symposium, January 22, Baton Rouge, Louisiana.

49. Sato F, Carlson NG, Rose JW, Minagar A and Tsunoda I. (2010). Possible neuroprotection and Th17 modulation by a red wine component, resveratrol, in a mouse model for multiple sclerosis, Theiler’s virus infection. 62nd American Academy of Neurology, April 10-17, Toronto, Canada. Neurology 74 (9) Suppl 2: A561.

50. Sato F, Martinez NE, Carlson NG, Rose JW and Tsunoda I. (2010). Resveratrol, a red wine component, exacerbated MOG-induced EAE. The 10th International Congress of Neuroimmunology, October 26-30, Barcelona, Spain. J. Neuroimmunol. 228 (1-2): 95-96.

51. Greenlee JE, Clawson SA, Hill KE, Wood BL, Tsunoda I, Carlson NG. (2010). Anti-Yo and anti-Hu antibodies affect different neuronal populations and induce cell death by different mechanisms in rat cerebellar slide cultures. The 10th International Congress of Neuroimmunology, October 26-30, Barcelona, Spain. J. Neuroimmunol. 228 (1-2): 189.

52. Sato F, Martinez NE, Omura S, Carlson NG, Rose JW and Tsunoda I. (2011). Resveratrol, a red wine component, exacerbated viral and autoimmune models for multiple sclerosis. Louisiana Biomedical Research Network (LBRN) 9th Annual Meeting, January 21-23, Shreveport, Louisiana.

53. Sato F, Martinez NE, Omura S, Carlson NG, Rose JW and Tsunoda I. (2011). Resveratrol, a red wine polyphenol component, exacerbated CNS inflammation in animal models for MS. Neuroscience Research Day. The Shreveport Chapter of the Society for Neuroscience and the Department of Pharmacology, Toxicology, and Neuroscience. Louisiana State University Health Sciences Center, March 18, Shreveport, Louisiana.

54. Omura S, Sato F, Martinez, NE, Kennett NJ, and Tsunoda I. (2011). Roles of Th1 and Th17 cells in autoimmune and viral models for relapsing-remitting versus progressive multiple sclerosis. 63rd Annual Meeting of the American Academy of Neurology, April 9-16. Honolulu Hawaii. Neurology 76 (9) Suppl 4: A40.

55. Sato F, Martinez NE, Omura S, Carlson NG, Rose JW and Tsunoda I. (2011). Resveratrol, a red wine polyphenol compound, exacerbated autoimmune and viral models for multiple sclerosis with increased central nervous system inflammation. The Consortium of Multiple Sclerosis Centers (CMSC) Annual Meeting, June 1-4, Montreal, Canada. Int. J. MS Care 13 (Suppl 3):15.

56. Omura S, Sato F, Martinez, NE, and Tsunoda I. (2011). Is MS a homogenous or heterogenous disease? Insight from Th1 and Th17 cytokines in autoimmune and viral models for relapsing-remitting versus primary progressive multiple sclerosis. The Consortium of Multiple Sclerosis Centers (CMSC) Annual Meeting, June 1-4, Montreal, Canada. Int. J. MS Care 13 (Suppl 3):13-14.

57. Martinez, NE, Karlsson F, Sato F, Omura S, Grisham MB, and Tsunoda I. (2011). Regulatory T cells play a detrimental role in a viral model for multiple sclerosis. The Consortium of Multiple Sclerosis Centers (CMSC) Annual Meeting, June 1-4, Montreal, Canada. Int. J. MS Care 13 (Suppl 3):14.

58. Alexander JS, Ganta CV, Orr AW, Funk S, Yurdagul A, Cromer W, Mathis JM, Erdreich-Epstein A, Nagra RM, Minagar A, Tsunoda I, Sato F, Martinez N, and Omura S. (2011). Ephrin/Eph receptor expression on brain microvascular endothelial cells and microparticles: regulation by inflammatory cytokines. BrainPET2011. XXVth International Symposium on Cerebral Blood Flow, Metabolism and Function and the Xth International Conference on Quantification of Brain Function with PET. May 24-28, Barcelona, Spain.

59. Sato F, Martinez NE, Omura S, Alexander JS, and Tsunoda I. (2011). Curdlan, a Th17 cell inducer, was both detrimental and protective in Theiler's virus infection. The International Union of Microbiological Societies (IUMS).. XV International Congress of Virology, September 6-16, Sapporo, Japan.

60. Martinez, NE, Karlsson F, Sato F, Omura S, Grisham MB, and Tsunoda I. (2011). Regulatory T cells play a detrimental role in a viral model for multiple sclerosis. The International Union of Microbiological Societies (IUMS). XV International Congress of Virology, September 6-16, Sapporo, Japan.
ルイジアナ州立大学医学部月報 On the Insideの2011年11月号で紹介されました。

61. Sato F, Martinez NE, Omura S, Alexander JS, and Tsunoda I. (2011). Effect of curdlan, a Th17 cell inducer, on a viral model for multiple sclerosis. The 23rd Annual Meeting of the Japanese Society for Neuroimmunology, September 15-17, Tokyo, Japan, p80.

62. Omura S, Sato F, Martinez NE, Kennett NJ, Alexander JS, Tsunoda I. (2011). System biology analysis of microarray data from animal models for relapsing-remitting versus primary progressive multiple sclerosis. The 23rd Annual Meeting of the Japanese Society for Neuroimmunology, September 15-17, Tokyo, Japan, p67.

63. Martinez, NE, Karlsson F, Sato F, Omura S, Grisham MB, and Tsunoda I. (2011). Contrasting roles of regulatory T cells in the Theiler’s virus model for multiple sclerosis. Regulatory T cells play a detrimental role in a viral model for multiple sclerosis. Southeast Regional IDeA Meeting, September 22-24, 2011, New Orleans, Louisiana.

64. Sato F, Martinez NE, Omura S, Alexander JS, and Tsunoda I. Curdlan, a Th17 cell inducer, plays contrasting roles in Theiler's virus infection. Southeast Regional IDeA Meeting, September 22-24, 2011, New Orleans, Louisiana.

65. Martinez, NE, Karlsson, F, Sato F, Omura S, Minagar A, Grisham MB, and Tsunoda I. (2011). Regulatory T cells play contrasting roles in a viral model for multiple sclerosis. The American Neurological Association (ANA) 136th Annual Meeting, September 25-27, 2011, San Diego, California. Ann Neurol 70 (Suppl 15): S90-1. iPoster

66. Tsunoda I, Omura S, Sato F, Martinez NE, Karlsson F, Grisham MB, Chaitanya GV, Alexander JS. (2011). Theiler’s virus infection: Animal models for multiple sclerosis and myocarditis. American Society for Microbiology (ASM) South Central Branch Annual Meeting, December 2-3, 2011, Monroe, Louisiana.

67. Sato F, Omura S, Martinez NE, Chaitanya GV, Alexander JS, Tsunoda I. (2011). Role of Toll-like receptor (TLR)4 in a viral model for myocarditis. American Society for Microbiology (ASM) South Central Branch Annual Meeting, December 2-3, 2011, Monroe, Louisiana.

68. Sato F, Martinez E, Omura S, Alexander S, Minagar A and Tsunoda I. (2012). Curdlan, a Th17 cell inducer, plays contrasting roles in viral model for multiple sclerosis. 64th Annual Meeting of the American Academy of Neurology, April 21-28. New Orleans, Louisiana.

69. Omura S, Sato F, Martinez NE, Kawai E, Trutschl M, Cvek U and Tsunoda I. (2012). Bioinformatics analysis of microarray data in cardiomyocytes and neuronal cells infected with Theiler’s virus. NIH, NIGMS Fourth Biennial National IDeA Symposium of Biomedical Research Excellence (NISBRE). June 25 – 27, 2012, Washington, DC.

70. Martinez NE, Sato F, Omura S, Kawai E, Takahashi S, Yoh K and Tsunoda I. (2012). Th17 bias renders mice susceptible to virus-induced demyelinating disease. NIH, NIGMS Fourth Biennial National IDeA Symposium of Biomedical Research Excellence (NISBRE). June 25 – 27, 2012, Washington, DC.

71. Rollyson P, Tsunoda I, Omura S Trutschl M and Cvek U. (2012). Combining visualization with data mining for bioinformatics-driven discovery. NIH, NIGHS Fourth Biennial National IDeA Symposium of Biomedical Research Excellence (NISBRE). June 25 – 27, 2012, Washington, DC.

72. Sato F, Omura S, Martinez NE, Kawai E, Chaitanya GV, Alexander JS and Tsunoda I. Detrimental role of Toll-like receptor 4 in cardiovirus-induced myocarditis. American Heart Association (AHA), Basic Cardiovascular Sciences (BCVS) 2012 Scientific Sessions. July 23-26, 2012. New Orleans, Louisiana.

73. Kawai E, Omura S, Sato, F, Martinez NE, Chaitanya GV, Claycomb WC, Alexander JS and Tsunoda I. (2012). Chemokine and autophagy-related genes in novel in vivo and in vitro models for viral myocarditis. American Heart Association (AHA), Basic Cardiovascular Sciences (BCVS) 2012 Scientific Sessions. July 23-26, 2012. New Orleans, Louisiana.

74. Omura S, Sato F, Martinez NE, Chaitanya GV, Claycomb WC, Alexander JS and Tsunoda I. (2012). Upregulation of chemokines and interferon-associated genes in a novel model for myocarditis induced by cardiovirus infection. 31st Annual Meeting of the American Society for Virology (ASV). July 21-25, 2012. Madison, Wisconsin. Scientific Program & Abstracts, p144.

75. Greenlee JE, Clawson S, Wood B, Hill K, Tsunoda I, and Carlson NG. (2013). Comparative uptake and cytotoxicity of anti-Hu and anti-Ri antibodies in rat cerebellar slice cultures. American Academy of Neurology 65th Annual Meeting, March 16-23, 2013, San Diego, California. Neurology 80 (Suppl): P02.161.

76. Omura S, Sato F, Kawai E, Martinez NE, Pearson SF, Rollyson P, Cvek U, Trutschl M and Tsunoda I. (2013). Computational analysis of microarray gene expression patterns discriminates the acute viral versus subacute immune phases of myocarditis induced by cardiovirus. 32nd Annual Meeting of the American Society for Virology (ASV). July 20-24, 2013. State College, Pennsylvania.

77. Sato F, Omura S, Martinez NE, Kawai E, Pearson SF, Fernando V, Acharya MM, C.V. Ganta CV, Alexander JS, Ajuebour MN, Taniguchi M, and Tsunoda I. (2013). Natural Killer T Cells Play Protective Roles in Cardiovirus-Induced Myocarditis by Induction of Anti-Viral and Regulatory Cytokines. American Heart Association (AHA), Basic Cardiovascular Sciences (BCVS) 2013 Scientific Sessions. July 22-25, 2013. Las Vegas, Nevada.

78. Kawai E, Omura S, Sato F, Martinez NE, Fernando V, Rollyson P, Cvek U, Trutschl M, and Tsunoda I. (2013). Determination of Phase-specific Biomarkers of Viral Myocarditis Induced by Theiler’s virus Using Multivariate Analyses of Viral Genome, Troponin, Transcriptome and Echocardiography Data. American Heart Association (AHA), Basic Cardiovascular Sciences (BCVS) 2013 Scientific Sessions. July 22-25, 2013. Las Vegas, Nevada.

79. Al-Kofahi M, Alexander JS, Woolard M, Tsunoda I, Wang Y, Boktor M, Jordan PA, Sheth A, Zawieja DC, Muthuchamy M, von der Weid P-Y, Ostanin D, Pinto K, Becker F. (2014). IL-1β inhibits contraction of intestinal lymphatic smooth muscle - Implications for chronic gut inflammation. Digestive Disease Weak (DDW) 2014, May 3-6, 2014. Chicago, Illinois. Gastroenterology 146 (5, Suppl 1): S830.

80. Shafiei F, Omura S, Kawai E, Sato F, Martinez NE, Fernando V, Morris L, Alexander JS, Cvek U, Trutschl M, Tsunoda I. (2014). Computational multivariate analyses for phase-specific biomarker identification in novel in vivo and in vitro viral myocarditis models induced by cardiovirus. 63rd Annual Scientific Session & Expo of the American College of Cardiology (ACC.14). March 29-31, 2014. Washington, DC. J Am Coll Cardiol, 63(12 Suppl): A971.

81. Greenlee JE, Clardy SL, Clawson SA, Wood B, Hill KE, Tsunoda I, Carlson NG. (2014). Specificity of antibody binding in anti-Yo antibody mediated Purkinje cell cytotoxicity. 139th Annual Meeting, American Neurological Association (ANA), October 12-14, Baltimore, Maryland. Ann Neurol 76 (Suppl 18), S78, 2014

82. Omura S, Cvek U, Trutschl M, Sato F, Martinez NE, Kawai E, Fernando V, Morris LA, Acharya M, Shafiei F, Alexander JS and Tsunoda I. (2014). Brain biomarkers and spleen surrogate markers for primary progressive MS models. International Workshop and Oral Presentation: MS Model 1, the 55th Annual Meeting of the Japanese Society of Neurology. May 21-24, 2014. Fukuoka, Japan.

83. Martinez NE, Sato F, Omura S, Kawai E, Takahashi S, Yoh K and Tsunoda I. (2014). Th17 biased transgenic mice show exacerbation of an autoimmune model for MS. International Workshop and Oral Presentation: MS Model 1, the 55th Annual Meeting of the Japanese Society of Neurology. May 21-24, 2014. Fukuoka, Japan.

84. Sato F, Fernando V, Omura S, Martinez NE, Kawai E, Shafiei F, Acharya MM, Takahashi S, Yoh K and Tsunoda I. (2014). Autoimmune and viral models of MS in Th2-biased GATA3 transgenic mice. International Workshop and Oral Presentation: MS Model 1, the 55th Annual Meeting of the Japanese Society of Neurology. May 21-24, 2014. Fukuoka, Japan.

85. Tsunoda I, Martinez NE, Omura S, Kawai E and Sato F. (2014). Inside-Out model of multiple sclerosis: Theiler’s virus infection. International Workshop and Oral Presentation: MS Model 2, the 55th Annual Meeting of the Japanese Society of Neurology. May 21-24, 2014. Fukuoka, Japan.

86. Omura S, Sato F, Kawai E, Martinez NE, Cvek U, Trutschl M, Alexander JS and Tsunoda I. (2014). Phase-specific cardiac biomarkers and blood surrogate markers for a mouse model of myocarditis induced by cardiovirus. 33rd Annual Meeting of the American Society for Virology (ASV). June 21-25, 2014. Fort Collins, Colorado. Scientific Program & Abstracts, p161. 87. Greenlee JE, Clardy SL, Clawson SA, Wood B, Hill KE, Tsunoda I, and Carlson NG. (2014). Specificity of antibody binding in anti-Yo antibody mediated Purkinje cell cytotoxicity. 139th Annual Meeting, American Neurological Association (ANA), October 12-14, Baltimore, Maryland. Ann Neurol 76 (Suppl 18), S78, 2014

88. Becker F, Witte M, Boktor M, Tsunoda I, Jordan PA, Bernas M, Abreo F, Orr AW, and Alexander JS (2015). Reduced intestinal leukocyte exit heightens the severity of DSS colitis in a murine model of lymphovascular deficiency. Digestive Disease Week (DDW) 2015, May 16-19, 2015. Washington DC. Gastroenterology 148 (4, Suppl 1): S-721.

89. Al-Kofahi M, Becker F, Wagn Y, Tsunoda I, Woolard MD, Jordan PA, Boktor M, and Alexander JS (2015). IL-1 receptor antagonist (Anakinra) restores mesenteric lymphatic muscle cell tonic contractility suppressed by acute or chronic colitis conditioned media in vitro. Digestive Disease Week (DDW) 2015, May 16-19, 2015. Washington DC. Gastroenterology 148 (4, Suppl 1): S-693.

90. Stevenson EV, Yun JW, Omura S, Sato F, Tsunoda I, Minagar A, Becker F, Castor T, Couraud P-O, Romero IA, Weksler B, Alexander JS. (2015). Fluid dynamic influences on Cerebrovascular endothelial activation responses. 5th Annual Meeting of the International Society for Neurovascular Disease (ISNDV), March 27-29, Naples, Italy. Program Book, p22.

91. Yun JW, Stevenson E, Omura S, Sato F, Tsunoda I, Minagar A, Becker F, Castor T, Xiao A, Alexander JS. (2015). Endothelial dysfunction in neurodegenerative disease. 5th Annual Meeting of the International Society for Neurovascular Disease (ISNDV), March 27-29, Naples, Italy. Program Book, p29.

92. Sato F, Kawai E, Martinez NE, Omura S, Cliburn EA, Takahashi S, Yoh K, and Tsunoda I. (2015). Th1 transcription factor T-bet, but not the Th2 transcription factor GATA3, overexpression is detrimental in neurotropic viral infection in the CNS. 34th Annual Meeting of the American Society for Virology (ASV). July 11-15, 2015. London, Ontario, Canada.

93. Sato F, Kawai E, Martinez NE, Omura S, Stewart EC, Takahashi S, Yoh K, and Tsunoda I. (2015). Th1/Th2 imbalance by “gain-of-function” mutations cause fatal Theiler’s virus infection in mice. 2015 Southeast Regional IDeA Meeting. November 11-13, 2015. Biloxi, Mississippi.

VI. 招待講演

1. XIIth International Congress of Neuropathology. “A comparative study on acute and chronic diseases induced by two subgroups of Theiler's murine encephalomyelitis viruses (TMEV).” Toronto, Canada, September 18-23, 1994.

2. Keystone Symposia on Molecular and Cellular Biology, Cell Biology of Virus Entry, Replication and Pathogenesis. “Apoptosis as a possible mechanism for elimination of virus infected cells from the central nervous system leading to demyelinating disease.” Santa Fe, New Mexico, February 10-16, 1996.

3. Biology of Neurologic Disease Meeting, Society for Experimental Neuropathology. “Apoptosis in Theiler's murine encephalomyelitis virus (TMEV) infection and experimental allergic encephalomyelitis (EAE).” Miami, Florida, October 12-13, 1996.

4. The Fifth International Symposium on Positive Strand RNA Viruses. “Enhancement of Theiler’s murine encephalomyelitis virus (TMEV) infection by immunization with plasmid DNA.” St. Petersburg, Florida, May 23-28, 1998.

5. Fukushima Medical University School of Medicine. “Exacerbation of viral and autoimmune models for multiple sclerosis by bacterial DNA.” Fukushima, Japan, April 19, 1999.
福島医科大学医学部神経内科学講座
 山本 悌司教授に招待していただきました.

6. Keystone Symposium on Molecular and Cellular Biology: Effects of Inflammation in the CNS. “Chronic progressive EAE induced with MOG peptide: Possible role of NK1.1+ T cell and Th2-type immune response.” Taos, New Mexico, March 9-14, 1999.

7. American Society for Virology, 18th Annual Meeting. “Splenic autoreactive cytotoxic response in Theiler’s murine encephalomyelitis virus (TMEV) infection.” University of Massachusetts, Amherst, Massachusetts, July 10-14, 1999.

8. American Society for Microbiology, 102nd General Meeting. “Axonal injury heralds demyelination in Theiler’s murine encephalomyelitis virus infection, animal model for multiple sclerosis.” Salt Lake City, Utah, May 19-23, 2002.

9. Fifth International Symposium of NeuroVirology--HIV Molecular and Clinical Neuroscience Workshop. “Lesion development from the axon (inside) to the myelin (outside) in Theiler’s virus infection, Inside-Out model: Retrograde axonal transport of toxic lectin targets inflammatory demyelinating lesions to the site of Wallerian degeneration.” Baltimore, Maryland, September 2-6, 2003.

10. Iwate Medical College. Neuroscience seminar. “Inside-Out versus Outside-In models for virus induced demyelination: Axonal damage triggering demyelination.” Morioka, Iwate, Japan November 18, 2004.
岩手医科大学医学部薬理学講座 平 英一教授に招待していただきました.平教授は、角田の東北大学医学部の同級生で、ユタ大学訪問の時は招待講演をしていただきました。

11. Fukushima Medical University School of Medicine. “Axonal injury in animal models of multiple sclerosis.” Fukushima, Fukushima, Japan, November 22, 2004.
福島医科大学医学部神経内科学講座 山本 悌司教授に招待していただきました.

12. Tohoku University School of Medicine. “Retrograde axonal transport of toxic lectin targets inflammatory demyelinating lesions to the site of Wallerian degeneration.” Sendai, Miyagi, Japan, November 25, 2004.
東北大学医学部免疫学講座 菅村 和夫教授に招待していただきました.

13. Multiple Sclerosis Update. “The Inside out model of multiple sclerosis.” Salt Lake City, UT, May 20-21, 2005

14. Fukushima Medical University School of Medicine. ”Autoreactive cytotoxic CD8+ T cells in Theiler’s murine encephalomyelitis virus infection” Fukushima, Fukushima, Japan, November, 17, 2005
福島医科大学医学部神経内科学講座 山本 悌司教授に招待していただきました.

15. Molecular Medical Science Institute, Otsuka Pharmaceutical Co. Ltd. “Multiple Sclerosis and Axon Injury.” Tokushima, Tokushima, November 21, 2005.

16. Kinki University School of Medicine. “Axonal injury in multiple sclerosis: Inside-Out model.” Osaka-Sayama, Osaka, November 22, 2005.
近畿大学医学部神経内科学講座 楠 進教授に招待していただきました. 楠教授が、ユタ州ソルトレークシティに学会参加された際に、グレート・ソルトレークを案内させていただきましたが、その時の写真などは楠先生のブログを参照ください。

17. The 2006 Consortium of Multiple Sclerosis Centers Annual Meeting. “Contrasting roles of axonal degeneration in autoimmune versus viral models for MS.” Scottsdale, AZ, May 31-June3, 2006.

18. Iwate Medical College. “Autoimmune Cytotoxic CD8+ T cells in Theiler’s Murine Encephalomyelitis Virus Infection.” Morioka, Iwate, Japan October 10, 2006.
岩手医科大学医学部薬理学講座 平 英一教授に招待していただきました.平教授は、角田の東北大学医学部の同級生で、ユタ大学訪問の時は招待講演をしていただきました。

19. The 8th International Congress of Neuroimmunology. “Axonal transport of toxic lectin from the PNS targets inflammatory demyelinating lesions to sites of Wallerian degeneration in the CNS in Theiler’s virus infection: Lesion development from the axon (inside) to the myelin (outside).” October 16-19, 2006, Nagoya, Japan.

20. The Brain Institute, The University of Utah, Multiple Sclerosis Research in Utah. “Does axonal degeneration precede demyelination in MS? An Inside-Out model.” Salt Lake City, Utah, October 18, 2007.

21. Hokkaido University. “Contrasting roles of axonal degeneration in virus infection and autoimmune disease. Animal models for multiple sclerosis and post-polio syndrome.” Sapporo, Hokkaido, Japan. October 24, 2007.
北海道大学人獣共通感染症リサーチセンター 分子病態・診断部門 澤 洋文教授に招待していただきました.

22. Second Institute of New Drug Discovery, Otsuka Pharmaceutical Co., Ltd. “Can axonal degeneration be beneficial or detrimental in an autoimmune versus viral model of multiple sclerosis?” Tokushima, Tokushima, Japan. October 30, 2007.

23. Kinki University Medical Association. “Axonal degeneration in viral and autoimmune models for multiple sclerosis. ” Osaka-Sayama, Osaka, Japan. October 21, 2007.
近畿大学医学部細菌学講座 義江 修教授に招待していただきました.

24. The 13th Neuroscience Seminar, The Juzen Medical Society Kanazawa University. “Contrasting roles of axonal degeneration in viral and autoimmune models for multiple sclerosis.” Kanazawa, Ishikawa, Japan. November 6, 2007.
金沢大学大学院 医学系研究科 脳医科学専攻  脳病態医学講座 脳老化・神経病態学講座 山田 正仁教授に招待していただきました.

25. American Society for Investigative Pathology (ASIP) Annual Meeting at Experimental Biology 2008. “Axonal degeneration as a self-destructive defense mechanism against neurotropic virus infection.” San Diego, California, April 5-9, 2008.

26. Institut Pasteur of Shanghai, Chinese Academy of Sciences. “Can axonal degeneration be beneficial or detrimental in neurotropic virus infection and autoimmune encephalitis?” Shanghai, China. June 2, 2008.

27. The University of Cincinnati, Neurology Grand Rounds “Axonal degeneration in viral and autoimmune models for multiple sclerosis: Inside-Out model.” Cincinnati, Ohio, January 14, 2009.
イシュトバン・ピルコ教授Dr. Istvan Pirko, MD, (現職 メーヨークリニック神経内科教授)に招待していただきました。

28. Tohoku University Graduate School of Medicine. “Axonal degeneration in neurotropic virus infection.” Sendai, Miyagi, Japan, January 27, 2009.PDF
東北大学医学部免疫学講座 菅村 和夫教授に招待していただきました.

29. Hiroshima University School of Medicine. “Compartmental neurodegeneration as a protection mechanism against neurotropic virus infection.” Hiroshima, Hiroshima, Japan, January 29, 2009.

30. Kinki University School of Medicine. “Autoimmune cytotoxic CD8+ T cells in Theiler’s virus infection.” Osaka-Sayama, Osaka, Japan, January 30, 2009.
近畿大学医学部免疫学教室 宮澤 正顯教授に招待していただきました.

31. The 483rd Brain Institute Conference, Kyushu University School of Medicine. ”Axonal degeneration in viral and autoimmune models for multiple sclerosis: Inside-Out model.” Hakata, Hukuoka, Japan, February 2, 2009.
九州大学医学部神経内科学講座 吉良 潤一教授に招待していただきました.

32. Louisiana State University Health Sciences Center. “Axonal degeneration as a self-destructive defense mechanism against neurotropic virus.” Shreveport, Louisiana, February 10, 2009.

33. High-Tech Research Center Grant and Japan Health Sciences Foundation International Research Grant on Animal Models for Human Diseases. “Inflammation, demyelination, neurodegeneration, and neuroprotection in the pathogenesis of a viral model for multiple sclerosis.” Izumisano, Osaka, Japan, June 13, 2009.
第18回翠嶂会(京極方久東北大学名誉教授の同門会)が平成21年 6月13日(土)、大阪で開催されましたが、その折に、開かれた合同シンポジウムで、招待講演をさせていただきました。私は、この時期、ユタ大学からルイジアナ州立大学に移籍する直前でありましたが、来日は、近畿大学医学部免疫学教室 宮澤 正顯教授の御招待により実現いたしました.

34. Research Institute of Environmental Medicine, Nagoya University. “Axonal degeneration in animal models for multiple sclerosis: Inside-Out model.” Nagoya, Aich, Japan, June 15, 2009.
名古屋大学大学院医学系研究科神経免疫学(環境医学研究所) 錫村 明生教授に招待していただきました.

35. Tohoku Medical Society. “Axonal degeneration in viral and autoimmune models for multiple sclerosis: Inside-Out model.” Sendai, Miyagi, Japan June 18, 2009.
東北医学会特別講演会 神経化学分野 堂浦克美教授に招待していただきました

36. The University of Basel. "Genetic Approaches in Medical Research" lecture series. ”Axonal degeneration in autoimmune and viral models for multiple sclerosis: Inside-Out model.” Basel, Switzerland, October 22, 2010.
臨床神経免疫学講座 Tobias Derfuss教授に角田郁生の招待講演を主催していたできました。 PDF.

37. 第330回つくば分子生命科学セミナー “多発性硬化症自己免疫モデルとウイルスモデルの軸索変性に対する赤ワイン成分の一つであるレスベラトロールの効果” Tsukuba Society for Molecular Medicine/TSMM, 筑波大学 2011年9月11日.
高橋智教授主催: PDF. 

38. 北海道大学保健科学セミナー. “多発性硬化症の自己免疫モデルとウイルスモデルにおける軸索変性の果たす役割 Inside-Out モデル” 北海道大学大学院保健科学研究院. 2011年9月12日. PDF
堤 香織 博士にセミナーを主催していただきました

39. 旭川医科大学講演。 “Resveratrol, a red wine component, exacerbates autoimmune and viral models for multiple sclerosis.” 内科学講座 消化器・血液腫瘍制御内科学分野(第3内科) 2011年9月13日.
 主催高後裕教授、田中宏樹先生

40. South Central Branch American Society for Microbiology (ASM) Annual Meeting. “Theiler’s virus infection: Animal models for multiple sclerosis and myocarditis.” Monroe, Louisiana, December 2, 2011.

41. テキサス工科大学医学部 Biomedical Sciences Biomedical Seminar Series. “Theiler’s virus infection: Animal models for multiple sclerosis and myocarditis.” Lubbock, Texas, November 14-16, 2013.

42. 近畿大学医学会 “The role of Th17 and regulatory T cells in viral and autoimmune models for multiple sclerosis. ” Osaka-Sayama, Osaka, Japan. May 19, 2014.

43. International Workshop and Oral Presentation: MS Model 2, 第55会日本神経学会学術大会 “Inside-Out model of multiple sclerosis: Theiler’s virus infection.” Fukuoka, Japan, May 21-24, 2014.


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